Ovarian Cancer

Find an Ovarian Cancer Specialist

At Houston Methodist Cancer Center, our gynecologic oncology specialists use a team-based approach to screen, diagnose and treat ovarian cancer. We provide advanced cancer care at seven locations across the Greater Houston area, allowing you or your loved one to receive treatment close to home or work.

Why Choose Houston Methodist for Ovarian Cancer Treatment

Our specialists, nurses and staff coordinate your cancer care in a compassionate, supportive environment that is supported by a team-based approach and research.


The benefits of choosing our ovarian cancer care team include:

  • Expert oncologists who work together to develop a treatment plan tailored to your specific type of ovarian cancer and unique lifestyle needs
  • Advanced diagnostics and treatment options, including hyperthermic (heated) intraoperative peritoneal chemotherapy (HIPEC)
  • Oncology nurse navigators who guide you through your cancer care — from diagnosis through survivorship
  • Support through and beyond your recovery


Our experts are also dedicated to ovarian cancer research, enabling us to improve present and future cancer care.

Access to Cutting-Edge Clinical Trials Close to Home

Our physicians support numerous cancer-specific clinical trials, meaning you may have access to new and potentially promising treatments that aren't available elsewhere.

About Ovarian Cancer

What Causes Ovarian Cancer?

While the exact cause of ovarian cancer is unknown, this cancer is linked to several risk factors, including:

  • Age – most common in women ages 50 to 60
  • Inherited gene mutations – breast cancer gene 1 (BRCA1), breast cancer gene 2 (BRCA2) and gene mutations that cause Lynch syndrome, which is also associated with colon cancer, increase a person's risk
  • Estrogen hormone replacement therapy
  • Starting menstruation early (before age 12) or beginning menopause late (after age 52)
  • Never being pregnant
  • Receiving fertility treatment
  • Smoking
  • Using intrauterine devices
  • Polycystic ovarian disease (POCD)


Keep in mind that having one or more risk factors does not mean you will definitely develop ovarian cancer, and having no risk factors does not mean you won't develop it.

What Are the Types of Ovarian Cancer?

Ovarian cancer occurs when cells within, near or on the ovaries grow out of control. There are three main types, which are distinguished by where exactly the cancer begins.


Ovarian cancer types include:

  • Epithelial tumors – accounting for most ovarian cancers, these begin in the tissue covering the outside of the ovaries
  • Stromal tumors – begin in the ovarian tissue that contains hormone-producing cells
  • Germ cell tumors – begin in the egg-producing cells


What Are the Symptoms of Ovarian Cancer?

Ovarian cancer symptoms include:

  • Abdominal bloating or swelling
  • Quickly feeling full when eating
  • Weight loss
  • Pelvic discomfort
  • Bowel habit changes, such as constipation
  • Frequent need to urinate
  • Nausea, indigestion, gas, constipation or diarrhea
  • Persistent fatigue
  • Pain during sex
  • Menstrual changes

Keep in mind that these symptoms can also indicate conditions other than ovarian cancer. If you are experiencing any of these symptoms, contact your doctor as soon as possible so the cause can be diagnosed and treated promptly.


About 20% of ovarian cancers are found at an early stage. When ovarian cancer is detected early at a localized stage, about 94% of patients live longer than five years after diagnosis.

How Is Ovarian Cancer Diagnosed?

If you are experiencing symptoms of ovarian cancer, your doctor will first ask you some questions and perform a pelvic exam to look for signs, such as an enlarged ovary or fluid in the abdomen, which is called ascites.


If your doctor suspects ovarian cancer, he or she may recommend the following diagnostic tests:

  • Blood tests – performed to check the level of several substances in your blood, including a cancer antigen called CA-125.
  • Ultrasound – uses sound waves to visualize organs inside the pelvis. For a better view of the ovaries, a small, lubricated probe (a transducer) may be inserted into the vagina for a test called a transvaginal ultrasound.
  • Computed tomography (CT) scan – uses X-rays to create cross-sectional pictures inside the body. CT scans may not show smaller ovarian tumors, but they can detect whether a larger tumor is growing into nearby structures or whether lymph nodes are enlarged.
  • Biopsy – tissue and fluid are removed from the pelvis and abdomen so that a pathologist can more closely examine it for the presence of cancer.

What Ovarian Cancer Treatment Options Are Available?

At Houston Methodist, we are dedicated to providing leading-edge diagnosis and treatment options for ovarian cancer. Depending on the type and stage of the cancer, your care team may use one or more of the following ovarian cancer treatment options:


Surgery for Ovarian Cancer

Surgery is the primary treatment for most ovarian cancers.


The goal of ovarian cancer surgery is to remove as much of the tumor as possible, a process called debulking. This procedure may involve removing one or more of the following organs:

  • One or both ovaries
  • The uterus and both fallopian tubes
  • Fatty tissue in the lower abdominal area that connects, covers and protects organs, called omentum
  • Pelvic and para-aortic lymph nodes
  • Any other tumor-bearing area, including a portion of the small or large intestine, appendix or spleen


For early-stage ovarian cancer, minimally invasive surgical techniques can sometimes be used, as well as fertility-sparing procedures in some cases.


Chemotherapy for Ovarian Cancer

Chemotherapy kills cancer cells using drugs that are given intravenously by IV or orally. With ovarian cancer, chemotherapy is most commonly used to destroy any cancer cells that may remain after surgery. In some cases, chemotherapy may be given before surgery to help shrink the tumor and make it easier to remove.


Hyperthermic (Heated) Intraoperative Peritoneal Chemotherapy (HIPEC) for Ovarian Cancer

HIPEC delivers heated chemotherapy directly into the abdomen during surgery. It's used to treat advanced ovarian cancer that has spread to the abdominal cavity lining, such as to the appendix, colon and stomach.


Radiation Therapy for Ovarian Cancer

Radiation therapy uses high-energy rays to kill cancer cells in a targeted, specific area. It is seldom used in the initial treatment of ovarian cancer, but may be used to relieve pain and other problems caused by advanced disease.

Lynnsey Tirey — Ovarian Cancer Survivor

Lynnsey’s normal, healthy life was upended by a fast-growing, leaking ovarian cyst that was later identified as cancer. She started six months of chemotherapy the day after her 32nd birthday. Lynnsey says her doctor and his staff, as well as her infusion nurses, became part of her family. She believes her doctor saved her life.

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