Showing 1-10 of 38 "Heart and Blood Diseases"

Status: Enrolling

Investigator: Dipan Shah

Study Coordinator: Nadia Alsalih

Phone: 713.441.3576

This study is designed to evaluate the efficacy of Dotarem enhanced MRI compared to Magnevist and Gadavist enhanced MRI in identifying myocardial infarct. Eighty patients will be recruited for this study. Patients with known CAD and undergoing c ... Read more >

Status: Open Not Enrolling

Investigator: Barry Trachtenberg

Study Coordinator: Arati Bhosale

Phone: 713.441.3910

This is a phase 2b, Multicenter, Randomize, Double –blind, placebo-controlled, parallel group study to evaluate the efficacy, safety, and tolerability of transendocardial injection of IXMYELOCEL-T in subjects with heart failure due to ischemic d ... Read more >

Status: Enrolling

Investigator: Alpesh Shah

Study Coordinator: Wesley Oglesby

Phone: 713.441.2788

A Clinical Evaluation of Absorb™ BVS, the Everolimus Eluting Bioresorbable Vascular Scaffold in the Treatment of Subjects with de novo Native Coronary Artery Lesions This is a prospective, randomized, single-blind, multi-center trial, conducte ... Read more >

Status: Enrolling

Investigator: Brian Bruckner

Study Coordinator: Deborah Barr

Phone: 713.441.3916

This study is evaluating the effectiveness of PleuraFlow System Active Clearance Technology (ACT) in the management of blood evacuation. The Pleuraflow System ACT is a guided wire with a distal loop that rests at the end of a chest tube. The sys ... Read more >

Status: Enrolling

Investigator: Arvind Bhimaraj

Study Coordinator: Arati Bhosale

Phone: 713.441.3910

The objective of this registry is to observe short and long term clinical outcomes in heart transplant recipients who receive regular AlloMap testing as part of allograft rejection surveillance ... Read more >

Status: Open Not Enrolling

Investigator: Byron Ellis

Study Coordinator: Sheila Moore

Phone: 713.441.3250

Current patterns of P2Y12 receptor inhibitor use provide an excellent opportunity to test the impact of copayment reduction on clinician choice of medication, patient adherence, and clinical outcomes. The ARTEMIS trial is a practical multicenter ... Read more >

Status: Enrolling

Investigator: Richard Klucznik

Study Coordinator: Bhavin Shah

Phone: 832.279.5111

.The primary objective of this study is to demonstrate effectiveness and safety of the NeuroForm Atlas stent system for use with bare metal embolic coils ... Read more >

Status: Enrolling

Investigator: Colin Barker

Study Coordinator: Amber Jacobs

Phone: 713.441.3905

The objective of this study is to assess the safety and efficacy of the Orsiro Sirolimus Eluting Coronary Stent System in the treatment of subjects with up to three native de novo or restenotic (standard PTCA only) coronary artery lesions compar ... Read more >

Status: Open Not Enrolling

Investigator: Neal Kleiman

Study Coordinator: Meagan Griffith

Phone: 318.560.8370

This is a prospective, randomized, parallel-controlled, multicenter clinical evaluation of the MitraClip device for the treatment of clinically significant functional mitral regurgitation in symptomatic subjects too high risk to undergo mitral v ... Read more >

Status: Open Not Enrolling

Investigator: Alpesh Shah

Study Coordinator: Mary Mata

Phone: 713.441.5981

This is a prospective, multi-center, non-randomized, single arm clinical trial that will be conducted at up to 40 sites in the United States and OUS. A minimum of 40% of total patients will be enrolled in the US. This study will enroll patient ... Read more >

Status: Enrolling

Investigator: Imran Mohiuddin

Study Coordinator: Sheila Moore

Phone: 713.441.3250

The objectives of this study are to collect post-market confirmatory evidence of the safety and effectiveness of the Bard® LifeStent® Vascular Stent System and LifeStent® XL Vascular Stent System (together the "LifeStent® Vascular Stent System") ... Read more >

Status: Enrolling

Investigator: Alan Lumsden

Study Coordinator: Kim Donlon

Phone: 713.441.9394

This prospective, multicenter, single-arm clinical study will further evaluate the safety and effectiveness of Cook's permanent and retrievable inferior vena cava (IVC) filters (specifically, the Günther Tulip® Vena Cava Filter and Cook Celect® ... Read more >

Status: Open Not Enrolling

Investigator: Neal Kleiman

Study Coordinator: LaShawna Green

Phone: 713.441.6548

The study is being done study to obtain data on the safety and performance of the Medtronic CoreValve® System. The Medtronic CoreValve® System has been developed to replace a diseased aortic heart valve without the need for open heart surgery. T ... Read more >

Status: Open Not Enrolling

Investigator: Neal Kleiman

Study Coordinator: LaShawna Green

Phone: 713.441.6548

The purpose of the study is to evaluate the safety and efficacy of the Medtronic CoreValve® System in the treatment of symptomatic severe aortic stenosis in subjects who have a predicted high risk for aortic valve surgery and/or very high risk f ... Read more >

Status: Enrolling

Investigator: Michael Reardon

Study Coordinator: LaShawna Green

Phone: 713.441.6548

The purpose of the study is to evaluate the safety and efficacy of the Medtronic CoreValve® System in the treatment of symptomatic severe aortic stenosis in subjects who have a predicted high risk for aortic valve surgery and/or very high risk f ... Read more >

Status: Enrolling

Investigator: Neal Kleiman

Study Coordinator: LaShawna Green

Phone: 713.441.6548

The primary objective of the study is to evaluate the safety and effectiveness of the Medtronic CoreValve® System (MCS) in a subset of subjects excluded from the U.S. Extreme Risk Pivotal Trial population due to one or more additional co-morbidi ... Read more >

Status: Open Not Enrolling

Investigator: Neal Kleiman

Study Coordinator: LaShawna Green

Phone: 713.441.6548

To evaluate the safety and efficacy of the CoreValve Evolut R System in patients with severe symptomatic aortic stenosis who are considered at high through extreme risk for surgical aortic valve replacement ... Read more >

Status: Enrolling

Investigator: David Chiu

Study Coordinator: Jason Lee

Phone: 713.394.6479

Carotid revascularization for primary prevention of stroke (CREST-2) is two independent multicenter, randomized controlled trials of carotid revascularization and intensive medical management versus medical management alone in patients with asym ... Read more >

Status: Open Not Enrolling

Investigator: Alpesh Shah

Study Coordinator: Mary Mata

Phone: 713.441.5981

To establish the safety and efficacy of the XIENCE PRIME or XIENCE V Everolimus Eluting Coronary Stent System (EECSS) in subjects with unprotected left main coronary artery disease by comparing to coronary artery bypass graft surgery ... Read more >

Status: Enrolling

Investigator: Alpesh Shah

Study Coordinator: Meagan Griffith

Phone: 318.560.8370

The purpose of this study is to determine whether Fractional flow reserve (FFR, (coronary pressure wire-based index for assessing the ischemic potential of a coronary lesion)-guided percutaneous coronary intervention (PCI) in patients with multi ... Read more >

Status: Open Not Enrolling

Investigator: Sherman Tang

Study Coordinator: Sheila Moore

Phone: 713.441.3250

In this part of the Registry Program patients with non-valvular atrial fibrillation (AF) at risk for stroke are enrolled to characterize the target population and to collect real world data on important outcome events. For administrative purpose ... Read more >

Status: Enrolling

Investigator: Sherif Nagueh

Study Coordinator: Christopher Mattair

Phone: 713.363.9956

Hypertrophic cardiomyopathy (HCM) is the most common monogenic heart disease and the most frequent cause of sudden cardiac death (SCD) in the young. It is characterized by unexplained left ventricular hypertrophy (LVH), diffuse and patchy fibros ... Read more >

Status: Enrolling

Investigator: Brian Bruckner

Study Coordinator: Deborah Barr

Phone: 713.441.3916

The MOMENTUM III Clinical Trial is designed to evaluate the safety and effectiveness of the HeartMate III Left Ventricular Assist System (LVAS) by demonstrating non-inferiority to the HeartMate II Left Ventricular Assist System when used for the ... Read more >

Status: Enrolling

Investigator: Brian Bruckner

Study Coordinator: Deborah Barr

Phone: 713.441.3916

atients will be approached to participate in this PAS after the HeartWare® Ventricular Assist System receives PMA approval for the indicated use as a bridge to cardiac transplantation. Patients who participated in prior trials will be approac ... Read more >

Status: Open Not Enrolling

Investigator: Alpesh Shah

Study Coordinator: Mary Mata

Phone: 713.441.5981

The purpose of this study is to evaluate acute and long term clinical and economic outcomes of endovascular procedures to treat Peripheral Arterial Disease (PAD) ... Read more >

Status: Open Not Enrolling

Investigator: Imran Mohiuddin

Study Coordinator: Sheila Moore

Phone: 713.441.3250

The purpose of this study is to evaluate acute and long term clinical and economic outcomes of endovascular procedures to treat Peripheral Arterial Disease (PAD). ... Read more >

Status: Enrolling

Investigator: Dipan Shah

Study Coordinator: Bevin Lopez

Phone: 713.441.6537

The American Diabetes Association estimates that 25.8 million individuals or 8.3% of the United States population have diabetes mellitus (DM). Individuals with diabetes have an increased risk for cardiovascular disease (CVD) and CVD events accou ... Read more >

Status: Enrolling

Investigator: Michael Reardon

Study Coordinator: Amber Jacobs

Phone: 713.441.3905

To evaluate the safety and effectiveness of the Model 400 bovine pericardial stented aortic bioprosthesis in a patient population undergoing surgical aortic valve replacement. The collected data will be used to support regulatory applications in ... Read more >

Status: Open Not Enrolling

Investigator: Miguel Valderrabano

Study Coordinator: Ramon Guardiola

Phone: 713.441.3958

This Continued Access Protocol is a prospective, non-randomized, multicenter study to allow continued access to the WATCHMAN LAA Closure Technology during the data analysis, reporting and review of the PREVAIL pivotal study Pre-Market Applicatio ... Read more >

Status: Enrolling

Investigator: Miguel Valderrabano

Study Coordinator: Michelle Prystash

Phone: 713.441.6564

The broad, long-term objective of this project is to evaluate the therapeutic value of vein of Marshall (VOM) ethanol infusion when added to catheter ablation of atrial fibrillation (AF). AF is the most common sustained arrhythmia in adults, and ... Read more >

Status: Open Not Enrolling

Investigator: Dipan Shah

Study Coordinator: Nadia Alsalih

Phone: 713.441.3576

This is a single center, open-label, pilot study in subjects scheduled for invasive coronary angiography for evaluation of coronary artery disease. The primary objective is to evaluate the profile of sensitivity, specificity, and diagnostic accu ... Read more >

Status: Enrolling

Investigator: Su Min Chang

Study Coordinator: Christopher Mattair

Phone: 713.363.9956

The aim of this study is to compare the image quality of the half radioisotope dose scans obtained using a CZT (cadmium zinc telluride) camera with scans acquired using a standard of care imaging protocol/radioisotope dose performed on a traditi ... Read more >

Status: Enrolling

Investigator: Neal Kleiman

Study Coordinator: LaShawna Green

Phone: 713.441.6548

The objective of this study is to evaluate the safety and effectiveness of the Lotus™ Valve System for transcatheter aortic valve replacement (TAVR) in symptomatic subjects with calcific, severe native aortic stenosis who are considered at extre ... Read more >

Status: Enrolling

Investigator: Neal Kleiman

Study Coordinator: LaShawna Green

Phone: 713.441.6548

The purpose of the study is to investigate the safety and efficacy of transcatheter aortic valve implantation (TAVI) in patients with severe, symptomatic Aortic Stenosis (AS) at intermediate surgical risk by randomizing patients to either Surgic ... Read more >

Status: Open Not Enrolling

Investigator: Jerry Estep

Study Coordinator: Arati Bhosale

Phone: 713.441.3910

This study will investigate the efficacy, safety, and tolerability of an oral dose of 20 mg or 80 mg tafamidis meglumine soft gel capsules in comparison to placebo and given once daily, in addition to standard of care, for 30 months in subjects ... Read more >

Status: Enrolling

Investigator: Stephen Little

Study Coordinator: Jeannie Arredondo

Phone: 713.441.3574

This study will create a registry of patient data associated with treatment provided at the Methodist DeBakey Heart & Vascular Center Valve Clinic. In the database, details of patients treated at the valve clinic will be entered, including pre-, ... Read more >

Status: Open Not Enrolling

Investigator: Alan Lumsden

Study Coordinator: Kim Donlon

Phone: 713.441.9394

The purpose of this trial is to determine if the Ventana Fenestrated Stent Graft System is safe and effective for the endovascular repair of juxtarenal or pararenal aortic aneurysms. ... Read more >

Status: Enrolling

Investigator: Alan Lumsden

Study Coordinator: Kim Donlon

Phone: 713.441.9394

The purpose of the Zenith® p-Branch® OTS Multicenter Study is to provide an early clinical experience and evaluate the safety and effectiveness of the Zenith® p-Branch® in the treatment of pararenal or juxtarenal abdominal aortic aneurysms (AAA) ... Read more >