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Tianfu Wu, PhD

Assistant Affiliate Member, Research Institute
Houston Methodist


Biography

Dr. Wu earned his Ph.D. in Chinese Academy of Sciences in 1999. He became an assistant affiliated member of Houston Methodist Research Institute in 2014. Dr. Wu is an assistant Professor of the Department of Biomedical Engineering at the University of Houston. Dr. Wu is an editorial member of the Journal of Data Mining in Genomics & Proteomics.

Description of Research

During the past years, Dr. Wu's research has primarily focused on biomarker discovery, disease mechanism and therapeutic intervention of autoimmune lupus. Lupus is a genetically complex autoimmune disease, where autoreactive B cells and T cells are hyperproliferative and hyperactive. Subsequently, high titers of autoantibodies are produced to form immune complex, and proinflammatory cytokines, chemokines and adhesion molecules are produced to form an environment of inflammation to promote end-organ damage, such as kidney damage. Lupus nephritis and related kidney diseases have become a considerable socioeconomic burden; however, there is no cure for these diseases. Apparently, there is an urgent need for the diagnosis and therapeutic intervention for these diseases. Research goals are:

-To discover early biomarker and non-invasive biomarkers of lupus nephritis
-To uncover signaling pathways that might be directly involved in the pathogenesis of inflammatory lupus
-To identify metabolic pathways associated with inflammatory kidney diseases

Areas Of Expertise

Inflammation Autoimmune Metabolomic analysis Proteomics
Education & Training

PhD, Chinese Academy of Sciences
Postdoctoral Fellowship, Institut Pasteur Paris
Postdoctoral Fellowship, Max-Planck Institute of Bioinorganic Chemistry, Mulheim
Postdoctoral Fellowship, UT Southwestern Medical Center
Publications

Insulin-like growth factor binding proteins in autoimmune diseases
Ding, H & Wu, T 2018, Frontiers in Endocrinology, vol. 9, no. AUG, 499. DOI: 10.3389/fendo.2018.00499

Proteomic approaches for novel systemic lupus erythematosus (SLE) drug discovery
Li, Y & Wu, T 2018, Expert Opinion on Drug Discovery, vol. 13, no. 8, pp. 765-777. DOI: 10.1080/17460441.2018.1480718

A Conductive Nanowire-Mesh Biosensor for Ultrasensitive Detection of Serum C-Reactive Protein in Melanoma
Lin, ZT, Li, Y, Gu, J, Wang, H, Zhu, Z, Hong, X, Zhang, Z, Lu, Q, Qiu, J, Wang, X, Bao, J & Wu, T 2018, Advanced Functional Materials, vol. 28, no. 31, 1802482. DOI: 10.1002/adfm.201802482

Autoantibodies as potential biomarkers in breast cancer
Qiu, J, Keyser, B, Lin, ZT & Wu, T 2018, Biosensors, vol. 8, no. 3, 67. DOI: 10.3390/bios8030067

Kissing Nevus of the Penis
Jiang, S, Chen, Y, Hinchliffe, TE, Wu, T & Stephen, T 2018, Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, vol. 28, no. 3, pp. S19-S20. DOI: 10.29271/jcpsp.2018.03.S19

Molecularly Imprinted Polymer-Based Biosensors
Lin, ZT, DeMarr, V, Bao, J & Wu, T 2018, IEEE Nanotechnology Magazine. DOI: 10.1109/MNANO.2017.2779718

Serum vascular endothelial growth factor receptor 3 as a potential biomarker in psoriasis
Hong, X, Jiang, S, Marmolejo, N, Vangipuram, R, Ramos-Rojas, E, Yuan, Y, Lin, ZT, Li, Y, Qiu, J, Xing, Y, Haley, C, Tyring, SK & Wu, T 2018, Experimental Dermatology. DOI: 10.1111/exd.13727

A Nanoparticle-Decorated Biomolecule-Responsive Polymer Enables Robust Signaling Cascade for Biosensing
Lin, ZT, Gu, J, Li, CH, Lee, TR, Xie, L, Chen, S, Cao, PY, Jiang, S, Yuan, Y, Hong, X, Wang, H, Wang, D, Wang, X, Jiang, GB, Heon, M & Wu, T 2017, Advanced Materials. DOI: 10.1002/adma.201702090

Protein arrays III: Reverse-phase protein arrays
Yuan, Y, Hong, X, Lin, ZT, Wang, H, Heon, M & Wu, T 2017, . in Methods in Molecular Biology. vol. 1654, Methods in Molecular Biology, vol. 1654, Humana Press, pp. 279-289. DOI: 10.1007/978-1-4939-7231-9_21

Protein arrays I: Antibody arrays
Yuan, Y, Lin, ZT, Wang, H, Hong, X, Heon, M & Wu, T 2017, . in Methods in Molecular Biology. vol. 1654, Methods in Molecular Biology, vol. 1654, Humana Press, pp. 261-269. DOI: 10.1007/978-1-4939-7231-9_19

Protein arrays II: Antigen arrays
Yuan, Y, Wang, H, Lin, ZT, Hong, X, Heon, M & Wu, T 2017, . in Methods in Molecular Biology. vol. 1654, Methods in Molecular Biology, vol. 1654, Humana Press, pp. 271-277. DOI: 10.1007/978-1-4939-7231-9_20

Immunosensors for Biomarker Detection in Autoimmune Diseases
Zhang, X, Zambrano, A, Lin, ZT, Xing, Y, Rippy, J & Wu, T 2016, Archivum Immunologiae et Therapiae Experimentalis, pp. 1-11. DOI: 10.1007/s00005-016-0419-5

Leukocyte beta-catenin expression is disturbed in systemic lupus erythematosus
Orme, JJ, Du, Y, Vanarsa, K, Wu, T, Satterthwaite, AB & Mohan, C 2016, PLoS ONE, vol. 11, no. 8, e0161682. DOI: 10.1371/journal.pone.0161682

Heightened cleavage of Axl receptor tyrosine kinase by ADAM metalloproteases may contribute to disease pathogenesis in SLE
Orme, JJ, Du, Y, Vanarsa, K, Mayeux, J, Li, L, Mutwally, A, Arriens, C, Min, S, Hutcheson, J, Davis, LS, Chong, BF, Satterthwaite, AB, Wu, T & Mohan, C 2016, Clinical Immunology, vol. 169, pp. 58-68. DOI: 10.1016/j.clim.2016.05.011

A Hydrogel-Based Hybrid Theranostic Contact Lens for Fungal Keratitis
Huang, JF, Zhong, J, Chen, GP, Lin, ZT, Deng, Y, Liu, YL, Cao, PY, Wang, B, Wei, Y, Wu, T, Yuan, J & Jiang, GB 2016, ACS Nano, vol. 10, no. 7, pp. 6464-6473. DOI: 10.1021/acsnano.6b00601

Identification of apoptosis and macrophage migration events in paraquat-induced oxidative stress using a zebrafish model
Wang, Q, Liu, S, Hu, D, Wang, Z, Wang, L, Wu, T, Wu, Z, Mohan, C & Peng, A 2016, Life Sciences, vol. 157, pp. 116-124. DOI: 10.1016/j.lfs.2016.06.009

Antibody-Array-Based Proteomic Screening of Serum Markers in Systemic Lupus Erythematosus: A Discovery Study
Wu, T, Ding, H, Han, J, Arriens, C, Wei, C, Han, W, Pedroza, C, Jiang, S, Anolik, J, Petri, M, Sanz, I, Saxena, R & Mohan, C 2016, Journal of Proteome Research, vol. 15, no. 7, pp. 2102-2114. DOI: 10.1021/acs.jproteome.5b00905

Protein arrays for biomarker discovery in lupus
Hinchliffe, TE, Lin, ZT & Wu, T 2016, Proteomics - Clinical Applications, vol. 10, no. 6, pp. 625-634. DOI: 10.1002/prca.201500060

Hyperamylasemia as an early predictor of mortality in patients with acute paraquat poisoning
Liu, S, Wang, Q, Zhou, R, Li, C, Hu, D, Xue, W, Wu, T, Mohan, C & Peng, A 2016, Medical Science Monitor, vol. 22, pp. 1342-1348. DOI: 10.12659/MSM.897930

Blockade of CD354 (TREM-1) Ameliorates Anti-GBM-Induced Nephritis
du, Y, Wu, T, Zhou, XJ, Davis, LS & Mohan, C 2016, Inflammation, pp. 1-8. DOI: 10.1007/s10753-016-0351-1