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Tianfu Wu, PhD

Assistant Affiliate Member, Research Institute
Houston Methodist


Biography

Dr. Wu earned his Ph.D. in Chinese Academy of Sciences in 1999. He became an assistant affiliated member of Houston Methodist Research Institute in 2014. Dr. Wu is an assistant Professor of the Department of Biomedical Engineering at the University of Houston. Dr. Wu is an editorial member of the Journal of Data Mining in Genomics & Proteomics.

Description of Research

During the past years, Dr. Wu's research has primarily focused on biomarker discovery, disease mechanism and therapeutic intervention of autoimmune lupus. Lupus is a genetically complex autoimmune disease, where autoreactive B cells and T cells are hyperproliferative and hyperactive. Subsequently, high titers of autoantibodies are produced to form immune complex, and proinflammatory cytokines, chemokines and adhesion molecules are produced to form an environment of inflammation to promote end-organ damage, such as kidney damage. Lupus nephritis and related kidney diseases have become a considerable socioeconomic burden; however, there is no cure for these diseases. Apparently, there is an urgent need for the diagnosis and therapeutic intervention for these diseases. Research goals are:

-To discover early biomarker and non-invasive biomarkers of lupus nephritis
-To uncover signaling pathways that might be directly involved in the pathogenesis of inflammatory lupus
-To identify metabolic pathways associated with inflammatory kidney diseases

Areas Of Expertise

Inflammation Autoimmune Metabolomic analysis Proteomics
Education & Training

PhD, Chinese Academy of Sciences
Postdoctoral Fellowship, Institut Pasteur Paris
Postdoctoral Fellowship, Max-Planck Institute of Bioinorganic Chemistry, Mulheim
Postdoctoral Fellowship, UT Southwestern Medical Center
Publications

Glucose-modification of cisplatin to facilitate cellular uptake, mitigate toxicity to normal cells, and improve anti-cancer effect in cancer cells
Quan, L, Lin, Z, Lin, Y, Wei, Y, Lei, L, Li, Y, Tan, G, Xiao, M & Wu, T 2020, Journal of Molecular Structure, vol. 1203, 127361. https://doi.org/10.1016/j.molstruc.2019.127361

Curcumin attenuates both acute and chronic immune nephritis
Wu, T, Marakkath, B, Ye, Y, Khobahy, E, Yan, M, Hutcheson, J, Zhu, J, Zhou, X & Mohan, C 2020, International journal of molecular sciences, vol. 21, no. 5, 1745. https://doi.org/10.3390/ijms21051745

Elevated oxidized lipids, anti-lipid autoantibodies and oxidized lipid immune complexes in active SLE
Ye, Y, Wu, T, Zhang, T, Han, J, Habazi, D, Saxena, R & Mohan, C 2019, , Clinical Immunology, vol. 205, pp. 43-48. https://doi.org/10.1016/j.clim.2019.05.004

A BODIPY biosensor to detect and drive self-assembly of diphenylalanine
Quan, L, Gu, J, Lin, W, Wei, Y, Lin, Y, Liu, L, DIng, H, Pan, C, Xie, Z & Wu, T 2019, Chemical Communications, vol. 55, no. 59, pp. 8564-8566. https://doi.org/10.1039/c9cc03810h

Identification of Novel Autoantibodies Associated With Psoriatic Arthritis
Yuan, Y, Qiu, J, Lin, ZT, Li, W, Haley, C, Mui, UN, Ning, J, Tyring, SK & Wu, T 2019, , Arthritis and Rheumatology. https://doi.org/10.1002/art.40830

Discovery of IgG4 Anti-Gliadin Autoantibody as a Potential Biomarker of Psoriasis Using an Autoantigen Array
Qiu, J, Yuan, Y, Li, Y, Haley, C, Mui, UN, Swali, R, Mohan, C, Tyring, SK & Wu, T 2019, Proteomics - Clinical Applications. https://doi.org/10.1002/prca.201800114

Relationship between serum bilirubin levels s and the progression of renal function in patients with chronic kidney disease and hyperuricemia
Li, M, Li, X, Liu, Y, Liu, X, Song, Y, Zhao, J, Mohan, C, Wu, T, Peng, A & Qin, L 2018, , Clinica Chimica Acta, vol. 486, pp. 156-161. https://doi.org/10.1016/j.cca.2018.07.045

Constructing 3D and Flexible Plasmonic Structure for High-Performance SERS Application
Li, C, Yu, J, Xu, S, Jiang, S, Xiu, X, Chen, C, Liu, A, Wu, T, Man, B & Zhang, C 2018, , Advanced Materials Technologies, vol. 3, no. 11, 1800174. https://doi.org/10.1002/admt.201800174

Insulin-like growth factor binding proteins in autoimmune diseases
Ding, H & Wu, T 2018, , Frontiers in Endocrinology, vol. 9, no. AUG, 499. https://doi.org/10.3389/fendo.2018.00499

SERS substrate based on the flexible hybrid of polydimethylsiloxane and silver colloid decorated with silver nanoparticles
Guo, Y, Yu, J, Li, C, Li, Z, Pan, J, Liu, A, Man, B, Wu, T, Xiu, X & Zhang, C 2018, , Optics Express, vol. 26, no. 17, pp. 21784-21796. https://doi.org/10.1364/OE.26.021784

Proteomic approaches for novel systemic lupus erythematosus (SLE) drug discovery
Li, Y & Wu, T 2018, , Expert Opinion on Drug Discovery, vol. 13, no. 8, pp. 765-777. https://doi.org/10.1080/17460441.2018.1480718

A Conductive Nanowire-Mesh Biosensor for Ultrasensitive Detection of Serum C-Reactive Protein in Melanoma
Lin, ZT, Li, Y, Gu, J, Wang, H, Zhu, Z, Hong, X, Zhang, Z, Lu, Q, Qiu, J, Wang, X, Bao, J & Wu, T 2018, , Advanced Functional Materials, vol. 28, no. 31, 1802482. https://doi.org/10.1002/adfm.201802482

Autoantibodies as potential biomarkers in breast cancer
Qiu, J, Keyser, B, Lin, ZT & Wu, T 2018, , Biosensors, vol. 8, no. 3, 67. https://doi.org/10.3390/bios8030067

Kissing Nevus of the Penis
Jiang, S, Chen, Y, Hinchliffe, TE, Wu, T & Stephen, T 2018, Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, vol. 28, no. 3, pp. S19-S20. https://doi.org/10.29271/jcpsp.2018.03.S19

Molecularly Imprinted Polymer-Based Biosensors
Lin, ZT, DeMarr, V, Bao, J & Wu, T 2018, IEEE Nanotechnology Magazine. https://doi.org/10.1109/MNANO.2017.2779718

Serum vascular endothelial growth factor receptor 3 as a potential biomarker in psoriasis
Hong, X, Jiang, S, Marmolejo, N, Vangipuram, R, Ramos-Rojas, E, Yuan, Y, Lin, ZT, Li, Y, Qiu, J, Xing, Y, Haley, C, Tyring, SK & Wu, T 2018, , Experimental Dermatology. https://doi.org/10.1111/exd.13727

Protein arrays II: Antigen arrays
Yuan, Y, Wang, H, Lin, ZT, Hong, X, Heon, M & Wu, T 2017, . in Methods in Molecular Biology. vol. 1654, Methods in Molecular Biology, vol. 1654, Humana Press, pp. 271-277. https://doi.org/10.1007/978-1-4939-7231-9_20

Protein arrays I: Antibody arrays
Yuan, Y, Lin, ZT, Wang, H, Hong, X, Heon, M & Wu, T 2017, . in Methods in Molecular Biology. vol. 1654, Methods in Molecular Biology, vol. 1654, Humana Press, pp. 261-269. https://doi.org/10.1007/978-1-4939-7231-9_19

Protein arrays III: Reverse-phase protein arrays
Yuan, Y, Hong, X, Lin, ZT, Wang, H, Heon, M & Wu, T 2017, . in Methods in Molecular Biology. vol. 1654, Methods in Molecular Biology, vol. 1654, Humana Press, pp. 279-289. https://doi.org/10.1007/978-1-4939-7231-9_21

Development and validation of an impedance biosensor for point-of-care detection of vascular cell adhesion molecule-1 toward lupus diagnostics
Selvam, AP, Wangzhou, A, Jacobs, M, Wu, T, Mohan, C & Prasad, S 2017, , Future Science OA, vol. 3, no. 3, FSO224. https://doi.org/10.4155/fsoa-2017-0047