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Thomas A. Kent, MD

Adjunct Professor of Neurology, Academic Institute
Full Affiliate Member, Research Institute
Houston Methodist


Biography

Dr. Thomas Kent is a neurologist and clinician scientist with a basic, translational and clinical research program, focused mostly on stroke and other brain injuries. He currently works at the Texas A&M Health Science Center-Houston Campus in the Institute of Biosciences and Technology and as Associate Dean for the Engineering Medical School. 

Areas Of Expertise

Stroke Neurology Neurological disease Brain
Publications

Pervasive Genomic Damage in Experimental Intracerebral Hemorrhage: Therapeutic Potential of a Mechanistic-Based Carbon Nanoparticle
Dharmalingam, P, Talakatta, G, Mitra, J, Wang, H, Derry, PJ, Nilewski, LG, McHugh, EA, Fabian, RH, Mendoza, K, Vasquez, V, Hegde, PM, Kakadiaris, E, Roy, T, Boldogh, I, Hegde, VL, Mitra, S, Tour, JM, Kent, TA & Hegde, M 2020, ACS Nano, vol. 14, no. 3, pp. 2827-2846. https://doi.org/10.1021/acsnano.9b05821

Use of a bioengineered antioxidant in mouse models of metabolic syndrome
Griffin, DM, Bitner, BR, Criss, Z, Marcano, D, Berlin, JM, Kent, TA, Tour, JM, Samson, SL & Pautler, RG 2020, Expert Opinion on Investigational Drugs, vol. 29, no. 2, pp. 209-219. https://doi.org/10.1080/13543784.2020.1716216

Revisiting the intersection of amyloid, pathologically modified tau and iron in Alzheimer's disease from a ferroptosis perspective
Derry, PJ, Hegde, ML, Jackson, GR, Kayed, R, Tour, JM, Kent, TA & Tsa, A-L 2020, Progress in Neurobiology, vol. 184, 101716, pp. 101716. https://doi.org/10.1016/j.pneurobio.2019.101716

Functional and Structural Improvement with a Catalytic Carbon Nano-Antioxidant in Experimental Traumatic Brain Injury Complicated by Hypotension and Resuscitation
Mendoza, K, Derry, PJ, Cherian, LM, Garcia, R, Nilewski, L, Goodman, JC, Mbye, L, Robertson, CS, Tour, JM & Kent, TA 2019, Journal of Neurotrauma, vol. 36, no. 13, pp. 2139-2146. https://doi.org/10.1089/neu.2018.6027

Endovascular equipoise shift in a phase III randomized clinical trial of sonothrombolysis for acute ischemic stroke
for the CLOTBUST-ER Trial Investigators 2019, Therapeutic Advances in Neurological Disorders, vol. 12. https://doi.org/10.1177/1756286419860652

Catalytic oxidation and reduction reactions of hydrophilic carbon clusters with NADH and cytochrome C: Features of an electron transport nanozyme
Derry, PJ, Nilewski, LG, Sikkema, WKA, Mendoza, K, Jalilov, A, Berka, V, McHugh, EA, Tsai, AL, Tour, JM & Kent, TA 2019, Nanoscale, vol. 11, no. 22, pp. 10791-10807. https://doi.org/10.1039/c9nr00807a

Highly Oxidized Graphene Quantum Dots from Coal as Efficient Antioxidants
Nilewski, L, Mendoza, K, Jalilov, AS, Berka, V, Wu, G, Sikkema, WKA, Metzger, A, Ye, R, Zhang, R, Luong, DX, Wang, T, McHugh, E, Derry, PJ, Samuel, EL, Kent, TA, Tsai, AL & Tour, JM 2019, ACS Applied Materials and Interfaces, vol. 11, no. 18, pp. 16815-16821. https://doi.org/10.1021/acsami.9b01082

Pooled analysis suggests benefit of catheter-based hematoma removal for intracerebral hemorrhage
Mandava, P, Murthy, SB, Shah, N, Samson, Y, Kimmel, M & Kent, TA 2019, Neurology, vol. 92, no. 15, pp. e1688-e1697. https://doi.org/10.1212/WNL.0000000000007269

Safety and efficacy of sonothrombolysis for acute ischaemic stroke: a multicentre, double-blind, phase 3, randomised controlled trial
CLOTBUST-ER Trial Investigators 2019, The Lancet Neurology, vol. 18, no. 4, pp. 338-347. https://doi.org/10.1016/S1474-4422(19)30026-2

Telemedicine in Prehospital Acute Stroke Care: An Expanding Infrastructure for Treatment and Research
Derry, PJ, Mandava, P & Kent, TA 2019, Journal of the American Heart Association, vol. 8, no. 6, e012259. https://doi.org/10.1161/JAHA.119.012259

Critical Comparison of the Superoxide Dismutase-like Activity of Carbon Antioxidant Nanozymes by Direct Superoxide Consumption Kinetic Measurements
Wu, G, Berka, V, Derry, PJ, Mendoza, K, Kakadiaris, E, Roy, T, Kent, TA, Tour, JM & Tsai, AL 2019, ACS Nano. https://doi.org/10.1021/acsnano.9b04229

Rho Guanine Nucleotide Exchange Factor ARHGEF17 Is a Risk Gene for Intracranial Aneurysms
Yang, X, Li, J, Fang, Y, Zhang, Z, Jin, D, Chen, X, Zhao, Y, Li, M, Huan, L, Kent, TA, Dong, JF, Jiang, R, Yang, S, Jin, L, Zhang, J, Zhong, TP & Yu, F 2018, Circulation. Genomic and precision medicine, vol. 11, no. 7, pp. e002099. https://doi.org/10.1161/CIRCGEN.117.002099

Efficacy of novel carbon nanoparticle antioxidant therapy in a severe model of Reversible middle cerebral artery stroke in acutely hyperglycemic rats
Fabian, RH, Derry, PJ, Rea, HC, Dalmeida, WV, Nilewski, LG, Sikkema, WKA, Mandava, P, Tsai, AL, Mendoza, K, Berka, V, Tour, JM & Kent, TA 2018, , Frontiers in Neurology, vol. 9, no. APR, 199. https://doi.org/10.3389/fneur.2018.00199

RIP1K Contributes to Neuronal and Astrocytic Cell Death in Ischemic Stroke via Activating Autophagic-lysosomal Pathway
Ni, Y, Gu, WW, Liu, ZH, Zhu, YM, Rong, JG, Kent, TA, Li, M, Qiao, SG, An, JZ & Zhang, HL 2018, , Neuroscience, vol. 371, pp. 60-74. https://doi.org/10.1016/j.neuroscience.2017.10.038

Inability of positive phase II clinical trials of investigational treatments to subsequently predict positive phase III clinical trials in glioblastoma
Mandel, JJ, Yust-Katz, S, Patel, AJ, Cachia, D, Liu, DI, Park, M, Yuan, Y, Kent, TA & De Groot, JF 2018, , Neuro-oncology, vol. 20, no. 1, pp. 113-122. https://doi.org/10.1093/neuonc/nox144

Correlating quantitative susceptibility mapping with cognitive decline in Alzheimer's disease
Derry, PJ & Kent, TA 2017, , Brain, vol. 140, no. 8, pp. 2069-2072. https://doi.org/10.1093/brain/awx167

Sevoflurane postconditioning attenuates reactive astrogliosis and glial scar formation after ischemia–reperfusion brain injury
Zhu, YM, Gao, X, Ni, Y, Li, W, Kent, TA, Qiao, SG, Wang, C, Xu, XX & Zhang, HL 2017, , Neuroscience, vol. 356, pp. 125-141. https://doi.org/10.1016/j.neuroscience.2017.05.004

Emotion dysregulation as an underlying mechanism of impulsive aggression: Reviewing empirical data to inform treatments for veterans who perpetrate violence
Miles, SR, Sharp, C, Tharp, AT, Stanford, MS, Stanley, M, Thompson, KE & Kent, TA 2017, , Aggression and Violent Behavior, vol. 34, pp. 147-153. https://doi.org/10.1016/j.avb.2017.01.017

Perylene Diimide as a Precise Graphene-like Superoxide Dismutase Mimetic
Jalilov, AS, Nilewski, LG, Berka, V, Zhang, C, Yakovenko, AA, Wu, G, Kent, TA, Tsai, AL & Tour, JM 2017, , ACS Nano, vol. 11, no. 2, pp. 2024-2032. https://doi.org/10.1021/acsnano.6b08211

Inhibition of autophagy blocks cathepsins-tBid-mitochondrial apoptotic signaling pathway via stabilization of lysosomal membrane in ischemic astrocytes
Zhou, XY, Luo, Y, Zhu, YM, Liu, ZH, Kent, TA, Rong, JG, Li, W, Qiao, SG, Li, M, Ni, Y, Ishidoh, K & Zhang, HL 2017, , Cell Death and Disease, vol. 8, no. 2, e2618. https://doi.org/10.1038/cddis.2017.34