Thomas A. Kent

Thomas A. Kent, MD

Adjunct Professor of Neurology, Academic Institute
Full Affiliate Member, Research Institute
Houston Methodist


Biography

Dr. Thomas Kent is a neurologist and clinician scientist with a basic, translational and clinical research program, focused mostly on stroke and other brain injuries. He currently works at the Texas A&M Health Science Center-Houston Campus in the Institute of Biosciences and Technology and as Associate Dean for the Engineering Medical School. 

Areas Of Expertise

Stroke Neurology Neurological disease Brain
Publications

Blood pressure excursions in acute ischemic stroke patients treatedwith intravenous thrombolysis
Tsivgoulis, G, Katsanos, AH, Mandava, P, Kohrmann, M, Soinne, L, Barreto, AD, Sharma, VK, Mikulik, R, Muir, KW, Rothlisberger, T, Grotta, JC, Levi, CR, Molina, CA, Saqqur, M, Mavridis, D, Psaltopoulou, T, Vosko, MR, Fiebach, JB, Sandset, EC, Kent, TA, Alexandrov, AW, Schellinger, PD & Alexandrov, AV 2021, , Journal of Hypertension, vol. 39, no. 2, pp. 266-272. https://doi.org/10.1097/HJH.0000000000002628

The Key Regulator of Necroptosis, RIP1 Kinase, Contributes to the Formation of Astrogliosis and Glial Scar in Ischemic Stroke
Zhu, YM, Lin, L, Wei, C, Guo, Y, Qin, Y, Li, ZS, Kent, TA, McCoy, CE, Wang, ZX, Ni, Y, Zhou, XY & Zhang, HL 2021, , Translational Stroke Research. https://doi.org/10.1007/s12975-021-00888-3

The Chemical Basis of Intracerebral Hemorrhage and Cell Toxicity With Contributions From Eryptosis and Ferroptosis
Derry, PJ, Vo, ATT, Gnanansekaran, A, Mitra, J, Liopo, AV, Hegde, ML, Tsai, AL, Tour, JM & Kent, TA 2020, , Frontiers in Cellular Neuroscience, vol. 14, 603043. https://doi.org/10.3389/fncel.2020.603043

Manage Emotions to Reduce Aggression: A Pilot Study of a Brief Treatment to Help Veterans Reduce Impulsive Aggression
Miles, SR, Kent, TA, Stanley, M, Thompson, KE, Sharp, C, Niles, BL, Young-Mccaughan, S, Mintz, J, Roache, JD, Litz, BT, Hale, WJ, Stanford, MS, Keane, TM & Peterson, AL 2020, , Journal of Nervous and Mental Disease, vol. 208, no. 11, pp. 897-903. https://doi.org/10.1097/NMD.0000000000001229

Oxidized Activated Charcoal Nanoparticles as Catalytic Superoxide Dismutase Mimetics: Evidence for Direct Participation of an Intrinsic Radical
Wu, G, McHugh, EA, Berka, V, Chen, W, Wang, Z, Beckham, JL, Derry, PJ, Roy, T, Kent, TA, Tour, JM & Tsai, AL 2020, , ACS Applied Nano Materials, vol. 3, no. 7, pp. 6962-6971. https://doi.org/10.1021/acsanm.0c01285

Pervasive Genomic Damage in Experimental Intracerebral Hemorrhage: Therapeutic Potential of a Mechanistic-Based Carbon Nanoparticle
Dharmalingam, P, Talakatta, G, Mitra, J, Wang, H, Derry, PJ, Nilewski, LG, McHugh, EA, Fabian, RH, Mendoza, K, Vasquez, V, Hegde, PM, Kakadiaris, E, Roy, T, Boldogh, I, Hegde, VL, Mitra, S, Tour, JM, Kent, TA & Hegde, M 2020, , ACS Nano, vol. 14, no. 3, pp. 2827-2846. https://doi.org/10.1021/acsnano.9b05821

Use of a bioengineered antioxidant in mouse models of metabolic syndrome
Griffin, DM, Bitner, BR, Criss, Z, Marcano, D, Berlin, JM, Kent, TA, Tour, JM, Samson, SL & Pautler, RG 2020, , Expert Opinion on Investigational Drugs, vol. 29, no. 2, pp. 209-219. https://doi.org/10.1080/13543784.2020.1716216

Pulse pressure variability is associated with unfavorable outcomes in acute ischaemic stroke patients treated with intravenous thrombolysis
Katsanos, AH, Alexandrov, AV, Mandava, P, Köhrmann, M, Soinne, L, Barreto, AD, Sharma, VK, Mikulik, R, Muir, KW, Rothlisberger, T, Grotta, JC, Levi, CR, Molina, CA, Saqqur, M, Palaiodimou, L, Psaltopoulou, T, Vosko, MR, Moreira, T, Fiebach, JB, Rubiera, M, Sandset, EC, de Havenon, A, Kent, TA, Alexandrov, AW, Schellinger, PD & Tsivgoulis, G 2020, , European Journal of Neurology, vol. 27, no. 12, pp. 2453-2462. https://doi.org/10.1111/ene.14447

Acute and chronic mitochondrial electron transport chain dysfunction treatments and Graphenic materials for use thereof
Hegde, M, Hegde, PM, Mitra, J, Dharmalingam, P, Kent, TA, M. Tour, J & Derry, PJ, , Patent No. 18730149.4-1112.

Lone Star Stroke Consortium: A Collaborative State-Funded Model for Research
Grotta, JC, Anderson, JA, Brey, RL, Kent, TA, Hurn, PD, Goldberg, MP, Savitz, SI, Cruz-Flores, S & Warach, SJ 2020, , Stroke, pp. 3778-3786. https://doi.org/10.1161/STROKEAHA.120.031547

Critical Comparison of the Superoxide Dismutase-like Activity of Carbon Antioxidant Nanozymes by Direct Superoxide Consumption Kinetic Measurements
Wu, G, Berka, V, Derry, PJ, Mendoza, K, Kakadiaris, E, Roy, T, Kent, TA, Tour, JM & Tsai, AL 2019, , ACS Nano, vol. 13, no. 10, pp. 11203-11213. https://doi.org/10.1021/acsnano.9b04229

Revisiting the intersection of amyloid, pathologically modified tau and iron in Alzheimer's disease from a ferroptosis perspective
Derry, PJ, Hegde, ML, Jackson, GR, Kayed, R, Tour, JM, Kent, TA & Tsa, A-L 2020, , Progress in Neurobiology, vol. 184, 101716, pp. 101716. https://doi.org/10.1016/j.pneurobio.2019.101716

Functional and Structural Improvement with a Catalytic Carbon Nano-Antioxidant in Experimental Traumatic Brain Injury Complicated by Hypotension and Resuscitation
Mendoza, K, Derry, PJ, Cherian, LM, Garcia, R, Nilewski, L, Goodman, JC, Mbye, L, Robertson, CS, Tour, JM & Kent, TA 2019, , Journal of Neurotrauma, vol. 36, no. 13, pp. 2139-2146. https://doi.org/10.1089/neu.2018.6027

Endovascular equipoise shift in a phase III randomized clinical trial of sonothrombolysis for acute ischemic stroke
for the CLOTBUST-ER Trial Investigators 2019, , Therapeutic Advances in Neurological Disorders, vol. 12. https://doi.org/10.1177/1756286419860652

Catalytic oxidation and reduction reactions of hydrophilic carbon clusters with NADH and cytochrome C: Features of an electron transport nanozyme
Derry, PJ, Nilewski, LG, Sikkema, WKA, Mendoza, K, Jalilov, A, Berka, V, McHugh, EA, Tsai, AL, Tour, JM & Kent, TA 2019, , Nanoscale, vol. 11, no. 22, pp. 10791-10807. https://doi.org/10.1039/c9nr00807a

Highly Oxidized Graphene Quantum Dots from Coal as Efficient Antioxidants
Nilewski, L, Mendoza, K, Jalilov, AS, Berka, V, Wu, G, Sikkema, WKA, Metzger, A, Ye, R, Zhang, R, Luong, DX, Wang, T, McHugh, E, Derry, PJ, Samuel, EL, Kent, TA, Tsai, AL & Tour, JM 2019, , ACS Applied Materials and Interfaces, vol. 11, no. 18, pp. 16815-16821. https://doi.org/10.1021/acsami.9b01082

Pooled analysis suggests benefit of catheter-based hematoma removal for intracerebral hemorrhage
Mandava, P, Murthy, SB, Shah, N, Samson, Y, Kimmel, M & Kent, TA 2019, , Neurology, vol. 92, no. 15, pp. e1688-e1697. https://doi.org/10.1212/WNL.0000000000007269

Safety and efficacy of sonothrombolysis for acute ischaemic stroke: a multicentre, double-blind, phase 3, randomised controlled trial
CLOTBUST-ER Trial Investigators 2019, , The Lancet Neurology, vol. 18, no. 4, pp. 338-347. https://doi.org/10.1016/S1474-4422(19)30026-2

Telemedicine in Prehospital Acute Stroke Care: An Expanding Infrastructure for Treatment and Research
Derry, PJ, Mandava, P & Kent, TA 2019, , Journal of the American Heart Association, vol. 8, no. 6, e012259. https://doi.org/10.1161/JAHA.119.012259

Rho Guanine Nucleotide Exchange Factor ARHGEF17 Is a Risk Gene for Intracranial Aneurysms
Yang, X, Li, J, Fang, Y, Zhang, Z, Jin, D, Chen, X, Zhao, Y, Li, M, Huan, L, Kent, TA, Dong, JF, Jiang, R, Yang, S, Jin, L, Zhang, J, Zhong, TP & Yu, F 2018, , Circulation. Genomic and precision medicine, vol. 11, no. 7, pp. e002099. https://doi.org/10.1161/CIRCGEN.117.002099