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Tej K. Pandita, PhD

Professor of Radiation Oncology, Institute for Academic Medicine
Full Member, Research Institute
Scientific Director, Department of Radiation Oncology
Houston Methodist
Weill Cornell Medical College


Biography

Dr. Pandita earned his Ph.D. in Cytogenetics from Panjab University in 1980. He held faculty appointments at Columbia University in New York, Washington University in St.  Louis, Missouri, and The University of Texas Southwestern Medical Center in Dallas, Texas before becoming a member of the Houston Methodist Research Institute in 2014.  As a member of the Cancer Research Program, he directs a research program focusing on DNA repair and radiotherapy.  Dr. Pandita was elected the Fellow of the American Association of Advancement of Science in 2013. He has also been a member of several NIH study sections and review boards. He is the past Chairman of A-T Workshop 2012 (ATW2012) International meeting. Dr. Pandita serves on the editorial board for the journals Cancer Research, Genomic Integrity, BMC Genomics, and served as a chartered member of the CMAD NIH Study Section.

Description of Research

Dr. Pandita's research employs radiation genetics and biology to study the relationships between DNA sequence, chromatin structure and sensitivity to IR. The long-term goal of the research projects is to understand the mechanistic role of chromatin structure in regulating the cell survival response to IR-induced DNA damage. This knowledge base will be used by the laboratory to develop clinically relevant methods to increase tumor cell response to IR-based therapies while decreasing injury to adjacent, normal tissue.

Dr. Pandita's main areas of research are the following:
-To define, at the chromatin level, the function of H4K16ac in DNA DSB repair.
-To determine the role of ATM dependent MOF phosphorylation in the cellular response to IR.
-To determine the pathobiology of mutant mice defective for MOF T392 phosphorylation in order to test the hypothesis that Mof plays a critical role in oncogenic transformation in vivo.
-To determine the mechanisitic basis for enhanced tumor cell radiosensitivity following HP1ß loss or hyperthermia.

Areas Of Expertise

DNA damage response DNA DSB repair Telomere metabolism Chromatin structure Radiation signaling
Education & Training

MSc, Kashmir University, Srinagar
Postdoctoral Fellowship, National Botanical Research Institute, Council of Scientific and Industrial Research, Lucknow
PhD, Punjab University, Chandigarh
Publications

ß1-Integrin Impacts Rad51 Stability and DNA Double-Strand Break Repair by Homologous Recombination
Ahmed, KM, Pandita, RK, Singh, DK, Hunt, CR & Pandita, TK 2018, Molecular and Cellular Biology, vol 38, no. 9. DOI: 10.1128/MCB.00672-17

MOF influences meiotic expansion of H2AX phosphorylation and spermatogenesis in mice
Jiang, H, Gao, Q, Zheng, W, Yin, S, Wang, L, Zhong, L, Ali, A, Khan, T, Hao, Q, Fang, H, Sun, X, Xu, P, Pandita, TK, Jiang, X & Shi, Q 2018, PLoS Genetics, vol 14, no. 5, e1007300. DOI: 10.1371/journal.pgen.1007300

Harnessing and Optimizing the Interplay between Immunotherapy and Radiotherapy to Improve Survival Outcomes
Mujoo, K, Hunt, CR, Pandita, RK, Ferrari, M, Krishnan, S, Cooke, JP, Hahn, S & Pandita, TK 2018, Molecular Cancer Research. DOI: 10.1158/1541-7786.MCR-17-0743

MOF suppresses replication stress and contributes to resolution of stalled replication forks
Singh, DK, Pandita, RK, Singh, M, Chakraborty, S, Hambarde, S, Ramnarain, D, Charaka, V, Ahmed, KM, Hunt, CR & Pandita, TK 2018, Molecular and Cellular Biology, vol 38, no. 6, e00484-17. DOI: 10.1128/MCB.00484-17

Cross Talk between Radiation and Immunotherapy: The Twain Shall Meet
Iyer, SP, Hunt, CR & Pandita, TK 2018, Radiation Research, vol 189, no. 3, pp. 219-224. DOI: 10.1667/RR14941.1

CDKN2A/p16 deletion in head and neck cancer cells is associated with cdk2 activation, replication stress, and vulnerability to CHK1 inhibition
Gadhikar, MA, Zhang, J, Shen, L, Rao, X, Wang, J, Zhao, M, Kalu, NN, Johnson, FM, Byers, LA, Heymach, J, Hittelman, WN, Udayakumar, D, Pandita, RK, Pandita, TK, Pickering, CR, Redwood, AB, Piwnica-Worms, H, Schlacher, K, Frederick, MJ & Myers, JN 2018, Cancer Research, vol 78, no. 3, pp. 781-797. DOI: 10.1158/0008-5472.CAN-17-2802

HER2 Confers Resistance to Foretinib Inhibition of MET-Amplified Esophageal Adenocarcinoma Cells
Goltsov, AA, Fang, B, Pandita, TK, Maru, DM, Swisher, SG & Hofstetter, WL 2018, Annals of Thoracic Surgery, vol 105, no. 2, pp. 363-370. DOI: 10.1016/j.athoracsur.2017.09.003

Cross Talk between Radiation and Immunotherapy: The Twain Shall Meet
Iyer, SP, Hunt, CR & Pandita, TK 2017, Radiation Research. DOI: 10.1667/RR14941.1

CDKN2A/p16 deletion in head and neck cancer cells is associated with Cdk2 activation, replication stress, and vulnerability to Chk1 inhibition
Gadhikar, MA, Zhang, J, Shen, L, Rao, X, Wang, J, Zhao, M, Kalu, NN, Johnson, FM, Byers, LA, Heymach, J, Hittelman, WN, Udayakumar, D, Pandita, RK, Pandita, TK, Pickering, CR, Redwood, A, Piwnica-Worms, H, Schlacher, K, Frederick, MJ & Myers, JN 2017, Cancer Research. DOI: 10.1158/0008-5472.CAN-17-2802

HER2 Confers Resistance to Foretinib Inhibition of MET-Amplified Esophageal Adenocarcinoma Cells
Goltsov, AA, Fang, B, Pandita, TK, Maru, DM, Swisher, SG & Hofstetter, WL 2017, Annals of Thoracic Surgery. DOI: 10.1016/j.athoracsur.2017.09.003

MiR-15a/miR-16 down-regulates BMI1, impacting Ub-H2A mediated DNA repair and breast cancer cell sensitivity to doxorubicin
Patel, N, Garikapati, KR, Pandita, RK, Singh, DK, Pandita, TK, Bhadra, U & Bhadra, MP 2017, Scientific Reports, vol 7, no. 1, 4263. DOI: 10.1038/s41598-017-02800-2

Transcription regulation of CDKN1A (p21/CIP1/WAF1) by TRF2 is epigenetically controlled through the REST repressor complex
Hussain, T, Saha, D, Purohit, G, Kar, A, Kishore Mukherjee, A, Sharma, S, Sengupta, S, Dhapola, P, Maji, B, Vedagopuram, S, Horikoshi, NT, Horikoshi, N, Pandita, RK, Bhattacharya, S, Bajaj, A, Riou, JF, Pandita, TK & Chowdhury, S 2017, Scientific Reports, vol 7, no. 1, 11541. DOI: 10.1038/s41598-017-11177-1

Differentiation of Human Induced Pluripotent or Embryonic Stem Cells Decreases the DNA Damage Repair by Homologous Recombination
Mujoo, K, Pandita, RK, Tiwari, A, Charaka, V, Chakraborty, S, Singh, DK, Hambarde, S, Hittelman, WN, Horikoshi, N, Hunt, CR, Khanna, KK, Kots, AY, Butler, EB, Murad, F & Pandita, TK 2017, Stem Cell Reports, vol 9, no. 5, pp. 1660-1674. DOI: 10.1016/j.stemcr.2017.10.002

Erratum: miR-15a/miR-16 down-regulates BMI1, impacting Ub-H2A mediated DNA repair and breast cancer cell sensitivity to doxorubicin
Patel, N, Garikapati, KR, Pandita, RK, Singh, DK, Pandita, TK, Bhadra, U & Bhadra, MP 2017, Scientific Reports, vol 7, no. 1, pp. 12932. DOI: 10.1038/s41598-017-12314-6

Ssb1 and Ssb2 cooperate to regulate mouse hematopoietic stem and progenitor cells by resolving replicative stress
Shi, W, Vu, T, Boucher, D, Biernacka, A, Nde, J, Pandita, RK, Straube, J, Boyle, GM, Al-Ejeh, F, Nag, P, Jeffery, J, Harris, JL, Bain, AL, Grzelak, M, Skrzypczak, M, Mitra, A, Dojer, N, Crosetto, N, Cloonan, N, Becherel, OJ, Finnie, J, Skaar, JR, Walkley, CR, Pandita, TK, Rowicka, M, Ginalski, K, Lane, SW & Khanna, KK 2017, Blood, vol 129, no. 18, pp. 2479-2492. DOI: 10.1182/blood-2016-06-725093

Histone Acetyltransferase Activity of MOF Is Required for MLL-AF9 Leukemogenesis
Valerio, DG, Xu, H, Chen, C-W, Hoshii, T, Eisold, ME, Delaney, C, Cusan, M, Deshpande, AJ, Huang, C-H, Lujambio, A, Zheng, YG, Zuber, J, Pandita, TK, Lowe, SW & Armstrong, SA 2017, Cancer Research, vol 77, no. 7, pp. 1753-1762. DOI: 10.1158/0008-5472.CAN-16-2374

Aurora kinase B dependent phosphorylation of 53BP1 is required for resolving merotelic kinetochore-microtubule attachment errors during mitosis
Wang, H, Peng, B, Pandita, RK, Engler, DA, Matsunami, RK, Xu, X, Hegde, PM, Butler, EB, Pandita, TK, Mitra, S, Xu, B & Hegde, ML 2017, Oncotarget, vol 8, no. 30, pp. 48671-48687. DOI: 10.18632/oncotarget.16225

MCL-1 depletion impairs DNA DSB repair and re-initiation of stalled DNA replication forks
Mattoo, AR, Pandita, RK, Chakraborty, S, Charaka, V, Mujoo, K, Hunt, CR & Pandita, TK 2017, Molecular and Cellular Biology, vol 37, no. no. 3 e00535-16, no. 3 e00535-16. DOI: 10.1128/MCB.00535-16

Histone acetyltransferase KAT8 is essential for mouse oocyte development by regulating reactive oxygen species levels
Yin, S, Jiang, X, Jiang, H, Gao, Q, Wang, F, Fan, S, Khan, T, Jabeen, N, Khan, M, Ali, A, Xu, P, Pandita, TK, Fan, HY, Zhang, Y & Shi, Q 2017, Development (Cambridge), vol 144, no. 12, pp. 2165-2174. DOI: 10.1242/dev.149518

Differentiation of Human Induced Pluripotent or Embryonic Stem Cells Decreases the DNA Damage Repair by Homologous Recombination
Pandita, TK 2017, Stem Cell Reports.