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Shu Meng, MD, PhD

Assistant Research Professor of Cardiovascular Sciences, Academic Institute
Assistant Research Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Publications

Dysfunction of iPSC-derived endothelial cells in human Hutchinson–Gilford progeria syndrome
Matrone, G, Amirthalingam Thandavarayan, R, Walther, BK, Meng, S, Mojiri, A & Cooke, JP 2019, Cell Cycle, vol. 18, no. 19, pp. 2495-2508. https://doi.org/10.1080/15384101.2019.1651587

Nuclear S-Nitrosylation Defines an Optimal Zone for Inducing Pluripotency
Chanda, PK, Meng, S, Lee, J, Leung, HE, Chen, K & Cooke, JP 2019, Circulation, vol. 140, no. 13, pp. 1081-1099. https://doi.org/10.1161/CIRCULATIONAHA.119.042371

AIBP-mediated cholesterol efflux instructs hematopoietic stem and progenitor cell fate
Gu, Q, Yang, X, Lv, J, Zhang, J, Xia, B, Kim, JD, Wang, R, Xiong, F, Meng, S, Clements, TP, Tandon, B, Wagner, DS, Diaz, MF, Wenzel, PL, Miller, YI, Traver, D, Cooke, JP, Li, W, Zon, LI, Chen, K, Bai, Y & Fang, L 2019, Science, pp. eaav1749. https://doi.org/10.1126/science.aav1749

TBX20 Regulates Angiogenesis Through the Prokineticin 2-Prokineticin Receptor 1 Pathway
Meng, S, Gu, Q, Yang, X, Lv, J, Owusu, I, Matrone, G, Chen, K, Cooke, JP & Fang, L 2018, Circulation, vol. 138, no. 9, pp. 913-928. https://doi.org/10.1161/CIRCULATIONAHA.118.033939

Transflammation: How Innate Immune Activation and Free Radicals Drive Nuclear Reprogramming
Meng, S, Chanda, P, Amirthalingam Thandavarayan, R & Cooke, JP 2018, Antioxidants and Redox Signaling, vol. 29, no. 2, pp. 205-218. https://doi.org/10.1089/ars.2017.7364

Small molecule disruption of G protein ß? subunit signaling reprograms human macrophage phenotype and prevents autoimmune myocarditis in rats
Karuppagounder, V, Bajpai, A, Meng, S, Arumugam, S, Sreedhar, R, Giridharan, VV, Guha, A, Bhimaraj, A, Youker, KA, Palaniyandi, SS, Karmouty-Quintana, H, Kamal, F, Spiller, KL, Watanabe, K & Amirthalingam Thandavarayan, R 2018, PLoS ONE, vol. 13, no. 7, e0200697. https://doi.org/10.1371/journal.pone.0200697

Lmo2 (LIM-Domain-Only 2) Modulates Sphk1 (Sphingosine Kinase) and Promotes Endothelial Cell Migration
Matrone, G, Meng, S, Gu, Q, Lv, J, Fang, L, Chen, K & Cooke, JP 2017, Arteriosclerosis, thrombosis, and vascular biology, vol. 37, no. 10, pp. 1860-1868. https://doi.org/10.1161/ATVBAHA.117.309609

Transflammation: Innate immune signaling in nuclear reprogramming
Meng, S, Chanda, P, Amirthalingam Thandavarayan, R & Cooke, JP 2017, Advanced Drug Delivery Reviews, vol. 120, pp. 133-141. https://doi.org/10.1016/j.addr.2017.09.010

AIBP Limits Angiogenesis Thorough ?-Secretase-Mediated Upregulation of Notch Signaling
Mao, R, Meng, S, Gu, Q, Araujo-Gutierrez, R, Kumar, S, Yan, Q, Almazan, F, Youker, KA, Fu, Y, Pownall, HJ, Cooke, JP, Miller, YI & Fang, L 2017, Circulation research. https://doi.org/10.1161/CIRCRESAHA.116.309754

Discovery of novel determinants of endothelial lineage using chimeric heterokaryons
Wong, J, Matrone, G, Tian, X, Tomoiaga, SA, Au, KF, Meng, S, Yamazoe, S, Sieveking, D, Chen, K, Burns, DM, Chen, JK, Blau, HM & Cooke, JP 2017, eLife, vol. 6, e23588. https://doi.org/10.7554/eLife.23588

Transdifferentiation Requires iNOS Activation: Role of RING1A S-Nitrosylation
Meng, S, Zhou, G, Gu, Q, Chanda, PK, Ospino, F & Cooke, JP 2016, Circulation research, vol. 119, no. 9, pp. e129-e138. https://doi.org/10.1161/CIRCRESAHA.116.308263

Optimal ROS Signaling Is Critical for Nuclear Reprogramming
Zhou, G, Meng, S, Li, Y, Ghebre, YT & Cooke, JP 2016, Cell Reports, vol. 15, no. 5, pp. 919-925. https://doi.org/10.1016/j.celrep.2016.03.084

Role of innate immune signaling in nuclear reprogramming
Meng, S, Chanda, P & Cooke, JP 2016, . in Regenerative Medicine - from Protocol to Patient: 1. Biology of Tissue Regeneration: Third Edition. Springer International Publishing, pp. 291-305. https://doi.org/10.1007/978-3-319-27583-3_9

Response to letter regarding article "Transdifferentiation of human fibroblasts to endothelial cells: Role of innate immunity"
Cooke, JP, Meng, S, Wong, WT, Sayed, N, Ospino, F, Lee, J, Jha, A, Dexheimer, P & Aronow, B 2015, Circulation, vol. 132, no. 15, pp. e197. https://doi.org/10.1161/CIRCULATIONAHA.115.016792

Interleukin-35 inhibits endothelial cell activation by suppressing MAPK-AP-1 Pathway
Sha, X, Meng, S, Li, X, Xi, H, Maddaloni, M, Pascual, DW, Shan, H, Jiang, X, Wang, H & Yang, XF 2015, Journal of Biological Chemistry, vol. 290, no. 31, pp. 19307-19318. https://doi.org/10.1074/jbc.M115.663286

Early Hyperlipidemia Promotes Endothelial Activation via a Caspase-1-Sirtuin 1 Pathway
Yin, Y, Li, X, Sha, X, Xi, H, Li, YF, Shao, Y, Mai, J, Virtue, A, Lopez-Pastrana, J, Meng, S, Tilley, DG, Monroy, MA, Choi, ET, Thomas, CJ, Jiang, X, Wang, H & Yang, XF 2015, Arteriosclerosis, thrombosis, and vascular biology, vol. 35, no. 4, pp. 804-816. https://doi.org/10.1161/ATVBAHA.115.305282

Methylation and Atherosclerosis
Xiong, XY, Meng, S, Yang, X & Wang, H 2015, . in Atherosclerosis: Risks, Mechanisms, and Therapies. Wiley, pp. 405-421. https://doi.org/10.1002/9781118828533.ch32

Monocytes and Macrophages in Atherosclerosis
Meng, S, Fang, P, Yang, X & Wang, H 2015, . in Atherosclerosis: Risks, Mechanisms, and Therapies. Wiley, pp. 141-153. https://doi.org/10.1002/9781118828533.ch12

Transdifferentiation of human fibroblasts to endothelial cells role of innate immunity
Sayed, N, Wong, WT, Ospino, F, Meng, S, Lee, J, Jha, A, Dexheimer, P, Aronow, BJ & Cooke, JP 2015, Circulation, vol. 131, no. 3, pp. 300-309. https://doi.org/10.1161/CIRCULATIONAHA.113.007394

Hyperhomocysteinemia potentiates hyperglycemia-induced inflammatory monocyte differentiation and atherosclerosis
Fang, P, Zhang, D, Cheng, Z, Yan, C, Jiang, X, Kruger, WD, Meng, S, Arning, E, Bottiglieri, T, Choi, ET, Han, Y, Yang, XF & Wang, H 2014, Diabetes, vol. 63, no. 12, pp. 4275-4290. https://doi.org/10.2337/db14-0809

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