Shu Meng, MD, PhD

Assistant Research Professor of Cardiovascular Sciences, Academic Institute
Assistant Research Member, Research Institute
Houston Methodist
Weill Cornell Medical College

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NETWORK

Publications

Dysfunction of iPSC-derived endothelial cells in human Hutchinson–Gilford progeria syndrome

Matrone, G, Amirthalingam Thandavarayan, R, Walther, BK, Meng, S, Mojiri, A & Cooke, JP 2019, Cell Cycle, vol. 18, no. 19, pp. 2495-2508. https://doi.org/10.1080/15384101.2019.1651587

Nuclear S-Nitrosylation Defines an Optimal Zone for Inducing Pluripotency

Chanda, PK, Meng, S, Lee, J, Leung, HE, Chen, K & Cooke, JP 2019, Circulation, vol. 140, no. 13, pp. 1081-1099. https://doi.org/10.1161/CIRCULATIONAHA.119.042371

AIBP-mediated cholesterol efflux instructs hematopoietic stem and progenitor cell fate

Gu, Q, Yang, X, Lv, J, Zhang, J, Xia, B, Kim, JD, Wang, R, Xiong, F, Meng, S, Clements, TP, Tandon, B, Wagner, DS, Diaz, MF, Wenzel, PL, Miller, YI, Traver, D, Cooke, JP, Li, W, Zon, LI, Chen, K, Bai, Y & Fang, L 2019, Science, pp. eaav1749. https://doi.org/10.1126/science.aav1749

TBX20 Regulates Angiogenesis Through the Prokineticin 2-Prokineticin Receptor 1 Pathway

Meng, S, Gu, Q, Yang, X, Lv, J, Owusu, I, Matrone, G, Chen, K, Cooke, JP & Fang, L 2018, Circulation, vol. 138, no. 9, pp. 913-928. https://doi.org/10.1161/CIRCULATIONAHA.118.033939

Transflammation: How Innate Immune Activation and Free Radicals Drive Nuclear Reprogramming

Meng, S, Chanda, P, Amirthalingam Thandavarayan, R & Cooke, JP 2018, Antioxidants and Redox Signaling, vol. 29, no. 2, pp. 205-218. https://doi.org/10.1089/ars.2017.7364

Small molecule disruption of G protein ß? subunit signaling reprograms human macrophage phenotype and prevents autoimmune myocarditis in rats

Karuppagounder, V, Bajpai, A, Meng, S, Arumugam, S, Sreedhar, R, Giridharan, VV, Guha, A, Bhimaraj, A, Youker, KA, Palaniyandi, SS, Karmouty-Quintana, H, Kamal, F, Spiller, KL, Watanabe, K & Amirthalingam Thandavarayan, R 2018, PLoS ONE, vol. 13, no. 7, e0200697. https://doi.org/10.1371/journal.pone.0200697

Lmo2 (LIM-Domain-Only 2) Modulates Sphk1 (Sphingosine Kinase) and Promotes Endothelial Cell Migration

Matrone, G, Meng, S, Gu, Q, Lv, J, Fang, L, Chen, K & Cooke, JP 2017, Arteriosclerosis, thrombosis, and vascular biology, vol. 37, no. 10, pp. 1860-1868. https://doi.org/10.1161/ATVBAHA.117.309609

Transflammation: Innate immune signaling in nuclear reprogramming

Meng, S, Chanda, P, Amirthalingam Thandavarayan, R & Cooke, JP 2017, Advanced Drug Delivery Reviews, vol. 120, pp. 133-141. https://doi.org/10.1016/j.addr.2017.09.010

AIBP Limits Angiogenesis Thorough ?-Secretase-Mediated Upregulation of Notch Signaling

Mao, R, Meng, S, Gu, Q, Araujo-Gutierrez, R, Kumar, S, Yan, Q, Almazan, F, Youker, KA, Fu, Y, Pownall, HJ, Cooke, JP, Miller, YI & Fang, L 2017, Circulation research. https://doi.org/10.1161/CIRCRESAHA.116.309754

Discovery of novel determinants of endothelial lineage using chimeric heterokaryons

Wong, J, Matrone, G, Tian, X, Tomoiaga, SA, Au, KF, Meng, S, Yamazoe, S, Sieveking, D, Chen, K, Burns, DM, Chen, JK, Blau, HM & Cooke, JP 2017, eLife, vol. 6, e23588. https://doi.org/10.7554/eLife.23588

Transdifferentiation Requires iNOS Activation: Role of RING1A S-Nitrosylation

Meng, S, Zhou, G, Gu, Q, Chanda, PK, Ospino, F & Cooke, JP 2016, Circulation research, vol. 119, no. 9, pp. e129-e138. https://doi.org/10.1161/CIRCRESAHA.116.308263

Optimal ROS Signaling Is Critical for Nuclear Reprogramming

Zhou, G, Meng, S, Li, Y, Ghebre, YT & Cooke, JP 2016, Cell Reports, vol. 15, no. 5, pp. 919-925. https://doi.org/10.1016/j.celrep.2016.03.084

Role of innate immune signaling in nuclear reprogramming

Meng, S, Chanda, P & Cooke, JP 2016, . in Regenerative Medicine - from Protocol to Patient: 1. Biology of Tissue Regeneration: Third Edition. Springer International Publishing, pp. 291-305. https://doi.org/10.1007/978-3-319-27583-3_9

Response to letter regarding article "Transdifferentiation of human fibroblasts to endothelial cells: Role of innate immunity"

Cooke, JP, Meng, S, Wong, WT, Sayed, N, Ospino, F, Lee, J, Jha, A, Dexheimer, P & Aronow, B 2015, Circulation, vol. 132, no. 15, pp. e197. https://doi.org/10.1161/CIRCULATIONAHA.115.016792

Interleukin-35 inhibits endothelial cell activation by suppressing MAPK-AP-1 Pathway

Sha, X, Meng, S, Li, X, Xi, H, Maddaloni, M, Pascual, DW, Shan, H, Jiang, X, Wang, H & Yang, XF 2015, Journal of Biological Chemistry, vol. 290, no. 31, pp. 19307-19318. https://doi.org/10.1074/jbc.M115.663286

Early Hyperlipidemia Promotes Endothelial Activation via a Caspase-1-Sirtuin 1 Pathway

Yin, Y, Li, X, Sha, X, Xi, H, Li, YF, Shao, Y, Mai, J, Virtue, A, Lopez-Pastrana, J, Meng, S, Tilley, DG, Monroy, MA, Choi, ET, Thomas, CJ, Jiang, X, Wang, H & Yang, XF 2015, Arteriosclerosis, thrombosis, and vascular biology, vol. 35, no. 4, pp. 804-816. https://doi.org/10.1161/ATVBAHA.115.305282

Methylation and Atherosclerosis

Xiong, XY, Meng, S, Yang, X & Wang, H 2015, . in Atherosclerosis: Risks, Mechanisms, and Therapies. Wiley, pp. 405-421. https://doi.org/10.1002/9781118828533.ch32

Monocytes and Macrophages in Atherosclerosis

Meng, S, Fang, P, Yang, X & Wang, H 2015, . in Atherosclerosis: Risks, Mechanisms, and Therapies. Wiley, pp. 141-153. https://doi.org/10.1002/9781118828533.ch12

Transdifferentiation of human fibroblasts to endothelial cells role of innate immunity

Sayed, N, Wong, WT, Ospino, F, Meng, S, Lee, J, Jha, A, Dexheimer, P, Aronow, BJ & Cooke, JP 2015, Circulation, vol. 131, no. 3, pp. 300-309. https://doi.org/10.1161/CIRCULATIONAHA.113.007394

Hyperhomocysteinemia potentiates hyperglycemia-induced inflammatory monocyte differentiation and atherosclerosis

Fang, P, Zhang, D, Cheng, Z, Yan, C, Jiang, X, Kruger, WD, Meng, S, Arning, E, Bottiglieri, T, Choi, ET, Han, Y, Yang, XF & Wang, H 2014, Diabetes, vol. 63, no. 12, pp. 4275-4290. https://doi.org/10.2337/db14-0809

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