Randa El-Zein

Randa El-Zein, MBChB, PhD

Professor of Epidemiology in Medicine, Academic Institute
Full Member, Research Institute
Houston Methodist


El-Zein Lab


rel-zein2@houstonmethodist.org
Biography

Dr. El-Zein earned her Medical Degree followed by a Masters in Human Genetics from the University of Alexandria. She then completed her Doctoral degree in Human Biological Chemistry and Genetics at the University of Texas Medical Branch with a focus on cancer genetics. In 1997, she joined the University of Texas MD Anderson Cancer Center as a postdoctoral fellow and rose through the ranks to Associate Professor in the Department of Epidemiology. In 2015, Dr. El-Zein joined Houston Methodist as a Professor in the Department of Radiology and a full member of the Research Institute.

Dr. El-Zein is an active member of the national and international scientific community. She serves/served as a reviewer for the National Institute of Health, National Lung, Heart and Blood Institute and the American Cancer Society. Internationally, she is a grant reviewer for the Italian Ministry of Health. Dr. El-Zein also serves as a peer reviewer for several high impact journals.

Description of Research

Dr. El-Zein’s research focus is on understanding the role of gene-environment interactions in the risk of cancer development. She has developed expertise in the area of biomarkers and genetic susceptibility to disease. She has applied unique markers to identify several inherited genetic traits that influence human sensitivity to different cancers such as lung, breast and lymphomas. Dr. El-Zein’s laboratory has a translational research approach, and is currently studying human populations using quantitative imaging coupled with molecular biomarkers to identify unique signatures that would improve the power of cancer risk assessment models. The results from these studies are providing new information that has significant and practical public health implications in the area of early detection and primary prevention of disease. The overall goal is to develop novel approaches to identify susceptible individuals at high risk of developing lung and breast cancers. New knowledge generated from these research endeavors are geared to fulfill the need for rapid and efficient translation of emerging new technologies and approaches for improved patient management, early detection and prevention.Dr. El-Zein’s research focus is on understanding the role of gene-environment interactions in the risk of cancer development. She has developed expertise in the area of genotypic and phenotypic biomarkers and genetic susceptibility to disease. She has applied these unique markers to identify several inherited genetic traits that influence human sensitivity to different cancers such as lung, breast and lymphomas. Dr. El-Zein’s laboratory has a translational research approach, and is currently studying human populations using quantitative imaging coupled with molecular biomarkers to identify unique signatures that would improve the power of cancer risk assessment models. The results from these studies are providing new information that has significant and practical public health implications in the area of early detection and primary prevention of disease. The overall goal is to develop novel approaches to identify susceptible individuals at high risk of developing lung and breast cancers. New knowledge generated from these research endeavors are geared to fulfill the need for rapid and efficient translation of emerging new technologies and approaches for improved patient management, early detection and prevention.

Areas Of Expertise

Breast cancer Lung cancer Genetic instability Genetic susceptibility
Education & Training

MBBCh, Alexandria University
MS, Alexandria University
Postdoctoral Fellowship, The University of Texas MD Anderson Cancer Center
PhD, The University of Texas Medical Branch
Publications

Integrative metabolomics and transcriptomics analysis reveals novel therapeutic vulnerabilities in lung cancer
Thaiparambil, J, Dong, J, Grimm, SL, Perera, D, Ambati, CSR, Putluri, V, Robertson, MJ, Patel, TD, Mistretta, B, Gunaratne, PH, Kim, MP, Yustein, JT, Putluri, N, Coarfa, C & El-Zein, R 2022, , Cancer Medicine. https://doi.org/10.1002/cam4.4933

Ultrastructural Analysis of Inflammatory Breast Cancer Cell Clusters in an Ex Vivo Environment Mechanically Mimicking the Lymph Vascular System
Fujii, Y, Krishnamurthy, S & El-Zein, R 2021, , Breast Cancer: Basic and Clinical Research, vol. 15. https://doi.org/10.1177/11782234211056134

Inflammatory breast cancer appearance at presentation is associated with overall survival
Balema, W, Liu, D, Shen, Y, El-Zein, R, Debeb, BG, Kai, M, Overmoyer, B, Miller, KD, Le-Petross, HT, Ueno, NT & Woodward, WA 2021, , Cancer Medicine, vol. 10, no. 18, pp. 6261-6272. https://doi.org/10.1002/cam4.4170

Genomic instability in chronic obstructive pulmonary disease and lung cancer: A systematic review and meta-analysis of studies using the micronucleus assay
Asanov, M, Bonassi, S, Proietti, S, Minina, VI, Tomino, C & El-Zein, R 2021, , Mutation Research - Reviews in Mutation Research, vol. 787, 108344. https://doi.org/10.1016/j.mrrev.2020.108344

Parenchymal field effect analysis for breast cancer risk assessment: Evaluation of FFDM radiomic similarity
Baughan, NM, Li, H, Lan, L, Chan, CW, Embury, M, Whitman, G, El-Zein, R, Bedrosian, I & Giger, ML 2021, . in MA Mazurowski & K Drukker (eds), Medical Imaging 2021: Computer-Aided Diagnosis., 115970Z, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 11597, SPIE, Medical Imaging 2021: Computer-Aided Diagnosis, Virtual, Online, United States, 2/15/21. https://doi.org/10.1117/12.2581791

Mitotic spindle apparatus abnormalities in chronic obstructive pulmonary disease cells: A potential pathway to lung cancer
Thaiparambil, J, Dong, L, Jasso, D, Huang, JA & El-Zein, RA 2020, , Cancer Prevention Research, vol. 13, no. 11, pp. 923-933. https://doi.org/10.1158/1940-6207.CAPR-19-0557

2-Methoxyestradiol sensitizes breast cancer cells to taxanes by targeting centrosomes
El-Zein, R, Thaiparambil, J & Abdel-Rahman, SZ 2020, , Oncotarget, vol. 0, no. 0. https://doi.org/10.18632/oncotarget.27810

XRCC1 promotes replication restart, nascent fork degradation and mutagenic DNA repair in BRCA2-deficient cells
Eckelmann, BJ, Bacolla, A, Wang, H, Ye, Z, Guerrero, EN, Jiang, W, El-Zein, R, Hegde, ML, Tomkinson, AE, Tainer, JA & Mitra, S 2020, , NAR cancer, vol. 2, no. 3, pp. zcaa013. https://doi.org/10.1093/narcan/zcaa013

XRCC1 promotes replication restart, nascent fork degradation and mutagenic DNA repair in BRCA2-deficient cells
Eckelmann, BJ, Bacolla, A, Wang, H, Ye, Z, Guerrero, EN, Jiang, W, El-Zein, R, Hegde, M, Tomkinson, AE, Tainer, JA & Mitra, S 2020, , NAR Cancer, vol. 2, no. 3, zcaa013. https://doi.org/10.1093/narcan/zcaa013

Identification of circulating tumor cells using 4-color fluorescence in situ hybridization: Validation of a noninvasive aid for ruling out lung cancer in patients with low-dose computed tomography–detected lung nodules
Katz, RL, Zaidi, TM, Pujara, D, Shanbhag, ND, Truong, D, Patil, S, Mehran, RJ, El-Zein, RA, Shete, SS & Kuban, JD 2020, , Cancer cytopathology, vol. 128, no. 8, pp. 553-562. https://doi.org/10.1002/cncy.22278

Micronuclei and disease – Report of HUMN project workshop at Rennes 2019 EEMGS conference
Fenech, M, Holland, N, Kirsch-Volders, M, Knudsen, LE, Wagner, KH, Stopper, H, Knasmueller, S, Bolognesi, C, El-Zein, R & Bonassi, S 2020, , Mutation Research - Genetic Toxicology and Environmental Mutagenesis, vol. 850-851, 503133. https://doi.org/10.1016/j.mrgentox.2020.503133

Precision Medicine Approaches for Stratification and Development of Novel Therapies of Latin(x) Patients at Risk of Lung Malignancy.
El-Zein, R 2020, in Advances in Cancer Research in Latinos.

Genomic Instability in Chronic Obstructive Pulmonary Disease and Lung cancer: A Systematic Review and Meta-analysis of studies using the Micronucleus Assay
Asanov, M, Bonassi , S, Proietti, S, Minina, VI, Tomino, C & El-Zein, R 2020, , Mutation Research - Reviews in Mutation Research.

Identification of circulating tumor cells using 4-color FISH: Validation of a noninvasive aid for ruling out lung cancer in patients with LDCT-detected lung nodules.
Katz, R, Zaidi , TM, Pujara, D, Shanbhag, ND, Truong, D, Patil, S, Mehran, RJ, El-Zein, R, Shete, SS & Kuban , JD 2020, , Cancer cytopathology. https://doi.org/10.1002/cncy.22278

2-methoxyestradiol sensitizes breast cancer cells to taxanes by targeting centrosomes
El-Zein, R, Thaiparambil, J & Abdel-Rahman, SZ 2020, , Oncotarget, vol. 11, no. 48, pp. 4479-4489. https://doi.org/10.18632/ONCOTARGET.27810

Driver mutations in normal airway epithelium elucidate spatiotemporal resolution of lung cancer
Kadara, H, Sivakumar, S, Jakubek, Y, Anthony San Lucas, F, Lang, W, McDowell, T, Weber, Z, Behrens, C, Davies, GE, Kalhor, N, Moran, C, El-Zein, R, Mehran, R, Swisher, SG, Wang, J, Zhang, J, Fujimoto, J, Fowler, J, Heymach, JV, Dubinett, S, Spira, AE, Ehli, EA, Wistuba, II & Scheet, P 2019, , American journal of respiratory and critical care medicine, vol. 200, no. 6, pp. 742-750. https://doi.org/10.1164/rccm.201806-1178OC

Temporal mammographic registration for evaluation of architecture changes in cancer risk assessment
Mendel, K, Li, H, Tayob, N, El-Zein, R, Bedrosian, I & Giger, M 2019, . in K Mori & HK Hahn (eds), Medical Imaging 2019: Computer-Aided Diagnosis., 1095041, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 10950, SPIE, Medical Imaging 2019: Computer-Aided Diagnosis, San Diego, United States, 2/17/19. https://doi.org/10.1117/12.2512792

Micronuclei and Disease – Report of HUMN Project workshop at Rennes 2019 EEMGS conference
El-Zein, R 2019, Mutation Research - Genetic Toxicology and Environmental Mutagenesis.

Distinct epidemiological profiles associated with inflammatory breast cancer (IBC): A comprehensive analysis of the IBC registry at the University of Texas MD Anderson Cancer Center
Fouad, TM, Ueno, NT, Yu, RK, Ensor, JE, Alvarez, RH, Krishnamurthy, S, Lucci, A, Reuben, JM, Yang, W, Willey, JS, Valero, V, Bondy, ML, Cristofinalli, M, Shete, S, Woodward, WA & El-Zein, R 2018, , PLoS ONE, vol. 13, no. 9, e0204372. https://doi.org/10.1371/journal.pone.0204372

The cytokinesis-blocked micronucleus assay as a novel biomarker for selection of lung cancer screening participants
El-Zein, RA, Etzel, CJ & Munden, RF 2018, , Translational Lung Cancer Research, vol. 7, no. 3, pp. 336-346. https://doi.org/10.21037/tlcr.2018.05.09