Philip T. Cagle, MD

Professor of Pathology and Genomic Medicine, Institute for Academic Medicine
Full Clinical Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Biography

Dr. Cagle received his MD degree from the University of Tennessee College of Medicine in Memphis in 1981. After completing his pathology residency at the Baylor College of Medicine in Houston, Texas, he completed a fellowship in pulmonary pathology research at the University of British Columbia in Vancouver. Dr. Cagle joined the faculty at the Baylor College of Medicine as an instructor in the Department of Pathology in 1984. He became a full professor there in 2000. Dr. Cagle joined Houston Methodist Hospital as an attending pathologist in 1987, and became the director of Pulmonary Pathology at Houston Methodist in 2004. In addition to being editor-in-chief of Archives of Pathology and Laboratory Medicine, Dr. Cagle is on the editorial boards of CAP Today and Human Pathology. Dr. Cagle served as co-chair and co-author of the College of American Pathologists (CAP) Lung Cancer Biomarker Guidelines and chaired the CAP Lung Cancer Biomarker Reporting Template Workgroup. Dr. Cagle is a recipient of the CAP Distinguished Patient Care Award, the CAP Pathologist of the Year Award (2013), and the Texas Society of Pathologists John J. Andujar, MD Citation of Merit Award. He is the author of over 150 peer-reviewed papers, editor of 15 textbooks, editor of two electronic books, and series editor for 3 book series. 

Description of Research

Dr. Cagle is a general surgical pathologist with subspecialty interest in pulmonary pathology. Dr. Cagle's research interests focus on predictive and prognostic biomarkers in lung cancer.

Areas Of Expertise

Predictive and prognostic biomarkers in lung cancer
Education & Training

Residency, Baylor College of Medicine
Clinical Fellowship, University of British Columbia
MD, University of Tennessee HSC College of Medicine
Publications

Correlation Between Programmed Death Receptor-1 Expression in Tumor-Infiltrating Lymphocytes and Programmed Death Ligand-1 Expression in Non-Small Cell Lung Carcinoma
Del C Monroig-Bosque, P, Driver, B, Morales-Rosado, JA, Deavers, M, Tacha, D, Bernicker, E, Cagle, PT & Miller, RA 2018, Archives of Pathology and Laboratory Medicine. DOI: 10.5858/arpa.2017-0516-OA

Updated molecular testing guideline for the selection of lung cancer patients for treatment with targeted tyrosine kinase inhibitors guideline from the college of American pathologists, the international association for the study of lung cancer, and the association for molecular pathology
Lindeman, NI, Cagle, PT, Aisner, DL, Arcila, ME, Beasley, MB, Bernicker, EH, Colasacco, C, Dacic, S, Hirsch, FR, Kerr, K, Kwiatkowski, DJ, Ladanyi, M, Nowak, JA, Sholl, L, Temple-Smolkin, R, Solomon, B, Souter, LH, Thunnissen, E, Tsao, MS, Ventura, CB, Wynes, MW & Yatabe, Y 2018, Archives of Pathology and Laboratory Medicine, vol 142, no. 3, pp. 321-346. DOI: 10.5858/arpa.2017-0388-CP

Immunohistochemistry of pulmonary biomarkers a perspective from members of the pulmonary pathology society
Thunnissen, E, Allen, TC, Adam, J, Aisner, DL, Beasley, MB, Borczuk, AC, Cagle, PT, Capelozzi, VL, Cooper, W, Hariri, LP, Kern, I, Lantuejoul, S, Miller, R, Mino-Kenudson, M, Radonic, T, Raparia, K, Rekhtman, N, Roy-Chowdhuri, S, Russell, P, Schneider, F, Sholl, LM, Tsao, MS, Vivero, M & Yatabe, Y 2018, Archives of Pathology and Laboratory Medicine, vol 142, no. 3, pp. 408-419. DOI: 10.5858/arpa.2017-0106-SA

Updated Molecular Testing Guideline for the Selection of Lung Cancer Patients for Treatment With Targeted Tyrosine Kinase Inhibitors. Guideline From the College of American Pathologists, the International Association for the Study of Lung Cancer, and the Association for Molecular Pathology
Lindeman, NI, Cagle, PT, Aisner, DL, Arcila, ME, Beasley, MB, Bernicker, E, Colasacco, C, Dacic, S, Hirsch, FR, Kerr, K, Kwiatkowski, DJ, Ladanyi, M, Nowak, JA, Sholl, L, Temple-Smolkin, R, Solomon, B, Souter, LH, Thunnissen, E, Tsao, MS, Ventura, CB, Wynes, MW & Yatabe, Y 2018, Journal of Thoracic Oncology. DOI: 10.1016/j.jtho.2017.12.001

Updated Molecular Testing Guideline for the Selection of Lung Cancer Patients for Treatment With Targeted Tyrosine Kinase Inhibitors. Guideline From the College of American Pathologists, the International Association for the Study of Lung Cancer, and the Association for Molecular Pathology
Lindeman, NI, Cagle, PT, Aisner, DL, Arcila, ME, Beasley, MB, Bernicker, E, Colasacco, C, Dacic, S, Hirsch, FR, Kerr, K, Kwiatkowski, DJ, Ladanyi, M, Nowak, JA, Sholl, L, Temple-Smolkin, R, Solomon, B, Souter, LH, Thunnissen, E, Tsao, MS, Ventura, CB, Wynes, MW & Yatabe, Y 2018, Journal of Molecular Diagnostics. DOI: 10.1016/j.jmoldx.2017.11.004

Adenocarcinoma
Monroig-Bosque, P, Miller, RA & Cagle, PT 2018, . in Pulmonary Pathology: An Atlas and Text. 3rd edn, Wolters Kluwer.

Lung Cancer Epidemiology and Demographics
Miller, RA & Cagle, PT 2018, . in P Cagle, TC Allen, MB Beasley, LR Chirieac, S Dacic, AC Borczuk, KM Kerr, LM Sholl, B Portier & EH Bernicker (eds), Precision Molecular Pathology of Lung Cancer. 2 edn, vol. 13, Springer, Switzerland, pp. 15-18. DOI: 10.1007/978-3-319-62941-4_2

Hypersensitivity pneumonitis: A perspective from members of the pulmonary pathology society
Miller, R, Allen, TC, Barrios, RJ, Beasley, MB, Burke, L, Cagle, PT, Capelozzi, VL, Ge, Y, Hariri, LP, Kerr, KM, Khoor, A, Larsen, BT, Mark, EJ, Matsubara, O, Mehrad, M, Mino-Kenudson, M, Raparia, K, Roden, AC, Russell, P, Schneider, F, Sholl, LM & Smith, ML 2018, Archives of Pathology and Laboratory Medicine, vol 142, no. 1, pp. 120-126. DOI: 10.5858/arpa.2017-0138-SA

Predictive Biomarkers for Squamous Cell Carcinoma
Miller, RA & Cagle, PT 2018, . in P Cagle, TC Allen, MB Beasley, LR Chirieac, S Dacic, AC Borczuk, KM Kerr, LM Sholl, B Portier & EH Bernicker (eds), Precision Molecular Pathology of Lung Cancer. 2 edn, vol. 13, Molecular Pathology Library, Springer, Switzerland, pp. 173-176. DOI: 10.1007/978-3-319-62941-4_13

Molecular and immune biomarkers in acute respiratory distress syndrome a perspective from members of the pulmonary pathology society
Capelozzi, VL, Allen, TC, Beasley, MB, Cagle, PT, Guinee, D, Hariri, LP, Husain, AN, Jain, D, Lantuejoul, S, Larsen, BT, Miller, R, Mino-Kenudson, M, Mehrad, M, Raparia, K, Roden, A, Schneider, F, Sholl, LM & Smith, ML 2017, Archives of Pathology and Laboratory Medicine, vol 141, no. 12, pp. 1719-1727. DOI: 10.5858/arpa.2017-0115-SA

Programmed death ligand-1 (pd-l1) expression in either tumor cells or tumor-infiltrating immune cells correlates with solid and high-grade lung adenocarcinomas
Driver, BR, Miller, RA, Miller, T, Deavers, M, Gorman, B, Mody, D, Ge, Y, Barrios, R, Bernicker, E, Kim, M & Cagle, PT 2017, Archives of Pathology and Laboratory Medicine, vol 141, no. 11, pp. 1529-1532. DOI: 10.5858/arpa.2017-0028-OA

The future of college of American pathologists cancer protocols: Maintaining a commitment to patient safety while improving the user experience
Nakhleh, RE, Fitzgibbons, PL, Washington, MK, Baker, TP, Berman, MA & Cagle, PT 2017, Archives of Pathology and Laboratory Medicine, vol 141, no. 9, pp. 1153-1154. DOI: 10.5858/arpa.2017-0161-ED

Management of the solitary pulmonary nodule
Chan, EY, Gaur, P, Ge, Y, Kopas, L, Santacruz, JF, Gupta, N, Munden, RF, Cagle, PT & Kim, MP 2017, Archives of Pathology and Laboratory Medicine, vol 141, no. 7, pp. 927-931. DOI: 10.5858/arpa.2016-0307-RA

Biomarkers for selection of therapy for adenocarcinoma of the lung
Bernicker, EH, Miller, RA & Cagle, PT 2017, Journal of Oncology Practice, vol 13, no. 4, pp. 221-227. DOI: 10.1200/JOP.2016.019182

#InSituPathologists: How the #USCAP2015 meeting went viral on Twitter and founded the social media movement for the United States and Canadian Academy of Pathology
Cohen, D, Allen, TC, Balci, S, Cagle, PT, Teruya-Feldstein, J, Fine, SW, Gondim, DD, Hunt, JL, Jacob, J, Jewett, K, Jiang, X, Kaplan, KJ, Kulac, I, Meunier, R, Riddle, ND, Rush, PS, Stall, J, Stuart, LN, Terrano, D, Uthman, E, Wasco, MJ, Williamson, SR, Wu, RI & Gardner, JM 2017, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, vol 30, no. 2, pp. 160-168. DOI: 10.1038/modpathol.2016.223

Diagnosis of Acute Cellular Rejection and Antibody-Mediated Rejection on Lung Transplant Biopsies: A Perspective From Members of the Pulmonary Pathology Society
Roden, AC, Aisner, DL, Allen, TC, Aubry, MC, Barrios, RJ, Beasley, MB, Cagle, PT, Capelozzi, VL, Dacic, S, Ge, Y, Hariri, LP, Lantuejoul, S, Miller, RA, Mino-Kenudson, M, Moreira, AL, Raparia, K, Rekhtman, N, Sholl, L, Smith, ML, Tsao, MS, Vivero, M, Yatabe, Y & Yi, ES 2016, Archives of Pathology and Laboratory Medicine. DOI: 10.5858/arpa.2016-0459-SA

Biomarker testing in lung carcinoma cytology specimens: A perspective from members of the Pulmonary Pathology Society
Roy-Chowdhuri, S, Aisner, DL, Allen, TC, Beasley, MB, Borczuk, A, Cagle, PT, Capelozzi, V, Dacic, S, Da Cunha Santos, G, Hariri, LP, Kerr, KM, Lantuejoul, S, Mino-Kenudson, M, Moreira, A, Raparia, K, Rekhtman, N, Sholl, L, Thunnissen, E, Tsao, MS, Vivero, M & Yatabe, Y 2016, Archives of Pathology and Laboratory Medicine, vol 140, no. 11, pp. 1267-1272. DOI: 10.5858/arpa.2016-0091-SA

Transbronchial lung cryobiopsy for interstitial lung disease diagnosis: A perspective from members of the pulmonary pathology society
Raparia, K, Aisner, DL, Allen, TC, Beasley, MB, Borczuk, A, Cagle, PT, Capelozzi, V, Dacic, S, Hariri, LP, Kerr, KM, Lantuejoul, S, Mino-Kenudson, M, Rekhtman, N, Roden, AC, Roy-Chowdhuri, S, Sholl, L, Smith, ML, Thunnissen, E, Tsao, MS & Yatabe, Y 2016, Archives of Pathology and Laboratory Medicine, vol 140, no. 11, pp. 1281-1284. DOI: 10.5858/arpa.2016-0258-SA

PD-1/PD-L1, Only a Piece of the Puzzle
Miller, RA, Miller, TN & Cagle, PT 2016, Archives of Pathology and Laboratory Medicine, vol 140, no. 11, pp. 1187-1188. DOI: 10.5858/arpa.2016-0252-ED

Naissance of the archives of pathology and laboratory medicine: A critical analysis of the January 1926, Volume 1 Issue
Gal, AA & Cagle, PT 2016, Archives of Pathology and Laboratory Medicine, vol 140, no. 10, pp. 1140-1152. DOI: 10.5858/arpa.2016-0250-SA