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Murali Chintagumpala, MD

Full Clinical Member, Research Institute
Houston Methodist


Biography

Dr. Chintagumpala is the principal investigator of two multi-institutional studies designed to improve survival in patients with osteosarcoma and the treatment of medulloblastoma. He is a member of the Brain Tumor Committee and study chairman for a new protocol for children with low-grade gliomas. He is also a key investigator in a study to better delineate the risk factors for the development of metastases in children with retinoblastomas, and a gene therapy study at the Texas Children's Cancer Center for the treatment of children with retinoblastomas.

Areas Of Expertise

Retinoblastoma Neuro-oncology Solid Tumors Osteosarcoma Wilms Tumors
Publications

Study of Unilateral Retinoblastoma With and Without Histopathologic High-Risk Features and the Role of Adjuvant Chemotherapy: A Children's Oncology Group Study
Chévez-Barrios, P, Eagle, RC, Krailo, M, Piao, J, Albert, DM, Gao, Y, Vemuganti, G, Ali, MJ, Khetan, V, Honavar, SG, OBrien, J, Leahey, A-M, Matthay, K, Meadows, A & Chintagumpala, M 2019, Journal of clinical oncology : official journal of the American Society of Clinical Oncology, pp. JCO1801808. https://doi.org/10.1200/JCO.18.01808

Adaptive functioning in pediatric brain tumor survivors: An examination of ethnicity and socioeconomic status
Raghubar, KP, Orobio, J, Ris, MD, Heitzer, AM, Roth, A, Brown, AL, Okcu, MF, Chintagumpala, M, Grosshans, DR, Paulino, AC, Mahajan, A & Kahalley, LS 2019, Pediatric Blood and Cancer, vol. 66, no. 9, e27800, pp. e27800. https://doi.org/10.1002/pbc.27800

Retinoblastoma in Low- and Middle-Income Countries
Chintagumpala, M 2019, Pediatric Hematology and Oncology, vol. 36, no. 2, pp. 53-54. https://doi.org/10.1080/08880018.2019.1624903

Prospective, longitudinal comparison of neurocognitive change in pediatric brain tumor patients treated with proton radiotherapy versus surgery only
Kahalley, LS, Douglas Ris, M, Mahajan, A, Fatih Okcu, M, Chintagumpala, M, Paulino, AC, Whitehead, WE, Minard, CG, Stancel, HH, Orobio, J, Xue, JJ, Warren, EA & Grosshans, DR 2019, Neuro-oncology, vol. 21, no. 6, pp. 809-818. https://doi.org/10.1093/neuonc/noz041

Epilepsy outcome following resection of low-grade brain tumors in children
Mohan, AC, Weiner, HL, Mohila, CA, Adesina, A, Chintagumpala, M, Curry, D, Jea, A, Lee, JJ, Lam, SK, Whitehead, WE, Dauser, R, Yoshor, D & Aldave, G 2019, Journal of Neurosurgery: Pediatrics, vol. 23, no. 6, pp. 726-731. https://doi.org/10.3171/2019.1.PEDS18367

Increased risk of pseudoprogression among pediatric low-grade glioma patients treated with proton versus photon radiotherapy
Ludmir, EB, Mahajan, A, Paulino, AC, Jones, JY, Ketonen, LM, Su, JM, Grosshans, DR, McAleer, MF, McGovern, SL, Lassen-Ramshad, YA, Adesina, AM, Dauser, RC, Weinberg, JS & Chintagumpala, M 2019, Neuro-oncology, vol. 21, no. 5, pp. 686-695. https://doi.org/10.1093/neuonc/noz042

Patterns of failure following proton beam therapy for head and neck rhabdomyosarcoma
Ludmir, EB, Grosshans, DR, McAleer, MF, McGovern, SL, Harrison, DJ, Okcu, MF, Chintagumpala, M, Mahajan, A & Paulino, AC 2019, Radiotherapy and Oncology, vol. 134, pp. 143-150. https://doi.org/10.1016/j.radonc.2019.02.002

Pilot study of DNA methylation-derived neutrophil-to-lymphocyte ratio and survival in pediatric medulloblastoma
Arroyo, VM, Lupo, PJ, Scheurer, ME, Rednam, SP, Murray, J, Okcu, MF, Chintagumpala, M & Brown, AL 2019, Cancer Epidemiology, vol. 59, pp. 71-74. https://doi.org/10.1016/j.canep.2019.01.011

Pediatric Bronchial Carcinoid Tumors: A Case Series and Review of the Literature
Potter, SL, HaDuong, J, Okcu, F, Wu, H, Chintagumpala, M & Venkatramani, R 2019, Journal of pediatric hematology/oncology, vol. 41, no. 1, pp. 67-70. https://doi.org/10.1097/MPH.0000000000001100

Technical and anatomical factors affecting intra-arterial chemotherapy fluoroscopy time and radiation dose for intraocular retinoblastoma
Area, C, Yen, CJ, Chévez-Barrios, P, Herzog, C, Kan, P, Zheng, W, Lin, F, Chintagumpala, M, Gambos, D & Chen, SR 2019, Journal of neurointerventional surgery. https://doi.org/10.1136/neurintsurg-2019-014910

Patterns of failure and toxicity profile following proton beam therapy for pediatric bladder and prostate rhabdomyosarcoma
Buszek, SM, Ludmir, EB, Grosshans, DR, McAleer, MF, McGovern, SL, Harrison, DJ, Okcu, MF, Chintagumpala, M, Mahajan, A & Paulino, AC 2019, Pediatric Blood and Cancer. https://doi.org/10.1002/pbc.27952

Clinical, radiologic, pathologic, and molecular characteristics of long-term survivors of Diffuse Intrinsic Pontine Glioma (DIPG): A collaborative report from the International and European Society for Pediatric Oncology DIPG registries
Hoffman, LM, Van Zanten, SEMV, Colditz, N, Baugh, J, Chaney, B, Hoffmann, M, Lane, A, Fuller, C, Miles, L, Hawkins, C, Bartels, U, Bouffet, E, Goldman, S, Leary, S, Foreman, NK, Packer, R, Warren, KE, Broniscer, A, Kieran, MW, Minturn, J, Comito, M, Broxson, E, Shih, CS, Khatua, S, Chintagumpala, M, Carret, AS, Escorza, NY, Hassall, T, Ziegler, DS, Gottardo, N, Dholaria, H, Doughman, R, Benesch, M, Drissi, R, Nazarian, J, Jabado, N, Boddaert, N, Varlet, P, Giraud, G, Castel, D, Puget, S, Jones, C, Hulleman, E, Modena, P, Giagnacovo, M, Antonelli, M, Pietsch, T, Gielen, GH, Jones, DTW, Sturm, D, Pfister, SM, Gerber, NU, Grotzer, MA, Pfaff, E, Von Bueren, AO, Hargrave, D, Solanki, GA, Cvrlje, FJ, Kaspers, GJL, Vandertop, WP, Grill, J, Bailey, S, Biassoni, V, Massimino, M, Calmon, R, Sanchez, E, Bison, B, Warmuth-Metz, M, Leach, J, Jones, B, Van Vuurden, DG, Kramm, CM & Fouladi, M 2018, Journal of Clinical Oncology, vol. 36, no. 19, pp. 1963-1972. https://doi.org/10.1200/JCO.2017.75.9308

Ototoxicity and cochlear sparing in children with medulloblastoma: Proton vs. photon radiotherapy
Paulino, AC, Mahajan, A, Ye, R, Grosshans, DR, Fatih Okcu, M, Su, J, McAleer, MF, McGovern, S, Mangona, VA & Chintagumpala, M 2018, Radiotherapy and Oncology, vol. 128, no. 1, pp. 128-132. https://doi.org/10.1016/j.radonc.2018.01.002

Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial cohort
Waszak, SM, Northcott, PA, Buchhalter, I, Robinson, GW, Sutter, C, Groebner, S, Grund, KB, Brugières, L, Jones, DTW, Pajtler, KW, Morrissy, AS, Kool, M, Sturm, D, Chavez, L, Ernst, A, Brabetz, S, Hain, M, Zichner, T, Segura-Wang, M, Weischenfeldt, J, Rausch, T, Mardin, BR, Zhou, X, Baciu, C, Lawerenz, C, Chan, JA, Varlet, P, Guerrini-Rousseau, L, Fults, DW, Grajkowska, W, Hauser, P, Jabado, N, Ra, YS, Zitterbart, K, Shringarpure, SS, De La Vega, FM, Bustamante, CD, Ng, HK, Perry, A, MacDonald, TJ, Hernáiz Driever, P, Bendel, AE, Bowers, DC, McCowage, G, Chintagumpala, M, Cohn, R, Hassall, T, Fleischhack, G, Eggen, T, Wesenberg, F, Feychting, M, Lannering, B, Schüz, J, Johansen, C, Andersen, TV, Röösli, M, Kuehni, CE, Grotzer, M, Kjaerheim, K, Monoranu, CM, Archer, TC, Duke, E, Pomeroy, SL, Shelagh, R, Frank, S, Sumerauer, D, Scheurlen, W, Ryzhova, MV, Milde, T, Kratz, CP, Samuel, D, Zhang, J, Solomon, DA, Marra, M, Eils, R, Bartram, CR, von Hoff, K, Rutkowski, S, Ramaswamy, V, Gilbertson, RJ, Korshunov, A, Taylor, MD, Lichter, P, Malkin, D, Gajjar, A, Korbel, JO & Pfister, SM 2018, The Lancet Oncology, vol. 19, no. 6, pp. 785-798. https://doi.org/10.1016/S1470-2045(18)30242-0

Local therapy to distant metastatic sites in stage IV rhabdomyosarcoma
Mohan, AC, Venkatramani, R, Okcu, MF, Nuchtern, JG, Vasudevan, SA, Mahajan, A, Rainusso, NC, Allen-Rhoades, W, Chintagumpala, M & Paulino, AC 2018, Pediatric Blood and Cancer, vol. 65, no. 2, e26859. https://doi.org/10.1002/pbc.26859

Meta-analysis of the incidence and patterns of second neoplasms after photon craniospinal irradiation in children with medulloblastoma
Bavle, A, Tewari, S, Sisson, A, Chintagumpala, M, Anderson, M & Paulino, AC 2018, Pediatric Blood and Cancer. https://doi.org/10.1002/pbc.27095

Hypothyroidism after craniospinal irradiation with proton or photon therapy in patients with medulloblastoma
Bielamowicz, K, Okcu, MF, Sonabend, R, Paulino, AC, Hilsenbeck, SG, Dreyer, Z, Suzawa, H, Bryant, R, Adesina, A, Dauser, R, Mahajan, A & Chintagumpala, M 2018, Pediatric Hematology and Oncology. https://doi.org/10.1080/08880018.2018.1471111

DNA methylation of a novel PAK4 locus influences ototoxicity susceptibility following cisplatin and radiation therapy for pediatric embryonal tumors
Brown, AL, Foster, KL, Lupo, PJ, Peckham-Gregory, EC, Murray, JC, Okcu, MF, Lau, CC, Rednam, SP, Chintagumpala, M & Scheurer, ME 2017, Neuro-Oncology, vol. 19, no. 10, pp. 1372-1379. https://doi.org/10.1093/neuonc/nox076

Contemporary survival endpoints: An international diffuse intrinsic pontine glioma registry study
Cooney, T, Lane, A, Bartels, U, Bouffet, E, Goldman, S, Leary, SES, Foreman, NK, Packer, RJ, Broniscer, A, Minturn, JE, Shih, CS, Chintagumpala, M, Hassall, T, Gottardo, NG, Dholaria, H, Hoffman, L, Chaney, B, Baugh, J, Doughman, R, Leach, JL, Jones, BV, Fouladi, M, Warren, KE & Monje, M 2017, Neuro-Oncology, vol. 19, no. 9, pp. 1279-1280. https://doi.org/10.1093/neuonc/nox107

Results of the First Prospective Multi-institutional Treatment Study in Children with Bilateral Wilms Tumor (AREN0534): A Report from the Children's Oncology Group
Ehrlich, P, Chi, YY, Chintagumpala, M, Hoffer, FA, Perlman, EJ, Kalapurakal, JA, Warwick, A, Shamberger, RC, Khanna, G, Hamilton, TE, Gow, KW, Paulino, AC, Gratias, EJ, Mullen, EA, Geller, JI, Grundy, PE, Fernandez, CV, Ritchey, ML & Dome, JS 2017, Annals of Surgery, vol. 266, no. 3, pp. 470-478. https://doi.org/10.1097/SLA.0000000000002356

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