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Murali Chintagumpala, MD

Full Clinical Member, Research Institute
Houston Methodist


Description of Research

Dr. Chintagumpala is the principal investigator of two multi-institutional studies designed to improve survival in patients with osteosarcoma and the treatment of medulloblastoma. He is a member of the Brain Tumor Committee and study chairman for a new protocol for children with low-grade gliomas. He is also a key investigator in a study to better delineate the risk factors for the development of metastases in children with retinoblastomas, and a gene therapy study at the Texas Children's Cancer Center for the treatment of children with retinoblastomas.

Areas Of Expertise

Retinoblastoma Neuro-oncology Solid Tumors Osteosarcoma Wilms Tumors
Publications

Impact of SCID mouse gender on tumorigenicity, xenograft growth and drug-response in a large panel of orthotopic PDX models of pediatric brain tumors
Qi, L, Kogiso, M, Du, Y, Zhang, H, Braun, FK, Huang, Y, Teo, WY, Lindsay, H, Zhao, S, Baxter, P, Zhao, X, Yu, L, Liu, Z, Zhang, X, Su, JMF, Adesina, A, Yang, J, Chintagumpala, M, Perlaky, L, Tsz-Kwong Man, C, Lau, CC & Li, XN 2020, , Cancer Letters, vol. 493, pp. 197-206. https://doi.org/10.1016/j.canlet.2020.08.035

A single-arm study of systemic and sub-Tenon chemotherapy for Groups C and D intraocular retinoblastoma: A Children's Oncology Group study (ARET 0231)
Jubran, RF, Villablanca, JG, Krailo, M, Piao, J, Huang, L, Murphree, AL, OBrien, J, Gombos, D, Shields, CL, Meadows, A & Chintagumpala, M 2020, , Pediatric Blood and Cancer, vol. 67, no. 9, e28502. https://doi.org/10.1002/pbc.28502

Development of second primary tumors and outcomes in medulloblastoma by treatment modality: A Surveillance, Epidemiology, and End Results analysis
Nantavithya, C, Paulino, AC, Liao, K, McGovern, SL, Grosshans, DR, McAleer, MF, Woodhouse, KD, Khatua, S, Chintagumpala, MM, Majd, NK & Yeboa, DN 2020, , Pediatric Blood and Cancer, vol. 67, no. 8, e28373. https://doi.org/10.1002/pbc.28373

Results of Treatment for Patients With Multicentric or Bilaterally Predisposed Unilateral Wilms Tumor (AREN0534): A report from the Children's Oncology Group
Ehrlich, PF, Chi, YY, Chintagumpala, MM, Hoffer, FA, Perlman, EJ, Kalapurakal, JA, Tornwall, B, Warwick, A, Shamberger, RC, Khanna, G, Hamilton, TE, Gow, KW, Paulino, AC, Gratias, EJ, Mullen, EA, Geller, JI, Grundy, PE, Fernandez, CV & Dome, JS 2020, , Cancer, vol. 126, no. 15, pp. 3516-3525. https://doi.org/10.1002/cncr.32958

Reply to S.A. Milgrom et al
Kahalley, LS, Peterson, R, Ris, MD, Janzen, L, Okcu, MF, Grosshans, DR, Ramaswamy, V, Paulino, AC, Hodgson, D, Mahajan, A, Tsang, DS, Laperriere, N, Whitehead, WE, Dauser, RC, Taylor, MD, Bouffet, E, Chintagumpala, M & Mabbott, D 2020, , Journal of Clinical Oncology, vol. 38, no. 19, pp. 2212-2213. https://doi.org/10.1200/JCO.20.00344

Response assessment in paediatric low-grade glioma: recommendations from the Response Assessment in Pediatric Neuro-Oncology (RAPNO) working group
Fangusaro, J, Witt, O, Hernáiz Driever, P, Bag, AK, de Blank, P, Kadom, N, Kilburn, L, Lober, RM, Robison, NJ, Fisher, MJ, Packer, RJ, Young Poussaint, T, Papusha, L, Avula, S, Brandes, AA, Bouffet, E, Bowers, D, Artemov, A, Chintagumpala, M, Zurakowski, D, van den Bent, M, Bison, B, Yeom, KW, Taal, W & Warren, KE 2020, , The Lancet Oncology, vol. 21, no. 6, pp. e305-e316. https://doi.org/10.1016/S1470-2045(20)30064-4

Germline Elongator mutations in Sonic Hedgehog medulloblastoma
Waszak, SM, Robinson, GW, Gudenas, BL, Smith, KS, Forget, A, Kojic, M, Garcia-Lopez, J, Hadley, J, Hamilton, KV, Indersie, E, Buchhalter, I, Kerssemakers, J, Jäger, N, Sharma, T, Rausch, T, Kool, M, Sturm, D, Jones, DTW, Vasilyeva, A, Tatevossian, RG, Neale, G, Lombard, B, Loew, D, Nakitandwe, J, Rusch, M, Bowers, DC, Bendel, A, Partap, S, Chintagumpala, M, Crawford, J, Gottardo, NG, Smith, A, Dufour, C, Rutkowski, S, Eggen, T, Wesenberg, F, Kjaerheim, K, Feychting, M, Lannering, B, Schüz, J, Johansen, C, Andersen, TV, Röösli, M, Kuehni, CE, Grotzer, M, Remke, M, Puget, S, Pajtler, KW, Milde, T, Witt, O, Ryzhova, M, Korshunov, A, Orr, BA, Ellison, DW, Brugieres, L, Lichter, P, Nichols, KE, Gajjar, A, Wainwright, BJ, Ayrault, O, Korbel, JO, Northcott, PA & Pfister, SM 2020, , Nature, vol. 580, no. 7803, pp. 396-401. https://doi.org/10.1038/s41586-020-2164-5

Provider views on perioperative steroid use for patients with newly diagnosed pediatric brain tumors
Malbari, F, Staggers, KA, Minard, CG, Weiner, HL, Chintagumpala, M & Levy, AS 2020, Journal of Neuro-Oncology, vol. 147, no. 1, pp. 205-212. https://doi.org/10.1007/s11060-020-03416-9

Global Disparities in Wilms Tumor
Cunningham, ME, Klug, TD, Nuchtern, JG, Chintagumpala, M, Venkatramani, R, Lubega, J & Naik-Mathuria, BJ 2020, , Journal of Surgical Research, vol. 247, pp. 34-51. https://doi.org/10.1016/j.jss.2019.10.044

Superior intellectual outcomes after proton radiotherapy compared with photon radiotherapy for pediatric medulloblastoma
Kahalley, LS, Peterson, R, Ris, MD, Janzen, L, Okcu, MF, Grosshans, DR, Ramaswamy, V, Paulino, AC, Hodgson, D, Mahajan, A, Tsang, DS, Laperriere, N, Whitehead, WE, Dauser, RC, Taylor, MD, Conklin, HM, Chintagumpala, M, Bouffet, E & Mabbott, D 2020, , Journal of Clinical Oncology, vol. 38, no. 5, pp. 454-461. https://doi.org/10.1200/JCO.19.01706

Cognitive mediators of adaptive functioning outcomes in survivors of pediatric brain tumors treated with proton radiotherapy
Roth, AK, Ris, MD, Orobio, J, Xue, J, Mahajan, A, Paulino, AC, Grosshans, D, Okcu, MF, Chintagumpala, M & Kahalley, LS 2020, , Pediatric Blood and Cancer, vol. 67, no. 2, e28064. https://doi.org/10.1002/pbc.28064

Risk-adapted therapy and biological heterogeneity in pineoblastoma: integrated clinico-pathological analysis from the prospective, multi-center SJMB03 and SJYC07 trials
Liu, APY, Gudenas, B, Lin, T, Orr, BA, Klimo, P, Kumar, R, Bouffet, E, Gururangan, S, Crawford, JR, Kellie, SJ, Chintagumpala, M, Fisher, MJ, Bowers, DC, Hassall, T, Indelicato, DJ, Onar-Thomas, A, Ellison, DW, Boop, FA, Merchant, TE, Robinson, GW, Northcott, PA & Gajjar, A 2020, , Acta Neuropathologica, vol. 139, no. 2, pp. 259-271. https://doi.org/10.1007/s00401-019-02106-9

Correction to: Risk-adapted therapy and biological heterogeneity in pineoblastoma: integrated clinico-pathological analysis from the prospective, multi-center SJMB03 and SJYC07 trials (Acta Neuropathologica, (2020), 139, 2, (259-271), 10.1007/s00401-019-02106-9)
Liu, APY, Gudenas, B, Lin, T, Orr, BA, Klimo, P, Kumar, R, Bouffet, E, Gururangan, S, Crawford, JR, Kellie, SJ, Chintagumpala, M, Fisher, MJ, Bowers, DC, Hassall, T, Indelicato, DJ, Onar-Thomas, A, Ellison, DW, Boop, FA, Merchant, TE, Robinson, GW, Northcott, PA & Gajjar, A 2020, , Acta Neuropathologica, vol. 139, no. 2, pp. 273-275. https://doi.org/10.1007/s00401-019-02115-8

Effect of sensorineural hearing loss on neurocognitive and adaptive functioning in survivors of pediatric embryonal brain tumor
Heitzer, AM, Villagran, AM, Raghubar, K, Brown, AL, Camet, ML, Ris, MD, Hanning, JH, Okcu, MF, Paulino, AC, Chintagumpala, M & Kahalley, LS 2020, Journal of Neuro-Oncology, vol. 146, no. 1, pp. 147-156. https://doi.org/10.1007/s11060-019-03356-z

Neuropsychological functioning following surgery for pediatric low-grade glioma: A prospective longitudinal study
Heitzer, AM, Raghubar, K, Douglas Ris, M, Minard, CG, Gragert, MN, Stancel, HH, Orobio, J, Xue, J, Whitehead, W, Fatih Okcu, M, Chintagumpala, M & Kahalley, LS 2020, , Journal of Neurosurgery: Pediatrics, vol. 25, no. 3, pp. 251-259. https://doi.org/10.3171/2019.9.PEDS19357

Germline GPR161 mutations predispose to pediatric medulloblastoma
Begemann, M, Waszak, SM, Robinson, GW, Jäger, N, Sharma, T, Knopp, C, Kraft, F, Moser, O, Mynarek, M, Guerrini-Rousseau, L, Brugieres, L, Varlet, P, Pietsch, T, Bowers, DC, Chintagumpala, M, Sahm, F, Korbel, JO, Rutkowski, S, Eggermann, T, Gajjar, A, Northcott, P, Elbracht, M, Pfister, SM, Kontny, U & Kurth, I 2020, , Journal of Clinical Oncology, vol. 38, no. 1, pp. 43-50. https://doi.org/10.1200/JCO.19.00577

Technical and anatomical factors affecting intra-arterial chemotherapy fluoroscopy time and radiation dose for intraocular retinoblastoma
Area, C, Yen, CJ, Chévez-Barrios, P, Herzog, C, Kan, P, Zheng, W, Lin, F, Chintagumpala, M, Gombos, D & Chen, SR 2019, , Journal of neurointerventional surgery, vol. 11, no. 12, pp. 1273-1276. https://doi.org/10.1136/neurintsurg-2019-014910

Adaptive functioning in pediatric brain tumor survivors: An examination of ethnicity and socioeconomic status
Raghubar, KP, Orobio, J, Ris, MD, Heitzer, AM, Roth, A, Brown, AL, Okcu, MF, Chintagumpala, M, Grosshans, DR, Paulino, AC, Mahajan, A & Kahalley, LS 2019, , Pediatric Blood and Cancer, vol. 66, no. 9, e27800, pp. e27800. https://doi.org/10.1002/pbc.27800

Retinoblastoma in Low- and Middle-Income Countries
Chintagumpala, M 2019, Pediatric Hematology and Oncology, vol. 36, no. 2, pp. 53-54. https://doi.org/10.1080/08880018.2019.1624903

Prospective, longitudinal comparison of neurocognitive change in pediatric brain tumor patients treated with proton radiotherapy versus surgery only
Kahalley, LS, Douglas Ris, M, Mahajan, A, Fatih Okcu, M, Chintagumpala, M, Paulino, AC, Whitehead, WE, Minard, CG, Stancel, HH, Orobio, J, Xue, JJ, Warren, EA & Grosshans, DR 2019, , Neuro-oncology, vol. 21, no. 6, pp. 809-818. https://doi.org/10.1093/neuonc/noz041