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Murali Chintagumpala, MD

Full Clinical Member, Research Institute
Houston Methodist


Biography

Dr. Chintagumpala is the principal investigator of two multi-institutional studies designed to improve survival in patients with osteosarcoma and the treatment of medulloblastoma. He is a member of the Brain Tumor Committee and study chairman for a new protocol for children with low-grade gliomas. He is also a key investigator in a study to better delineate the risk factors for the development of metastases in children with retinoblastomas, and a gene therapy study at the Texas Children's Cancer Center for the treatment of children with retinoblastomas.

Areas Of Expertise

Retinoblastoma Neuro-oncology Solid Tumors Osteosarcoma Wilms Tumors
Publications

Local therapy to distant metastatic sites in stage IV rhabdomyosarcoma
Mohan, AC, Venkatramani, R, Okcu, MF, Nuchtern, JG, Vasudevan, SA, Mahajan, A, Rainusso, NC, Allen-Rhoades, W, Chintagumpala, M & Paulino, AC 2018, Pediatric Blood and Cancer, vol 65, no. 2, e26859. DOI: 10.1002/pbc.26859

Meta-analysis of the incidence and patterns of second neoplasms after photon craniospinal irradiation in children with medulloblastoma
Bavle, A, Tewari, S, Sisson, A, Chintagumpala, M, Anderson, M & Paulino, AC 2018, Pediatric Blood and Cancer. DOI: 10.1002/pbc.27095

A pediatric brain tumor consortium phase II trial of capecitabine rapidly disintegrating tablets with concomitant radiation therapy in children with newly diagnosed diffuse intrinsic pontine gliomas
Kilburn, LB, Kocak, M, Baxter, P, Poussaint, TY, Paulino, AC, Mcintyre, C, Lemenuel-Diot, A, Lopez-Diaz, C, Kun, L, Chintagumpala, M, Su, JM, Broniscer, A, Baker, JN, Hwang, EI, Fouladi, M, Boyett, JM & Blaney, SM 2017, Pediatric Blood and Cancer. DOI: 10.1002/pbc.26832

DNA methylation of a novel PAK4 locus influences ototoxicity susceptibility following cisplatin and radiation therapy for pediatric embryonal tumors
Brown, AL, Foster, KL, Lupo, PJ, Peckham-Gregory, EC, Murray, JC, Okcu, MF, Lau, CC, Rednam, SP, Chintagumpala, M & Scheurer, ME 2017, Neuro-Oncology, vol 19, no. 10, pp. 1372-1379. DOI: 10.1093/neuonc/nox076

Results of the First Prospective Multi-institutional Treatment Study in Children with Bilateral Wilms Tumor (AREN0534): A Report from the Children's Oncology Group
Ehrlich, P, Chi, YY, Chintagumpala, MM, Hoffer, FA, Perlman, EJ, Kalapurakal, JA, Warwick, A, Shamberger, RC, Khanna, G, Hamilton, TE, Gow, KW, Paulino, AC, Gratias, EJ, Mullen, EA, Geller, JI, Grundy, PE, Fernandez, CV, Ritchey, ML & Dome, JS 2017, Annals of Surgery, vol 266, no. 3, pp. 470-478. DOI: 10.1097/SLA.0000000000002356

Contemporary survival endpoints: An international diffuse intrinsic pontine glioma registry study
Cooney, T, Lane, A, Bartels, U, Bouffet, E, Goldman, S, Leary, SES, Foreman, NK, Packer, RJ, Broniscer, A, Minturn, JE, Shih, CS, Chintagumpala, M, Hassall, T, Gottardo, NG, Dholaria, H, Hoffman, L, Chaney, B, Baugh, J, Doughman, R, Leach, JL, Jones, BV, Fouladi, M, Warren, KE & Monje, M 2017, Neuro-Oncology, vol 19, no. 9, pp. 1279-1280. DOI: 10.1093/neuonc/nox107

Systemic neoadjuvant chemotherapy for Group B intraocular retinoblastoma (ARET0331): A report from the Children's Oncology Group
Friedman, DL, Krailo, M, Villaluna, D, Gombos, D, Langholz, B, Jubran, R, Shields, C, Murphree, L, OBrien, J, Kessel, S, Rodriguez-Galindo, C, Chintagumpala, M & Meadows, AT 2017, Pediatric Blood and Cancer, vol 64, no. 7, e26394. DOI: 10.1002/pbc.26394

Progression-free survival of children with localized ependymoma treated with intensity-modulated radiation therapy or proton-beam radiation therapy
Sato, M, Gunther, JR, Mahajan, A, Jo, E, Paulino, AC, Adesina, AM, Jones, JY, Ketonen, LM, Su, JM, Okcu, MF, Khatua, S, Dauser, RC, Whitehead, WE, Weinberg, J & Chintagumpala, MM 2017, Cancer, vol 123, no. 13, pp. 2570-2578. DOI: 10.1002/cncr.30623

Vitreous Seeds in Retinoblastoma. Clinicopathologic Classification and Correlation
Amram, AL, Rico, G, Kim, JW, Chintagumpala, M, Herzog, CE, Gombos, DS & Chévez-Barrios, P 2017, Ophthalmology. DOI: 10.1016/j.ophtha.2017.04.015

Attention, processing speed, and executive functioning in pediatric brain tumor survivors treated with proton beam radiation therapy
Antonini, TN, Ris, MD, Grosshans, DR, Mahajan, A, Okcu, MF, Chintagumpala, M, Paulino, A, Child, AE, Orobio, J, Stancel, HH & Kahalley, LS 2017, Radiotherapy and Oncology. DOI: 10.1016/j.radonc.2017.06.010

Genomic analysis of hepatoblastoma identifies distinct molecular and prognostic subgroups
Sumazin, P, Chen, Y, Treviño, LR, Sarabia, SF, Hampton, OA, Patel, K, Mistretta, TA, Zorman, B, Thompson, P, Heczey, A, Comerford, S, Wheeler, DA, Chintagumpala, M, Meyers, R, Rakheja, D, Finegold, MJ, Tomlinson, G, Parsons, DW & López-Terrada, D 2017, Hepatology, vol 65, no. 1, pp. 104-121. DOI: 10.1002/hep.28888

Myofibroma in Infancy and Childhood
Mahajan, P, Hicks, J, Chintagumpala, M & Venkatramani, R 2017, Journal of Pediatric Hematology/Oncology, vol 39, no. 3, pp. e136-e139. DOI: 10.1097/MPH.0000000000000732

Xenotransplantation of pediatric low grade gliomas confirms the enrichment of BRAF V600E mutation and preservation of CDKN2A deletion in a novel orthotopic xenograft mouse model of progressive pleomorphic xanthoastrocytoma
Kogiso, M, Qi, L, Lindsay, H, Huang, Y, Zhao, X, Liu, Z, Braun, FK, Du, Y, Zhang, H, Bae, G, Zhao, S, Injac, SG, Sobieski, M, Brunell, D, Mehta, V, Tran, D, Murray, J, Baxter, PA, Yuan, XJ, Su, JM, Adesina, A, Perlaky, L, Chintagumpala, M, Williams Parsons, D, Lau, CC, Stephan, CC, Lu, X & Li, XN 2017, Oncotarget, vol 8, no. 50, pp. 87455-87471. DOI: 10.18632/oncotarget.20713

Epidemiology of childhood brain tumors
Lupo, PJ, Rednam, SP & Chintagumpala, M 2017, . in Radiation Oncology for Pediatric CNS Tumors. Springer International Publishing, pp. 3-19. DOI: 10.1007/978-3-319-55430-3_1

Exploratory analysis of ERCC2 DNA methylation in survival among pediatric medulloblastoma patients
Banfield, E, Brown, AL, Peckham, EC, Rednam, SP, Murray, J, Okcu, MF, Mitchell, LE, Chintagumpala, MM, Lau, CC, Scheurer, ME & Lupo, PJ 2016, Cancer Epidemiology, vol 44, pp. 161-166. DOI: 10.1016/j.canep.2016.08.020

Correlation of Insurance, Race, and Ethnicity with Pathologic Risk in a Controlled Retinoblastoma Cohort. A Children's Oncology Group Study
Green, AL, Chintagumpala, M, Krailo, M, Langholz, B, Albert, D, Eagle, R, Cockburn, M, Chevez-Barrios, P & Rodriguez-Galindo, C 2015, Ophthalmology. DOI: 10.1016/j.ophtha.2016.04.043

Neuroendocrine Tumor of the Appendix in Children
Wu, H, Chintagumpala, M, Hicks, J, Nuchtern, JG, Okcu, MF & Venkatramani, R 2016, Journal of Pediatric Hematology/Oncology. DOI: 10.1097/MPH.0000000000000598

Primitive myxoid mesenchymal tumor of infancy involving chest wall in an infant: A case report and clinicopathologic correlation
Foster, JH, Vasudevan, SA, Hicks, MJ, Schady, D & Chintagumpala, M 2016, Pediatric and Developmental Pathology, vol 19, no. 3, pp. 244-248. DOI: 10.2350/15-05-1644-CR.1

Diagnostic yield of clinical tumor and germline whole-exome sequencing for children with solid tumors
Parsons, DW, Roy, A, Yang, Y, Wang, T, Scollon, S, Bergstrom, K, Kerstein, RA, Gutierrez, S, Petersen, AK, Bavle, A, Lin, FY, López-Terrada, DH, Monzon, FA, Hicks, MJ, Eldin, KW, Quintanilla, NM, Adesina, AM, Mohila, CA, Whitehead, W, Jea, A, Vasudevan, SA, Nuchtern, JG, Ramamurthy, U, McGuire, AL, Hilsenbeck, SG, Reid, JG, Muzny, DM, Wheeler, DA, Berg, SL, Chintagumpala, MM, Eng, CM, Gibbs, RA & Plon, SE 2016, JAMA Oncology, vol 2, no. 5, pp. 616-624. DOI: 10.1001/jamaoncol.2015.5699

Comparing intelligence quotient change after treatment with proton versus photon radiation therapy for pediatric brain tumors
Kahalley, LS, Ris, MD, Grosshans, DR, Okcu, MF, Paulino, AC, Chintagumpala, M, Moore, BD, Guffey, D, Minard, CG, Stancel, HH & Mahajan, A 2016, Journal of Clinical Oncology, vol 34, no. 10, pp. 1043-1049. DOI: 10.1200/JCO.2015.62.1383