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Lili Zhang, PhD

Assistant Research Professor of Cardiovascular Sciences, Academic Institute
Assistant Research Member, Research Institute
Houston Methodist
Weill Cornell Medical College

Center for Cardiovascular Regeneration

Machine learning uncovers cell identity regulator by histone code
Xia, B, Zhao, D, Wang, G, Zhang, M, Lv, J, Tomoiaga, AS, Li, Y, Wang, X, Meng, S, Cooke, JP, Cao, Q, Zhang, L & Chen, K 2020, Nature Communications, vol. 11, no. 1, 2696.

TADsplimer reveals splits and mergers of topologically associating domains for epigenetic regulation of transcription
Wang, G, Meng, Q, Xia, B, Zhang, S, Lv, J, Zhao, D, Li, Y, Wang, X, Zhang, L, Cooke, JP, Cao, Q & Chen, K 2020, Genome Biology, vol. 21, no. 1, 84.

BMI1 is directly regulated by androgen receptor to promote castration-resistance in prostate cancer
Zhu, S, Zhao, D, Li, C, Li, Q, Jiang, W, Liu, Q, Wang, R, Fazli, L, Li, Y, Zhang, L, Yi, Y, Meng, Q, Wang, W, Wang, G, Zhang, M, Zu, X, Zhao, W, Deng, T, Yu, J, Dong, X, Chen, K & Cao, Q 2020, , Oncogene, vol. 39, no. 1, pp. 17-29.

Polycomb group proteins EZH2 and EED directly regulate androgen receptor in advanced prostate cancer
Liu, Q, Wang, G, Li, Q, Jiang, W, Kim, JS, Wang, R, Zhu, S, Wang, X, Yan, L, Yi, Y, Zhang, L, Meng, Q, Li, C, Zhao, D, Qiao, Y, Li, Y, Gursel, DB, Chinnaiyan, AM, Chen, K & Cao, Q 2019, , International Journal of Cancer, vol. 145, no. 2, pp. 415-426.

Mitochondrial DNA oxidation induces imbalanced activity of NLRP3/NLRP6 inflammasomes by activation of caspase-8 and BRCC36 in dry eye
Chi, W, Hua, X, Chen, X, Bian, F, Yuan, X, Zhang, L, Wang, X, Chen, D, Deng, R, Li, Z, Liu, Y, de Paiva, CS, Pflugfelder, SC & Li, D-Q 2017, , Journal of Autoimmunity, vol. 80, pp. 65-76.

Pollen/TLR4 Innate Immunity Signaling Initiates IL-33/ST2/Th2 Pathways in Allergic Inflammation
Li, J, Zhang, L, Chen, X, Chen, D, Hua, X, Bian, F, Deng, R, Lu, F, Li, Z, Pflugfelder, SC & Li, D-Q 2016, , Scientific Reports, vol. 6, pp. 36150 EP -.

Blueberry Component Pterostilbene Protects Corneal Epithelial Cells from Inflammation via Anti-oxidative Pathway
Li, J, Ruzhi Deng, Hua, X, Zhang, L, Lu, F, Coursey, TG, Pflugfelder, SC & Li, D-Q 2016, , Scientific Reports, vol. 6, pp. 19408.

Effects of azithromycin on gene expression profiles of proinflammatory and anti-inflammatory mediators in the eyelid margin and conjunctiva of patients with meibomian gland disease
Zhang, L, Su, Z, Zhang, Z, Lin, J, Li, DQ & Pflugfelder, SC 2015, , JAMA Ophthalmology, vol. 133, no. 10, pp. 1117-1123.

Broad H3K4me3 is associated with increased transcription elongation and enhancer activity at tumor-suppressor genes
Chen, K, Chen, Z, Wu, D, Zhang, L, Lin, X, Su, J, Rodriguez, B, Xi, Y, Xia, Z, Chen, X, Shi, X, Wang, Q & Li, W 2015, , Nature Genetics, vol. 47, no. 10, pp. 1149-1157.

Oxidative stress markers induced by hyperosmolarity in primary human corneal epithelial cells
Deng, R, Hua, X, Li, J, Chi, W, Zhang, Z, Lu, F, Zhang, L, Pflugfelder, SC & Li, D-Q 2015, , PLoS ONE, vol. 10, no. 5, pp. e0126561.

A potential link between bacterial pathogens and allergic conjunctivitis by dendritic cells
Deng, R, Su, Z, Lu, F, Zhang, L, Lin, J, Zhang, X, de Paiva, CS, Pflugfelder, SC & Li, D-Q 2014, Experimental Eye Research, vol. 120, pp. 118-26.

Potential autocrine regulation of interleukin-33/ST2 signaling of dendritic cells in allergic inflammation
Su, Z, Lin, J, Lu, F, Zhang, X, Zhang, L, Gandhi, NB, de Paiva, CS, Pflugfelder, SC & Li, D-Q 2013, , Mucosal Immunology, vol. 6, no. 5, pp. 921-30.

TLR-mediated induction of proinflammatory cytokine IL-32 in corneal epithelium
Zhang, L, Che, C, Lin, J, Liu, K, Li, D-Q & Zhao, G 2013, , Current Eye Research, vol. 38, no. 6, pp. 630-8.

A novel interleukin 33/ST2 signaling regulates inflammatory response in human corneal epithelium
Lin, J, Zhang, L, Zhao, G, Su, Z, Deng, R, Pflugfelder, SC & Li, D-Q 2013, , PLoS ONE, vol. 8, no. 4, pp. e60963.

A native-like corneal construct using donor corneal stroma for tissue engineering
Lin, J, Yoon, K-C, Zhang, L, Su, Z, Lu, R, Ma, P, De Paiva, CS, Pflugfelder, SC & Li, D-Q 2012, , PLoS ONE, vol. 7, no. 11, pp. e49571.

Transcription factor TCF4 maintains the properties of human corneal epithelial stem cells
Lu, R, Qu, Y, Ge, J, Zhang, L, Su, Z, Pflugfelder, SC & Li, D-Q 2012, Stem cells (Dayton, Ohio), vol. 30, no. 4, pp. 753-61.

Short ragweed pollen triggers allergic inflammation through Toll-like receptor 4-dependent thymic stromal lymphopoietin/OX40 ligand/OX40 signaling pathways
Li, D-Q, Zhang, L, Pflugfelder, SC, De Paiva, CS, Zhang, X, Zhao, G, Zheng, X, Su, Z & Qu, Y 2011, , The Journal of Allergy and Clinical Immunology, vol. 128, no. 6, pp. 1318-1325.e2.

TLR-mediated induction of pro-allergic cytokine IL-33 in ocular mucosal epithelium
Zhang, L, Lu, R, Zhao, G, Pflugfelder, SC & Li, D-Q 2011, International Journal of Biochemistry and Cell Biology, vol. 43, no. 9, pp. 1383-91.

An immunoprotective privilege of corneal epithelial stem cells against Th17 inflammatory stress by producing glial cell-derived neurotrophic factor
Bian, F, Qi, H, Ma, P, Zhang, L, Yoon, K-C, Pflugfelder, SC & Li, D-Q 2010, Stem cells (Dayton, Ohio), vol. 28, no. 12, pp. 2172-81.

Suppressive effects of azithromycin on zymosan-induced production of proinflammatory mediators by human corneal epithelial cells
Li, D-Q, Zhou, N, Zhang, L, Ma, P & Pflugfelder, SC 2010, , Investigative ophthalmology & visual science, vol. 51, no. 11, pp. 5623-9.