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John P. Cooke, MD, PhD

Joseph C. “Rusty” Walter and Carole Walter Looke Presidential Distinguished Chair in Cardiovascular Disease Research, Department of Cardiovascular Sciences
Professor of Cardiovascular Sciences, Institute for Academic Medicine
Full Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Center for Cardiovascular Regeneration


Biography

Dr. John P. Cooke is the chair of the Department of Cardiovascular Sciences at the Houston Methodist Research Institute and the director of the Center for Cardiovascular Regeneration in the Houston Methodist DeBakey Heart and Vascular Center in Houston, Texas.

He trained in cardiovascular medicine and obtained a Ph.D. in physiology at the Mayo Clinic. He was recruited to Harvard Medical School as an assistant professor of medicine. In 1990, he was recruited to Stanford University to spearhead the program in vascular biology and medicine, and was appointed professor in the Division of Cardiovascular Medicine at Stanford University School of Medicine, and associate director of the Stanford Cardiovascular Institute until his recruitment to Houston Methodist in 2013.

Dr. Cooke has published over 500 research papers, position papers, reviews, book chapters and patents in the arena of vascular medicine and biology with over 20,000 citations. He serves on national and international committees that deal with cardiovascular diseases, including the American Heart Association, American College of Cardiology, Society for Vascular Medicine, and the National Heart, Lung and Blood Institute. He has served as president of the Society for Vascular Medicine, as a director of the American Board of Vascular Medicine, and as an associate editor of Vascular Medicine.

Description of Research

Dr. Cooke’s translational research program is focused on vascular regeneration. The program is funded by grants from the National Institutes of Health, the American Heart Association, and industry.

The focus is on restoration or stimulation of endothelial functions such as vasodilation and angiogenesis, using small molecules or stem cell therapies. In his 25 years of translational endothelial biology, he first described and characterized the anti-atherogenic effects of endothelium-derived nitric oxide; the anti-angiogenic effect of the NO synthase inhibitor ADMA; the angiogenic pathway mediated by endothelial nicotinic acetylcholine receptors; the role for this pathway in states of pathological angiogenesis; and developed an antagonist of the pathway that is now in Phase II clinical trials. His clinical research group has explored the use of angiogenic agents and adult stem cells in the treatment of peripheral arterial disease. More recently, he has generated and characterized endothelial cells derived from human iPSCs, and explored their role in angiogenesis and vascular regeneration. Recent insights from the laboratory have clarified the role of innate immune signaling in nuclear reprogramming to pluripotency and therapeutic transdifferentiation for vascular disease.

Areas Of Expertise

Regenerative medicine Stem cell Vascular disease Endothelium
Education & Training

Clinical Fellowship, Mayo Graduate School of Medicine, Rochester, MN
Residency, Mayo Graduate School of Medicine, Rochester, MN
Internship, Mayo Graduate School of Medicine, Rochester, MN
MD, Wayne State Univ. School of Medicine
PhD, Mayo Graduate School of Medicine, Rochester, NY
Research Fellowship, Mayo Graduate School of Medicine, Rochester, NY
Publications

Transflammation: How Innate Immune Activation and Free Radicals Drive Nuclear Reprogramming
Meng, S, Chanda, P, Thandavarayan, RA & Cooke, JP 2018, Antioxidants and Redox Signaling, vol 29, no. 2, pp. 205-218. DOI: 10.1089/ars.2017.7364

Harnessing and Optimizing the Interplay between Immunotherapy and Radiotherapy to Improve Survival Outcomes
Mujoo, K, Hunt, CR, Pandita, RK, Ferrari, M, Krishnan, S, Cooke, JP, Hahn, S & Pandita, TK 2018, Molecular Cancer Research. DOI: 10.1158/1541-7786.MCR-17-0743

Integration of induced pluripotent stem cell-derived endothelial cells with polycaprolactone/gelatin-based electrospun scaffolds for enhanced therapeutic angiogenesis
Tan, RP, Chan, AHP, Lennartsson, K, Miravet, MM, Lee, BSL, Rnjak-Kovacina, J, Clayton, ZE, Cooke, JP, Ng, MKC, Patel, S & Wise, SG 2018, Stem Cell Research and Therapy, vol 9, no. 1, 70. DOI: 10.1186/s13287-018-0824-2

Biomimetic nanoparticles with enhanced affinity towards activated endothelium as versatile tools for theranostic drug delivery
Martinez, JO, Molinaro, R, Hartman, KA, Boada, C, Sukhovershin, R, De Rosa, E, Kirui, D, Zhang, S, Evangelopoulos, M, Carter, AM, Bibb, JA, Cooke, JP & Tasciotti, E 2018, Theranostics, vol 8, no. 4, pp. 1131-1145. DOI: 10.7150/thno.22078

Steroid Receptor Coactivator-2 (SRC-2) coordinates cardiomyocyte paracrine signaling to promote pressure overload-induced angiogenesis.
Suh, JH, Lai, L, Nam, D, Kim, J, Jo, J, Taffet, G, Kim, E, Kaelber, J, Lee, H, Entman, ML, Cooke, JP & Reineke, EL 2017, Journal of Biological Chemistry.

Lmo2 (LIM-Domain-Only 2) Modulates Sphk1 (Sphingosine Kinase) and Promotes Endothelial Cell Migration
Matrone, G, Meng, S, Gu, Q, Lv, J, Fang, L, Chen, K & Cooke, JP 2017, Arteriosclerosis, Thrombosis, and Vascular Biology, vol 37, no. 10, pp. 1860-1868. DOI: 10.1161/ATVBAHA.117.309609

Transflammation: Innate immune signaling in nuclear reprogramming
Meng, S, Chanda, P, Thandavarayan, RA & Cooke, JP 2017, Advanced Drug Delivery Reviews, vol 120, pp. 133-141. DOI: 10.1016/j.addr.2017.09.010

A Missing LNC in Vascular Diseases
Cooke, JP & Leeper, NJ 2017, Circulation Research, vol 121, no. 4, pp. 320-322. DOI: 10.1161/CIRCRESAHA.117.311493

Telomerase mRNA Reverses Senescence in Progeria Cells
Li, Y, Zhou, G, Bruno, IG & Cooke, JP 2017, Journal of the American College of Cardiology, vol 70, no. 6, pp. 804-805. DOI: 10.1016/j.jacc.2017.06.017

Peripheral Blood Cytokine Levels After Acute Myocardial Infarction: IL-1ß and IL-6 Related Impairment of Bone Marrow Function
Shahrivari, M, Wise, E, Resende, M, Shuster, JJ, Zhang, J, Bolli, R, Cooke, JP, Hare, JM, Henry, TD, Khan, A, Taylor, DA, Traverse, JH, Yang, PC, Pepine, CJ & Cogle, CR 2017, Circulation research. DOI: 10.1161/CIRCRESAHA.116.309947

The senescence accelerated mouse prone 8 (SAMP8): A novel murine model for cardiac aging
Karuppagounder, V, Arumugam, S, Babu, SS, Palaniyandi, SS, Watanabe, K, Cooke, JP & Amirthalingam Thandavarayan, R 2017, Ageing Research Reviews, vol 35, pp. 291-296. DOI: 10.1016/j.arr.2016.10.006

AIBP Limits Angiogenesis Thorough ?-Secretase-Mediated Upregulation of Notch Signaling
Mao, R, Meng, S, Gu, Q, Araujo-Gutierrez, R, Kumar, S, Yan, Q, Almazan, F, Youker, KA, Fu, Y, Pownall, HJ, Cooke, JP, Miller, YI & Fang, L 2017, Circulation Research. DOI: 10.1161/CIRCRESAHA.116.309754

Discovery of novel determinants of endothelial lineage using chimeric heterokaryons
Wong, J, Matrone, G, Tian, X, Tomoiaga, SA, Au, KF, Meng, S, Yamazoe, S, Sieveking, D, Chen, K, Burns, DM, Chen, JK, Blau, HM & Cooke, JP 2017, eLife, vol 6, e23588. DOI: 10.7554/eLife.23588

A comparison of the pro-angiogenic potential of human induced pluripotent stem cell derived endothelial cells and induced endothelial cells in a murine model of peripheral arterial disease
Clayton, ZE, Yuen, GSC, Sadeghipour, S, Hywood, JD, Wong, JWT, Huang, NF, Ng, MKC, Cooke, JP & Patel, S 2016, International Journal of Cardiology. DOI: 10.1016/j.ijcard.2017.01.125

The nicotinic cholinergic pathway contributes to retinal neovascularization in a mouse model of retinopathy of prematurity
Hackett, SF, Seidel, C, Abraham, S, Chadha, R, Fortmann, SD, Campochiaro, PA & Cooke, JP 2017, Investigative Ophthalmology and Visual Science, vol 58, no. 2, pp. 1296-1303. DOI: 10.1167/iovs.16-20670

Retinoic Acid Inducible Gene 1 Protein (RIG1)-Like Receptor Pathway Is Required for Efficient Nuclear Reprogramming
Sayed, N, Ospino, F, Himmati, F, Lee, J, Chanda, P, Mocarski, ES & Cooke, JP 2017, Stem Cells. DOI: 10.1002/stem.2607

Identification of cardiovascular risk factors associated with bone marrow cell subsets in patients with STEMI: a biorepository evaluation from the CCTRN TIME and LateTIME clinical trials
Contreras, A, Orozco, AF, Resende, M, Schutt, RC, Traverse, JH, Henry, TD, Lai, D, Cooke, JP, Bolli, R, Cohen, ML, Moyé, L, Pepine, CJ, Yang, PC, Perin, EC, Willerson, JT, Taylor, DA & For the Cardiovascular Cell Therapy Research Network (CCTRN), TCCTRNCCTRN 2017, Basic Research in Cardiology, vol 112, no. 1, 3. DOI: 10.1007/s00395-016-0592-z

Steroid receptor coactivator-2 (SRC-2) coordinates cardiomyocyte paracrine signaling to promote pressure overload-induced angiogenesis
Suh, JH, Lai, L, Nam, D, Kim, J, Jo, J, Taffet, GE, Kim, E, Kaelber, JT, Lee, HK, Entman, ML, Cooke, JP & Reineke, EL 2017, Journal of Biological Chemistry, vol 292, no. 52, pp. 21643-21652. DOI: 10.1074/jbc.M117.804740

Transdifferentiation Requires iNOS Activation: Role of RING1A S-Nitrosylation
Meng, S, Zhou, G, Gu, Q, Chanda, PK, Ospino, F & Cooke, JP 2016, Circulation Research, vol 119, no. 9, pp. e129-e138. DOI: 10.1161/CIRCRESAHA.116.308263

LIM domain only 2 regulates endothelial proliferation, angiogenesis, and tissue regeneration
Meng, S, Matrone, G, Lv, J, Chen, K, Wong, JWT & Cooke, JP 2016, Journal of the American Heart Association, vol 5, no. 10, e004117. DOI: 10.1161/JAHA.116.004117