Not found

John P. Cooke, MD, PhD

Joseph C. “Rusty” Walter and Carole Walter Looke Presidential Distinguished Chair in Cardiovascular Disease Research, Department of Cardiovascular Sciences
Professor of Cardiovascular Sciences, Institute for Academic Medicine
Full Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Center for Cardiovascular Regeneration


Biography

Dr. John P. Cooke is the Chair of the Department of Cardiovascular Sciences at the Houston Methodist Research Institute, Director of the Center for Cardiovascular Regeneration, and Director of the RNA Therapeutics Program in the Houston Methodist DeBakey Heart and Vascular Center in Houston, Texas.

He trained in cardiovascular medicine and obtained a Ph.D. in physiology at the Mayo Clinic. He was recruited to Harvard Medical School as an assistant professor of medicine. In 1990, he was recruited to Stanford University to spearhead the program in vascular biology and medicine, and was appointed professor in the Division of Cardiovascular Medicine at Stanford University School of Medicine, and associate director of the Stanford Cardiovascular Institute until his recruitment to Houston Methodist in 2013.

Dr. Cooke has published over 500 research papers, position papers, reviews, book chapters and patents in the arena of vascular medicine and biology with over 20,000 citations. He serves on national and international committees that deal with cardiovascular diseases, including the American Heart Association, American College of Cardiology, Society for Vascular Medicine, and the National Heart, Lung and Blood Institute. He has served as president of the Society for Vascular Medicine, as a director of the American Board of Vascular Medicine, and as an associate editor of Vascular Medicine.

Description of Research

Dr. Cooke’s research program is focused on vascular regeneration, vascular cell identity and nuclear reprogramming. The program is funded by grants from the National Institutes of Health, the American Heart Association, Cancer Prevention Research Institute, and industry.

The Cooke group aims to understand the mechanisms underlying epigenetic plasticity that are required for functional adaptation to cellular challenges.  Innate immune signaling causes global changes in the expression and activity of epigenetic modifiers with metabolic coupling that favors an open chromatin configuration.  The translational output of this work is vascular regeneration via therapeutic transdifferentiation using small molecules or mRNA. In his 25 years of translational vascular biology, Dr. Cooke first described and characterized the anti-atherogenic effects of endothelium-derived nitric oxide; the anti-angiogenic effect of the NO synthase inhibitor ADMA; the angiogenic pathway mediated by endothelial nicotinic acetylcholine receptors; the role for this pathway in states of pathological angiogenesis; and developed an antagonist of the pathway that is now in Phase II clinical trials. His clinical research group has explored the use of angiogenic agents and adult stem cells in the treatment of peripheral arterial disease. More recently, he has generated and characterized endothelial cells derived from human iPSCs, and explored their role in angiogenesis and vascular regeneration. Recent insights from the laboratory have clarified the role of innate immune signaling in nuclear reprogramming to pluripotency and therapeutic transdifferentiation for vascular disease.

Areas Of Expertise

Regenerative medicine Stem cell Vascular disease Endothelium
Education & Training

Clinical Fellowship, Mayo Graduate School of Medicine, Rochester, MN
Residency, Mayo Graduate School of Medicine, Rochester, MN
Internship, Mayo Graduate School of Medicine, Rochester, MN
MD, Wayne State Univ. School of Medicine
PhD, Mayo Graduate School of Medicine, Rochester, NY
Research Fellowship, Mayo Graduate School of Medicine, Rochester, NY
Publications

Dysfunction of iPSC-derived endothelial cells in human Hutchinson–Gilford progeria syndrome
Matrone, G, Amirthalingam Thandavarayan, R, Walther, BK, Meng, S, Mojiri, A & Cooke, JP 2019, Cell Cycle, vol. 18, no. 19, pp. 2495-2508. https://doi.org/10.1080/15384101.2019.1651587

Nuclear S-Nitrosylation Defines an Optimal Zone for Inducing Pluripotency
Chanda, PK, Meng, S, Lee, J, Leung, HE, Chen, K & Cooke, JP 2019, Circulation, vol. 140, no. 13, pp. 1081-1099. https://doi.org/10.1161/CIRCULATIONAHA.119.042371

Transient introduction of human telomerase mRNA improves hallmarks of progeria cells
Li, Y, Zhou, G, Bruno, IG, Zhang, N, Sho, S, Tedone, E, Lai, TP, Cooke, JP & Shay, JW 2019, Aging Cell, vol. 18, no. 4, e12979. https://doi.org/10.1111/acel.12979

Endothelial senescence is induced by phosphorylation and nuclear export of telomeric repeat binding factor 2–interacting protein
Kotla, S, Vu, HT, Ko, KA, Wang, Y, Imanishi, M, Heo, K-S, Fujii, Y, Thomas, TN, Gi, YJ, Mazhar, H, Paez-Mayorga, J, Shin, J-H, Tao, Y, Giancursio, CJ, Medina, JLM, Taunton, J, Lusis, AJ, Cooke, JP, Fujiwara, K, Le, N-T & Abe, J 2019, JCI Insight, vol. 4, no. 9, e124867. https://doi.org/10.1172/jci.insight.124867

Inflammation and Its Role in Regeneration and Repair
Cooke, JP 2019, Circulation Research, vol. 124, no. 8, pp. 1166-1168. https://doi.org/10.1161/CIRCRESAHA.118.314669

MAGI1 as a link between endothelial activation and ER stress drives atherosclerosis
Abe, J-I, Ko, KA, Kotla, S, Wang, Y, Paez-Mayorga, J, Shin, IJ, Imanishi, M, Vu, HT, Tao, Y, Leiva-Juarez, MM, Thomas, TN, Medina, JL, Won, JH, Fujii, Y, Giancursio, CJ, McBeath, E, Shin, J-H, Guzman, L, Abe, RJ, Taunton, J, Mochizuki, N, Faubion, W, Cooke, JP, Fujiwara, K, Evans, SE & Le, N-T 2019, JCI Insight, vol. 4, no. 7. https://doi.org/10.1172/jci.insight.125570

AIBP-mediated cholesterol efflux instructs hematopoietic stem and progenitor cell fate
Gu, Q, Yang, X, Lv, J, Zhang, J, Xia, B, Kim, JD, Wang, R, Xiong, F, Meng, S, Clements, TP, Tandon, B, Wagner, DS, Diaz, MF, Wenzel, PL, Miller, YI, Traver, D, Cooke, JP, Li, W, Zon, LI, Chen, K, Bai, Y & Fang, L 2019, Science, pp. eaav1749. https://doi.org/10.1126/science.aav1749

Convergences of Life Sciences and Engineering in Understanding and Treating Heart Failure
Berry, JL, Zhu, W, Tang, YL, Krishnamurthy, P, Ge, Y, Cooke, JP, Chen, Y, Garry, DJ, Yang, HT, Rajasekaran, NS, Koch, WJ, Li, S, Domae, K, Qin, G, Cheng, K, Kamp, TJ, Ye, L, Hu, S, Ogle, BM, Rogers, JM, Abel, ED, Davis, ME, Prabhu, SD, Liao, R, Pu, WT, Wang, Y, Ping, P, Bursac, N, Vunjak-Novakovic, G, Wu, JC, Bolli, R, Menasché, P & Zhang, J 2019, Circulation Research, vol. 124, no. 1, pp. 161-169. https://doi.org/10.1161/CIRCRESAHA.118.314216

Asymmetric dimethylarginine predicts impaired epicardial coronary vasomotion in patients with angina in the absence of obstructive coronary artery disease
Parikh, RV, Pargaonkar, V, Ball, RL, Kobayashi, Y, Kimura, T, Yeung, AC, Cooke, JP & Tremmel, JA 2019, International Journal of Cardiology. https://doi.org/10.1016/j.ijcard.2019.07.062

Glycolytic Switch Is Required for Transdifferentiation to Endothelial Lineage
Lai, L, Reineke, EL, Hamilton, DJ & Cooke, JP 2019, Circulation, vol. 139, no. 1, pp. 119-133. https://doi.org/10.1161/CIRCULATIONAHA.118.035741, https://doi.org/10.1161/CIRCULATIONAHA.118.035741

TBX20 Regulates Angiogenesis Through the Prokineticin 2-Prokineticin Receptor 1 Pathway
Meng, S, Gu, Q, Yang, X, Lv, J, Owusu, I, Matrone, G, Chen, K, Cooke, JP & Fang, L 2018, Circulation, vol. 138, no. 9, pp. 913-928. https://doi.org/10.1161/CIRCULATIONAHA.118.033939

Novel Markers for Adverse Events in Atrial Fibrillation
Cooke, JP & Sukhovershin, R 2018, Journal of the American College of Cardiology, vol. 72, no. 7, pp. 734-737. https://doi.org/10.1016/j.jacc.2018.04.091

Cardiomyocyte Maturation Requires TLR3 Activated Nuclear Factor Kappa B
Hodgkinson, CP, Pratt, RE, Kirste, I, Dal-Pra, S, Cooke, JP & Dzau, VJ 2018, Stem Cells, vol. 36, no. 8, pp. 1198-1209. https://doi.org/10.1002/stem.2833

Induced pluripotent stem cell-derived endothelial cells promote angiogenesis and accelerate wound closure in a murine excisional wound healing model
Clayton, ZE, Tan, RP, Miravet, MM, Lennartsson, K, Cooke, JP, Bursill, CA, Wise, SG & Patel, S 2018, Bioscience Reports, vol. 38, no. 4, BSR20180563. https://doi.org/10.1042/BSR20180563

Transflammation: How Innate Immune Activation and Free Radicals Drive Nuclear Reprogramming
Meng, S, Chanda, P, Thandavarayan, RA & Cooke, JP 2018, Antioxidants and Redox Signaling, vol. 29, no. 2, pp. 205-218. https://doi.org/10.1089/ars.2017.7364

Arachidonic acid as a target for treating hypertriglyceridemia reproduced by a causal network analysis and an intervention study
Yazdani, A, Yazdani, A, Bowman, TA, Marotta, F, Cooke, JP & Samiei, A 2018, Metabolomics, vol. 14, no. 6, 78. https://doi.org/10.1007/s11306-018-1368-2

Interdisciplinary Models for Research and Clinical Endeavors in Genomic Medicine: A Scientific Statement From the American Heart Association
American Heart Association Council on Genomic and Precision Medicine; Council on Cardiovascular Disease in the Young; Council on Cardiovascular and Stroke Nursing; Council on Cardiovascular Radiology and Intervention; Council on Peripheral Vascular Disease; Council on Quality of Care and Outcomes Research; and Stroke Council 2018, Circulation. Genomic and precision medicine, vol. 11, no. 6, pp. e000046. https://doi.org/10.1161/HCG.0000000000000046

Inflammation-targeted vascular nanomedicine
Cooke, JP & Ferrari, M 2018, Nature Biomedical Engineering, vol. 2, no. 5, pp. 269-270. https://doi.org/10.1038/s41551-018-0241-y

Harnessing and Optimizing the Interplay between Immunotherapy and Radiotherapy to Improve Survival Outcomes
Mujoo, K, Hunt, CR, Pandita, RK, Ferrari, M, Krishnan, S, Cooke, JP, Hahn, S & Pandita, TK 2018, Molecular Cancer Research, vol. 16, no. 8, pp. 1209-1214. https://doi.org/10.1158/1541-7786.MCR-17-0743

Integration of induced pluripotent stem cell-derived endothelial cells with polycaprolactone/gelatin-based electrospun scaffolds for enhanced therapeutic angiogenesis
Tan, RP, Chan, AHP, Lennartsson, K, Miravet, MM, Lee, BSL, Rnjak-Kovacina, J, Clayton, ZE, Cooke, JP, Ng, MKC, Patel, S & Wise, SG 2018, Stem Cell Research and Therapy, vol. 9, no. 1, 70. https://doi.org/10.1186/s13287-018-0824-2

Live Chat Available