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Haibo Wang, PhD

Assistant Research Professor of Neurosurgery, Academic Institute
Assistant Research Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Publications

DNA Damage and Repair Deficiency in ALS/FTD-Associated Neurodegeneration: From Molecular Mechanisms to Therapeutic Implication
Wang, H, Kodavati, M, Britz, GW & Hegde, M 2021, , Frontiers in Molecular Neuroscience, vol. 14, 784361. https://doi.org/10.3389/fnmol.2021.784361

DNA damage and repair deficiency in ALS/FTD-associated neurodegeneration: from molecular mechanisms to therapeutic implication
Wang, H, Kodavati, M, Britz, GW & Hegde, M 2021, , Frontiers in Molecular Neuroscience.

Emerging Roles of Non-canonical RNA Binding Proteins in the Repair of Genome Damage Linked to Human Pathologies
Mitra, J, Wang, H, Kodavati, M, Mitra, S & Hegde, ML 2020, . in DNA Damage, DNA Repair and Disease: Volume 1. vol. 1, The Royal Society of Chemistry, United Kingdom, pp. 301-322. https://doi.org/10.1039/9781839160769-00301

Ligand-induced gene activation is associated with oxidative genome damage whose repair is required for transcription
Sengupta, S, Wang, H, Yang, C, Szczesny, B, Hegde, ML & Mitra, S 2020, , Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 36, pp. 22183-22192. https://doi.org/10.1073/pnas.1919445117

XRCC1 promotes replication restart, nascent fork degradation and mutagenic DNA repair in BRCA2-deficient cells
Eckelmann, BJ, Bacolla, A, Wang, H, Ye, Z, Guerrero, EN, Jiang, W, El-Zein, R, Hegde, ML, Tomkinson, AE, Tainer, JA & Mitra, S 2020, , NAR cancer, vol. 2, no. 3, pp. zcaa013. https://doi.org/10.1093/narcan/zcaa013

Molecular Basis of DNA Repair Defects in FUS-Associated ALS: Implications of a New Paradigm and Its Potential as Therapeutic Target
Wang, H 2020, . in IntechOpen.

Molecular basis of DNA repair defects in FUS-associated ALS: implications of a new paradigm and its potential as therapeutic target
Wang, H & Hegde, M 2020, . in IntechOpen Open Access book, "Amyotrophic Lateral Sclerosis - Recent Advances and Therapeutic Challenges" edited by Dr. Muralidhar L. Hegde, 2020 . InTech. https://doi.org/10.5772/intechopen.92637

Altered Mitochondrial Dynamics in Motor Neuron Disease: An Emerging Perspective
Kodavati, M, Wang, H & Hegde, M 2020, , Cells, vol. 9, no. 4. https://doi.org/10.3390/cells9041065

A multi-faceted genotoxic network of alpha-synuclein in the nucleus and mitochondria of dopaminergic neurons in Parkinson's disease: Emerging concepts and challenges
Vasquez, V, Mitra, J, Wang, H, Hegde, PM, Rao, KS & Hegde, ML 2020, , Progress in Neurobiology, vol. 185, 101729. https://doi.org/10.1016/j.pneurobio.2019.101729

Emerging Roles of Non-Canonical RNA Binding Proteins in Repair of Genome Damage Linked to Human Pathologies
Hegde, M, Mitra, J, Wang, H, Kodavati, M & Mitra, S 2020, . in Royal Society of Chemistry (UK) Book on DNA Damage, Repair and Disease, edited by M. Didzagaralu and Lloyd S. 2020.

Pervasive Genomic Damage in Experimental Intracerebral Hemorrhage: Therapeutic Potential of a Mechanistic-Based Carbon Nanoparticle
Dharmalingam, P, Talakatta, G, Mitra, J, Wang, H, Derry, PJ, Nilewski, LG, McHugh, E, Fabian, RH, Mendoza, K, Vasquez, V, Hegde, PM, Kakadiaris, E, Roy, T, Boldogh, I, Hegde, VL, Mitra, S, Tour, JM, Kent, TA & Hegde, M 2020, , ACS Nano.

RT2 PCR array screening reveals distinct perturbations in DNA damage response signaling in FUS-associated motor neuron disease
Wang, H, Rangaswamy, S, Kodavati, M, Mitra, J, Guo, W, Guerrero, EN, Van Den Bosch, L & Hegde, M 2019, , Molecular Brain, vol. 12, no. 1, 103. https://doi.org/10.1186/s13041-019-0526-4

Amyotrophic lateral sclerosis-associated TDP-43 mutation Q331K prevents nuclear translocation of XRCC4-DNA ligase 4 complex and is linked to genome damage-mediated neuronal apoptosis
Guerrero, EN, Mitra, J, Wang, H, Rangaswamy, S, Hegde, PM, Basu, P, Rao, KS & Hegde, ML 2019, , Human Molecular Genetics, vol. 28, no. 18, pp. 3161-3162. https://doi.org/10.1093/hmg/ddz141

New mechanisms of dna repair defects in fused in sarcoma–associated neurodegeneration: Stage set for dna repair-based therapeutics?
Wang, H & Hegde, M 2019, , Journal of Experimental Neuroscience, vol. 13. https://doi.org/10.1177/1179069519856358

Motor neuron disease-associated loss of nuclear TDP-43 is linked to DNA double-strand break repair defects
Mitra, J, Guerrero, EN, Hegde, PM, Liachko, NF, Wang, H, Vasquez, V, Gao, J, Pandey, A, Paul Taylor, J, Kraemer, BC, Wu, P, Boldogh, I, Garruto, RM, Mitra, S, Rao, KS & Hegde, M 2019, , Proceedings of the National Academy of Sciences of the United States of America, vol. 116, no. 10, pp. 4696-4705. https://doi.org/10.1073/pnas.1818415116

Sinomenine hydrochloride sensitizes cervical cancer cells to ionizing radiation by impairing DNA damage response
Zhang, D, Dong, Y, Zhao, Y, Zhou, C, Qian, Y, Hegde, ML, Wang, H & Han, S 2018, , Oncology Reports, vol. 40, no. 5, pp. 2886-2895. https://doi.org/10.3892/or.2018.6693

Mutant FUS causes DNA ligation defects to inhibit oxidative damage repair in Amyotrophic Lateral Sclerosis
Wang, H, Guo, W, Mitra, J, Hegde, PM, Vandoorne, T, Eckelmann, BJ, Mitra, S, Tomkinson, AE, Bosch, LVD & Hegde, M 2018, , Nature Communications, vol. 9, no. 3683.

Aurora kinase B dependent phosphorylation of 53BP1 is required for resolving merotelic kinetochore-microtubule attachment errors during mitosis
Wang, H, Peng, B, Pandita, RK, Engler, DA, Matsunami, RK, Xu, X, Hegde, PM, Butler, EB, Pandita, TK, Mitra, S, Xu, B & Hegde, ML 2017, , Oncotarget, vol. 8, no. 30, pp. 48671-48687. https://doi.org/10.18632/oncotarget.16225

TDP-43/FUS in motor neuron disease: Complexity and challenges
Guerrero, EN, Wang, H, Mitra, J, Hegde, PM, Stowell, SE, Liachko, NF, Kraemer, BC, Garruto, RM & Hegde, M 2016, , Progress in Neurobiology.

Chronic oxidative damage together with genome repair deficiency in the neurons is a double whammy for neurodegeneration: Is damage response signaling a potential therapeutic target?
Wang, H, Dharmalingam, P, Vasquez, V, Mitra, J, Boldogh, I, Kent, TA, Mitra, S & Hegde, M 2016, , Mechanisms of Ageing and Development.