DNA Damage and Repair Deficiency in ALS/FTD-Associated Neurodegeneration: From Molecular Mechanisms to Therapeutic ImplicationWang, H, Kodavati, M
, Britz, GW & Hegde, M 2021, ,
Frontiers in Molecular Neuroscience, vol. 14, 784361.
https://doi.org/10.3389/fnmol.2021.784361 Emerging Roles of Non-canonical RNA Binding Proteins in the Repair of Genome Damage Linked to Human PathologiesMitra, J
, Wang, H, Kodavati, M
, Mitra, S & Hegde, ML 2020, . in
DNA Damage, DNA Repair and Disease: Volume 1. vol. 1, The Royal Society of Chemistry, United Kingdom, pp. 301-322.
https://doi.org/10.1039/9781839160769-00301 Ligand-induced gene activation is associated with oxidative genome damage whose repair is required for transcriptionSengupta, S
, Wang, H, Yang, C, Szczesny, B
, Hegde, ML & Mitra, S 2020, ,
Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 36, pp. 22183-22192.
https://doi.org/10.1073/pnas.1919445117 XRCC1 promotes replication restart, nascent fork degradation and mutagenic DNA repair in BRCA2-deficient cellsEckelmann, BJ, Bacolla, A
, Wang, H, Ye, Z, Guerrero, EN, Jiang, W
, El-Zein, R, Hegde, ML, Tomkinson, AE, Tainer, JA
& Mitra, S 2020, ,
NAR cancer, vol. 2, no. 3, pp. zcaa013.
https://doi.org/10.1093/narcan/zcaa013 A multi-faceted genotoxic network of alpha-synuclein in the nucleus and mitochondria of dopaminergic neurons in Parkinson's disease: Emerging concepts and challengesVasquez, V
, Mitra, J, Wang, H, Hegde, PM, Rao, KS
& Hegde, ML 2020, ,
Progress in Neurobiology, vol. 185, 101729.
https://doi.org/10.1016/j.pneurobio.2019.101729 Emerging Roles of Non-Canonical RNA Binding Proteins in Repair of Genome Damage Linked to Human PathologiesHegde, M, Mitra, J, Wang, H, Kodavati, M & Mitra, S 2020, . in Royal Society of Chemistry (UK) Book on DNA Damage, Repair and Disease, edited by M. Didzagaralu and Lloyd S. 2020.
Pervasive Genomic Damage in Experimental Intracerebral Hemorrhage: Therapeutic Potential of a Mechanistic-Based Carbon NanoparticleDharmalingam, P, Talakatta, G, Mitra, J, Wang, H, Derry, PJ, Nilewski, LG, McHugh, E, Fabian, RH, Mendoza, K, Vasquez, V, Hegde, PM, Kakadiaris, E, Roy, T, Boldogh, I, Hegde, VL, Mitra, S, Tour, JM, Kent, TA & Hegde, M 2020, , ACS Nano.
RT2 PCR array screening reveals distinct perturbations in DNA damage response signaling in FUS-associated motor neuron diseaseWang, H, Rangaswamy, S, Kodavati, M, Mitra, J, Guo, W, Guerrero, EN, Van Den Bosch, L
& Hegde, M 2019, ,
Molecular Brain, vol. 12, no. 1, 103.
https://doi.org/10.1186/s13041-019-0526-4 Amyotrophic lateral sclerosis-associated TDP-43 mutation Q331K prevents nuclear translocation of XRCC4-DNA ligase 4 complex and is linked to genome damage-mediated neuronal apoptosisGuerrero, EN, Mitra, J
, Wang, H, Rangaswamy, S, Hegde, PM, Basu, P, Rao, KS
& Hegde, ML 2019, ,
Human Molecular Genetics, vol. 28, no. 18, pp. 3161-3162.
https://doi.org/10.1093/hmg/ddz141 Motor neuron disease-associated loss of nuclear TDP-43 is linked to DNA double-strand break repair defectsMitra, J, Guerrero, EN, Hegde, PM, Liachko, NF
, Wang, H, Vasquez, V, Gao, J, Pandey, A, Paul Taylor, J, Kraemer, BC, Wu, P, Boldogh, I, Garruto, RM
, Mitra, S, Rao, KS
& Hegde, M 2019, ,
Proceedings of the National Academy of Sciences of the United States of America, vol. 116, no. 10, pp. 4696-4705.
https://doi.org/10.1073/pnas.1818415116 Sinomenine hydrochloride sensitizes cervical cancer cells to ionizing radiation by impairing DNA damage responseZhang, D, Dong, Y, Zhao, Y, Zhou, C, Qian, Y
, Hegde, ML, Wang, H & Han, S 2018, ,
Oncology Reports, vol. 40, no. 5, pp. 2886-2895.
https://doi.org/10.3892/or.2018.6693 Mutant FUS causes DNA ligation defects to inhibit oxidative damage repair in Amyotrophic Lateral SclerosisWang, H, Guo, W, Mitra, J, Hegde, PM, Vandoorne, T, Eckelmann, BJ, Mitra, S, Tomkinson, AE, Bosch, LVD & Hegde, M 2018, , Nature Communications, vol. 9, no. 3683.
Aurora kinase B dependent phosphorylation of 53BP1 is required for resolving merotelic kinetochore-microtubule attachment errors during mitosisWang, H, Peng, B, Pandita, RK, Engler, DA, Matsunami, RK, Xu, X, Hegde, PM
, Butler, EB, Pandita, TK
, Mitra, S, Xu, B
& Hegde, ML 2017, ,
Oncotarget, vol. 8, no. 30, pp. 48671-48687.
https://doi.org/10.18632/oncotarget.16225 TDP-43/FUS in motor neuron disease: Complexity and challengesGuerrero, EN, Wang, H, Mitra, J, Hegde, PM, Stowell, SE, Liachko, NF, Kraemer, BC, Garruto, RM & Hegde, M 2016, , Progress in Neurobiology.
Chronic oxidative damage together with genome repair deficiency in the neurons is a double whammy for neurodegeneration: Is damage response signaling a potential therapeutic target?Wang, H, Dharmalingam, P, Vasquez, V, Mitra, J, Boldogh, I, Kent, TA, Mitra, S & Hegde, M 2016, , Mechanisms of Ageing and Development.
