David Chiu, MD

Elizabeth Blanton Wareing Chair in the Eddy Scurlock Stroke Center, Stanley H. Appel Department of Neurology
Professor of Clinical Neurology, Academic Institute
Associate Clinical Member, Research Institute
Houston Methodist
Weill Cornell Medical College


David Chiu, M.D. is medical director of the Houston Methodist Eddy Scurlock Stroke Center in Houston and neurologist at the Houston Methodist Neurological Institute. He serves on the board of directors for the American Heart Association and is an active member of the American Academy of Neurology, American Heart Association Stroke Council, Texas Medical Association and Harris County Medical Association. He is also a reviewer for Stroke and Journal of Neurology, Neurosurgery and Psychiatry.

Dr. Chiu is professor of clinical neurology at the Weill Medical College of Cornell University He received his M.D. from Yale University School of Medicine. He completed his residency in neurology at the University of California at San Francisco and his fellowship in cerebrovascular disease at University of Texas at Houston School of Medicine.

Description of Research

Dr. Chiu has an active clinical practice that benefits from extensive translational research. His research interests lie in extending the time and quality of life for stroke patients, acute stroke treatment, and stroke prevention in those who have experienced TIA and stroke.

Education & Training

Residency, University of California San Francisco, School of Medicine
Internship, University of California San Francisco, School of Medicine
MD, Yale School of Medicine
Clinical Fellowship, University of Texas Health Science Center at Houston

Randomized Secondary Prevention Trials in Participants with Symptomatic Intracranial Atherosclerotic Stenosis
Dunn, LE, Wang, Y, Kass-Hout, T & Chiu, D 2024, , Stroke, vol. 55, no. 2, pp. 324-334. https://doi.org/10.1161/STROKEAHA.123.043632

Stroke severity mediates the effect of socioeconomic disadvantage on poor outcomes among patients with intracerebral hemorrhage
Potter, TBH, Tannous, J, Pan, AP, Bako, A, Johnson, C, Baig, E, Kelly, H, McCane, CD, Garg, T, Gadhia, R, Misra, V, Volpi, J, Britz, G, Chiu, D & Vahidy, FS 2023, , Frontiers in Neurology, vol. 14, 1176924, pp. 1176924. https://doi.org/10.3389/fneur.2023.1176924

Long-Term Disability Outcomes for Patients With Ischemic Stroke Presenting With Visual Deficits
Johnson, N, Nisar, T, Criswell, A, McCane, D, Lee, J, Chiu, D & Gadhia, R 2022, , Journal of Neuro-Ophthalmology, vol. 42, no. 4, pp. 518-523. https://doi.org/10.1097/WNO.0000000000001624

Prospective, Multicenter, Controlled Trial of Mobile Stroke Units
Grotta, JC, Yamal, JM, Parker, SA, Rajan, SS, Gonzales, NR, Jones, WJ, Alexandrov, AW, Navi, BB, Nour, M, Spokoyny, I, MacKey, J, Persse, D, Jacob, AP, Wang, M, Singh, N, Alexandrov, AV, Fink, ME, Saver, JL, English, J, Barazangi, N, Bratina, PL, Gonzalez, M, Schimpf, BD, Ackerson, K, Sherman, C, Lerario, M, Mir, S, Im, J, Willey, JZ, Chiu, D, Eisshofer, M, Miller, J, Ornelas, D, Rhudy, JP, Brown, KM, Villareal, BM, Gausche-Hill, M, Bosson, N, Gilbert, G, Collins, SQ, Silnes, K, Volpi, J, Misra, V, McCarthy, J, Flanagan, T, Rao, CPV, Kass, JS, Griffin, L, Rangel-Gutierrez, N, Lechuga, E, Stephenson, J, Phan, K, Sanders, Y, Noser, EA & Bowry, R 2021, , New England Journal of Medicine, vol. 385, no. 11, pp. 971-982. https://doi.org/10.1056/NEJMoa2103879

Severe Cerebral Small Vessel Disease Burden Is Associated With Poor Outcomes After Endovascular Thrombectomy in Acute Ischemic Stroke With Large Vessel Occlusion
Hooper, D, Nisar, T, McCane, D, Lee, J, Ling, KC, Vahidy, F, Wong, K, Wong, S, Chiu, D & Gadhia, R 2021, , Cureus, vol. 13, no. 2, pp. e13122. https://doi.org/10.7759/cureus.13122

Cerebrovascular Disease in Patients with COVID-19: A Review of the Literature and Case Series
Reddy, ST, Garg, T, Shah, C, Nascimento, FA, Imran, R, Kan, P, Bowry, R, Gonzales, N, Barreto, A, Kumar, A, Volpi, J, Misra, V, Chiu, D, Gadhia, R & Savitz, SI 2020, , Case Reports in Neurology, vol. 12, no. 2, pp. 199-209. https://doi.org/10.1159/000508958

Multifocal transcranial stimulation in chronic ischemic stroke: A phase 1/2a randomized trial
Chiu, D, McCane, CD, Lee, J, John, B, Nguyen, L, Butler, K, Gadhia, R, Misra, V, Volpi, JJ, Verma, A & Helekar, SA 2020, , Journal of Stroke and Cerebrovascular Diseases, vol. 29, no. 6, 104816, pp. 104816. https://doi.org/10.1016/j.jstrokecerebrovasdis.2020.104816

Effect of alteplase vs aspirin on functional outcome for patients with acute ischemic stroke and minor nondisabling neurologic deficits the PRISMS randomized clinical trial
PRISMS Investigators 2018, , JAMA - Journal of the American Medical Association, vol. 320, no. 2, pp. 156-166. https://doi.org/10.1001/jama.2018.8496

Evaluation of the harmony exoskeleton as an upper extremity rehabilitation tool after stroke
Ogden, EM, Chiu, D, Clearman, R, Card, C & Deshpande, AD 2018, . in 2017 International Symposium on Wearable Robotics and Rehabilitation, WeRob 2017. 2017 International Symposium on Wearable Robotics and Rehabilitation, WeRob 2017, Institute of Electrical and Electronics Engineers Inc. pp. 1-2, 2017 International Symposium on Wearable Robotics and Rehabilitation, WeRob 2017, Houston, United States, 11/5/17. https://doi.org/10.1109/WEROB.2017.8383834

Benefits of stroke treatment delivered using a mobile stroke unit trial
Yamal, JM, Rajan, SS, Parker, SA, Jacob, AP, Gonzalez, MO, Gonzales, NR, Bowry, R, Barreto, AD, Wu, TC, Lairson, DR, Persse, D, Tilley, BC, Chiu, D, Suarez, JI, Jones, WJ, Alexandrov, A & Grotta, JC 2018, , International Journal of Stroke, vol. 13, no. 3, pp. 321-327. https://doi.org/10.1177/1747493017711950

The HOPES Registry – Houston Methodist Hospital Outcomes-based Prospective Endpoints in Stroke
Gadhia, R, McCane, D, Lee, J, Ling, KC, Jiang, K & Chiu, D 2018, , Journal of Stroke and Cerebrovascular Diseases, vol. 27, no. 11, pp. 2973-2976. https://doi.org/10.1016/j.jstrokecerebrovasdis.2018.06.029

Challenge and yield of enrolling racially and ethnically diverse patient populations in low event rate clinical trials
Sheffet, AJ, Howard, G, Sam, A, Jamil, Z, Weaver, F, Chiu, D, Voeks, JH, Howard, VJ, Hughes, SE, Flaxman, L, Longbottom, ME & Brott, TG 2018, , Stroke, vol. 49, no. 1, pp. 84-89. https://doi.org/10.1161/STROKEAHA.117.018063

Safety and efficacy of multipotent adult progenitor cells in acute ischaemic stroke (MASTERS): a randomised, double-blind, placebo-controlled, phase 2 trial
Hess, DC, Wechsler, LR, Clark, WM, Savitz, SI, Ford, GA, Chiu, D, Yavagal, DR, Uchino, K, Liebeskind, DS, Auchus, AP, Sen, S, Sila, CA, Vest, JD & Mays, RW 2017, , The Lancet Neurology, vol. 16, no. 5, pp. 360-368. https://doi.org/10.1016/S1474-4422(17)30046-7

Aspiration Thrombectomy after Intravenous Alteplase Versus Intravenous Alteplase Alone
THERAPY Trial Investigators 2016, , Stroke, vol. 47, no. 9, pp. 2331-2338. https://doi.org/10.1161/STROKEAHA.116.013372

Enrollment volume effect on risk factor control and outcomes in the SAMMPRIS trial
Chiu, D, Klucznik, RP, Turan, TN, Lynn, MJ, McCane, CD, Katz, LB, Nizam, A, Derdeyn, CP, Fiorella, D, Lane, BF, Montgomery, J, Janis, S & Chimowitz, MI 2015, , Neurology, vol. 85, no. 24, pp. 2090-2097. https://doi.org/10.1212/WNL.0000000000002191

Quantifying cerebrovascular reactivity and identifying regions at risk from cerebrovascular steal with arterial spin labeling
Fung, SH, Diaz, O, Klucznik, RP, Zhang, Y, Britz, GW, Volpi, J, Thomas, AP & Chiu, D 2015, , Interventional Neuroradiology, vol. 21S1.

Aggressive medical treatment with or without stenting in high-risk patients with intracranial artery stenosis (SAMMPRIS): The final results of a randomised trial
Derdeyn, CP, Chimowitz, MI, Lynn, MJ, Fiorella, D, Turan, TN, Janis, LS, Montgomery, J, Nizam, A, Lane, BF, Lutsep, HL, Barnwell, SL, Waters, MF, Hoh, BL, Hourihane, JM, Levy, EI, Alexandrov, AV, Harrigan, MR, Chiu, D, Klucznik, RP, Clark, JM, McDougall, CG, Johnson, MD, Pride, GL, Lynch, JR, Zaidat, OO, Rumboldt, Z & Cloft, HJ 2014, , The Lancet, vol. 383, no. 9914, pp. 333-341. https://doi.org/10.1016/S0140-6736(13)62038-3

Transcranial laser therapy in acute stroke treatment: Results of neurothera effectiveness and safety trial 3, a phase III clinical end point device trial
Hacke, W, Schellinger, PD, Albers, GW, Bornstein, NM, Dahlof, BL, Fulton, R, Kasner, SE, Shuaib, A, Richieri, SP, Dilly, SG, Zivin, J, Lees, KR, Zivin, JA, Broderick, J, Ivanova, A, Johnston, K, Norrving, B, Albars, G, Alexandrov, A, Brown, D, Capone, P, Chiu, D, Clark, W, Cochran, J, Deredyn, C, Devlin, T, Hickling, W, Howell, G, Huang, D, Hussain, S, Mallenbaum, S, Moonis, M, Nash, M, Rymer, M, Taylor, R, Tremwel, M, Buck, B, Perez, J, Gerloff, C, Greiwing, B, Grond, M, Hamman, G, Haarmeiter, T, Jander, S, Köhrmann, M, Ritter, M, Schallinger, P, Schneider, D, Sobesky, J, Steiner, T, Steinmetz, H, Veltkamp, R, Weimar, C, Gruber, F, Andersson, B, Welin, L, Leys, D, Tatlisumak, T, Luft, A, Lyrer, P, Michel, P, Molina, C & Segura, T 2014, , Stroke, vol. 45, no. 11, pp. 3187-3193. https://doi.org/10.1161/STROKEAHA.114.005795

Management of vascular risk factors in the carotid revascularization endarterectomy versus stenting trial (CREST)
Meschia, JF, Voeks, JH, Leimgruber, PP, Mantese, VA, Timaran, CH, Chiu, D, Demaerschalk, BM, Howard, VJ, Hughes, SE, Longbottom, M, Howard, AG & Brott, TG 2014, , Journal of the American Heart Association, vol. 3, no. 6, 001180. https://doi.org/10.1161/JAHA.114.001180

Detailed analysis of periprocedural strokes in patients undergoing intracranial stenting in stenting and aggressive medical management for preventing recurrent stroke in intracranial stenosis (SAMMPRIS)
Fiorella, D, Derdeyn, CP, Lynn, MJ, Barnwell, SL, Hoh, BL, Levy, EI, Harrigan, MR, Klucznik, RP, McDougall, CG, Pride, GL, Zaidat, OO, Lutsep, HL, Waters, MF, Hourihane, JM, Alexandrov, AV, Chiu, D, Clark, JM, Johnson, MD, Torbey, MT, Rumboldt, Z, Cloft, HJ, Turan, TN, Lane, BF, Janis, LS & Chimowitz, MI 2012, , Stroke, vol. 43, no. 10, pp. 2682-2688. https://doi.org/10.1161/STROKEAHA.112.661173