Bruna Corradetti

Bruna Corradetti, PhD, MSc

Assistant Research Professor of Nanomedicine, Academic Institute
Assistant Research Member, Research Institute
Houston Methodist


Phone:
346.238.1001


bcorradetti2@houstonmethodist.org
Biography

Bruna Corradetti received a Ph.D. in Biomolecular Science from Polytechnic University of Marche (Italy) in 2012 working on the development of stem cell-based therapeutic approaches for the treatment of spontaneous tendon injuries. In 2013 she was appointed as Assistant Professor in Genetics in the same university and joined the Houston Methodist Research Institute in the context of a Fellowship for Molecular Medicine. There, Dr. Corradetti expanded her research to material science and nanotechnology and to their applications in the fields of tissue engineering, regenerative medicine, and immunomodulation. She conceived and developed naturally inspired platforms and delivery systems able to support tissue regeneration by modulating stem and immune cells behavior. Since 2015 Dr. Corradetti has served as Associate Member for the Houston Methodist Research Institute and in 2016 as Visiting Professor at the Department of Mechanics and Materials at ETH Zurich (Switzerland).

In 2016 Dr. Corradetti was nominated Fellow of the Academy of Translational Medicine Professionals and since then she serves as Secretary of the European Society for Translational Medicine. In 2017 Dr. Corradetti has been recognized among the “100 Italian Excellences.” Dr. Corradetti has published more than 40 peer-reviewed papers and served as the sole Editor of the book entitled “The Immune Response to Implanted Materials and Devices. The Impact of the Immune System on the Success of an Implant” published by Springer International in 2017.

In 2018 Dr. Corradetti has joined the Houston Methodist Research Institute as Assistant Research Professor and was appointed as Associate Professor in the School of Medicine at Swansea University (Wales, UK). Her work is partially supported through the Sêr Cymru II program, funded by the European Commission through the Horizon 2020 Marie Sklodowska-Curie Actions (MSCA) COFUND scheme and the Welsh European Funding Office (WEFO) under the European Regional Development Fund (ERDF).

Description of Research

- Natural and bio-inspired artificial platforms for the delivery of RNA therapeutics.

- Biomimetic strategies to improve tissue regeneration and modulate the immune response.

- Synthetic biomimetic extracellular matrices for the healing of chronic wounds and cell transplantation.

- Development of exosome-based vaccines to induce anti-cancer immune response.

Areas Of Expertise

Immunotherapy Stem cells Immunomodulation RNA therapeutics Exosomes Tissue engineering Ovarian cancer Macrophages
Education & Training

PhD, Universitá Politecnica delle Marche
MSc, Universitá Politecnica delle Marche
BS, Università Politecnica delle Marche
Publications

TFEB, SIRT1, CARM1, Beclin-1 expression and PITX2 methylation in breast cancer chemoresistance: a retrospective study
Bertozzi, S, Londero, AP, Viola, L, Orsaria, M, Bulfoni, M, Marzinotto, S, Corradetti, B, Baccarani, U, Cesselli, D, Cedolini, C & Mariuzzi, L 2021, , BMC Cancer, vol. 21, no. 1, 1118. https://doi.org/10.1186/s12885-021-08844-y

Early prediction of clinical response to checkpoint inhibitor therapy in human solid tumors through mathematical modeling
Butner, JD, Martin, GV, Wang, Z, Corradetti, B, Ferrari, M, Esnaola, N, Chung, C, Hong, DS, Welsh, JW, Hasegawa, N, Mittendorf, EA, Curley, SA, Chen, S-H, Pan, P-Y, Libutti, SK, Ganesan, S, Sidman, RL, Pasqualini, R, Arap, W, Koay, EJ & Cristini, V 2021, , eLife, vol. 10. https://doi.org/10.7554/eLife.70130

Early prediction of clinical response to checkpoint inhibitor therapy in human solid tumors through mathematical modeling
Butner, JD, Martin, GV, Wang, Z, Corradetti, B, Ferrari, M, Esnaola, N, Chung, C, Hong, DS, Welsh, JW, Hasegawa, N, Mittendorf, EA, Curley, SA, Chen, SH, Pan, PY, Libutti, SK, Ganesan, S, Sidman, RL, Pasqualini, R, Arap, W, Koay, EJ & Cristini, V 2021, , eLife, vol. 10, e70130. https://doi.org/10.7554/eLife.70130

TFEB, SIRT1, CARM1, Beclin-1 expression and PITX2 methylation in breast cancer chemoresistance: a retrospective study
Bertozzi, S, Londero, AP, Viola, L, Orsaria, M, Bulfoni, M, Marzinotto, S, Corradetti, B, Baccarani, U, Cesselli, D, Cedolini, C & Mariuzzi, L 2021, , BMC Cancer, vol. 21, no. 1, pp. 1118. https://doi.org/10.1186/s12885-021-08844-y

Assessment of the immune landscapes of advanced ovarian cancer in an optimized in vivo model
Pisano, S, Lenna, S, Healey, GD, Izardi, F, Meeks, L, Jimenez, YS, Velazquez, OS, Gonzalez, D, Conlan, RS & Corradetti, B 2021, , Clinical and translational medicine, vol. 11, no. 10, pp. e551. https://doi.org/10.1002/ctm2.551

Biomimetic immunomodulation strategies for effective tissue repair and restoration
Villarreal-Leal, RA, Healey, GD & Corradetti, B 2021, , Advanced Drug Delivery Reviews, pp. 113913. https://doi.org/10.1016/j.addr.2021.113913

Editorial: Exosomes as Therapeutic Systems
Corradetti, B, Gonzalez, D, Mendes Pinto, I & Conlan, RS 2021, , Frontiers in Cell and Developmental Biology, vol. 9, 714743. https://doi.org/10.3389/fcell.2021.714743

Biomimetic and immunomodulatory therapeutics as an alternative to natural exosomes for vascular and cardiac applications
Villarreal-Leal, RA, Cooke, JP & Corradetti, B 2021, , Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 35, 102385, pp. 102385. https://doi.org/10.1016/j.nano.2021.102385

Stem cells from the amniotic fluid: a promising tool to face the cytokine storm associated to SARS-CoV-2 infections
Vaiasicca, S & Corradetti, B 2021, , FASEB journal : official publication of the Federation of American Societies for Experimental Biology. https://doi.org/10.1096/fasebj.2021.35.S1.03786

Amphibian regeneration and mammalian cancer: Similarities and contrasts from an evolutionary biology perspective: Comparing the regenerative potential of mammalian embryos and urodeles to develop effective strategies against human cancer
Corradetti, B, Dogra, P, Pisano, S, Wang, Z, Ferrari, M, Chen, S-H, Sidman, RL, Pasqualini, R, Arap, W & Cristini, V 2021, , BioEssays, vol. 43, no. 7, pp. e2000339. https://doi.org/10.1002/bies.202000339

Translating Stem Cell-Based Regenerative Approaches into Clinical Therapies for Musculoskeletal Tissue Repair
Lovati, AB, Corradetti, B & Narcisi, R 2021, , Stem Cells International, vol. 2021. https://doi.org/10.1155/2021/9354863

Biomimetic immunomodulation strategies for effective tissue repair and restoration
Villarreal-Leal, RA, Healey, GD & Corradetti, B 2021, , Advanced Drug Delivery Reviews, vol. 179, 113913, pp. 113913. https://doi.org/10.1016/j.addr.2021.113913

Exosomes as Therapeutic Systems
Corradetti, B, Gonzalez, D, Mendes Pinto, I & Conlan, RS 2021, , Frontiers in Cell and Developmental Biology, vol. 9, pp. 714743. https://doi.org/10.3389/fcell.2021.714743

Cell-free vaccine: the role of exosomes in the treatment of immunologically cold tumors
Jimenez, YS, Pisano, S & Corradetti, B 2021, , Texas A&M University 2021 Virtual Medical Research Colloquium .

Biodistribution of dendritic-cell derivatives in epithelial ovarian cancer bearing mice
Jimenez, YS, Pisano, S, Healey, G & Corradetti, B 2021, . in Texas A&M Senior Research Showcase .

The Use of Image Stream flow cytometry for precise receptor quantification of exosomes
Jimenez, YS, Bottley, G & Corradetti, B 2021, , Annual Methodist Association for Postdoctoral and Trainee Affairs Summer Research Symposium .

Early prediction of clinical response to checkpoint inhibitor therapy in human solid cancers through mathematical modeling
Butner, J, Martin, G, Wang, Z, Corradetti, B, Ferrari, M, Esnaola, NF, Chung, C, Hong, DS, Welsh, J, Mittendorf, EA, Curley, SA, Sidman, RL, Pasqualini, R, Arap, W, Koay, EJ & Cristini, V 2020, , JCO Precision Oncology.

Neovascularized implantable cell homing encapsulation platform with tunable local immunosuppressant delivery for allogeneic cell transplantation
Paez-Mayorga, J, Capuani, S, Hernandez, N, Farina, M, Chua, YX, Blanchard, R, Sizovs, A, Liu, HC, Fraga, DW, Niles, JA, Salazar, HF, Corradetti, B, Sikora, AG, Kloc, M, Li, XC, Gaber, AO, Nichols, J & Grattoni, A 2020, , Biomaterials, vol. 257, 120232. https://doi.org/10.1016/j.biomaterials.2020.120232

Immune (Cell) Derived Exosome Mimetics (IDEM) as a Treatment for Ovarian Cancer
Pisano, S, Pierini, I, Gu, J, Gazze, A, Francis, LW, Gonzalez, D, Conlan, RS & Corradetti, B 2020, , Frontiers in Cell and Developmental Biology, vol. 8, pp. 553576. https://doi.org/10.3389/fcell.2020.553576

xosomes as a novel immunotherapeutic approach for metastatic ovarian cancer treatment.
Pisano, S, Gonzalez, D, Ferrari, M, Conlan, RS & Corradetti, B 2020, Advanced Cancer Therapies, Society of Surgical Oncology (SSO), Orlando, United States, 2/16/20 - 2/17/21, .