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Bruna Corradetti, PhD, MSc

Assistant Research Professor of Nanomedicine, Institute for Academic Medicine
Assistant Research Member, Research Institute
Houston Methodist


Phone:
346.238.1001


bcorradetti2@houstonmethodist.org
Biography

Bruna Corradetti received a Ph.D. in Biomolecular Science from Polytechnic University of Marche (Italy) in 2012 working on the development of stem cell-based therapeutic approaches for the treatment of spontaneous tendon injuries. In 2013 she was appointed as Assistant Professor in Genetics in the same university and joined the Houston Methodist Research Institute in the context of a Fellowship for Molecular Medicine. There, Dr. Corradetti expanded her research to material science and nanotechnology and to their applications in the fields of tissue engineering, regenerative medicine, and immunomodulation. She conceived and developed naturally inspired platforms and delivery systems able to support tissue regeneration by modulating stem and immune cells behavior. Since 2015 Dr. Corradetti has served as Associate Member for the Houston Methodist Research Institute and in 2016 as Visiting Professor at the Department of Mechanics and Materials at ETH Zurich working with Prof. Chiara Daraio.

In 2016 Dr. Corradetti was nominated Fellow of the Academy of Translational Medicine Professionals and since then she serves as Secretary of the European Society for Translational Medicine. In 2017 Dr. Corradetti has been recognized among the “100 Italian Excellences.” Dr. Corradetti has published more than 40 peer-reviewed papers and served as the sole Editor of the book entitled “The Immune Response to Implanted Materials and Devices. The Impact of the Immune System on the Success of an Implant” published by Springer International in 2017.

In 2018 Dr. Corradetti has joined the Houston Methodist Research Institute as Assistant Research Professor and was appointed as Associate Professor in the School of Medicine at Swansea University (Wales, UK). Her work is partially supported through the Sêr Cymru II program, funded by the European Commission through the Horizon 2020 Marie Sklodowska-Curie Actions (MSCA) COFUND scheme and the Welsh European Funding Office (WEFO) under the European Regional Development Fund (ERDF).

Description of Research

- Natural and bio-inspired artificial platforms for the delivery of RNA therapeutics.

- Biomimetic strategies to improve tissue regeneration and modulate the immune response.

- Synthetic biomimetic extracellular matrices for the healing of chronic wounds and cell transplantation.

- Development of exosome-based vaccines to induce anti-cancer immune response.

Areas Of Expertise

Immunotherapy Stem cells Immunomodulation RNA therapeutics Exosomes Tissue engineering Ovarian cancer Macrophages
Education & Training

PhD, Universitá Politecnica delle Marche
MSc, Universitá Politecnica delle Marche
BS, Università Politecnica delle Marche
Publications

Regenerative Medicine to Trump Cancer
Corradetti, B, Dogra, P, Ferrari, M & Cristini, V 2018, Open Access Government.

Corrigendum: Heparan Sulfate: A Potential Candidate for the Development of Biomimetic Immunomodulatory Membranes
Corradetti, B, Taraballi, F, Giretti, I, Bauza, G, Pistillo, RS, Niclot, FB, Pandolfi, L, Demarchi, D & Tasciotti, E 2018, Frontiers in Bioengineering and Biotechnology, vol. 5, no. JAN, 86, pp. 86. https://doi.org/10.3389/fbioe.2017.00086

Immune tuning scaffold for the local induction of a pro-regenerative environment
Corradetti, B, Taraballi, F, Corbo, C, Cabrera, F, Pandolfi, L, Minardi, S, Wang, X, Van Eps, J, Bauza, G, Weiner, B & Tasciotti, E 2017, Scientific Reports, vol. 7, no. 1, 17030. https://doi.org/10.1038/s41598-017-16895-0

Hyaluronic acid coatings as a simple and efficient approach to improve MSC homing toward the site of inflammation
Corradetti, B, Taraballi, F, Martinez, JO, Minardi, S, Basu, N, Bauza, G, Evangelopoulos, M, Powell, S, Corbo, C & Tasciotti, E 2017, Scientific Reports, vol. 7, no. 1, 7991, pp. 7991. https://doi.org/10.1038/s41598-017-08687-3

Heparan Sulfate: A Potential Candidate for the Development of Biomimetic Immunomodulatory Membranes
Corradetti, B, Taraballi, F, Giretti, I, Bauza, G, Pistillo, RS, Banche Niclot, F, Pandolfi, L & Tasciotti, E 2017, Frontiers in Bioengineering and Biotechnology, vol. 5, pp. 54. https://doi.org/10.3389/fbioe.2017.00054

Microvesicles secreted from equine amniotic-derived cells and their potential role in reducing inflammation in endometrial cells in an in-vitro model
Perrini, C, Strillacci, MG, Bagnato, A, Esposti, P, Marini, MG, Corradetti, B, Bizzaro, D, Idda, A, Ledda, S, Capra, E, Pizzi, F, Lange-Consiglio, A & Cremonesi, F 2016, Stem Cell Research and Therapy, vol. 7, no. 1, pp. 1-15. https://doi.org/10.1186/s13287-016-0429-6

Effects of platelet-rich plasma in a model of bovine endometrial inflammation in vitro
Marini, MG, Perrini, C, Esposti, P, Corradetti, B, Bizzaro, D, Riccaboni, P, Fantinato, E, Urbani, G, Gelati, G, Cremonesi, F & Lange-Consiglio, A 2016, Reproductive Biology and Endocrinology, vol. 14, no. 1, 58. https://doi.org/10.1186/s12958-016-0195-4

One-pot synthesis of pH-responsive hybrid nanogel particles for the intracellular delivery of small interfering RNA
Khaled, SZ, Cevenini, A, Yazdi, IK, Parodi, A, Evangelopoulos, M, Corbo, C, Scaria, S, Hu, Y, Haddix, SG, Corradetti, B, Salvatore, F & Tasciotti, E 2016, Biomaterials, vol. 87, pp. 57-68. https://doi.org/10.1016/j.biomaterials.2016.01.052

Equine Amniotic Microvesicles and Their Anti-Inflammatory Potential in a Tenocyte Model in Vitro
Lange-Consiglio, A, Perrini, C, Tasquier, R, Deregibus, MC, Camussi, G, Pascucci, L, Marini, MG, Corradetti, B, Bizzaro, D, De Vita, B, Romele, P, Parolini, O & Cremonesi, F 2016, Stem Cells and Development, vol. 25, no. 8, pp. 610-621. https://doi.org/10.1089/scd.2015.0348

Does the Bovine Pre-Ovulatory Follicle Harbor Progenitor Stem Cells?
Lange-Consiglio, A, Romaldini, A, Correani, A, Corradetti, B, Esposti, P, Cannatà, MF, Perrini, C, Marini, MG, Bizzaro, D & Cremonesi, F 2016, Cellular Reprogramming, vol. 18, no. 2, pp. 116-126. https://doi.org/10.1089/cell.2015.0062

Chondroitin sulfate immobilized on a biomimetic scaffold modulates inflammation while driving chondrogenesis
Corradetti, B, Taraballi, F, Minardi, S, Van Eps, J, Cabrera, F, Francis, LW, Gazze, SA, Ferrari, M, Weiner, BK & Tasciotti, E 2016, Stem Cells Translational Medicine, vol. 5, no. 5, pp. 670-682. https://doi.org/10.5966/sctm.2015-0233

Biomimetic nanostructured platforms for biologically inspired medicine
Minardi, S, Parodi, A, Taraballi, F, Corradetti, B, Weiner, BK & Tasciotti, E 2016, . in Bio-Inspired Regenerative Medicine: Materials, Processes and Clinical Applications. Pan Stanford Publishing Pte. Ltd. pp. 21-45.

IL-4 Release from a Biomimetic Scaffold for the Temporally Controlled Modulation of Macrophage Response
Minardi, S, Corradetti, B, Taraballi, F, Byun, JH, Cabrera, F, Liu, X, Ferrari, M, Weiner, BK & Tasciotti, E 2016, Annals of Biomedical Engineering, vol. 44, no. 6, pp. 2008-19. https://doi.org/10.1007/s10439-016-1580-z

Tissue Engineering: Biomimetic Concealing of PLGA Microspheres in a 3D Scaffold to Prevent Macrophage Uptake (Small 11/2016)
Minardi, S, Corradetti, B, Taraballi, F, Sandri, M, Martinez, JO, Powell, ST, Tampieri, A, Weiner, BK & Tasciotti, E 2016, Small (Weinheim an der Bergstrasse, Germany), vol. 12, no. 11, pp. 1394. https://doi.org/10.1002/smll.201670055

Biomimetic collagenous scaffold to tune inflammation by targeting macrophages
Taraballi, F, Corradetti, B, Minardi, S, Powel, S, Cabrera, F, Van Eps, JL, Weiner, BK & Tasciotti, E 2016, Journal of Tissue Engineering, vol. 7, pp. 2041731415624667. https://doi.org/10.1177/2041731415624667

Biomimetic Concealing of PLGA Microspheres in a 3D Scaffold to Prevent Macrophage Uptake
Minardi, S, Corradetti, B, Taraballi, F, Sandri, M, Martinez, JO, Powell, ST, Tampieri, A, Weiner, BK & Tasciotti, E 2016, Small, vol. 12, no. 11, pp. 1479-88. https://doi.org/10.1002/smll.201503484

Leptin and leptin receptor are detectable in equine spermatozoa but are not involved in in vitro fertilisation
Lange-Consiglio, A, Corradetti, B, Perrini, C, Bizzaro, D & Cremonesi, F 2016, Reproduction, Fertility and Development, vol. 28, no. 5, pp. 574-585. https://doi.org/10.1071/RD14130

The immune response to implanted materials and devices: The impact of the immune system on the success of an implant
Corradetti, B 2016, . Springer International Publishing. https://doi.org/10.1007/978-3-319-45433-7

Preface
Corradetti, B 2016, . in The Immune Response to Implanted Materials and Devices: The Impact of the Immune System on the Success of an Implant. Springer International Publishing, pp. vii-vii. https://doi.org/10.1007/978-3-319-45433-7

Characterization of Mesenchymal Stem Cells from Human Cortical Bone
Fernandez-Moure, J, Corradetti, B, Janecek, T, Van Epps, J, Burn, MB, Weiner, BK, Rameshwar, P & Tasciotti, E 2016, International Journal of Translational Science, no. 1, pp. 71-86. https://doi.org/10.13052/ijts2246-8765.2016.005

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