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Bruna Corradetti, PhD, MSc

Assistant Research Professor of Nanomedicine, Academic Institute
Assistant Research Member, Research Institute
Houston Methodist


Phone:
346.238.1001


bcorradetti2@houstonmethodist.org
Biography

Bruna Corradetti received a Ph.D. in Biomolecular Science from Polytechnic University of Marche (Italy) in 2012 working on the development of stem cell-based therapeutic approaches for the treatment of spontaneous tendon injuries. In 2013 she was appointed as Assistant Professor in Genetics in the same university and joined the Houston Methodist Research Institute in the context of a Fellowship for Molecular Medicine. There, Dr. Corradetti expanded her research to material science and nanotechnology and to their applications in the fields of tissue engineering, regenerative medicine, and immunomodulation. She conceived and developed naturally inspired platforms and delivery systems able to support tissue regeneration by modulating stem and immune cells behavior. Since 2015 Dr. Corradetti has served as Associate Member for the Houston Methodist Research Institute and in 2016 as Visiting Professor at the Department of Mechanics and Materials at ETH Zurich working with Prof. Chiara Daraio.

In 2016 Dr. Corradetti was nominated Fellow of the Academy of Translational Medicine Professionals and since then she serves as Secretary of the European Society for Translational Medicine. In 2017 Dr. Corradetti has been recognized among the “100 Italian Excellences.” Dr. Corradetti has published more than 40 peer-reviewed papers and served as the sole Editor of the book entitled “The Immune Response to Implanted Materials and Devices. The Impact of the Immune System on the Success of an Implant” published by Springer International in 2017.

In 2018 Dr. Corradetti has joined the Houston Methodist Research Institute as Assistant Research Professor and was appointed as Associate Professor in the School of Medicine at Swansea University (Wales, UK). Her work is partially supported through the Sêr Cymru II program, funded by the European Commission through the Horizon 2020 Marie Sklodowska-Curie Actions (MSCA) COFUND scheme and the Welsh European Funding Office (WEFO) under the European Regional Development Fund (ERDF).

Description of Research

- Natural and bio-inspired artificial platforms for the delivery of RNA therapeutics.

- Biomimetic strategies to improve tissue regeneration and modulate the immune response.

- Synthetic biomimetic extracellular matrices for the healing of chronic wounds and cell transplantation.

- Development of exosome-based vaccines to induce anti-cancer immune response.

Areas Of Expertise

Immunotherapy Stem cells Immunomodulation RNA therapeutics Exosomes Tissue engineering Ovarian cancer Macrophages
Education & Training

PhD, Universitá Politecnica delle Marche
MSc, Universitá Politecnica delle Marche
BS, Università Politecnica delle Marche
Publications

xosomes as a novel immunotherapeutic approach for metastatic ovarian cancer treatment.
Pisano, S, Gonzalez, D, Ferrari, M, Conlan, RS & Corradetti, B 2020, Advanced Cancer Therapies, Society of Surgical Oncology (SSO), Orlando, United States, 2/16/20 - 2/17/21, .

Immunotherapeutic Transport Oncophysics: space, time, and immune activation against cancer.
Nizzero, S, Shen, H, Ferrari, M & Corradetti, B 2019, Trends in Cancer.

Harnessing immune-cell derived exosomes as a novel immunotherapeutic platform for ovarian cancer
Corradetti, B 2019, End2Cancer Conference, Oklahoma, United States, 11/21/19 - 11/22/19, .

Exosomes as natural nanodelivery systems for immunotherapy
Pisano, S, Walsh, J, Velazquez, O, Vaiasicca, S & Corradetti, B 2019, European Society for Translational Medicine, Austria, 10/1/16, .

Enhancing the anti-tumor immunity using exosomes derived from dendritic cells pulsed with porous silicon microparticles
Velazquez, O, Pisano, S, Walsh, J, Ferrari, M & Corradetti, B 2019, 2019 PS-ON Annual Investigators Meeting, Minneapolis, United States, 12/18/19 - 12/20/19, .

Employing exosomes as a novel immunotherapeutic approach for ovarian cancer
Pisano, S, Gonzalez, D, Conlan, RS, Ferrari, M & Corradetti, B 2019, 7th Annual Houston Methodist Cancer Symposium, Houston, United States, 8/16/19, .

Employing exosomes as a novel immunotherapeutic approach for ovarian cancer
Pisano, S, Gonzalez, D, Conlan, S, Ferrari, M & Corradetti, B 2019, 2019 MAPTA Summer Science Symposium, Houston, United States, 8/8/19 - 8/9/19, .

Dendritic cells pulsed with tumor antigen-loaded porous silicon microparticles secrete exosomes capable of stimulating T-cells
Velazquez, O, Pisano, S, Walsh, J & Corradetti, B 2019, 2019 MAPTA Summer Science Symposium, Houston, United States, 8/8/19 - 8/9/19, .

Bioactive Immunomodulatory Compounds: A Novel Combinatorial Strategy for Integrated Medicine in Oncology? BAIC Exposure in Cancer Cells
Corradetti, B, Vaiasicca, S, Mantovani, M, Virgili, E, Bonucci, M & Hammarberg Ferri, I 2019, Integrative Cancer Therapies, vol. 18. https://doi.org/10.1177/1534735419866908

Nanotechnology and immunotherapy in ovarian cancer: Tracing new landscapes
Corradetti, B, Pisano, S, Conlan, RS & Ferrari, M 2019, Journal of Pharmacology and Experimental Therapeutics, vol. 370, no. 3, pp. 636-646. https://doi.org/10.1124/jpet.118.254979

Dendritic cells-derived exosomes as a novel therapeutic approach for metastatic ovarian cancer.
Pisano, S, Gonzalez, D, Ferrari, M, Conlan, RS & Corradetti, B 2019, CSBC/PS-ON Annual Junior Investigators’ Meeting, , Bethesda , United States, 8/22/19 - 8/23/19, .

Regenerative Medicine to Trump Cancer
Corradetti, B, Dogra, P, Ferrari, M & Cristini, V 2018, Open Access Government.

Corrigendum: Heparan Sulfate: A Potential Candidate for the Development of Biomimetic Immunomodulatory Membranes
Corradetti, B, Taraballi, F, Giretti, I, Bauza, G, Pistillo, RS, Niclot, FB, Pandolfi, L, Demarchi, D & Tasciotti, E 2018, Frontiers in Bioengineering and Biotechnology, vol. 5, no. JAN, 86, pp. 86. https://doi.org/10.3389/fbioe.2017.00086

Immune tuning scaffold for the local induction of a pro-regenerative environment
Corradetti, B, Taraballi, F, Corbo, C, Cabrera, F, Pandolfi, L, Minardi, S, Wang, X, Van Eps, J, Bauza, G, Weiner, B & Tasciotti, E 2017, Scientific Reports, vol. 7, no. 1, 17030. https://doi.org/10.1038/s41598-017-16895-0

Hyaluronic acid coatings as a simple and efficient approach to improve MSC homing toward the site of inflammation
Corradetti, B, Taraballi, F, Martinez, JO, Minardi, S, Basu, N, Bauza, G, Evangelopoulos, M, Powell, S, Corbo, C & Tasciotti, E 2017, Scientific Reports, vol. 7, no. 1, 7991, pp. 7991. https://doi.org/10.1038/s41598-017-08687-3

Heparan Sulfate: A Potential Candidate for the Development of Biomimetic Immunomodulatory Membranes
Corradetti, B, Taraballi, F, Giretti, I, Bauza, G, Pistillo, RS, Banche Niclot, F, Pandolfi, L & Tasciotti, E 2017, Frontiers in Bioengineering and Biotechnology, vol. 5, pp. 54. https://doi.org/10.3389/fbioe.2017.00054

Microvesicles secreted from equine amniotic-derived cells and their potential role in reducing inflammation in endometrial cells in an in-vitro model
Perrini, C, Strillacci, MG, Bagnato, A, Esposti, P, Marini, MG, Corradetti, B, Bizzaro, D, Idda, A, Ledda, S, Capra, E, Pizzi, F, Lange-Consiglio, A & Cremonesi, F 2016, Stem Cell Research and Therapy, vol. 7, no. 1, pp. 1-15. https://doi.org/10.1186/s13287-016-0429-6

Effects of platelet-rich plasma in a model of bovine endometrial inflammation in vitro
Marini, MG, Perrini, C, Esposti, P, Corradetti, B, Bizzaro, D, Riccaboni, P, Fantinato, E, Urbani, G, Gelati, G, Cremonesi, F & Lange-Consiglio, A 2016, Reproductive Biology and Endocrinology, vol. 14, no. 1, 58. https://doi.org/10.1186/s12958-016-0195-4

IL-4 Release from a Biomimetic Scaffold for the Temporally Controlled Modulation of Macrophage Response
Minardi, S, Corradetti, B, Taraballi, F, Byun, JH, Cabrera, F, Liu, X, Ferrari, M, Weiner, BK & Tasciotti, E 2016, Annals of Biomedical Engineering, vol. 44, no. 6, pp. 2008-19. https://doi.org/10.1007/s10439-016-1580-z

One-pot synthesis of pH-responsive hybrid nanogel particles for the intracellular delivery of small interfering RNA
Khaled, SZ, Cevenini, A, Yazdi, IK, Parodi, A, Evangelopoulos, M, Corbo, C, Scaria, S, Hu, Y, Haddix, SG, Corradetti, B, Salvatore, F & Tasciotti, E 2016, Biomaterials, vol. 87, pp. 57-68. https://doi.org/10.1016/j.biomaterials.2016.01.052

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