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Anna Tampieri, PhD

Full Affiliate Member, Research Institute
Houston Methodist


Biography

Dr. Tampieri's research focus is materials science with special attention to inorganic chemistry applications in ceramic materials and bio-hybrid composites. Early in her career from 1986 to 1995, Dr. Tampieri coordinated research collaborations for the development of High-Tc Ceramic Superconductors.

Beginning in 1995, Dr. Tampieri created a new research group dedicated to the development of biomaterials and biotechnology for regenerative medicine. Her research team combines a high degree of technical specialization with broad interdisciplinary expertise that supports a large number of national and international research projects.

Dr. Tampieri's research is internationally recognized for contributions to global health. Her research on osteochondral substitutes was named one of the most important contributions to human healthcare in 2008 by the Literature Awareness System (UK). The commercial development of this innovation by Dr. Tampieri, resulted in a CE marked osteochondral scaffold product, which has been adopted for orthopaedic surgical practice in Europe as the first step toward a completely biologic prosthesis.

The Dr. Tampieri's approach to research is to tackle new and complex problems from a technological perspective. TIME magazine named her research project From Wood to Bone one of 50 most important inventions of 2009. This innovation received worldwide media attention including interviews, articles in specialized and popular magazines, and international TV and radio appearances. The BBC, Sidney Broadcasting News, The Discovery Channel, and Reuter Television have reported on Dr. Tampieri's research initiatives.

Description of Research

Dr. Tampieri's research program focuses on synthesis methodologies, forming methods, sintering processes, and the relationships between microstructural properties and material performance.

Specific initiatives include development of:
-highly porous bioactive bone scaffolds endowed with intrinsic magnetic properties
-biomorphic ceramics with hierarchically organized morphology, derived from the transformation of native ligneous structures for load-bearing applications
-ceramic pastes/cements, designed to exhibit high interconnected porosity and mechanical strength
-bio-hybrid composites based on natural polymers and mineralized with nanostructured biomimetic apatites following biologically inspired processes
-bio-hybrid scaffolds exhibiting mineralization gradients, obtained through interpenetration of bio-hybrid composites for the selective regeneration of bone and osteo-cartilaginous tissues
-organomorphic transformations to obtain three-dimensional polymeric scaffolds that reproduce the morphology and functionality of stromal/vascular systems
-innovative filters for nanoparticles
-recycling technology for nanopowders to reduce environmental toxicity
-intelligent drug delivery systems using nanoparticles driven by magnetic signals

Areas Of Expertise

Drug delivery Biologically inspired processes Bioactive nano-powders Bio-hybrid composites Scaffold for bone and cartilage regeneration
Education & Training

Postdoctoral Fellowship, Government Industrial Research Institute, Nagoya
Postdoctoral Fellowship, National Institute for Inorganic Materials, Tsukuba
Postdoctoral Fellowship, USDA, San Francisco, CA
PhD, University of Bologna
MSc, University of Bologna
Research Fellowship, University of Bologna
Publications

Prospective Clinical and Histologic Evaluation of Alveolar Socket Healing Following Ridge Preservation Using a Combination of Hydroxyapatite and Collagen Biomimetic Xenograft Versus Demineralized Bovine Bone
Taschieri, S, Del Fabbro, M, Panda, S, Goker, F, Babina, KS, Tampieri, A & Mortellaro, C 2019, The Journal of craniofacial surgery, vol. 30, no. 4, pp. 1089-1094. https://doi.org/10.1097/SCS.0000000000005416

A Composite Chitosan-Reinforced Scaffold Fails to Provide Osteochondral Regeneration
Roffi, A, Kon, E, Perdisa, F, Fini, M, Di Martino, A, Parrilli, A, Salamanna, F, Sandri, M, Sartori, M, Sprio, S, Tampieri, A, Marcacci, M & Filardo, G 2019, International journal of molecular sciences, vol. 20, no. 9. https://doi.org/10.3390/ijms20092227

Superparamagnetic hybrid microspheres affecting osteoblasts behaviour
Fernandes Patrício, TM, Panseri, S, Montesi, M, Iafisco, M, Sandri, M, Tampieri, A & Sprio, S 2019, Materials Science and Engineering C, vol. 96, pp. 234-247. https://doi.org/10.1016/j.msec.2018.11.014

Polymeric 3D scaffolds for tissue regeneration: Evaluation of biopolymer nanocomposite reinforced with cellulose nanofibrils
Campodoni, E, Heggset, EB, Rashad, A, Ramírez-Rodríguez, GB, Mustafa, K, Syverud, K, Tampieri, A & Sandri, M 2019, Materials Science and Engineering C, vol. 94, pp. 867-878. https://doi.org/10.1016/j.msec.2018.10.026

Heterogeneous chemistry in the 3-D state: An original approach to generate bioactive, mechanically-competent bone scaffolds
Tampieri, A, Ruffini, A, Ballardini, A, Montesi, M, Panseri, S, Salamanna, F, Fini, M & Sprio, S 2019, Biomaterials Science, vol. 7, no. 1, pp. 307-321. https://doi.org/10.1039/c8bm01145a

Vegetable hierarchical structures as template for bone regeneration: New bio-ceramization process for the development of a bone scaffold applied to an experimental sheep model
Filardo, G, Roffi, A, Fey, T, Fini, M, Giavaresi, G, Marcacci, M, Martínez-Fernández, J, Martini, L, Ramírez-Rico, J, Salamanna, F, Sandri, M, Sprio, S, Tampieri, A & Kon, E 2019, Journal of Biomedical Materials Research - Part B Applied Biomaterials. https://doi.org/10.1002/jbm.b.34414

Magnetic calcium phosphates nanocomposites for the intracellular hyperthermia of cancers of bone and brain
Adamiano, A, Wu, VM, Carella, F, Lamura, G, Canepa, F, Tampieri, A, Iafisco, M & Uskokovic, V 2019, Nanomedicine, vol. 14, no. 10, pp. 1267-1289. https://doi.org/10.2217/nnm-2018-0372

Collagen-hydroxyapatite composite substitute and bone marrow nuclear cells on posterolateral spine fusion in sheep
Ding, M, Koroma, KE, Sorensen, JR, Sandri, M, Tampieri, A, Jespersen, SM & Overgaard, S 2019, Journal of Biomaterials Applications. https://doi.org/10.1177/0885328219851315

Gene Modification and Three-Dimensional Scaffolds as Novel Tools to Allow the Use of Postnatal Thymic Epithelial Cells for Thymus Regeneration Approaches
Bortolomai, I, Sandri, M, Draghici, E, Fontana, E, Campodoni, E, Marcovecchio, GE, Ferrua, F, Perani, L, Spinelli, A, Canu, T, Catucci, M, Di Tomaso, T, Sergi Sergi, L, Esposito, A, Lombardo, A, Naldini, L, Tampieri, A, Hollander, GA, Villa, A & Bosticardo, M 2019, Stem Cells Translational Medicine. https://doi.org/10.1002/sctm.18-0218

A Graded Multifunctional Hybrid Scaffold with Superparamagnetic Ability for Periodontal Regeneration
Sprio, S, Campodoni, E, Sandri, M, Preti, L, Keppler, T, Müller, FA, Pugno, NM & Tampieri, A 2018, International journal of molecular sciences, vol. 19, no. 11, 3604. https://doi.org/10.3390/ijms19113604

Interaction of Folic Acid with Nanocrystalline Apatites and Extension to Methotrexate (Antifolate) in View of Anticancer Applications
Sarda, S, Iafisco, M, Pascaud-Mathieu, P, Adamiano, A, Montesi, M, Panseri, S, Marsan, O, Thouron, C, Dupret-Bories, A, Tampieri, A & Drouet, C 2018, Langmuir, vol. 34, no. 40, pp. 12036-12048. https://doi.org/10.1021/acs.langmuir.8b02602

Biomineralization process generating hybrid nano-and micro-carriers
Campodoni, E, Patricio, T, Montesi, M, Tampieri, A, Sandri, M & Sprio, S 2018, . in Core-Shell Nanostructures for Drug Delivery and Theranostics: Challenges, Strategies, and Prospects for Novel Carrier Systems. Elsevier, pp. 19-42. https://doi.org/10.1016/C2016-0-03458-7

Core-shell nanostructures for drug delivery and theranostics: Challenges, strategies, and prospects for novel carrier systems
Focarete, ML & Tampieri, A 2018, . Elsevier. https://doi.org/10.1016/C2016-0-03458-7

Introduction to "Core-shell nanostructures for drug delivery and theranostics: Challenges, strategies, and prospects for novel carrier systems"
Focarete, ML & Tampieri, A 2018, . in Core-Shell Nanostructures for Drug Delivery and Theranostics: Challenges, Strategies, and Prospects for Novel Carrier Systems. Elsevier, pp. 3-5. https://doi.org/10.1016/C2016-0-03458-7

Magnetic core-shell nanoparticles: Remote driving, hyperthermia, and controlled drug release
Adamiano, A, Iafisco, M & Tampieri, A 2018, . in ML Focarete & A Tampieri (eds), Core-Shell Nanostructures for Drug Delivery and Theranostics: Challenges, Strategies, and Prospects for Novel Carrier Systems. Elsevier, pp. 259-296. https://doi.org/10.1016/C2016-0-03458-7

A combined low-frequency electromagnetic and fluidic stimulation for a controlled drug release from superparamagnetic calcium phosphate nanoparticles: Potential application for cardiovascular diseases
Marrella, A, Iafisco, M, Adamiano, A, Rossi, S, Aiello, M, Barandalla-Sobrados, M, Carullo, P, Miragoli, M, Tampieri, A, Scaglione, S & Catalucci, D 2018, Journal of the Royal Society Interface, vol. 15, no. 144, 20180236. https://doi.org/10.1098/rsif.2018.0236

Treatment of biofilm communities: An update on new tools from the nanosized world
Bertoglio, F, Bloise, N, Oriano, M, Petrini, P, Sprio, S, Imbriani, M, Tampieri, A & Visai, L 2018, Applied Sciences (Switzerland), vol. 8, no. 6, 845. https://doi.org/10.3390/app8060845

Calcium phosphate-based nanosystems for advanced targeted nanomedicine
Degli Esposti, L, Carella, F, Adamiano, A, Tampieri, A & Iafisco, M 2018, Drug Development and Industrial Pharmacy, pp. 1-16. https://doi.org/10.1080/03639045.2018.1451879

Inhalation of peptide-loaded nanoparticles improves heart failure
Miragoli, M, Ceriotti, P, Iafisco, M, Vacchiano, M, Salvarani, N, Alogna, A, Carullo, P, Ramirez-Rodríguez, GB, Patrício, T, Degli Esposti, L, Rossi, F, Ravanetti, F, Pinelli, S, Alinovi, R, Erreni, M, Rossi, S, Condorelli, G, Post, H, Tampieri, A & Catalucci, D 2018, Science Translational Medicine, vol. 10, no. 424, Y. https://doi.org/10.1126/scitranslmed.aan6205

Cermodel 2017: Modelling and Simulation Meet Innovation in Ceramics Technology. July 26-28, 2017, Trento, Italy
Bigoni, D, Tampieri, A & Zannini, P 2018, Journal of the European Ceramic Society. https://doi.org/10.1016/j.jeurceramsoc.2018.02.034

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