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Anna Tampieri, PhD

Full Affiliate Member, Research Institute
Houston Methodist


Dr. Tampieri's research focus is materials science with special attention to inorganic chemistry applications in ceramic materials and bio-hybrid composites. Early in her career from 1986 to 1995, Dr. Tampieri coordinated research collaborations for the development of High-Tc Ceramic Superconductors.

Beginning in 1995, Dr. Tampieri created a new research group dedicated to the development of biomaterials and biotechnology for regenerative medicine. Her research team combines a high degree of technical specialization with broad interdisciplinary expertise that supports a large number of national and international research projects.

Dr. Tampieri's research is internationally recognized for contributions to global health. Her research on osteochondral substitutes was named one of the most important contributions to human healthcare in 2008 by the Literature Awareness System (UK). The commercial development of this innovation by Dr. Tampieri, resulted in a CE marked osteochondral scaffold product, which has been adopted for orthopaedic surgical practice in Europe as the first step toward a completely biologic prosthesis.

The Dr. Tampieri's approach to research is to tackle new and complex problems from a technological perspective. TIME magazine named her research project From Wood to Bone one of 50 most important inventions of 2009. This innovation received worldwide media attention including interviews, articles in specialized and popular magazines, and international TV and radio appearances. The BBC, Sidney Broadcasting News, The Discovery Channel, and Reuter Television have reported on Dr. Tampieri's research initiatives.

Description of Research

Dr. Tampieri's research program focuses on synthesis methodologies, forming methods, sintering processes, and the relationships between microstructural properties and material performance.

Specific initiatives include development of:
-highly porous bioactive bone scaffolds endowed with intrinsic magnetic properties
-biomorphic ceramics with hierarchically organized morphology, derived from the transformation of native ligneous structures for load-bearing applications
-ceramic pastes/cements, designed to exhibit high interconnected porosity and mechanical strength
-bio-hybrid composites based on natural polymers and mineralized with nanostructured biomimetic apatites following biologically inspired processes
-bio-hybrid scaffolds exhibiting mineralization gradients, obtained through interpenetration of bio-hybrid composites for the selective regeneration of bone and osteo-cartilaginous tissues
-organomorphic transformations to obtain three-dimensional polymeric scaffolds that reproduce the morphology and functionality of stromal/vascular systems
-innovative filters for nanoparticles
-recycling technology for nanopowders to reduce environmental toxicity
-intelligent drug delivery systems using nanoparticles driven by magnetic signals

Areas Of Expertise

Drug delivery Biologically inspired processes Bioactive nano-powders Bio-hybrid composites Scaffold for bone and cartilage regeneration
Education & Training

Postdoctoral Fellowship, Government Industrial Research Institute, Nagoya
Postdoctoral Fellowship, National Institute for Inorganic Materials, Tsukuba
Postdoctoral Fellowship, USDA, San Francisco, CA
PhD, University of Bologna
MSc, University of Bologna
Research Fellowship, University of Bologna

Superparamagnetic hybrid microspheres affecting osteoblasts behaviour
Fernandes Patrício, TM, Panseri, S, Montesi, M, Iafisco, M, Sandri, M, Tampieri, A & Sprio, S 2019, Materials Science and Engineering C, vol. 96, pp. 234-247.

Polymeric 3D scaffolds for tissue regeneration: Evaluation of biopolymer nanocomposite reinforced with cellulose nanofibrils
Campodoni, E, Heggset, EB, Rashad, A, Ramírez-Rodríguez, GB, Mustafa, K, Syverud, K, Tampieri, A & Sandri, M 2019, Materials Science and Engineering C, vol. 94, pp. 867-878.

Heterogeneous chemistry in the 3-D state: An original approach to generate bioactive, mechanically-competent bone scaffolds
Tampieri, A, Ruffini, A, Ballardini, A, Montesi, M, Panseri, S, Salamanna, F, Fini, M & Sprio, S 2019, Biomaterials Science, vol. 7, no. 1, pp. 307-321.

A Graded Multifunctional Hybrid Scaffold with Superparamagnetic Ability for Periodontal Regeneration
Sprio, S, Campodoni, E, Sandri, M, Preti, L, Keppler, T, Müller, FA, Pugno, NM & Tampieri, A 2018, International journal of molecular sciences, vol. 19, no. 11, 3604.

Interaction of Folic Acid with Nanocrystalline Apatites and Extension to Methotrexate (Antifolate) in View of Anticancer Applications
Sarda, S, Iafisco, M, Pascaud-Mathieu, P, Adamiano, A, Montesi, M, Panseri, S, Marsan, O, Thouron, C, Dupret-Bories, A, Tampieri, A & Drouet, C 2018, Langmuir, vol. 34, no. 40, pp. 12036-12048.

Biomineralization process generating hybrid nano-and micro-carriers
Campodoni, E, Patricio, T, Montesi, M, Tampieri, A, Sandri, M & Sprio, S 2018, . in Core-Shell Nanostructures for Drug Delivery and Theranostics: Challenges, Strategies, and Prospects for Novel Carrier Systems. Elsevier, pp. 19-42.

Core-shell nanostructures for drug delivery and theranostics: Challenges, strategies, and prospects for novel carrier systems
Focarete, ML & Tampieri, A 2018, . Elsevier.

Introduction to "Core-shell nanostructures for drug delivery and theranostics: Challenges, strategies, and prospects for novel carrier systems"
Focarete, ML & Tampieri, A 2018, . in Core-Shell Nanostructures for Drug Delivery and Theranostics: Challenges, Strategies, and Prospects for Novel Carrier Systems. Elsevier, pp. 3-5.

Magnetic core-shell nanoparticles: Remote driving, hyperthermia, and controlled drug release
Adamiano, A, Iafisco, M & Tampieri, A 2018, . in ML Focarete & A Tampieri (eds), Core-Shell Nanostructures for Drug Delivery and Theranostics: Challenges, Strategies, and Prospects for Novel Carrier Systems. Elsevier, pp. 259-296.

A combined low-frequency electromagnetic and fluidic stimulation for a controlled drug release from superparamagnetic calcium phosphate nanoparticles: Potential application for cardiovascular diseases
Marrella, A, Iafisco, M, Adamiano, A, Rossi, S, Aiello, M, Barandalla-Sobrados, M, Carullo, P, Miragoli, M, Tampieri, A, Scaglione, S & Catalucci, D 2018, Journal of the Royal Society Interface, vol. 15, no. 144, 20180236.

Treatment of biofilm communities: An update on new tools from the nanosized world
Bertoglio, F, Bloise, N, Oriano, M, Petrini, P, Sprio, S, Imbriani, M, Tampieri, A & Visai, L 2018, Applied Sciences (Switzerland), vol. 8, no. 6, 845.

Calcium phosphate-based nanosystems for advanced targeted nanomedicine
Degli Esposti, L, Carella, F, Adamiano, A, Tampieri, A & Iafisco, M 2018, Drug Development and Industrial Pharmacy, pp. 1-16.

Inhalation of peptide-loaded nanoparticles improves heart failure
Miragoli, M, Ceriotti, P, Iafisco, M, Vacchiano, M, Salvarani, N, Alogna, A, Carullo, P, Ramirez-Rodríguez, GB, Patrício, T, Degli Esposti, L, Rossi, F, Ravanetti, F, Pinelli, S, Alinovi, R, Erreni, M, Rossi, S, Condorelli, G, Post, H, Tampieri, A & Catalucci, D 2018, Science Translational Medicine, vol. 10, no. 424, Y.

Cermodel 2017: Modelling and Simulation Meet Innovation in Ceramics Technology. July 26-28, 2017, Trento, Italy
Bigoni, D, Tampieri, A & Zannini, P 2018, Journal of the European Ceramic Society.

On the use of superparamagnetic hydroxyapatite nanoparticles as an agent for magnetic and nuclear in vivo imaging
Adamiano, A, Iafisco, M, Sandri, M, Basini, M, Arosio, P, Canu, T, Sitia, G, Esposito, A, Iannotti, V, Ausanio, G, Fragogeorgi, E, Rouchota, M, Loudos, G, Lascialfari, A & Tampieri, A 2018, Acta Biomaterialia.

MSC-Seeded Biomimetic Scaffolds as a Factory of Soluble RANKL in Rankl-Deficient Osteopetrosis
Menale, C, Campodoni, E, Palagano, E, Mantero, S, Erreni, M, Inforzato, A, Fontana, E, Schena, F, vant Hof, R, Sandri, M, Tampieri, A, Villa, A & Sobacchi, C 2018, Stem Cells Translational Medicine.

On the surface effects of citrates on nano-apatites: Evidence of a decreased hydrophilicity
Ivanchenko, P, Delgado-López, JM, Iafisco, M, Gómez-Morales, J, Tampieri, A, Martra, G & Sakhno, Y 2017, Scientific Reports, vol. 7, no. 1, 8901.

Biomineralized recombinant collagen-based scaffold mimicking native bone enhances mesenchymal stem cell interaction and differentiation
Ramírez-Rodríguez, GB, Montesi, M, Panseri, S, Sprio, S, Tampieri, A & Sandri, M 2017, Tissue Engineering - Part A, vol. 23, no. 23-24, pp. 1423-1435.

Targeted and theranostic applications for nanotechnologies in medicine: Nanostructured calcium phosphates for theranostic nanomedicine
Esposti, LD, Tampieri, A & Iafisco, M 2017, . in Nanotechnologies in Preventive and Regenerative Medicine: An Emerging Big Picture. Elsevier Inc. pp. 465-487.

3D porous collagen scaffolds reinforced by glycation with ribose for tissue engineering application
Gostynska, N, Shankar Krishnakumar, G, Campodoni, E, Panseri, S, Montesi, M, Sprio, S, Kon, E, Marcacci, M, Tampieri, A & Sandri, M 2017, Biomedical Materials (Bristol), vol. 12, no. 5, 055002.

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