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Anna Tampieri, PhD

Full Affiliate Member, Research Institute
Houston Methodist


Dr. Tampieri's research focus is materials science with special attention to inorganic chemistry applications in ceramic materials and bio-hybrid composites. Early in her career from 1986 to 1995, Dr. Tampieri coordinated research collaborations for the development of High-Tc Ceramic Superconductors.

Beginning in 1995, Dr. Tampieri created a new research group dedicated to the development of biomaterials and biotechnology for regenerative medicine. Her research team combines a high degree of technical specialization with broad interdisciplinary expertise that supports a large number of national and international research projects.

Dr. Tampieri's research is internationally recognized for contributions to global health. Her research on osteochondral substitutes was named one of the most important contributions to human healthcare in 2008 by the Literature Awareness System (UK). The commercial development of this innovation by Dr. Tampieri, resulted in a CE marked osteochondral scaffold product, which has been adopted for orthopaedic surgical practice in Europe as the first step toward a completely biologic prosthesis.

The Dr. Tampieri's approach to research is to tackle new and complex problems from a technological perspective. TIME magazine named her research project From Wood to Bone one of 50 most important inventions of 2009. This innovation received worldwide media attention including interviews, articles in specialized and popular magazines, and international TV and radio appearances. The BBC, Sidney Broadcasting News, The Discovery Channel, and Reuter Television have reported on Dr. Tampieri's research initiatives.

Description of Research

Dr. Tampieri's research program focuses on synthesis methodologies, forming methods, sintering processes, and the relationships between microstructural properties and material performance.

Specific initiatives include development of:
-highly porous bioactive bone scaffolds endowed with intrinsic magnetic properties
-biomorphic ceramics with hierarchically organized morphology, derived from the transformation of native ligneous structures for load-bearing applications
-ceramic pastes/cements, designed to exhibit high interconnected porosity and mechanical strength
-bio-hybrid composites based on natural polymers and mineralized with nanostructured biomimetic apatites following biologically inspired processes
-bio-hybrid scaffolds exhibiting mineralization gradients, obtained through interpenetration of bio-hybrid composites for the selective regeneration of bone and osteo-cartilaginous tissues
-organomorphic transformations to obtain three-dimensional polymeric scaffolds that reproduce the morphology and functionality of stromal/vascular systems
-innovative filters for nanoparticles
-recycling technology for nanopowders to reduce environmental toxicity
-intelligent drug delivery systems using nanoparticles driven by magnetic signals

Areas Of Expertise

Drug delivery Biologically inspired processes Bioactive nano-powders Bio-hybrid composites Scaffold for bone and cartilage regeneration
Education & Training

Postdoctoral Fellowship, Government Industrial Research Institute, Nagoya
Postdoctoral Fellowship, National Institute for Inorganic Materials, Tsukuba
Postdoctoral Fellowship, USDA, San Francisco, CA
PhD, University of Bologna
MSc, University of Bologna
Research Fellowship, University of Bologna

Differences in osteogenic induction of human mesenchymal stem cells between a tailored 3D hybrid scaffold and a 2D standard culture
Dozio, SM, Montesi, M, Campodoni, E, Sandri, M, Piattelli, A, Tampieri, A & Panseri, S 2019, Journal of Materials Science: Materials in Medicine, vol. 30, no. 12, 136.

Optimized production of a high-performance hybrid biomaterial: biomineralized spider silk for bone tissue engineering
Dellaquila, A, Greco, G, Campodoni, E, Mazzocchi, M, Mazzolai, B, Tampieri, A, Pugno, NM & Sandri, M 2019, Journal of Applied Polymer Science.

Adult Stem Cells for Bone Regeneration and Repair
Iaquinta, MR, Mazzoni, E, Bononi, I, Rotondo, JC, Mazziotta, C, Montesi, M, Sprio, S, Tampieri, A, Tognon, M & Martini, F 2019, Frontiers in Cell and Developmental Biology, vol. 7, 268.

Prospective Clinical and Histologic Evaluation of Alveolar Socket Healing Following Ridge Preservation Using a Combination of Hydroxyapatite and Collagen Biomimetic Xenograft Versus Demineralized Bovine Bone
Taschieri, S, Del Fabbro, M, Panda, S, Goker, F, Babina, KS, Tampieri, A & Mortellaro, C 2019, The Journal of craniofacial surgery, vol. 30, no. 4, pp. 1089-1094.

A Composite Chitosan-Reinforced Scaffold Fails to Provide Osteochondral Regeneration
Roffi, A, Kon, E, Perdisa, F, Fini, M, Di Martino, A, Parrilli, A, Salamanna, F, Sandri, M, Sartori, M, Sprio, S, Tampieri, A, Marcacci, M & Filardo, G 2019, International journal of molecular sciences, vol. 20, no. 9.

Superparamagnetic hybrid microspheres affecting osteoblasts behaviour
Fernandes Patrício, TM, Panseri, S, Montesi, M, Iafisco, M, Sandri, M, Tampieri, A & Sprio, S 2019, Materials Science and Engineering C, vol. 96, pp. 234-247.

Polymeric 3D scaffolds for tissue regeneration: Evaluation of biopolymer nanocomposite reinforced with cellulose nanofibrils
Campodoni, E, Heggset, EB, Rashad, A, Ramírez-Rodríguez, GB, Mustafa, K, Syverud, K, Tampieri, A & Sandri, M 2019, Materials Science and Engineering C, vol. 94, pp. 867-878.

Heterogeneous chemistry in the 3-D state: An original approach to generate bioactive, mechanically-competent bone scaffolds
Tampieri, A, Ruffini, A, Ballardini, A, Montesi, M, Panseri, S, Salamanna, F, Fini, M & Sprio, S 2019, Biomaterials Science, vol. 7, no. 1, pp. 307-321.

Vegetable hierarchical structures as template for bone regeneration: New bio-ceramization process for the development of a bone scaffold applied to an experimental sheep model
Filardo, G, Roffi, A, Fey, T, Fini, M, Giavaresi, G, Marcacci, M, Martínez-Fernández, J, Martini, L, Ramírez-Rico, J, Salamanna, F, Sandri, M, Sprio, S, Tampieri, A & Kon, E 2019, Journal of Biomedical Materials Research - Part B Applied Biomaterials.

Magnetic calcium phosphates nanocomposites for the intracellular hyperthermia of cancers of bone and brain
Adamiano, A, Wu, VM, Carella, F, Lamura, G, Canepa, F, Tampieri, A, Iafisco, M & Uskokovic, V 2019, Nanomedicine, vol. 14, no. 10, pp. 1267-1289.

Collagen-hydroxyapatite composite substitute and bone marrow nuclear cells on posterolateral spine fusion in sheep
Ding, M, Koroma, KE, Sorensen, JR, Sandri, M, Tampieri, A, Jespersen, SM & Overgaard, S 2019, Journal of Biomaterials Applications.

Gene Modification and Three-Dimensional Scaffolds as Novel Tools to Allow the Use of Postnatal Thymic Epithelial Cells for Thymus Regeneration Approaches
Bortolomai, I, Sandri, M, Draghici, E, Fontana, E, Campodoni, E, Marcovecchio, GE, Ferrua, F, Perani, L, Spinelli, A, Canu, T, Catucci, M, Di Tomaso, T, Sergi Sergi, L, Esposito, A, Lombardo, A, Naldini, L, Tampieri, A, Hollander, GA, Villa, A & Bosticardo, M 2019, Stem Cells Translational Medicine.

Role of citrate in the formation of enamel-like calcium phosphate oriented nanorod arrays
Carella, F, Degli Esposti, L, Barreca, D, Rizzi, GA, Martra, G, Ivanchenko, P, Escolano Casado, G, Gomez Morales, J, Delgado Lòpez, JM, Tampieri, A & Iafisco, M 2019, CrystEngComm, vol. 21, no. 32, pp. 4684-4689.

Surface Phenomena Enhancing the Antibacterial and Osteogenic Ability of Nanocrystalline Hydroxyapatite, Activated by Multiple-Ion Doping
Sprio, S, Preti, L, Montesi, M, Panseri, S, Adamiano, A, Vandini, A, Pugno, NM & Tampieri, A 2019, ACS Biomaterials Science and Engineering.

Nanotechnological approach and bio-inspired materials to face degenerative diseases in aging
Tampieri, A, Sandri, M, Iafisco, M, Panseri, S, Montesi, M, Adamiano, A, Dapporto, M, Campodoni, E, Dozio, SM, Degli Esposti, L & Sprio, S 2019, Aging Clinical and Experimental Research.

Hierarchical porosity inherited by natural sources affects the mechanical and biological behaviour of bone scaffolds
Sprio, S, Panseri, S, Montesi, M, Dapporto, M, Ruffini, A, Dozio, SM, Cavuoto, R, Misseroni, D, Paggi, M, Bigoni, D & Tampieri, A 2019, Journal of the European Ceramic Society.

A Graded Multifunctional Hybrid Scaffold with Superparamagnetic Ability for Periodontal Regeneration
Sprio, S, Campodoni, E, Sandri, M, Preti, L, Keppler, T, Müller, FA, Pugno, NM & Tampieri, A 2018, International journal of molecular sciences, vol. 19, no. 11, 3604.

Interaction of Folic Acid with Nanocrystalline Apatites and Extension to Methotrexate (Antifolate) in View of Anticancer Applications
Sarda, S, Iafisco, M, Pascaud-Mathieu, P, Adamiano, A, Montesi, M, Panseri, S, Marsan, O, Thouron, C, Dupret-Bories, A, Tampieri, A & Drouet, C 2018, Langmuir, vol. 34, no. 40, pp. 12036-12048.

Biomineralization process generating hybrid nano-and micro-carriers
Campodoni, E, Patricio, T, Montesi, M, Tampieri, A, Sandri, M & Sprio, S 2018, . in Core-Shell Nanostructures for Drug Delivery and Theranostics: Challenges, Strategies, and Prospects for Novel Carrier Systems. Elsevier, pp. 19-42.

Core-shell nanostructures for drug delivery and theranostics: Challenges, strategies, and prospects for novel carrier systems
Focarete, ML & Tampieri, A 2018, . Elsevier.

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