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Anna Tampieri, PhD

Full Affiliate Member, Research Institute
Houston Methodist


Dr. Tampieri's research focus is materials science with special attention to inorganic chemistry applications in ceramic materials and bio-hybrid composites. Early in her career from 1986 to 1995, Dr. Tampieri coordinated research collaborations for the development of High-Tc Ceramic Superconductors.

Beginning in 1995, Dr. Tampieri created a new research group dedicated to the development of biomaterials and biotechnology for regenerative medicine. Her research team combines a high degree of technical specialization with broad interdisciplinary expertise that supports a large number of national and international research projects.

Dr. Tampieri's research is internationally recognized for contributions to global health. Her research on osteochondral substitutes was named one of the most important contributions to human healthcare in 2008 by the Literature Awareness System (UK). The commercial development of this innovation by Dr. Tampieri, resulted in a CE marked osteochondral scaffold product, which has been adopted for orthopaedic surgical practice in Europe as the first step toward a completely biologic prosthesis.

The Dr. Tampieri's approach to research is to tackle new and complex problems from a technological perspective. TIME magazine named her research project From Wood to Bone one of 50 most important inventions of 2009. This innovation received worldwide media attention including interviews, articles in specialized and popular magazines, and international TV and radio appearances. The BBC, Sidney Broadcasting News, The Discovery Channel, and Reuter Television have reported on Dr. Tampieri's research initiatives.

Description of Research

Dr. Tampieri's research program focuses on synthesis methodologies, forming methods, sintering processes, and the relationships between microstructural properties and material performance.

Specific initiatives include development of:
-highly porous bioactive bone scaffolds endowed with intrinsic magnetic properties
-biomorphic ceramics with hierarchically organized morphology, derived from the transformation of native ligneous structures for load-bearing applications
-ceramic pastes/cements, designed to exhibit high interconnected porosity and mechanical strength
-bio-hybrid composites based on natural polymers and mineralized with nanostructured biomimetic apatites following biologically inspired processes
-bio-hybrid scaffolds exhibiting mineralization gradients, obtained through interpenetration of bio-hybrid composites for the selective regeneration of bone and osteo-cartilaginous tissues
-organomorphic transformations to obtain three-dimensional polymeric scaffolds that reproduce the morphology and functionality of stromal/vascular systems
-innovative filters for nanoparticles
-recycling technology for nanopowders to reduce environmental toxicity
-intelligent drug delivery systems using nanoparticles driven by magnetic signals

Areas Of Expertise

Drug delivery Biologically inspired processes Bioactive nano-powders Bio-hybrid composites Scaffold for bone and cartilage regeneration
Education & Training

Postdoctoral Fellowship, Government Industrial Research Institute, Nagoya
Postdoctoral Fellowship, National Institute for Inorganic Materials, Tsukuba
Postdoctoral Fellowship, USDA, San Francisco, CA
PhD, University of Bologna
MSc, University of Bologna
Research Fellowship, University of Bologna

Bioactive Materials for Soft Tissue Repair
Mazzoni, E, Iaquinta, MR, Lanzillotti, C, Mazziotta, C, Maritati, M, Montesi, M, Sprio, S, Tampieri, A, Tognon, M & Martini, F 2021, , Frontiers in Bioengineering and Biotechnology, vol. 9, 613787.

Biomimetic mineralization promotes viability and differentiation of human mesenchymal stem cells in a perfusion bioreactor
Ramírez-Rodríguez, GB, Pereira, AR, Hermann, M, Hansmann, J, Delgado-López, JM, Sprio, S, Tampieri, A & Sandri, M 2021, , International journal of molecular sciences, vol. 22, no. 3, 1447, pp. 1-15.

Bio-inspired polymeric iron-doped hydroxyapatite microspheres as a tunable carrier of rhBMP-2
Fernandes Patrício, TM, Mumcuoglu, D, Montesi, M, Panseri, S, Witte-Bouma, J, Garcia, SF, Sandri, M, Tampieri, A, Farrell, E & Sprio, S 2021, , Materials Science and Engineering C, vol. 119, 111410.

Bone-like ceramic scaffolds designed with bioinspired porosity induce a different stem cell response
Panseri, S, Montesi, M, Hautcoeur, D, Dozio, SM, Chamary, S, De Barra, E, Tampieri, A & Leriche, A 2021, , Journal of Materials Science: Materials in Medicine, vol. 32, no. 1, 3.

Scaffold-based 3D cellular models mimicking the heterogeneity of osteosarcoma stem cell niche
Bassi, G, Panseri, S, Dozio, SM, Sandri, M, Campodoni, E, Dapporto, M, Sprio, S, Tampieri, A & Montesi, M 2020, , Scientific Reports, vol. 10, no. 1, 22294.

Innovative Options for Bone Metastasis Treatment: An Extensive Analysis on Biomaterials-Based Strategies for Orthopedic Surgeons
Guerrieri, AN, Montesi, M, Sprio, S, Laranga, R, Mercatali, L, Tampieri, A, Donati, DM & Lucarelli, E 2020, , Frontiers in Bioengineering and Biotechnology, vol. 8, 589964.

Microtopography of Immune Cells in Osteoporosis and Bone Lesions by Endocrine Disruptors
Toni, R, Di Conza, G, Barbaro, F, Zini, N, Consolini, E, Dallatana, D, Antoniel, M, Quarantini, E, Quarantini, M, Maioli, S, Bruni, CA, Elviri, L, Panseri, S, Sprio, S, Sandri, M & Tampieri, A 2020, , Frontiers in immunology, vol. 11, 1737.

Enhancement of the Biological and Mechanical Performances of Sintered Hydroxyapatite by Multiple Ions Doping
Sprio, S, Dapporto, M, Preti, L, Mazzoni, E, Iaquinta, MR, Martini, F, Tognon, M, Pugno, NM, Restivo, E, Visai, L & Tampieri, A 2020, , Frontiers in Materials, vol. 7, 224.

Mimicking Natural Microenvironments: Design of 3D-Aligned Hybrid Scaffold for Dentin Regeneration
Campodoni, E, Dozio, SM, Panseri, S, Montesi, M, Tampieri, A & Sandri, M 2020, , Frontiers in Bioengineering and Biotechnology, vol. 8, 836.

Overcoming the Design Challenge in 3D Biomimetic Hybrid Scaffolds for Bone and Osteochondral Regeneration by Factorial Design
Dellaquila, A, Campodoni, E, Tampieri, A & Sandri, M 2020, , Frontiers in Bioengineering and Biotechnology, vol. 8, 743.

Characterization of a toothpaste containing bioactive hydroxyapatites and in vitro evaluation of its efficacy to remineralize enamel and to occlude dentinal tubules
Esposti, LD, Ionescu, AC, Brambilla, E, Tampieri, A & Iafisco, M 2020, , Materials, vol. 13, no. 13, 2928, pp. 1-13.

Blending gelatin and cellulose nanofibrils: Biocomposites with tunable degradability and mechanical behavior
Campodoni, E, Montanari, M, Dozio, SM, Heggset, EB, Panseri, S, Montesi, M, Tampieri, A, Syverud, K & Sandri, M 2020, , Nanomaterials, vol. 10, no. 6, 1219, pp. 1-18.

Combined Effect of Citrate and Fluoride Ions on Hydroxyapatite Nanoparticles
Degli Esposti, L, Adamiano, A, Tampieri, A, Ramirez-Rodriguez, GB, Siliqi, D, Giannini, C, Ivanchenko, P, Martra, G, Lin, FH, Delgado-López, JM & Iafisco, M 2020, , Crystal Growth and Design, vol. 20, no. 5, pp. 3163-3172.

Vegetable hierarchical structures as template for bone regeneration: New bio-ceramization process for the development of a bone scaffold applied to an experimental sheep model
Filardo, G, Roffi, A, Fey, T, Fini, M, Giavaresi, G, Marcacci, M, Martínez-Fernández, J, Martini, L, Ramírez-Rico, J, Salamanna, F, Sandri, M, Sprio, S, Tampieri, A & Kon, E 2020, , Journal of Biomedical Materials Research - Part B Applied Biomaterials, vol. 108, no. 3, pp. 600-611.

3D Patterning of cells in Magnetic Scaffolds for Tissue Engineering
Goranov, V, Shelyakova, T, De Santis, R, Haranava, Y, Makhaniok, A, Gloria, A, Tampieri, A, Russo, A, Kon, E, Marcacci, M, Ambrosio, L & Dediu, VA 2020, , Scientific Reports, vol. 10, no. 1, 2289.

Ceramics with the signature of wood: a mechanical insight
Bigoni, D, Cavuoto, R, Misseroni, D, Paggi, M, Ruffini, A, Sprio, S & Tampieri, A 2020, , Materials Today Bio, vol. 5, 100032.

Titanium-doped hydroxyapatites photoanodes for Dye-Sensitized Solar Cells
Sangiorgi, N, Bendoni, R, Sangiorgi, A, Aversa, L, Tatti, R, Verucchi, R, Adamiano, A, Sandri, M, Tampieri, A & Sanson, A 2021, , Ceramics International, vol. 47, no. 7, pp. 9701-9710.

Differences in osteogenic induction of human mesenchymal stem cells between a tailored 3D hybrid scaffold and a 2D standard culture
Dozio, SM, Montesi, M, Campodoni, E, Sandri, M, Piattelli, A, Tampieri, A & Panseri, S 2019, , Journal of Materials Science: Materials in Medicine, vol. 30, no. 12, 136.

Optimized production of a high-performance hybrid biomaterial: biomineralized spider silk for bone tissue engineering
Dellaquila, A, Greco, G, Campodoni, E, Mazzocchi, M, Mazzolai, B, Tampieri, A, Pugno, NM & Sandri, M 2019, , Journal of Applied Polymer Science, vol. 137, no. 22, 48739.

Adult Stem Cells for Bone Regeneration and Repair
Iaquinta, MR, Mazzoni, E, Bononi, I, Rotondo, JC, Mazziotta, C, Montesi, M, Sprio, S, Tampieri, A, Tognon, M & Martini, F 2019, , Frontiers in Cell and Developmental Biology, vol. 7, 268.