Publications
A phase 1 proof-of-concept study evaluating safety, tolerability, and biological marker responses with combination therapy of CTLA4-Ig and interleukin-2 in amyotrophic lateral sclerosis
Thonhoff, JR, Beers, DR, Zhao, W, Faridar, A, Thome, A, Wen, S, Zhang, A, Wang, J & Appel, SH 2024, , Frontiers in Neurology, vol. 15, 1415106, pp. 1415106. https://doi.org/10.3389/fneur.2024.1415106
A phase 1 open-label pilot study of low-dose interleukine-2 immunotherapy in patients with Alzheimer’s disease
Faridar, A, Eid, AM, Thome, AD, Zhao, W, Beers, DR, Pascual, MB, Nakawah, MO, Roman, GC, Davis, CS, Grundman, M, Masdeu, JC & Appel, SH 2023, , Translational Neurodegeneration, vol. 12, no. 1, 54, pp. 54. https://doi.org/10.1186/s40035-023-00387-5
A phase 1 open-label pilot study of low-dose interleukine-2 immunotherapy in patients with Alzheimer's disease
Faridar, A, Eid, AM, Thome, AD, Zhao, W, Beers, DR, Pascual, MB, Nakawah, MO, Roman, GC, Davis, CS, Grundman, M, Masdeu, JC & Appel, SH 2023, , Translational Neurodegeneration, vol. 12, no. 1, pp. 54. https://doi.org/10.1186/s40035-023-00387-5
Design and Statistical Innovations in a Platform Trial for Amyotrophic Lateral Sclerosis
for the Healey ALS Platform Trial Study Group 2023, , Annals of Neurology. https://doi.org/10.1002/ana.26714
Primary visual cortex pathology in ALS patients with C9ORF72 expansion
Cykowski, MD, Arumanayagam, AS, Powell, SZ & Appel, SH 2024, , Brain Pathology, vol. 34, no. 5, e13229. https://doi.org/10.1111/bpa.13229
Neuroinflammation co-localizes highly with tau in amnestic mild cognitive impairment
Appleton, J, Funk, Q, Bradbury, K, Yu, M, Faridar, A, Beers, D, Appel, SH, Fujita, M, Masdeu, JC & Pascual, B 2022, , Alzheimers and Dementia, vol. 18, no. S1, e068025. https://doi.org/10.1002/alz.068025
Combined Regulatory T-Lymphocyte and IL-2 Treatment Is Safe, Tolerable, and Biologically Active for 1 Year in Persons With Amyotrophic Lateral Sclerosis
Thonhoff, JR, Berry, JD, Macklin, EA, Beers, DR, Mendoza, PA, Zhao, W, Thome, AD, Triolo, F, Moon, JJ, Paganoni, S, Cudkowicz, M & Appel, SH 2022, , Neurology: Neuroimmunology and NeuroInflammation, vol. 9, no. 6, e200019. https://doi.org/10.1212/NXI.0000000000200019
Ex vivo expanded human regulatory T cells modify neuroinflammation in a preclinical model of Alzheimer’s disease
Faridar, A, Vasquez, M, Thome, AD, Yin, Z, Xuan, H, Wang, JH, Wen, S, Li, X, Thonhoff, JR, Zhao, W, Zhao, H, Beers, DR, Wong, STC, Masdeu, JC & Appel, SH 2022, , Acta Neuropathologica Communications, vol. 10, no. 1, 144. https://doi.org/10.1186/s40478-022-01447-z
Extracellular Vesicles Derived From Ex Vivo Expanded Regulatory T Cells Modulate In Vitro and In Vivo Inflammation
Thome, AD, Thonhoff, JR, Zhao, W, Faridar, A, Wang, J, Beers, DR & Appel, SH 2022, , Frontiers in immunology, vol. 13, 875825, pp. 875825. https://doi.org/10.3389/fimmu.2022.875825
Adaptive Platform Trials to Transform Amyotrophic Lateral Sclerosis Therapy Development
for the Healey ALS Platform Trial Study Group, HEALEY ALS Platform Trial Study Group, Biostatisticians, Investigators, Clinical Operations Team & Medical Monitors 2022, , Annals of Neurology, vol. 91, no. 2, pp. 165-175. https://doi.org/10.1002/ana.26285
Tregs Attenuate Peripheral Oxidative Stress and Acute Phase Proteins in ALS
Beers, DR, Thonhoff, JR, Faridar, A, Thome, AD, Zhao, W, Wen, S & Appel, SH 2022, , Annals of Neurology, vol. 92, no. 2, pp. 195-200. https://doi.org/10.1002/ana.26375
Modulation of spontaneous motor unit potentials by a new motor cortical magnetic stimulation method in amyotrophic lateral sclerosis
Helekar, SA, Thonhoff, J, John, BS, Nguyen, L, Rosenfield, DB & Appel, SH 2022, , Journal of Neurology. https://doi.org/10.1007/s00415-022-11214-8
The role of inflammation in neurodegenerative diseases
Appel, SH, Beers, DR & Zhao, W 2022, . in Neurobiology of Brain Disorders: Biological Basis of Neurological and Psychiatric Disorders, Second Edition. Elsevier, pp. 403-421. https://doi.org/10.1016/B978-0-323-85654-6.00036-8
Amyotrophic lateral sclerosis is a systemic disease: peripheral contributions to inflammation-mediated neurodegeneration
Appel, SH, Beers, DR & Zhao, W 2021, , Current opinion in neurology, vol. 34, no. 5, pp. 765-772. https://doi.org/10.1097/WCO.0000000000000983
Beneficial effects of transplanted human bone marrow endothelial progenitors on functional and cellular components of blood-spinal cord barrier in ALSMice
Garbuzova-Davis, S, Boccio, KJ, Llauget, A, Shell, R, Hailu, S, Mustafa, H, Ehrhart, J, Sanberg, PR, Appel, SH & Borlongan, CV 2021, , eNeuro, vol. 8, no. 5, ENEURO.0314-21.2021. https://doi.org/10.1523/ENEURO.0314-21.2021
Fast progression in amyotrophic lateral sclerosis is associated with greater tdp-43 burden in spinal cord
Cathcart, SJ, Appel, SH, Peterson, LE, Greene, EP, Powell, SZ, Arumanayagam, AS, Rivera, AL & Cykowski, MD 2021, , Journal of Neuropathology and Experimental Neurology, vol. 80, no. 8, pp. 754-763. https://doi.org/10.1093/jnen/nlab061
Radicava/Edaravone Findings in Biomarkers From Amyotrophic Lateral Sclerosis (REFINE-ALS): Protocol and Study Design
Berry, J, Brooks, B, Genge, A, Heiman-Patterson, T, Appel, S, Benatar, M, Bowser, R, Cudkowicz, M, Gooch, C, Shefner, J, Westra, J, Agnese, W, Merrill, C, Nelson, S & Apple, S 2021, , Neurology: Clinical Practice, vol. 11, no. 4, pp. E472-E479. https://doi.org/10.1212/CPJ.0000000000000968
Ex vivo expansion of dysfunctional regulatory T lymphocytes restores suppressive function in Parkinson’s disease
Thome, AD, Atassi, F, Wang, J, Faridar, A, Zhao, W, Thonhoff, JR, Beers, DR, Lai, EC & Appel, SH 2021, , npj Parkinsons Disease, vol. 7, no. 1, 41, pp. 41. https://doi.org/10.1038/s41531-021-00188-5
Detection of endothelial cell-associated human DNA reveals transplanted human bone marrow stem cell engraftment into CNS capillaries of ALS mice
Garbuzova-Davis, S, Boccio, KJ, Ehrhart, J, Sanberg, PR, Appel, SH & Borlongan, CV 2021, , Brain Research Bulletin, vol. 170, pp. 22-28. https://doi.org/10.1016/j.brainresbull.2021.01.020
Neuroinflammation is highest in areas of disease progression in semantic dementia
Pascual, B, Funk, Q, Zanotti Fregonara, P, Cykowski, MD, Veronese, M, Rockers, E, Bradbury, K, Yu, M, Nakawah, MO, Román, GC, Schulz, PE, Arumanayagam, AS, Beers, D, Faridar, A, Fujita, M, Appel, SH & Masdeu, JC 2021, , Brain, vol. 144, no. 5, pp. 1565-1575. https://doi.org/10.1093/brain/awab057