Publications


Neuroinflammation co-localizes highly with tau in amnestic mild cognitive impairment
Appleton, J, Funk, Q, Bradbury, K, Yu, M, Faridar, A, Beers, D, Appel, SH, Fujita, M, Masdeu, JC & Pascual, B 2022, , Alzheimers and Dementia, vol. 18, no. S1, e068025. https://doi.org/10.1002/alz.068025

Combined Regulatory T-Lymphocyte and IL-2 Treatment Is Safe, Tolerable, and Biologically Active for 1 Year in Persons With Amyotrophic Lateral Sclerosis
Thonhoff, JR, Berry, JD, Macklin, EA, Beers, DR, Mendoza, PA, Zhao, W, Thome, AD, Triolo, F, Moon, JJ, Paganoni, S, Cudkowicz, M & Appel, SH 2022, , Neurology(R) neuroimmunology & neuroinflammation, vol. 9, no. 6. https://doi.org/10.1212/NXI.0000000000200019

Ex vivo expanded human regulatory T cells modify neuroinflammation in a preclinical model of Alzheimer’s disease
Faridar, A, Vasquez, M, Thome, AD, Yin, Z, Xuan, H, Wang, JH, Wen, S, Li, X, Thonhoff, JR, Zhao, W, Zhao, H, Beers, DR, Wong, ST, Masdeu, JC & Appel, SH 2022, , Acta Neuropathologica Communications, vol. 10, no. 1, 144. https://doi.org/10.1186/s40478-022-01447-z

Extracellular Vesicles Derived From Ex Vivo Expanded Regulatory T Cells Modulate In Vitro and In Vivo Inflammation
Thome, AD, Thonhoff, JR, Zhao, W, Faridar, A, Wang, J, Beers, DR & Appel, SH 2022, , Frontiers in immunology, vol. 13, 875825. https://doi.org/10.3389/fimmu.2022.875825

Adaptive Platform Trials to Transform Amyotrophic Lateral Sclerosis Therapy Development
for the Healey ALS Platform Trial Study Group, HEALEY ALS Platform Trial Study Group, Biostatisticians, Investigators, Clinical Operations Team & Medical Monitors 2022, , Annals of Neurology, vol. 91, no. 2, pp. 165-175. https://doi.org/10.1002/ana.26285

Tregs Attenuate Peripheral Oxidative Stress and Acute Phase Proteins in ALS
Beers, DR, Thonhoff, JR, Faridar, A, Thome, AD, Zhao, W, Wen, S & Appel, SH 2022, , Annals of Neurology, vol. 92, no. 2, pp. 195-200. https://doi.org/10.1002/ana.26375

Modulation of spontaneous motor unit potentials by a new motor cortical magnetic stimulation method in amyotrophic lateral sclerosis
Helekar, SA, Thonhoff, J, John, BS, Nguyen, L, Rosenfield, DB & Appel, SH 2022, , Journal of Neurology, vol. 269, no. 10, pp. 5487-5496. https://doi.org/10.1007/s00415-022-11214-8

The role of inflammation in neurodegenerative diseases
Appel, SH, Beers, DR & Zhao, W 2022, . in Neurobiology of Brain Disorders: Biological Basis of Neurological and Psychiatric Disorders, Second Edition. Elsevier, pp. 403-421. https://doi.org/10.1016/B978-0-323-85654-6.00036-8

Ex vivo expansion of dysfunctional regulatory T lymphocytes restores suppressive function in Parkinson’s disease
Thome, AD, Atassi, F, Wang, J, Faridar, A, Zhao, W, Thonhoff, JR, Beers, DR, Lai, EC & Appel, SH 2021, , npj Parkinsons Disease, vol. 7, no. 1, 41. https://doi.org/10.1038/s41531-021-00188-5


Beneficial effects of transplanted human bone marrow endothelial progenitors on functional and cellular components of blood-spinal cord barrier in ALSMice
Garbuzova-Davis, S, Boccio, KJ, Llauget, A, Shell, R, Hailu, S, Mustafa, H, Ehrhart, J, Sanberg, PR, Appel, SH & Borlongan, CV 2021, , eNeuro, vol. 8, no. 5, ENEURO.0314-21.2021. https://doi.org/10.1523/ENEURO.0314-21.2021

Fast progression in amyotrophic lateral sclerosis is associated with greater tdp-43 burden in spinal cord
Cathcart, SJ, Appel, SH, Peterson, LE, Greene, EP, Powell, SZ, Arumanayagam, AS, Rivera, AL & Cykowski, MD 2021, , Journal of Neuropathology and Experimental Neurology, vol. 80, no. 8, pp. 754-763. https://doi.org/10.1093/jnen/nlab061

Detection of endothelial cell-associated human DNA reveals transplanted human bone marrow stem cell engraftment into CNS capillaries of ALS mice
Garbuzova-Davis, S, Boccio, KJ, Ehrhart, J, Sanberg, PR, Appel, SH & Borlongan, CV 2021, , Brain Research Bulletin, vol. 170, pp. 22-28. https://doi.org/10.1016/j.brainresbull.2021.01.020

Neuroinflammation is highest in areas of disease progression in semantic dementia
Pascual, B, Funk, Q, Zanotti Fregonara, P, Cykowski, MD, Veronese, M, Rockers, E, Bradbury, K, Yu, M, Nakawah, MO, Román, GC, Schulz, PE, Arumanayagam, AS, Beers, D, Faridar, A, Fujita, M, Appel, SH & Masdeu, JC 2021, , Brain, vol. 144, no. 5, pp. 1565-1575. https://doi.org/10.1093/brain/awab057

Neuroinflammation is highest in areas of disease progression in semantic dementia
Pascual, B, Funk, Q, Zanotti-Fregonara, P, Cykowski, MD, Veronese, M, Rockers, E, Bradbury, K, Yu, M, Nakawah, MO, Román, GC, Schulz, PE, Arumanayagam, AS, Beers, D, Faridar, A, Fujita, M, Appel, SH & Masdeu, JC 2021, , Brain, vol. 144, no. 5, pp. 1565-1575. https://doi.org/10.1093/brain/awab057

Serum programmed cell death proteins in amyotrophic lateral sclerosis
Beers, DR, Zhao, W, Thonhoff, JR, Faridar, A, Thome, AD, Wen, S, Wang, J & Appel, SH 2021, , Brain, behavior, & immunity - health, vol. 12, 100209. https://doi.org/10.1016/j.bbih.2021.100209, https://doi.org/10.1016/j.bbih.2021.100209

Serum programmed cell death proteins in amyotrophic lateral sclerosis
Beers, DR, Zhao, W, Thonhoff, JR, Faridar, A, Thome, AD, Wen, S, Wang, J & Appel, SH 2021, , Brain, Behavior, and Immunity - Health, vol. 12, 100209. https://doi.org/10.1016/j.bbih.2021.100209

Spinal cord and motor neuron TDP-43 pathology in a sporadic inclusion body myositis patient
Cathcart, SJ, Greene, EP, Powell, SZ, Arumanayagam, AS, Rivera, AL, Tawil, R, Appel, SH & Cykowski, MD 2021, , Journal of Neuropathology and Experimental Neurology, vol. 79, no. 10, pp. 1130-1133. https://doi.org/10.1093/JNEN/NLAA066

ALSUntangled #61: melatonin
THE ALSUNTANGLED GROUP 2021, , Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. https://doi.org/10.1080/21678421.2021.1927103

Elevated acute phase proteins reflect peripheral inflammation and disease severity in patients with amyotrophic lateral sclerosis
Beers, DR, Zhao, W, Neal, DW, Thonhoff, JR, Thome, AD, Faridar, A, Wen, S, Wang, J & Appel, SH 2020, , Scientific Reports, vol. 10, no. 1, 15295, pp. 15295. https://doi.org/10.1038/s41598-020-72247-5