Not found

Xiaofeng Xia, PhD

Assistant Professor of Systems Medicine and Bioengineering, Institute for Academic Medicine
Assistant Member, Research Institute
Houston Methodist
Weill Cornell Medical College

Dr. Xia received his Ph.D. at Tsinghua University, in China in 2002. From 2002 to 2006, he completed a postdoctoral fellowship at the University of Wisconsin in Madison. After that, he joined the WiCell Research Institute and worked as an assistant scientist until joining Houston Methodist Research Institute in 2007. He has worked in a number of areas including bioinformatics, neurotransmitter releasing, and neuronal differentiation of stem cells. He is currently collaborating with other investigators on high content drug screening on neural stem cells.

Description of Research

Dr. Xia’s research focuses on developing novel high-content screening techniques on neurodegeneration and neuroregeneration research.

Areas Of Expertise

Neural stem cells High-content screening Bioinformatics
Education & Training

, Tsinghua University
, University of Wisconsin-Madison

Cell type-dependent Erk-Akt pathway crosstalk regulates the proliferation of fetal neural progenitor cells
Rhim, JH, Luo, X, Gao, D, Xu, X, Zhou, T, Li, F, Wang, P, Wong, STC & Xia, X 2016, Scientific Reports, vol 6, 26547. DOI:

DrugMoaMiner: A computational tool for mechanism of action discovery and personalized drug sensitivity prediction
Li, F, Wang, L, Kong, R, Sheng, J, Cao, H, Mancuso, J, Xia, X, Stephan, C & Wong, STC 2016, . in 3rd IEEE EMBS International Conference on Biomedical and Health Informatics, BHI 2016., 7455911, Institute of Electrical and Electronics Engineers Inc. pp. 368-371, 3rd IEEE EMBS International Conference on Biomedical and Health Informatics, BHI 2016, Las Vegas, United States, 24-27 February. DOI:

Grifolin directly targets ERK1/2 to epigenetically suppress cancer cell metastasis
Luo, X, Yang, L, Xiao, L, Xia, X, Dong, X, Zhong, J, Liu, Y, Li, N, Chen, L, Li, H, Li, W, Liu, W, Yu, X, Chen, H, Tang, M, Weng, X, Yi, W, Bode, A, Dong, Z, Liu, J & Cao, Y 2015, Oncotarget, vol 6, no. 40, pp. 42704-42716. DOI:

A High-content screen identifies compounds promoting the neuronal differentiation and the midbrain dopamine neuron specification of human neural progenitor cells
Rhim, JH, Luo, X, Xu, X, Gao, D, Zhou, T, Li, F, Qin, L, Wang, P, Xia, X & Wong, STC 2015, Scientific reports, vol 5, pp. 16237. DOI:

Integration of multiscale dendritic spine structure and function data into systems biology models
Mancuso, JJ, Cheng, J, Yin, Z, Gilliam, JC, Xia, X, Li, X & Wong, STC 2014, Frontiers in Neuroanatomy, vol 8, no. November, 130. DOI:

DrugComboRanker: Drug combination discovery based on target network analysis
Huang, L, Li, F, Sheng, J, Xia, X, Ma, J, Zhan, M & Wong, STC 2014, Bioinformatics, vol 30, no. 12. DOI:

Block-Cell-Printing for live single-cell printing
Zhang, K, Chou, CK, Xia, X, Hung, MC & Qin, L 2014, Proceedings of the National Academy of Sciences of the United States of America, vol 111, no. 8, pp. 2948-2953. DOI:

A screen for morphological complexity identifies regulators of switch-like transitions between discrete cell shapes
Yin, Z, Sadok, A, Sailem, H, McCarthy, A, Xia, X, Li, F, Garcia, MA, Evans, L, Barr, AR, Perrimon, N, Marshall, CJ, Wong, STC & Bakal, C 2013, Nature Cell Biology, vol 15, no. 7, pp. 860-871. DOI:

Genome-Wide RNAi Screening Identifies Genes Inhibiting the Migration of Glioblastoma Cells
Yang, J, Fan, J, Li, Y, Li, F, Chen, P, Fan, Y, Xia, X & Wong, ST 2013, PLoS ONE, vol 8, no. 4, e61915. DOI:

A 3D multiscale model of cancer stem cell in tumor development.
Li, F, Tan, H, Singh, J, Yang, J, Xia, X, Bao, J, Ma, J, Zhan, M & Wong, STC 2013, BMC systems biology, vol 7 Suppl 2.

A 3-dimentional multiscale model to simulate tumor progression in response to interactions between cancer stem cells and tumor microenvironmental factors
Tan, H, Li, F, Singh, J, Xia, X, Cridebring, D, Yang, J, Zhan, M, Wong, STC, Bao, J & Ma, J 2012, . in 2012 IEEE 6th International Conference on Systems Biology, ISB 2012., 6314153, pp. 297-303, 2012 IEEE 6th International Conference on Systems Biology, ISB 2012, Xian, China, 18-20 August. DOI:

Concise review: A high-content screening approach to stem cell research and drug discovery
Xia, X & Wong, ST 2012, Stem Cells, vol 30, no. 9, pp. 1800-1807. DOI:

A quantitative analytic pipeline for evaluating neuronal activities by high-throughput synaptic vesicle imaging
Fan, J, Xia, X, Li, Y, Dy, JG & Wong, STC 2012, NeuroImage, vol 62, no. 3, pp. 2040-2054. DOI:

Differential diagnosis of lung carcinoma with three-dimensional quantitative molecular vibrational imaging
Gao, L, Hammoudi, AA, Li, F, Thrall, MJ, Cagle, PT, Chen, Y, Yang, J, Xia, X, Fan, Y, Massoud, Y, Wang, Z & Wong, STC 2012, Journal of Biomedical Optics, vol 17, no. 6, 066017. DOI:

Identification of small molecule inhibitors of neurite loss induced by Aß peptide using high content screening
Ofengeim, D, Shi, P, Miao, B, Fan, J, Xia, O, Fan, Y, Lipinski, MM, Hashimoto, T, Polydoro, M, Yuan, J, Wong, STC & Degterev, A 2012, Journal of Biological Chemistry, vol 287, no. 12, pp. 8714-8723. DOI:

Quantitative synaptic vesicle imaging for evaluating neuron activities in neurodegenerative diseases
Fan, J, Xia, X, Dy, J & Wong, S 2011, . in Conference Record - Asilomar Conference on Signals, Systems and Computers., 6190033, pp. 421-425, 45th Asilomar Conference on Signals, Systems and Computers, ASILOMAR 2011, Pacific Grove, CA, United States, 6-9 November. DOI:

Image-based chemical screening identifies drug efflux inhibitors in lung cancer cells
Xia, X, Yang, J, Li, F, Li, Y, Zhou, X, Dai, Y & Wong, STC 2010, Cancer Research, vol 70, no. 19, pp. 7723-7733. DOI:

Differentiation of neuroepithelia from human embryonic stem cells
Xia, X & Zhang, SC 2009, . in Methods in Molecular Biology. vol. 549, Methods in Molecular Biology, vol. 549, pp. 51-58. DOI:

Integrating multi-scale blob/curvilinear detector techniques and multilevel sets for automated segmentation of stem cell images
Peng, H, Zhou, X, Li, F, Xia, X & Wong, STC 2009, . in Proceedings - 2009 IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2009., 5193318, pp. 1362-1365, 2009 IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2009, Boston, MA, United States, 28-1 July. DOI:

Scopoletin induces apoptosis of fibroblast-like synoviocytes from adjuvant arthritis rats by a mitochondrial-dependent pathway
Li, Y, Dai, Y, Liu, M, Pan, R, Luo, Y, Xia, Y & Xia, X 2009, Drug Development Research, vol 70, no. 5, pp. 378-385. DOI: