Stephen Little, MD

Associate Professor of Clinical Cardiology, Institute for Academic Medicine
Assistant Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Biography

Dr. Little, a cardiologist with the Houston Methodist DeBakey Heart & Vascular Center, is medical director of The Valve Clinic – a multidisciplinary medical clinic focused on the assessment and treatment of complex valvular heart disease. He also serves as Director of the Houston Methodist Valve Institute and is director of the Cardiovascular Hemodynamics Imaging Laboratory (CHIL).

Dr. Little’s recent research activities and peer-reviewed publications have focused on novel use of 3-D echocardiography for the quantification of native and prosthetic valve dysfunction as well as imaging guidance for percutaneous structural heart interventions. His team has created a robust in vitro flow system for multimodality functional valve imaging under tailored hemodynamic conditions. In collaboration with research scientists and mathematicians, Dr. Little’s research group creates complex heart valve constructs to address an increasingly important clinical need - To improve our understanding of heart valve dysfunction by employing multimodality imaging to better characterize and quantify these complex intra- cardiac flow conditions.

He received his medical degree from McMaster University and completed post graduate training in internal medicine and cardiology at the University of Western Ontario. Dr. Little completed research fellowships in echocardiography at the University of Ottawa Heart Institute and at Baylor College of Medicine, Houston. He is a fellow of the Royal College of Physicians and Surgeons of Canada, the American College of Cardiology, and the American Society of Echocardiography. Dr. Little serves on the Board of Directors for the American Society of Echocardiography as well as on ASE committees for Industry Relations, Public Relations, and writing groups.

Dr. Little has given more than 100 invited lectures nationally and internationally. He is an associate professor of clinical Medicine at Weill Cornell Medical College, and adjunct associate professor at Rice University, Dept. of Bioengineering.

Description of Research

After completing sub-specialty Cardiology training (Royal College of Physicians and Surgeon of Canada), I completed a postdoctoral fellowship in echocardiography at the Ottawa Heart Institute. I then completed a second postdoctoral fellowship, under the supervision of Dr. W. Zoghbi at Baylor College of Medicine, Houston.  As an assistant  professor  in Canada, I continued to develop novel  strategies to visualize  the prosthetic valve function using 3D transesophageal echocardiography.  In 2007 I was recruited back to Houston to join the Cardiovascular Imaging Institute of the Methodist DeBakey Heart & Vascular Center. As medical director of the MDHVC Heart Valve Clinic, and as a cardiologist interpreting ~3000 patient echocardiograms/year, I have established research programs based on the multi-modality imaging of native and prosthetic valves. Over the last five years I have also lead a team to create a robust in vitro flow system to simulate simple and complex heart valve constructs. As a natural extension of my interest in valve disease and my expertise in 3D imaging, our research group has recently begun collaborations with research scientists and mathematicians to address an increasingly important clinical need - To improve our understanding of heart valve dysfunction by employing multimodality imaging to better characterize and quantity these complex intra- cardiac flow conditions.

Areas Of Expertise

Valvular disease Mitral regurgitation Echocardiography
Education & Training

, Baylor College of Medicine
, Western University
, McMaster University School of Medicine
Publications

Erratum to: 3D Printed Modeling of the Mitral Valve for Catheter-Based Structural Interventions
Vukicevic, M, Puperi, DS, Grande-Allen, KJ & Little, SH 2016, Annals of Biomedical Engineering, pp. 1. DOI:

Erratum to: 3D Printed Modeling of the Mitral Valve for Catheter-Based Structural Interventions
Vukicevic, M, Puperi, DS, Grande-Allen, KJ & Little, SH 2016, Annals of Biomedical Engineering. DOI:

3D Printed Modeling of the Mitral Valve for Catheter-Based Structural Interventions
Vukicevic, M, Puperi, DS, Jane Grande-Allen, K & Little, SH 2016, Annals of Biomedical Engineering, pp. 1-12. DOI:

Self-expanding transcatheter aortic valve replacement versus surgical valve replacement in patients at high risk for surgery: A study of echocardiographic change and risk prediction
Little, SH, Oh, JK, Gillam, L, Sengupta, PP, Orsinelli, DA, Cavalcante, JL, Chang, JD, Adams, DH, Zorn, GL, Pollak, AW, Abdelmoneim, SS, Reardon, MJ, Qiao, H & Popma, JJ 2016, Circulation: Cardiovascular Interventions, vol 9, no. 6, e003426. DOI:

Early recovery of left ventricular systolic function after corevalve transcatheter aortic valve replacement
Dauerman, HL, Reardon, MJ, Popma, JJ, Little, SH, Cavalcante, JL, Adams, DH, Kleiman, NS & Oh, JK 2016, Circulation: Cardiovascular Interventions, vol 9, no. 6, e003425. DOI:

3D Printed Modeling for Patient-Specific Mitral Valve Intervention Repair with a Clip and a Plug
Little, SH , Vukicevic, M, Avenatti, E, Ramchandani, M & Barker, CM 2016, JACC: Cardiovascular Interventions, vol 9, no. 9, pp. 973-975. DOI:

Prosthesis-patient mismatch in high-risk patients with severe aortic stenosis: A randomized trial of a self-expanding prosthesis
Zorn, GL, Little, SH, Tadros, P, Deeb, GM, Gleason, TG, Heiser, J, Kleiman, NS, Oh, JK, Popma, JJ, Adams, D, Huang, J & Reardon, MJ 2016, Journal of Thoracic and Cardiovascular Surgery, vol 151, no. 4, pp. 1014-1023.e3. DOI:

One Hundred Percent Reparability of Degenerative Mitral Regurgitation: Intermediate-Term Results of a Dynamic Engineered Approach
Lawrie, GM , Zoghbi, W , Little, S , Shah, D, Ben-Zekry, Z, Earle, N & Earle, E 2016, Annals of Thoracic Surgery, vol 101, no. 2. DOI:

Comparative Assessment of Mitral Regurgitation Severity by Transthoracic Echocardiography and Cardiac Magnetic Resonance Using an Integrative and Quantitative Approach
Lopez-Mattei, JC, Ibrahim, H, Shaikh, KA, Little, SH, Shah, DJ, Maragiannis, D & Zoghbi, WA 2016, American Journal of Cardiology, vol 117, no. 2, pp. 264-70. DOI:

Patient-specific quantitation of mitral valve strain by computer analysis of three-dimensional echocardiography: A pilot study
Ben Zekry, S, Freeman, J, Jajoo, A, He, J, Little, SH, Lawrie, GM, Azencott, R & Zoghbi, WA 2016, Circulation. Cardiovascular imaging, vol 9, no. 1, e003254. DOI:

Patient-Specific Modeling for Transcatheter Aortic Valve Replacement
Vukicevic, M, Avenatti, E & Little, S 2016, . in Rapid Prototyping in Cardiac Disease: 3D Printing the Heart.

Prosthetic Mitral Valve Thrombosis
Maragiannis, D, Gramze, N, Ramlawi, B & Little, SH 2015, Methodist DeBakey Cardiovascular Journal, vol 11, no. 3, pp. 195. DOI:

Association of left ventricular diastolic dysfunction with subclinical coronary atherosclerotic disease burden using coronary artery calcium scoring
Maragiannis, D, Schutt, RC, Gramze, NL, Chaikriangkrai, K, McGregor, K, Chin, K, Nabi, F, Little, SH, Nagueh, SF & Chang, SM 2015, Journal of Atherosclerosis and Thrombosis, vol 22, no. 12, pp. 1278-1286. DOI:

Prevalence and Characteristics of Left Ventricular Fibrosis in Patients With Mitral Valve Prolapse
Kitkungvan, D, Nabi, F, Quiñones, MA, Jiaqiong, X, Lawrie, GM, Little, S, Zoghbi, WA & Shah, D 2015, AHA-Scientific Sessions, Orlando, United States, 11/7/15, .

Vortex Formation Time in Patients with Hypertrophic Cardiomyopathy
Maragiannis, D, Schutt, R, Alvarez, P, Chin, K, Buergler, J, Little, S, Shah, D & Nagueh, S 2015, AHA-Scientific Sessions, Orlando, United States, 11/7/15, .

Functional Evaluation of a Patient-Specific 3D Printed Model of Aortic Regurgitation
Vukicevic, M, Maragiannis, D, Jackson, MS & Little, S 2015, AHA-Scientific Sessions, Orlando, United States, 11/7/15, .

Replicating Patient-Specific Severe Aortic Valve Stenosis with Functional 3D Modeling
Maragiannis, D, Jackson, MS, Igo, SR, Schutt, RC, Connell, P, Grande-Allen, J, Barker, CM, Chang, SM, Reardon, MJ, Zoghbi, WA & Little, SH 2015, Circulation: Cardiovascular Imaging, vol 8, no. 10, e003626. DOI:

Paravalvular Regurgitation after TAVR A Doppler Dilemma: A Doppler Dilemma
Little, SH 2015, JACC: Cardiovascular Imaging, vol 8, no. 9, pp. 1004-1006. DOI:

Bioprosthetic mitral transcatheter transapical valve-in-valve implantation for mitral stenosis in an end-stage renal disease patient
Chaikriangkrai, K, Goswami, R, Little, S, Chang, SM, Ramlawi, B, Jhun, HY, Kleiman, N, Reardon, MJ & Barker, C 2015, Journal of Cardiac Surgery, vol 30, no. 9, pp. 697-700. DOI:

Emerging Trends in Heart Valve Engineering: Part IV. Computational Modeling and Experimental Studies
Kheradvar, A, Groves, EM, Falahatpisheh, A, Mofrad, MK, Hamed Alavi, S, Tranquillo, R, Dasi, LP, Simmons, CA, Jane Grande-Allen, K, Goergen, CJ, Baaijens, F, Little, SH, Canic, S & Griffith, B 2015, Annals of Biomedical Engineering, vol 43, no. 10, pp. 2314-2333. DOI: