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Paul Webb, PhD

Professor of Genomic Medicine, Institute for Academic Medicine
Full Affiliate Member, Research Institute
Houston Methodist
Weill Cornell Medical College


After completion of his fellowship in the Metabolic Research Unit at the University of California at San Francisco (UCSF) in 1994, Dr. Webb joined the permanent research staff there in the laboratory of Dr. John Baxter. He rose through the ranks and, in 1999, became an Assistant Research Biochemist Level IV. In 2001, Dr. Webb joined the Diabetes Center at UCSF where he was quickly promoted to an Associate Researcher Level IV. He spent a year as a visiting professor in Biochemistry at the University of San Francisco in 2005 where he taught several courses in biochemistry. He has co-written over 130 manuscripts that have been published in peer-reviewed publications.

Description of Research

Dr. Webb's main research interests are investigations into the principles of nuclear hormone receptor structure and function, as well as studies of the actions of pharmaceutical agents to selectively modulate actions of these proteins. Research approaches include X-ray structural analysis, targeted mutagenesis to understand receptor structure, detailed analysis of gene expression and genome wide sequence interactions and collaborative studies to determine the metabolic effects of drugs in preclinical models.

Areas Of Expertise

Diabetes Nuclear hormone receptor Ligand design
Education & Training

Postdoctoral Fellowship , Immunology Department, University of California, San Francisco, CA
PhD , Imperial Cancer Research Fund, London University, London
Postdoctoral Fellowship , Metabolic Research Unit, University of California, San Francisco, CA
MA , Pembroke College, Oxford University

3,5-diodothyronine (3,5-T2) Reduces Blood Glucose Independently of Insulin Sensitization in Obese Mice
Teixeira, SDS, Filgueira, CS, Sieglaff, DH, Benod, C, Villagomez, R, Minze, LJ, Zhang, A, Webb, P & Nunes, MT 2016, Acta physiologica (Oxford, England). DOI: 10.1111/apha.12821

Ligand independent and subtype-selective actions of thyroid hormone receptors in human adipose derived stem cells
Cvoro, A, Bajic, A, Zhang, A, Simon, M, Golic, I, Sieglaff, DH, Maletic-Savatic, M, Korac, A & Webb, P 2016, PLoS ONE, vol 11, no. 10, e0164407. DOI: 10.1371/journal.pone.0164407

Sustained zero-order delivery of GC-1 from a nanochannel membrane device alleviates metabolic syndrome
Filgueira, CS, Nicolov, E, Hood, RL, Ballerini, A, Garcia-Huidobro, J, Lin, JZ, Fraga, D, Webb, P, Sabek, O, Gaber, AO, Phillips, KJ & Grattoni, A 2016, International Journal of Obesity. DOI: 10.1038/ijo.2016.129

Structural dataset for the PPAR? V290M mutant
Puhl, AC, Webb, P & Polikarpov, I 2016, Data in Brief, vol 7, pp. 1430-1437. DOI: 10.1016/j.dib.2016.03.082

TLX: An elusive receptor
Benod, C, Villagomez, R & Webb, P 2016, Journal of Steroid Biochemistry and Molecular Biology, vol 157, pp. 41-47. DOI: 10.1016/j.jsbmb.2015.11.001

Gustafsson, JA & Webb, P 2016, Journal of Steroid Biochemistry and Molecular Biology, vol 157, pp. 1-2. DOI: 10.1016/j.jsbmb.2015.12.027

Sobetirome: The past, present and questions about the future
Lammel Lindemann, J & Webb, P 2016, Expert Opinion on Therapeutic Targets, vol 20, no. 2, pp. 145-149. DOI: 10.1517/14728222.2016.1090429

Pharmacophore elucidation of phosphoiodyn A - Potent and selective peroxisome proliferator-activated receptor ß/d agonists with neuroprotective activity
Kinarivala, N, Suh, JH, Botros, M, Webb, P & Trippier, PC 2016, Bioorganic and Medicinal Chemistry Letters. DOI: 10.1016/j.bmcl.2016.03.028

Pharmacological Activation of Thyroid Hormone Receptors Elicits a Functional Conversion of White to Brown Fat
Lin, JZ, Martagón, AJ, Cimini, SL, Gonzalez, DD, Tinkey, DW, Biter, A, Baxter, JD, Webb, P, Gustafsson, JÅ, Hartig, SM & Phillips, KJ 2015, Cell Reports, vol 13, no. 8, pp. 1528-1537. DOI: 10.1016/j.celrep.2015.10.022

Similarities and distinctions in actions of surface-directed and classic androgen receptor antagonists
Suh, JH, Chattopadhyay, A, Sieglaff, DH, Samaniego, CS, Cox, MB & Webb, P 2015, PLoS ONE, vol 10, no. 9, e0137103. DOI: 10.1371/journal.pone.0137103

The FKBP52 Cochaperone Acts in Synergy with ß-Catenin to Potentiate Androgen Receptor Signaling
Samaniego, CS, Suh, JH, Chattopadhyay, A, Olivares, K, Guy, N, Sivils, JC, Dey, P, Yumoto, F, Fletterick, RJ, Strom, AM, Gustafsson, JA, Webb, P & Cox, MB 2015, PLoS ONE, vol 10, no. 7, e0134015. DOI: 10.1371/journal.pone.0134015

Correction: Estrogen receptor ß2 induces hypoxia signature of gene expression by stabilizing HIF-1a in prostate cancer
Dey, P, Velazquez-Villegas, LA, Faria, M, Turner, A, Jonsson, P, Webb, P, Williams, C, Gustafsson, JÅ & Ström, AM 2015, PLoS ONE, vol 10, no. 6, e0132085. DOI: 10.1371/journal.pone.0132085

PPAR? partial agonist GQ-16 strongly represses a subset of genes in 3T3-L1 adipocytes
Milton, FA, Cvoro, A, Amato, AA, Sieglaff, DH, Filgueira, CS, Arumanayagam, AS, De Lima, MDCA, Pitta, IR, De Assis Rocha Neves, F & Webb, P 2015, Biochemical and Biophysical Research Communications, vol 464, no. 3, 34219, pp. 718-723. DOI: 10.1016/j.bbrc.2015.07.011

Estrogen receptor ß2 induces hypoxia signature of gene expression by stabilizing HIF-1a in prostate cancer
Dey, P, Velazquez-Villegas, LA, Faria, M, Turner, A, Jonsson, P, Webb, P, Williams, C, Gustafsson, JÅ & Ström, AM 2015, PLoS ONE, vol 10, no. 5, e0128239. DOI: 10.1371/journal.pone.0128239

The amelioration of hepatic steatosis by thyroid hormone receptor agonists is insufficient to restore insulin sensitivity in ob/ob mice
Martagón, AJ, Lin, JZ, Cimini, SL, Webb, P & Phillips, KJ 2015, PLoS ONE, vol 10, no. 4, e0122987. DOI: 10.1371/journal.pone.0122987

Silencing LRH-1 in colon cancer cell lines impairs proliferation and alters gene expression programs
Bayrer, JR, Mukkamala, S, Sablin, EP, Webb, P & Fletterick, RJ 2015, Proceedings of the National Academy of Sciences of the United States of America, vol 112, no. 8, pp. 2467-2472. DOI: 10.1073/pnas.1500978112

A Thyroid hormone receptor/KLF9 axis in human hepatocytes and pluripotent stem cells
Cvoro, A, Devito, L, Milton, FA, Noli, L, Zhang, A, Filippi, C, Sakai, K, Suh, JH, H. Sieglaff, D, Dhawan, A, Sakai, T, Ilic, D & Webb, P 2015, Stem Cells, vol 33, no. 2, pp. 416-428. DOI: 10.1002/stem.1875

Phosphorylation of glucocorticoid receptor tau1c transactivation domain enhances binding to CREB binding protein (CBP) TAZ2
Carruthers, CW, Suh, JH, Gustafsson, JA & Webb, P 2015, Biochemical and Biophysical Research Communications, vol 457, no. 1, pp. 119-123. DOI: 10.1016/j.bbrc.2014.12.021

Thyroid hormone receptor regulates most genes independently of fibroblast growth factor 21 in liver
Zhang, A, Sieglaff, DH, York, JP, Suh, JH, Ayers, SD, Winnier, GE, Kharitonenkov, A, Pin, C, Zhang, P, Webb, P & Xia, X 2015, Journal of Endocrinology, vol 224, no. 3, pp. 289-301. DOI: 10.1530/JOE-14-0440

Recruited metastasis suppressor NM23-H2 attenuates expression and activity of peroxisome proliferator-activated receptor d (PPARd) in human cholangiocarcinoma
He, F, York, JP, Burroughs, SG, Qin, L, Xia, J, Chen, D, Quigley, EM, Webb, P, LeSage, GD & Xia, X 2015, Digestive and Liver Disease, vol 47, no. 1, pp. 62-67. DOI: 10.1016/j.dld.2014.09.002