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Nobuo Horikoshi, PhD

Assistant Research Professor of Radiation Oncology, Institute for Academic Medicine
Assistant Research Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Publications

Classical non-homologous end-joining pathway utilizes nascent RNA for error-free double-strand break repair of transcribed genes
Chakraborty, A, Tapryal, N, Venkova, T, Horikoshi, N, Pandita, RK, Sarker, AH, Sarkar, PS, Pandita, TK & Hazra, TK 2016, Nature communications, vol 7, pp. 13049. DOI:

ß2-spectrin depletion impairs DNA damage repair
Horikoshi, N, Pandita, RK, Mujoo, K, Hambarde, S, Sharma, D, Mattoo, AR, Chakraborty, S, Charaka, V, Hunt, CR & Pandita, TK 2016, Oncotarget, vol 7, no. 23, pp. 33557-33570. DOI:

Torin2 suppresses ionizing radiation-induced DNA damage repair
Udayakumar, D, Pandita, RK, Horikoshi, N, Liu, Y, Liu, Q, Wong, KK, Hunt, CR, Gray, NS, Minna, JD, Pandita, TK & Westover, KD 2016, Radiation Research, vol 185, no. 5, pp. 527-538. DOI:

A multifaceted role for MOF histone modifying factor in genome maintenance
Mujoo, K, Hunt, CR, Horikoshi, N & Pandita, TK 2016, Mechanisms of Ageing and Development. DOI:

More complex transcriptional regulation and stress response by MOF
Horikoshi, N, Hunt, CR & Pandita, TK 2015, Oncogene. DOI:

Detecting ATM-dependent chromatin modification in DNA damage response
Udayakumar, D, Horikoshi, N, Mishra, L, Hunt, C & Pandita, TK 2015, . in Chromatin Protocols: Third Edition. Springer New York, pp. 317-336. DOI:

Single-strand DNA-binding protein SSB1 facilitates TERT recruitment to telomeres and maintains telomere G-overhangs
Pandita, RK, Chow, TT, Udayakumar, D, Bain, AL, Cubeddu, L, Hunt, CR, Shi, W, Horikoshi, N, Zhao, Y, Wright, WE, Khanna, KK, Shay, JW & Pandita, TK 2015, Cancer Research, vol 75, no. 5, pp. 858-869. DOI:

Targeted inhibition of histone deacetylases and hedgehog signaling suppress tumor growth and homologous recombination in aerodigestive cancers
Chun, SG, Park, H, Pandita, RK, Horikoshi, N, Pandita, TK, Schwartz, DL & Yordy, JS 2015, BMC Cancer, vol 5, no. 4, pp. 1337-52.

Identification and characterization of a cell division-regulating kinase AKB1 (associated kinase of Trypanosoma brucei 14-3-3) through proteomics study of the Tb14-3-3 binding proteins
Inoue, M, Okamoto, K, Uemura, H, Yasuda, K, Motohara, Y, Morita, K, Hiromura, M, Reddy, EP, Fukuma, T & Horikoshi, N 2015, Journal of Biochemistry, vol 158, no. 1, pp. 49-60. DOI:

Role of the exocyst complex component Sec6/8 in genomic stability
Torres, MJ, Pandita, RK, Kulak, O, Kumar, R, Formstecher, E, Horikoshi, N, Mujoo, K, Hunt, CR, Zhao, Y, Lum, L, Zaman, A, Yeaman, C, White, MA & Pandita, TK 2015, Molecular and Cellular Biology, vol 35, no. 21, pp. 3633-3645. DOI:

Detecting ATM-dependent chromatin modification in DNA damage response
Udayakumar, D, Horikoshi, N, Mishra, L, Hunt, C & Pandita, TK 2015, Methods in Molecular Biology, vol 1288, pp. 317-336. DOI:

MOF Phosphorylation by ATM Regulates 53BP1-Mediated Double-Strand Break Repair Pathway Choice
Gupta, A, Hunt, CR, Hegde, ML, Chakraborty, S, Udayakumar, D, Horikoshi, N, Singh, M, Ramnarain, DB, Hittelman, WN, Namjoshi, S, Asaithamby, A, Hazra, TK, Ludwig, T, Pandita, RK, Tyler, JK & Pandita, TK 2014, Cell Reports, vol 8, no. 1. DOI:

MOF phosphorylation by ATM regulates 53BP1-mediated double-strand break repair pathway choice
Gupta, A, Hunt, CR, Hegde, ML, Chakraborty, S, Udayakumar, D, Horikoshi, N, Singh, M, Ramnarain, DB, Hittelman, WN, Namjoshi, S, Asaithamby, A, Hazra, TK, Ludwig, T, Pandita, RK, Tyler, JK & Pandita, TK 2014, Cell Reports, vol 8, no. 1, pp. 177-189. DOI:

A new paradigm for transcription factor TFIIB functionality
Gelev, V, Zabolotny, JM, Lange, M, Hiromura, M, Yoo, SW, Orlando, JS, Kushnir, A, Horikoshi, N, Paquet, E, Bachvarov, D, Schaffer, PA & Usheva, A 2014, Scientific Reports, vol 4, 3664. DOI:

Role of 53BP1 in the regulation of DNA double-strand break repair pathway choice
Gupta, A, Hunt, CR, Chakraborty, S, Pandita, RK, Yordy, J, Ramnarain, DB, Horikoshi, N & Pandita, TK 2014, Radiation Research, vol 181, no. 1, pp. 1-8. DOI:

Chromatin modifications and the DNA damage response to ionizing radiation
Kumar, R, Horikoshi, N, Singh, M, Gupta, A, Misra, HS, Albuquerque, K, Hunt, CR & Pandita, TK 2013, Frontiers in Oncology, vol 2 JAN, Article 00214. DOI:

Lamin A/C depletion enhances DNA damage-induced stalled replication fork arrest
Singh, M, Hunt, CR, Pandita, RK, Kumar, R, Yang, CR, Horikoshi, N, Bachoo, R, Serag, S, Story, MD, Shay, JW, Powell, SN, Gupta, A, Jeffery, J, Pandita, S, Chen, BPC, Deckbar, D, Löbrich, M, Yang, Q, Khanna, KK, Worman, HJ & Pandita, TK 2013, Molecular and Cellular Biology, vol 33, no. 16. DOI:

Trypanosoma brucei 14-3-3I and II proteins predominantly form a heterodimer structure that acts as a potent cell cycle regulator in vivo
Inoue, M, Yasuda, K, Uemura, H, Yasaka, N, Schnaufer, A, Yano, M, Kido, H, Kohda, D, Doi, H, Fukuma, T, Tsuji, A & Horikoshi, N 2013, Journal of Biochemistry, vol 153, no. 5, pp. 431-439. DOI:

T-cell-specific deletion of Mof blocks their differentiation and results in genomic instability in mice
Gupta, A, Hunt, CR, Pandita, RK, Pae, J, Komal, K, Singh, M, Shay, JW, Kumar, R, Ariizumi, K, Horikoshi, N, Hittelman, WN, Guha, C, Ludwig, T & Pandita, TK 2013, Mutagenesis, vol 28, no. 3, pp. 263-270. DOI:

Genome-wide distribution of histone H4 Lysine 16 acetylation sites and their relationship to gene expression
Horikoshi, N, Kumar, P, Sharma, GG, Chen, M, Hunt, CR, Westover, K, Chowdhury, S & Pandita, TK 2013, Genome Integrity, vol 4, no. 1, 3. DOI: