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Nianxi Zhao, PhD

Instructor in Pathology and Genomic Medicine, Institute for Academic Medicine
Instructor, Research Institute
Houston Methodist


Oligonucleotide aptamer-drug conjugates for targeted therapy of acute myeloid leukemia
Zhao, N, Pei, SN, Qi, J, Zeng, Z, Iyer, SP, Lin, P, Tung, CH & Zu, Y 2015, Biomaterials, vol 67, pp. 42-51. DOI:

Blocking interaction of viral gp120 and CD4-expressing T cells by single-stranded DNA aptamers
Zhao, N, Pei, SN, Parekh, P, Salazar, E & Zu, Y 2014, International Journal of Biochemistry and Cell Biology, vol 51, no. 1, pp. 10-18. DOI:

Immunotherapy of CD30-expressing lymphoma using a highly stable ssDNA aptamer
Parekh, P, Kamble, S, Zhao, N, Zeng, Z, Portier, BP & Zu, Y 2013, Biomaterials, vol 34, no. 35, pp. 8909-8917. DOI:

Biostable ssDNA aptamers specific for Hodgkin lymphoma.
Parekh, P, Kamble, S, Zhao, N, Zeng, Z, Wen, J, Yuan, B & Zu, Y 2013, Sensors (Basel, Switzerland), vol 13, no. 11, pp. 14543-14557. DOI:

Biostable ssDNA aptamers specific for Hodgkin lymphoma
Parekh, P, Kamble, S, Zhao, N, Zeng, Z, Wen, J, Yuan, B & Zu, Y 2013, Sensors (Switzerland), vol 13, no. 11, pp. 14543-14557.

An ultra pH-sensitive and aptamer-equipped nanoscale drug-delivery system for selective killing of tumor cells
Zhao, N, You, J, Zeng, Z, Li, C & Zu, Y 2013, Small, vol 9, no. 20, pp. 3477-3484. DOI:

Host gene-encoded severe lung TB: From genes to the potential pathways
Ganachari, M, Guio, H, Zhao, N & Flores-Villanueva, PO 2012, Genes and Immunity, vol 13, no. 8, pp. 605-620. DOI:

Transfecting the hard-to-transfect lymphoma/leukemia cells using a simple cationic polymer nanocomplex
Zhao, N, Qi, J, Zeng, Z, Parekh, P, Chang, CC, Tung, CH & Zu, Y 2012, Journal of Controlled Release, vol 159, no. 1, pp. 104-110. DOI:

Interleukin-2 functions in anaplastic large cell lymphoma cells through augmentation of extracellular signal-regulated kinases 1/2 activation
Ito, M, Zhao, N, Zeng, Z, Zhou, X, Chang, CC & Zu, Y 2011, International Journal of Biomedical Science, vol 7, no. 3, pp. 181-190.

Transfection of shRNA-encoding Minivector DNA of a few hundred base pairs to regulate gene expression in lymphoma cells
Zhao, N, Fogg, JM, Zechiedrich, L & Zu, Y 2011, Gene Therapy, vol 18, no. 3, pp. 220-224. DOI:

A nanocomplex that is both tumor cell-selective and cancer gene-specific for anaplastic large cell lymphoma
Zhao, N, Bagaria, HG, Wong, MS & Zu, Y 2011, Journal of Nanobiotechnology, vol 9, 2. DOI:

Using oligonucleotide aptamer probes for immunostaining of formalin-fixed and paraffin-embedded tissues
Zeng, Z, Zhang, P, Zhao, N, Sheehan, AM, Tung, CH, Chang, CC & Zu, Y 2010, Modern Pathology, vol 23, no. 12, pp. 1553-1558. DOI:

Combination of an aptamer probe to CD4 and antibodies for multicolored cell phenotyping
Zhang, P, Zhao, N, Zeng, Z, Chang, CC & Zu, Y 2010, American Journal of Clinical Pathology, vol 134, no. 4, pp. 586-593. DOI:

Synergistic growth inhibition of anaplastic large cell lymphoma cells by combining cellular ALK gene silencing and a low dose of the kinase inhibitor U0126
Ito, M, Zhao, N, Zeng, Z, Chang, CC & Zu, Y 2010, Cancer Gene Therapy, vol 17, no. 9, pp. 633-644. DOI:

Using an RNA aptamer probe for flow cytometry detection of CD30-expressing lymphoma cells
Zhang, P, Zhao, N, Zeng, Z, Feng, Y, Tung, CH, Chang, CC & Zu, Y 2009, Laboratory Investigation, vol 89, no. 12, pp. 1423-1432. DOI:

The interplay between hMLH1 and hMRE11: Role in MMR and the effect of hMLH1 mutations
Zhao, N, Zhu, F, Yuan, F, Haick, AK, Fukushige, S, Gu, L & Her, C 2008, Biochemical and Biophysical Research Communications, vol 370, no. 2, pp. 338-343. DOI:

MutS homologues hMSH4 and hMSH5: Diverse functional implications in humans
Her, C, Zhao, N, Wu, X & Tompkins, JD 2007, Frontiers in Bioscience, vol 12, no. 3, pp. 905-911. DOI:

Role for Msh5 in the regulation of Ig class switch recombination
Sekine, H, Ferreira, RC, Pan-Hammarström, Q, Graham, RR, Ziemba, B, De Vries, SS, Liu, J, Hippen, K, Koeuth, T, Ortmann, W, Iwahori, A, Elliott, MK, Offer, S, Skon, C, Du, L, Novitzke, J, Lee, AT, Zhao, N, Tompkins, JD, Altshuler, D, Gregersen, PK, Cunningham-Rundles, C, Harris, RS, Her, C, Nelson, DL, Hammarström, L, Gilkeson, GS & Behrens, TW 2007, Proceedings of the National Academy of Sciences of the United States of America, vol 104, no. 17, pp. 7193-7198. DOI:

ECRG1, a novel candidate of tumor suppressor gene in the esophageal carcinoma, triggers a senescent program in NIH3T3 cells
Zhao, N, Huang, GE, Guo, L & Lu, SH 2006, Experimental Biology and Medicine, vol 231, no. 1, pp. 84-90.

Monoclonal antibodies to esophageal cancer-related gene2 protein
Huang, G, Wang, D, Guo, L, Zhao, N, Li, Y & Lu, SH 2005, Hybridoma, vol 24, no. 2, pp. 86-91.