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Magnus Hook, PhD

Full Affiliate Member, Research Institute
Houston Methodist


Biography

Dr. Hook earned his Ph.D. in Medical Chemistry from the University of Uppsala in Uppsala, Sweden in 1974. He held faculty appointments at the Swedish University of Agricultural Sciences in Ultuna, Uppsala, Sweden and the University of Alabama at Birmingham in Birmingham, Alabama before joining the faculty at Texas A&M University in 1992. Dr. Höök also holds adjunct faculty appointments at The University of Texas Medical School at Houston, Baylor College of Medicine, and MD Anderson Cancer Center. In addition to directing the very active research efforts of the Center for Infectious and Inflammatory Diseases at the Institute of Biosciences and Technology, he has also been a member of 9 NIH study sections and review boards and chaired the Pathobiochemistry Study Section from 1986-1988. Dr. Höök is a founding member of the American Society of Matrix Biology and served as the Associate Editor of the Matrix Biology journal from 1994-2000.

Description of Research

Dr. Höök’s research focuses on the molecular analysis of host-pathogen interactions, especially as they pertain to pathogenic bacteria. Current research efforts aim to understand the structural function of extracellular matrix proteins and their corresponding adhesins and virulence factors.

Areas Of Expertise

Infectious diseases Host-pathogen interactions Bacteria Extracellular matrix proteins Adhesins
Education & Training

, University of Uppsala
Publications

Allosteric Regulation of Fibronectin/a5 ß1 Interaction by Fibronectin-Binding MSCRAMMs
Liang, X, Garcia, BL, Visai, L, Prabhakaran, S, Meenan, NAG, Potts, JR, Humphries, MJ & Höök, M 2016, PLoS ONE, vol 11, no. 7, e0159118. DOI:

A novel MSCRAMM subfamily in coagulase negative staphylococcal species
Arora, S, Uhlemann, AC, Lowy, FD & Hook, M 2016, Frontiers in Microbiology, vol 7, no. APR, 540. DOI:

Coagulase and Efb of Staphylococcus aureus have a common fibrinogen binding motif
Ko, YP, Kang, M, Ganesh, VK, Ravirajan, D, Li, B & Höök, M 2016, mBio, vol 7, no. 1, e01885-15. DOI:

Borrelia burgdorferi BBK32 Inhibits the Classical Pathway by Blocking Activation of the C1 Complement Complex
Garcia, BL, Zhi, H, Wager, B, Höök, M & Skare, JT 2016, PLoS Pathogens, vol 12, no. 1, e1005404. DOI:

Mice expressing a mutant form of fibrinogen that cannot support fibrin formation exhibit compromised antimicrobial host defense
Prasad, JM, Gorkun, OV, Raghu, H, Thornton, S, Mullins, ES, Palumbo, JS, Ko, YP, Höök, M, David, T, Coughlin, SR, Degen, JL & Flick, MJ 2015, Blood, vol 126, no. 17, pp. 2047-2058. DOI:

The BBA33 lipoprotein binds collagen and impacts Borrelia burgdorferi pathogenesis
Zhi, H, Weening, EH, Barbu, EM, Hyde, JA, Höök, M & Skare, JT 2015, Molecular Microbiology, vol 96, no. 1, pp. 68-83. DOI:

The identification and functional characterization of WxL proteins from Enterococcus faecium reveal surface proteins involved in extracellular matrix interactions
Galloway-Peña, JR, Liang, X, Singh, KV, Yadav, P, Chang, C, La Rosa, SL, Shelburne, S, Ton-That, H, Höök, M & Murray, BE 2015, Journal of Bacteriology, vol 197, no. 5, pp. 882-892. DOI:

The fibronectin-binding protein fnm contributes to adherence to extracellular matrix components and virulence of Enterococcus faecium
Somarajan, SR, La Rosa, SL, Singh, KV, Roh, JH, Höök, M & Murray, BE 2015, Infection and Immunity, vol 83, no. 12, pp. 4653-4661. DOI:

Collagen-mimetic hydrogels promote human endothelial cell adhesion, migration and phenotypic maturation
Munoz-Pinto, DJ, Guiza-Arguello, VR, Becerra-Bayona, SM, Erndt-Marino, J, Samavedi, S, Malmut, S, Russell, B, Höök, M & Hahn, MS 2015, Journal of Materials Chemistry B, vol 3, no. 40, pp. 7912-7919. DOI:

Endothelial cell response to chemical, biological, and physical cues in bioactive hydrogels
Browning, MB, Guiza, V, Russell, B, Rivera, J, Cereceres, S, Hoök, M, Hahn, MS & Cosgriff-Hernandez, EM 2014, Tissue Engineering - Part A, vol 20, no. 23-24, pp. 3130-3141. DOI:

Staphylococcal biofilm formation and development: Related diseases, host immune responses and therapy
Visai, L, Ferrari, D, Barbu, EM, Liang, X, Ganesh, VK, Höök, M & Imbriani, M 2014, . in Prokaryotes: Physiology, Biochemistry and Cell Behavior. Nova Science Publishers, Inc. pp. 1-33.

SdrC induces staphylococcal biofilm formation through a homophilic interaction
Barbu, EM, Mackenzie, C, Foster, TJ & Höök, M 2014, Molecular Microbiology, vol 94, no. 1, pp. 172-185. DOI:

A multifunctional streptococcal collagen-mimetic protein coating prevents bacterial adhesion and promotes osteoid formation on titanium
Bronk, JK, Russell, BH, Rivera, JJ, Pasqualini, R, Arap, W, Höök, M & Barbu, EM 2014, Acta Biomaterialia, vol 10, no. 7, pp. 3354-3362. DOI:

Adhesion, invasion and evasion: The many functions of the surface proteins of Staphylococcus aureus
Foster, TJ, Geoghegan, JA, Ganesh, VK & Höök, M 2014, Nature Reviews Microbiology, vol 12, no. 1, pp. 49-62. DOI:

Collagen-binding microbial surface components recognizing adhesive matrix molecule (MSCRAMM) of gram-positive bacteria inhibit complement activation via the classical pathway
Kang, M, Ko, YP, Liang, X, Ross, CL, Liu, Q, Murray, BE & Höök, M 2013, Journal of Biological Chemistry, vol 288, no. 28, pp. 20520-20531. DOI:

Bioactive hydrogels with enhanced initial and sustained cell interactions
Browning, MB, Russell, B, Rivera, J, Höök, M & Cosgriff-Hernandez, EM 2013, Biomacromolecules, vol 14, no. 7, pp. 2225-2233. DOI:

Expression of the collagen adhesin ace by Enterococcus faecalis strain OG1RF is not repressed by Ers but requires the Ers box
Cohen, ALV, Roh, JH, Nallapareddy, SR, Höök, M & Murray, BE 2013, FEMS Microbiology Letters, vol 344, no. 1, pp. 18-24. DOI:

Endorepellin causes endothelial cell disassembly of actin cytoskeleton and focal adhesions through a2ß1 integrin
Bix, G, Fu, J, Gonzalez, EM, Macro, L, Barker, A, Campbell, S, Zutter, MM, Santoro, SA, Kim, JK, Höök, M, Reed, CC & Lozzo, RV 2013, Journal of Cell Biology, vol 201, no. 4. DOI:

Genetic elimination of the binding motif on fibrinogen for the S. aureus virulence factor ClfA improves host survival in septicemia
Flick, MJ, Du, X, Prasad, JM, Raghu, H, Palumbo, JS, Smeds, E, ?öok, M & Degen, JL 2013, Blood, vol 121, no. 10, pp. 1783-1794. DOI:

Phagocytosis Escape by a Staphylococcus aureus Protein That Connects Complement and Coagulation Proteins at the Bacterial Surface
Ko, YP, Kuipers, A, Freitag, CM, Jongerius, I, Medina, E, van Rooijen, WJ, Spaan, AN, van Kessel, KPM, Höök, M & Rooijakkers, SHM 2013, PLoS Pathogens, vol 9, no. 12, e1003816, pp. 1-13. DOI: