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Lidong Qin, PhD

Professor of Nanomedicine, Institute for Academic Medicine
Full Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Research Lab


Biography

Dr. Qin received his Ph.D. in Chemistry from Northwestern University, Evanston, Illinois and completed a postdoctoral traineeship in Cancer Nanotechnology at the California Institute of Technology. In Prof. Chad Mirkin's lab at the Northwestern University, Dr. Qin worked on functional metallic nanorods, with the invention of on-wire lithography and the development of Raman spectrum-based imaging and sensing methods. His research provided insightful understanding of Surface Enhanced Raman Spectroscopy and Surface Plasmon Resonance, which are the basics of Raman-based cancer imaging and nanomaterial-based cancer thermal therapeutics. Because of his pioneering work in metal nanomaterial synthesis and biological applications, he was awarded the International Precious Metal Institute (IPMI) graduate student prize. His other awards include the Materials Research Society graduate student award, Chinese government award for graduate students studying abroad, and Searle center for teaching excellence award. During his four years at Northwestern University, Dr. Qin received eight patents and published fourteen peer-reviewed journal articles, in journals including Science, PNAS, JACS and Nano Letters.

Later, Dr. Qin moved to Caltech as a postdoctoral fellow, working with Prof. James Heath. He developed automatic proteomic barcode chips that allow highly multiplexed plasma cancer biomarker measurements from a finger-prick of blood. Dr. Qin's method is recognized as a significant improvement over the cost and speed of standard laboratory tests to analyze proteins in blood. In his three-year postdoctoral research position, he also worked on integrated microfluidic chips to handle prostate cancer cell culture and study proteomic profiles from individual cells. He continued to excel and make major contributions to his field, receiving another patent and publishing three peer-reviewed papers in Nature Nanotechnology, Lab on a Chip and Nature Biotechnology.

Dr. Qin joined the TMHRI Department of Nanomedicine in July 2010 and was awarded with a prestigious startup award, the Cancer Prevention and Research Institute of Texas (CPRIT) recruitment award for first-time, tenure-track faculty.

Description of Research

Translational cancer medicine is the focus of my research group. In particular, we develop nonconventional technology platforms for cancer diagnosis and risk analysis, measurement of cancer cell mechanical properties and phenotype enrichment, and in vitro models for study of the cancer cell microenvironment. Our technological expertise includes rational design of microfluidics platforms that allows for rapid and high-throughput molecular and cellular assays, fabrication of bio-inspired microstructures that simulate the cancer cell microenvironment, and development of nanotools that assist molecular signal amplification. Our biological targets address the cancer metastatic cascade, with focuses on cancer cell phenotype transition in the primary tumor, detection of circulating biomarkers and circulating tumor cells in the blood, and cancer cell migration and invasion at the metastatic site. The combination of our technological strengths and understanding of cancer cell biology has helped us develop several interesting technological innovations and opened many new avenues of future research direction.

Areas Of Expertise

Cancer Microfluidics Regenerative Medicine
Education & Training

MS , Jilin University
Postdoctoral Fellowship , NanoSystems Biology Cancer Center, California Institute of Technology, Pasadena, CA
PhD , Northwestern U.
Publications

Microfluidic Mapping of Cancer Cell-Protein Binding Interaction
Liu, Z, Han, X, Chen, R, Zhang, K, Li, Y, Fruge, S, Jang, JH, Ma, Y & Qin, L 2017, ACS Applied Materials and Interfaces, vol 9, no. 27, pp. 22143-22148. DOI: 10.1021/acsami.7b03728

Highly efficient genome editing of human hematopoietic stem cells via a nano-silicon-blade delivery approach
Ma, Y, Han, X, Quintana Bustamante, O, Bessa De Castro, R, Zhang, K, Zhang, P, Li, Y, Liu, Z, Liu, X, Ferrari, M, Hu, Z, Carlos Segovia, J & Qin, L 2017, Integrative Biology (United Kingdom), vol 9, no. 6, pp. 548-554. DOI: 10.1039/c7ib00060j

Volumetric bar-chart chips for biosensing
Song, Y, Li, Y & Qin, L 2017, . in Methods in Molecular Biology. vol. 1570, Methods in Molecular Biology, vol. 1570, Humana Press Inc. pp. 105-115. DOI: 10.1007/978-1-4939-6840-4_7

Bridging the gap: microfluidic devices for short and long distance cell-cell communication
Vu, TQ, De Castro, RMB & Qin, L 2017, Lab on a Chip - Miniaturisation for Chemistry and Biology, vol 17, no. 6, pp. 1009-1023. DOI: 10.1039/c6lc01367h

SINGLE-CELL PIPETTE ASSEMBLY COMPRISING SINGLE-CELL PIPETTE HANDLE AND SINGLE-CELL PIPETTE TIP
QIN, L & ZHANG, K 2016, , Patent No. EP3099411, IPC No. B01L 3/ 02 A I.

Single-cell isolation by a modular single-cell pipette for RNA-sequencing
Zhang, K, Gao, M, Chong, Z, Li, Y, Han, X, Chen, R & Qin, L 2016, Lab on a Chip - Miniaturisation for Chemistry and Biology, vol 16, no. 24, pp. 4742-4748. DOI: 10.1039/c6lc01241h

SINGLE-CELL PIPETTE ASSEMBLY COMPRISING SINGLE-CELL PIPETTE HANDLE AND SINGLE-CELL PIPETTE TIP
Qin, L & Zhang, K 2016, , Patent No. US2016339422, IPC No. B01L 3/ 02 A I.

SINGLE-CELL PIPETTE ASSEMBLY COMPRISING SINGLE-CELL PIPETTE HANDLE AND SINGLE-CELL PIPETTE TIP
QIN, LIDONG & ZHANG, KAI 2016, , Patent No. SG11201605894V, IPC No. B01L 3/ 02 A I.

Recent Progress of Microfluidics in Translational Applications
Liu, Z, Han, X & Qin, L 2016, Advanced Healthcare Materials, vol 5, no. 8, pp. 871-888. DOI: 10.1002/adhm.201600009

Nanoporous glass integrated in volumetric bar-chart chip for point-of-care diagnostics of non-small cell lung cancer
Li, Y, Xuan, J, Song, Y, Qi, W, He, B, Wang, P & Qin, L 2016, ACS Nano, vol 10, no. 1, pp. 1640-1647. DOI: 10.1021/acsnano.5b07357

Microfluidic Platforms for Yeast-Based Aging Studies
Jo, MC & Qin, L 2016, Small. DOI: 10.1002/smll.201602006

Integrative volumetric bar-chart chip for rapid and quantitative point-of-care detection of myocardial infarction biomarkers
Song, Y, Wang, Y, Qi, W, Li, Y, Xuan, J, Wang, P & Qin, L 2016, Lab on a Chip - Miniaturisation for Chemistry and Biology, vol 16, no. 15, pp. 2955-2962. DOI: 10.1039/c6lc00561f

Microfluidic Cell Deformability Assay for Rapid and Efficient Kinase Screening with the CRISPR-Cas9 System
Han, X, Liu, Z, Zhao, L, Wang, F, Yu, Y, Yang, J, Chen, R & Qin, L 2016, Angewandte Chemie - International Edition. DOI: 10.1002/anie.201601984

Microfluidic cytometric analysis of cancer cell transportability and invasiveness
Liu, Z, Lee, Y, Jang, JH, Li, Y, Han, X, Yokoi, K, Ferrari, M, Zhou, L & Qin, L 2015, Scientific Reports, vol 5, 14272. DOI: 10.1038/srep14272

High-Throughput, Label-Free Isolation of Cancer Stem Cells on the Basis of Cell Adhesion Capacity
Zhang, Y, Wu, M, Han, X, Wang, P & Qin, L 2015, Angewandte Chemie - International Edition, vol 54, no. 37, pp. 10838-10842. DOI: 10.1002/anie.201505294

Retinal synaptic regeneration via microfluidic guiding channels
Su, PJ, Liu, Z, Zhang, K, Han, X, Saito, Y, Xia, X, Yokoi, K, Shen, H & Qin, L 2015, Scientific Reports, vol 5, 13591. DOI: 10.1038/srep13591

A microfluidic platform with digital readout and ultra-low detection limit for quantitative point-of-care diagnostics
Li, Y, Xuan, J, Song, Y, Wang, P & Qin, L 2015, Lab on a Chip - Miniaturisation for Chemistry and Biology, vol 15, no. 16, pp. 3300-3306. DOI: 10.1039/c5lc00529a

SINGLE-CELL PIPETTE ASSEMBLY COMPRISING SINGLE-CELL PIPETTE HANDLE AND SINGLE-CELL PIPETTE TIP
QIN, LIDONG & ZHANG, KAI 2015, , Patent No. WO2015116714, IPC No. B01L 3/ 02 A I.

CRISPR-Cas9 delivery to hard-to-transfect cells via membrane deformation
Han, X, Liu, Z, Jo, MC, Zhang, K, Li, Y, Zeng, Z, Li, N, Zu, Y & Qin, L 2015, Science advances, vol 1, no. 7, pp. e1500454. DOI: 10.1126/sciadv.1500454

Imaging of cell-cell communication in a vertical orientation reveals high-resolution structure of immunological synapse and novel PD-1 dynamics
Jang, JH, Huang, Y, Zheng, P, Chan Jo, M, Bertolet, G, Zhu, MX, Qin, L & Liu, D 2015, Journal of Immunology, vol 195, no. 3, pp. 1320-1330. DOI: 10.4049/jimmunol.1403143