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Santosh Helekar, MD, PhD

Associate Professor of Neurology, Institute for Academic Medicine
Associate Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Neuromodulation Lab


Biography

Dr. Santosh A. Helekar earned his medical degree (Bachelor of Medicine and Bachelor of Surgery) from the University of Bombay in 1982. He earned a Ph.D. in Neuroscience from Baylor College of Medicine. He held faculty appointments in the Departments of Neurology and Neuroscience at Baylor College of Medicine, Department of Neurology at The Methodist Hospital Research Institute and Weill Medical College (WMC) of Cornell University before rejoining as an associate member of The Methodist Hospital Research Institute in 2007. Dr. Helekar also holds an adjunct faculty appointment in the Department of Biology at Texas A & M University. As a member of the Research Institute Neurosciences Research Program, he directs the Neurophysiology and Neuromodulation Laboratory in the Speech and Language Center of the Department of Neurology, where he conducts neuroscientific research on stuttering, chronic ischemic stroke, motor control, and conscious perception using neuroimaging and magnetic brain stimulation with a new portable wearable device developed by him and Dr. Henning Voss of WMC. He also collaborates with other members of the Research Institute on functional magnetic resonance imaging studies of neurological conditions. Dr. Helekar has been a member of the National Institutes of Health, National Science Foundation, Department of Defense and Alzheimer's Association grant review boards. He has also been an E-print editor of Association for the Scientific Study of Consciousness, and a reviewer for several international research foundations and scientific journals in his fields of interest. He serves on the editorial board of The Open Zoology Journal.

Description of Research

Dr. Helekar's current research program focuses on the development and refinement of multifocal magnetic brain stimulation using a new portable wearable device called Transcranial Rotating Permanent Magnet Stimulator (TRPMS) invented by him and Dr. Henning Voss of Weill Medical College of Cornell University. Ongoing projects in his laboratory involve studying the effects of TRPMS stimulation using brain functional magnetic resonance imaging, positron emission tomography and electrophysiological approaches for application in basic neuroscience research and neuromodulatory therapy in neurobehavioral disorders, including stuttering and chronic ischemic stroke. He is also interested in quantitative functional network-based analysis and theoretical research related to neural processes underlying conscious perception.

Areas Of Expertise

fMRI Motor control Vocal learning Speech and language disorders Conscious perception Neurophysiology Neuromodulation
Education & Training

Postdoctoral Fellowship, Baylor College of Medicine
PhD, Baylor College of Medicine
Publications

The strength and spread of the electric field induced by transcranial rotating permanent magnet stimulation in comparison with conventional transcranial magnetic stimulation
Helekar, S, Convento, S, Nguyen, L, John, BS, Patel, A, Yau, JM & Voss, HU 2018, Journal of Neuroscience Methods, vol. 309, pp. 153-160. https://doi.org/10.1016/j.jneumeth.2018.09.002

WO2017193078 (A1) - METHOD AND APPARATUS FOR PROVIDING TRANSCRANIAL MAGNETIC STIMULATION (TMS) TO AN INDIVIDUAL
Helekar, S & Voss, HU 2017, , Patent No. WO2017193078 (A1).

Sexual dimorphism in striatal dopaminergic responses promotes monogamy in social songbirds
Tokarev, K, Bruno, JH, Ljubicic, I, Kothari, PJ, Helekar, S, Tchernichovski, O & Voss, HU 2017, eLife, vol. 6, e25819. https://doi.org/10.7554/eLife.25819

Method and apparatus for providing transcranial magnetic stimulation (TMS) to a patient
Helekar, S & Voss, HU 2016, , Patent No. US9456784B2.

Transcranial Brain Stimulation with Rapidly Spinning High-Field Permanent Magnets
Helekar, S & Voss, HU 2016, IEEE Access, vol. 4, 7473846, pp. 2520-2528. https://doi.org/10.1109/ACCESS.2016.2568739

Stuttered birdsong
Helekar, S, Salgado-Commissariat, D, Rosenfield, DB & Voss, HU 2013, . in SA Helekar (ed.), Animal Models of Speech and Language Disorders. Springer New York, pp. 185-208. https://doi.org/10.1007/978-1-4614-8400-4_7

Preface
Helekar, SA 2013, . in SA Helekar (ed.), Animal Models of Speech and Language Disorders. Springer, Unknown Journal, pp. v-vii. https://doi.org/10.1007/978-1-4614-8400-4

Animal models of speech and language disorders
Helekar, SA (ed.) 2013, . Springer New York. https://doi.org/10.1007/978-1-4614-8400-4

Functional brain network changes associated with maintenance of cognitive function in multiple sclerosis
Helekar, SA, Shin, JC, Mattson, BJ, Bartley, K, Stosic, M, Saldana-King, T, Read Montague, P & Hutton, GJ 2010, Frontiers in Human Neuroscience, vol. 4, 219. https://doi.org/10.3389/fnhum.2010.00219

Altered auditory BOLD response to conspecific birdsong in zebra finches with stuttered syllables
Voss, HU, Salgado-Commissariat, D & Helekar, S 2010, PLoS ONE, vol. 5, no. 12, e14415. https://doi.org/10.1371/journal.pone.0014415

The development of stimulus-specific auditory responses requires song exposure in male but not female zebra finches
Maul, KK, Voss, HU, Parra, LC, Salgado-Commissariat, D, Ballon, D, Tchernichovski, O & Helekar, S 2010, Developmental Neurobiology, vol. 70, no. 1, pp. 28-40. https://doi.org/10.1002/dneu.20751

Proteomics of the nucleus ovoidalis and field L brain regions of zebra finch
Benjamin, A, Kashem, M, Cohen, C, Caldwell Busby, JA, Salgado-Commissariat, D, Helekar, S & Bhattacharya, SK 2008, Journal of Proteome Research, vol. 7, no. 5, pp. 2121-2132. https://doi.org/10.1021/pr7008687

Functional MRI of the zebra finch brain during song stimulation suggests a lateralized response topography
Voss, HU, Tabelow, K, Polzehl, J, Tchernichovski, O, Maul, KK, Salgado-Commissariat, D, Ballon, D & Helekar, S 2007, Proceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 25, pp. 10667-10672. https://doi.org/10.1073/pnas.0611515104

Nicotine-mediated plasticity in robust nucleus of the archistriatum of the adult zebra finch
Salgado-Commissariat, D, Rosenfield, DB & Helekar, S 2004, Brain Research, vol. 1018, no. 1, pp. 97-105. https://doi.org/10.1016/j.brainres.2004.05.051

Modulation of ?/a frequency profiles of slow auditory-evoked responses in the songbird zebra finch
Espino, GG, Lewis, C, Rosenfield, DB & Helekar, S 2003, Neuroscience, vol. 122, no. 2, pp. 521-529. https://doi.org/10.1016/S0306-4522(03)00549-9

Development and adult phase plasticity of syllable repetitions in the birdsong of captive zebra finches (Taeniopygia guttata)
Helekar, S, Espino, GG, Botas, A & Rosenfield, DB 2003, Behavioral Neuroscience, vol. 117, no. 5, pp. 939-951. https://doi.org/10.1037/0735-7044.117.5.939

Reduction of female-directed song motifs induced by repeated singing in laboratory-bred zebra finches
Botas, A, Espino, G, Rosenfield, DB & Helekar, S 2001, Neuroscience Letters, vol. 297, no. 3, pp. 203-206. https://doi.org/10.1016/S0304-3940(00)01693-1

Acoustic pattern variations in the female-directed birdsongs of a colony of laboratory-bred zebra finches
Helekar, S, Marsh, S, Viswanath, NS & Rosenfield, DB 2000, Behavioural Processes, vol. 49, no. 2, pp. 99-110. https://doi.org/10.1016/S0376-6357(00)00081-4

On the Possibility of Universal Neural Coding of Subjective Experience
Helekar, S 1999, Consciousness and Cognition, vol. 8, no. 4, pp. 423-446. https://doi.org/10.1006/ccog.1998.0377

In defense of experience-coding nonarbitrary temporal neural activity patterns
Helekar, S 1999, Consciousness and Cognition, vol. 8, no. 4, pp. 455-461.

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