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Omkar B. Ijare, PhD

Instructor, Academic Institute
Instructor, Research Institute
Houston Methodist


Baskin Lab


oijare@houstonmethodist.org
Biography

Dr. Ijare is an analytical chemist trained in nuclear magnetic resonance (NMR) and mass spectrometry (MS) techniques. His research is centered on applying NMR and MS techniques to biomedical problems. Previously he worked on the detection of hepatobiliary and pancreatic malignancies through the analysis of pancreaticobiliary fluids such as bile and pancreatic juice using NMR spectroscopy. He has also worked on the analysis of sputum and exhaled breath condensate to detect lung cancer. At the Kenneth R. Peak Brain and Pituitary Tumor Treatment Center, he is working with Dr. Kumar Pichumani, studying the metabolism of pituitary tumors and gliomas using NMR and MS technologies. He is also interested in developing new diagnostic methods for the early detection of human cancers.

Areas Of Expertise

Nuclear magnetic resonance Cell metabolism Metabolomics
Publications

Metabolic fate of glucose in atypical meningioma studied by 13C NMR isotopomer analysis
Pichumani, K, Ijare, OB & Baskin, DS 2019, . in Metabolic fate of glucose in atypical meningioma studied by 13C NMR isotopomer. Proc. Intl. Soc. Mag. Reson. Med. 27 (2019) 2507 edn, vol. 27, Internatioal Society for magnetic resonance in medicine, pp. 2507.

In vivo 1 H MRS of human gallbladder bile in understanding the pathophysiology of primary sclerosing cholangitis (PSC): Immune-mediated disease versus bile acid-induced injury
Mohajeri, S, Bezabeh, T, Ijare, OB, King, SB, Thomas, MA, Minuk, G, Lipschitz, J, Kirkpatrick, I, Micflikier, AB, Summers, R & Smith, ICP 2019, NMR in Biomedicine, vol. 32, no. 5, e4065. https://doi.org/10.1002/nbm.4065

Ex Vivo 1 H NMR study of pituitary adenomas to differentiate various immunohistochemical subtypes
Ijare, OB, Baskin, DS & Pichumani, K 2019, Scientific Reports, vol. 9, no. 1, 3007. https://doi.org/10.1038/s41598-019-38542-6

NMR-Based Urinary Metabolomics Applications
Bezabeh, T, Capati, A & Ijare, OB 2019, . in Methods in Molecular Biology. Methods in Molecular Biology, vol. 2037, Humana Press, pp. 215-229. https://doi.org/10.1007/978-1-4939-9690-2_13

Metabolism of fructose in B-cells: A 13C NMR spectroscopy based stable isotope tracer study
Ijare, OB, Baskin, DS, Sharpe, MA & Pichumani, K 2018, Analytical Biochemistry, vol. 552, pp. 110-117. https://doi.org/10.1016/j.ab.2018.04.003

Measurement of 13C turnover into glutamate and glutamine pools in brain tumor patients
Pichumani, K, Mashimo, T, Vemireddy, V, Ijare, OB, Mickey, BE, Malloy, CR, Marin-Valencia, I, Baskin, DS, Bachoo, RM & Maher, EA 2017, FEBS Letters, vol. 591, no. 21, pp. 3548-3554. https://doi.org/10.1002/1873-3468.12867

In vivo 1 H MRS of human gallbladder bile at 3 T in one and two dimensions: Detection and quantification of major biliary lipids
Mohajeri, S, Ijare, OB, Bezabeh, T, King, SB, Thomas, MA, Minuk, G, Lipschitz, J, Kirkpatrick, I, Smith, M & Smith, ICP 2014, NMR in Biomedicine, vol. 27, no. 10, pp. 1192-1202. https://doi.org/10.1002/nbm.3173

Proton magnetic resonance spectroscopy of sputum for the non-invasive diagnosis of lung cancer: Preliminary findings
Bezabeh, T, Ijare, OB, Marginean, EC & Nicholas, G 2012, Journal of Analytical Oncology, vol. 1, no. 1, pp. 14-18. https://doi.org/10.6000/1927-7229.2012.01.01.3

Magnetic resonance spectroscopy of bile in the detection of cholangiocarcinoma
Ijare, OB, Bezabeh, T, Albiin, N & Smith, ICP 2011, Journal of Hepatology, vol. 54, no. 2, pp. 398-399. https://doi.org/10.1016/j.jhep.2010.08.039

Simultaneous quantification of glycine- and taurine-conjugated bile acids, total bile acids, and choline-containing phospholipids in human bile using 1H NMR spectroscopy
Ijare, OB, Bezabeh, T, Albiin, N, Bergquist, A, Arnelo, U, Lindberg, B & Smith, ICP 2010, Journal of Pharmaceutical and Biomedical Analysis, vol. 53, no. 3, pp. 667-673. https://doi.org/10.1016/j.jpba.2010.05.028

Potential of magnetic resonance spectroscopy in assessing the effect of fatty acids on inflammatory bowel disease in an animal model
Varma, S, Eskin, MNA, Bird, R, Dolenko, B, Raju, J, Ijare, OB & Bezabeh, T 2010, Lipids, vol. 45, no. 9, pp. 843-854. https://doi.org/10.1007/s11745-010-3455-7

Detection and quantification of d-glucuronic acid in human bile using 1H NMR spectroscopy: Relevance to the diagnosis of pancreatic cancer
Bezabeh, T, Ijare, OB, Albiin, N, Arnelo, U, Lindberg, B & Smith, ICP 2009, Magnetic Resonance Materials in Physics, Biology and Medicine, vol. 22, no. 5, pp. 267-275. https://doi.org/10.1007/s10334-009-0171-5

Absence of glycochenodeoxycholic acid (GCDCA) in human bile is an indication of cholestasis: A 1H MRS study
Ijare, OB, Bezabeh, T, Albiin, N, Arnelo, U, Bergquist, A, Lindberg, B & Smith, ICP 2009, NMR in Biomedicine, vol. 22, no. 5, pp. 471-479. https://doi.org/10.1002/nbm.1355

Combining nuclear magnetic resonance spectroscopy and mass spectrometry in biomarker discovery
Gowda, GAN, Ijare, OB & Shanaiah, N 2009, Biomarkers in Medicine, vol. 3, no. 3, pp. 307-322. https://doi.org/10.2217/bmm.09.22

Phenoxo-bridged symmetrical homobinuclear complexes derived from an "end-off" compartmental ligand, 2,6-bis[5'-chloro-3'-phenyl-1H-indole-2'-carboxamidyliminomethyl]-4-methylphenol
Rahaman, F, Ijare, OB, Jadegoud, Y & Mruthyunjayaswamy, BHM 2009, Journal of Coordination Chemistry, vol. 62, no. 9, pp. 1457-1467. https://doi.org/10.1080/00958970802600888

Implementation of wavelet encoding spectroscopic imaging technique on a 3 Tesla whole body MR scanner: In vitro results
Fu, Y, Ijare, OB, Thomas, G, Fazel-Rezai, R & Serrai, H 2009, . in Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009., 5332453, Institute of Electrical and Electronics Engineers Inc. pp. 2688-2691, 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009, Minneapolis, MN, United States, 9/2/09. https://doi.org/10.1109/IEMBS.2009.5332453

Synthesis, characterization and antimicrobial activity of homodinuclear complexes derived from 2,6-bis[3'-methyl- 2'- carboxamidyliminomethyl(6',7')benzindole]-4-methylphenol, an end-off compartmental ligand
Jadegoud, Y, Ijare, OB, Somashekar, BS, Gowda, GAN & Mruthyunjayaswamy, BHM 2008, Journal of Coordination Chemistry, vol. 61, no. 4, pp. 508-527. https://doi.org/10.1080/00958970701362523

Simple pulse-acquire NMR methods for the quantitative analysis of calcium, magnesium and sodium in human serum
Somashekar, BS, Ijare, OB, Nagana Gowda, GA, Ramesh, V, Gupta, S & Khetrapal, CL 2006, Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, vol. 65, no. 2, pp. 254-260. https://doi.org/10.1016/j.saa.2005.10.039

One-step analysis of major bile components in human bile using 1 H NMR spectroscopy
Gowda, GAN, Somashekar, BS, Ijare, OB, Sharma, A, Kapoor, VK & Khetrapal, CL 2006, Lipids, vol. 41, no. 6, pp. 577-589. https://doi.org/10.1007/s11745-006-5007-8

Single-step analysis of individual conjugated bile acids in human bile using1H NMR spectroscopy
Gowda, GAN, Ijare, OB, Somashekar, BS, Sharma, A, Kapoor, VK & Khetrapal, CL 2006, Lipids, vol. 41, no. 6, pp. 591-603. https://doi.org/10.1007/s11745-006-5008-7

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