Nestor F. Esnaola, MD, MPH, MBA, FACS

Professor of Surgery, Academic Institute
Full Member, Research Institute
Associate Director, Cancer Control and Population Science, Cancer Center
Houston Methodist
Weill Cornell Medical College


Dr. Nestor Esnaola is division head of surgical oncology and gastrointestional surgery, Department of Surgery, Surgical Director, Houston Methodist Cancer Center, Associate Director, Cancer Control and Population Science, Katz Investigator, Houston Methodist Research Institute  

Description of Research

Dr. Esnaola will lead cancer center efforts in the areas of cancer prevention, community outreach and engagement, cancer health disparities, and population science research in accordance with NCI cancer center guidelines.


Acetyl-CoA Synthetase 2: A Critical Linkage in Obesity-Induced Tumorigenesis in Myeloma
Li, Z, Liu, H, He, J, Wang, Z, Yin, Z, You, G, Wang, Z, Davis, RE, Lin, P, Bergsagel, PL, Manasanch, EE, Wong, STC, Esnaola, NF, Chang, JC, Orlowski, RZ, Yi, Q & Yang, J 2021, , Cell Metabolism, vol. 33, no. 1, pp. 78-93.e7.

The Effect of Discrimination on Likelihood of Participation in a Clinical Trial
Devlin, A, Gonzalez, E, Ramsey, F, Esnaola, N & Fisher, S 2020, , Journal of Racial and Ethnic Health Disparities, vol. 7, no. 6, pp. 1124-1129.

Early prediction of clinical response to checkpoint inhibitor therapy in human solid cancers through mathematical modeling
Butner, J, Martin, G, Wang, Z, Corradetti, B, Ferrari, M, Esnaola, NF, Chung, C, Hong, DS, Welsh, J, Mittendorf, EA, Curley, SA, Sidman, RL, Pasqualini, R, Arap, W, Koay, EJ & Cristini, V 2020, , JCO Precision Oncology.

Mathematical prediction of clinical outcomes in advanced cancer patients treated with checkpoint inhibitor immunotherapy
Butner, JD, Elganainy, D, Wang, CX, Wang, Z, Chen, SH, Esnaola, NF, Pasqualini, R, Arap, W, Hong, DS, Welsh, J, Koay, EJ & Cristini, V 2020, , Science advances, vol. 6, no. 18, eaay6298.

Derivation of a cost-saving screening strategy for asymptomatic primary hyperparathyroidism
Nguyen-Lee, JJ, Paciuc, M, Guerra, R, Esnaola, N, Zanocco, KA & Zheng, F 2020, , Surgery (United States), vol. 167, no. 1, pp. 155-159.

Ford, ME, Esnaola, NF & Salley, JD 2020, . in ME Ford, NF Esnaola & JD Salley (eds), Advances in Cancer Research. Advances in Cancer Research, vol. 146, Academic Press, pp. xv-xx.

BMI, physical activity, and breast cancer subtype in white, black, and Sea Island breast cancer survivors
Ford, ME, Bauza, CE, Findlay, VJ, Turner, DP, Abraham, LM, Moore, LA, Magwood, G, Alberg, AJ, Gaymon, K, Knight, KD, Hilton, E, Malek, AM, Kramer, RM, Peterson, LL, Gregoski, MJ, Bolick, S, Hurley, D, Mosley, C, Hazelton, TR, Burshell, DR, Nogueira, L, Mack, F, Brown, ET, Salley, JD, Whitfield, KE, Esnaola, NF & Cunningham, JE 2020, . in ME Ford, NF Esnaola & JD Salley (eds), Advances in Cancer Research. Advances in Cancer Research, vol. 146, Academic Press, pp. 83-102.

Managing change
Uohara, MY, Ward, WH, Goel, N, Atchley, K & Esnaola, NF 2019, . in Quality in Obesity Treatment. Springer International Publishing, pp. 197-205.

US cancer centers of excellence strategies for increased inclusion of racial and ethnic minorities in clinical trials
Regnante, JM, Richie, NA, Fashoyin-Aje, L, Vichnin, M, Ford, M, Roy, UB, Turner, K, Hall, LL, Gonzalez, E, Esnaola, N, Clark, LT, Adams, HC, Alese, OB, Gogineni, K, McNeill, L, Petereit, D, Sargeant, I, Dang, J, Obasaju, C, Highsmith, Q, Lee, SC, Hoover, SC, Williams, EL & Chen, MS 2019, , Journal of oncology practice, vol. 15, no. 7, pp. E289-E299.

Does the Surgical Apgar Score predict serious complications after elective major cancer surgery?
Goel, N, Manstein, SM, Ward, WH, DeMora, L, Smaldone, MC, Farma, JM, Uzzo, RG & Esnaola, NF 2018, , Journal of Surgical Research, vol. 231, pp. 242-247.

Concurrent chemoradiation for resected gall bladder cancers and cholangiocarcinomas
Fareed, MM, DeMora, L, Esnaola, NF, Denlinger, CS, Karachristos, A, Ross, EE, Hoffman, J & Meyer, JE 2018, , Journal of Gastrointestinal Oncology, vol. 9, no. 4, pp. 762-768.

Granular cell tumor experience at a comprehensive cancer center
Moten, AS, Movva, S, von Mehren, M, Wu, H, Esnaola, NF, Reddy, SS & Farma, JM 2018, , Journal of Surgical Research, vol. 226, pp. 1-7.

Comparative Effectiveness and Risks of Bowel Preparation before Elective Colorectal Surgery
Koller, SE, Bauer, KW, Egleston, BL, Smith, R, Philp, MM, Ross, HM & Esnaola, NF 2018, , Annals of surgery, vol. 267, no. 4, pp. 734-742.

Availability of patient-centered cancer support services: A statewide survey of cancer centers
Cartmell, KB, Sterba, KR, Pickett, K, Zapka, J, Alberg, AJ, Sood, AJ & Esnaola, NF 2018, , PLoS ONE, vol. 13, no. 3, e0194649.

Mismatch repair deficiency testing in patients with colorectal cancer and nonadherence to testing guidelines in young adults
Shaikh, T, Handorf, EA, Meyer, JE, Hall, MJ & Esnaola, NF 2018, , JAMA oncology, vol. 4, no. 2, e173580.

Optimal preoperative assessment of the geriatric patient
Ward, WH, Manstein, SM, Goel, N, Chow, WB, Ko, CY, Rosenthal, RA & Esnaola, NF 2017, , Perioperative Care and Operating Room Management, vol. 9, pp. 33-38.

A structured framework for optimizing surgical quality through process-of-care trials
Waingankar, N, Esnaola, NF & Uzzo, RG 2017, , Urologic Oncology: Seminars and Original Investigations, vol. 35, no. 5, pp. 177-179.

Splenic irradiation for splenomegaly: A systematic review
Zaorsky, NG, Williams, GR, Barta, SK, Esnaola, NF, Kropf, PL, Hayes, SB & Meyer, JE 2017, , Cancer Treatment Reviews, vol. 53, pp. 47-52.

Evaluation and management of intrahepatic and extrahepatic cholangiocarcinoma
Esnaola, NF, Meyer, JE, Karachristos, A, Maranki, JL, Camp, ER & Denlinger, CS 2016, , Cancer, vol. 122, no. 9, pp. 1349-1369.

Optimal Perioperative Management of the Geriatric Patient: A Best Practices Guideline from the American College of Surgeons NSQIP and the American Geriatrics Society
Mohanty, S, Rosenthal, RA, Russell, MM, Neuman, MD, Ko, CY & Esnaola, NF 2016, , Journal of the American College of Surgeons, vol. 222, no. 5, pp. 930-947.