Nestor F. Esnaola VIEW CLINICAL PROFILE

Nestor F. Esnaola, MD, MPH, MBA, FACS

Diane Harkins Modesett Chair, Dr. Mary and Ron Neal Cancer Center
Professor of Surgery, Academic Institute
Jerold B. Katz Investigator, Academic Institute
Associate Director, Cancer Control and Population Science, Dr. Mary and Ron Neal Cancer Center
Houston Methodist
Weill Cornell Medical College


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Biography

Dr. Nestor Esnaola is division head of surgical oncology and gastrointestional surgery, Department of Surgery, Surgical Director, Houston Methodist Cancer Center, Associate Director, Cancer Control and Population Science, Katz Investigator, Houston Methodist Research Institute  

Description of Research

Dr. Esnaola leads Cancer Center efforts in the areas of cancer prevention, community outreach and engagement, cancer health disparities, and population science research in accordance with NCI cancer center guidelines.

Active Clinical Trials

Neoadjuvant Folfirinox Combined With Pembrolizumab Followed by Surgery for Patients With Resectable Pancreatic Cancer

NCT05132504


Neoadjuvant Atezolizumab in Patients With Non-Metastatic Resectable High-Risk Cutaneous Melanoma

NCT04020809

Publications

Extracellular Vesicles, Circadian Rhythms, and Cancer: A Comprehensive Review with Emphasis on Hepatocellular Carcinoma
Fekry, B, Ugartemendia, L, Esnaola, NF & Goetzl, L 2024, , Cancers, vol. 16, no. 14, 2552. https://doi.org/10.3390/cancers16142552

Comparative molecular profiling of pancreatic ductal adenocarcinoma of the head versus body and tail
Abdelrahim, M, Esmail, A, Kasi, A, Esnaola, NF, Xiu, J, Baca, Y & Weinberg, BA 2024, , npj Precision Oncology, vol. 8, no. 1, 85, pp. 85. https://doi.org/10.1038/s41698-024-00571-4

Effect of neighborhood and individual-level socioeconomic factors on breast cancer screening adherence in a multi-ethnic study
Kasper, G, Momen, M, Sorice, KA, Mayhand, KN, Handorf, EA, Gonzalez, ET, Devlin, A, Brownstein, K, Esnaola, N, Fisher, SG & Lynch, SM 2024, , BMC Public Health, vol. 24, no. 1, 63, pp. 63. https://doi.org/10.1186/s12889-023-17252-9

A Randomized, Controlled Trial Evaluating Perioperative Risk-Stratification and Risk-Based, Protocol-Driven Management After Elective Major Cancer Surgery
Esnaola, NF, Chelluri, R, Castellanos, J, Altman, A, Chen, DYT, Chu, C, Farma, JM, Haber, A, Sheriff, F, Huang, C, Kutikov, A, Patel, S, Patrick, K, Reddy, S, Rubin, S, Viterbo, R, Ridge, JA, Edelman, M, Ross, E, Smaldone, M & Uzzo, RG 2024, , Annals of surgery. https://doi.org/10.1097/SLA.0000000000006446

Postoperative Discharge Destination Impacts 30-Day Outcomes: A National Surgical Quality Improvement Program Multi-Specialty Surgical Cohort Analysis
Riveros, C, Ranganathan, S, Shah, YB, Huang, E, Xu, J, Geng, M, Melchiode, Z, Hu, S, Miles, BJ, Esnaola, N, Kaushik, D, Jerath, A, Wallis, CJD & Satkunasivam, R 2023, , Journal of Clinical Medicine, vol. 12, no. 21, 6784. https://doi.org/10.3390/jcm12216784

Morbidity and mortality of multivisceral resection with radical nephrectomy for locally advanced renal cell carcinoma: An analysis of the National Surgical Quality Improvement Program (NSQIP) database
Lim, K, Riveros, C, Ranganathan, S, Xu, J, Patel, A, Slawin, J, Ordonez, A, Aghazadeh, M, Morgan, M, Miles, BJ, Esnaola, N, Klaassen, Z, Allenson, K, Brooks, M, Wallis, CJD & Satkunasivam, R 2023, , Urologic Oncology: Seminars and Original Investigations. https://doi.org/10.1016/j.urolonc.2023.01.003

Morbidity and mortality of multivisceral resection with radical nephrectomy for locally advanced renal cell carcinoma: An analysis of the National Surgical Quality Improvement Program (NSQIP) database
Lim, K, Riveros, C, Ranganathan, S, Xu, J, Patel, A, Slawin, J, Ordonez, A, Aghazadeh, M, Morgan, M, Miles, BJ, Esnaola, N, Klaassen, Z, Allenson, K, Brooks, M, Wallis, CJD & Satkunasivam, R 2023, , Urologic Oncology: Seminars and Original Investigations, vol. 41, no. 4, pp. 209.e1-209.e9. https://doi.org/10.1016/j.urolonc.2023.01.003

Glomerular hyperfiltration is an independent predictor of postoperative outcomes: A NSQIP multi-specialty surgical cohort analysis
Riveros, C, Ranganathan, S, Huang, E, Ordonez, A, Xu, J, Geng, M, Miles, BJ, Esnaola, N, Klaassen, Z, Jerath, A, Kim, SJ, Wallis, CJD & Satkunasivam, R 2023, , Nephrology, vol. 28, no. 10, pp. 548-556. https://doi.org/10.1111/nep.14221

Comparative molecular profiling of pancreatic ductal adenocarcinoma of the head versus body/tail reveals differences in the tumor immune microenvironment (time)
Weinberg, B, Abdelrahim, M, Esmail, A, Kasi, A, Esnaola, NF, Xiu, JJ & Baca, Y 2023, , Research square. https://doi.org/10.21203/rs.3.rs-3317962/v1

Transition to Value-based Healthcare: Development, Implementation, and Results of an Optimal Surgical Care Framework at a National Cancer Institute–designated Comprehensive Cancer Center
Lee, RA, Masic, S, Bland, J, Handorf, E, Kutikov, A, Esnaola, N, Farma, J, Su, S, Ridge, JA, Chu, C, Patel, S, Curcillo, P, Helstrom, JL & Uzzo, RG 2024, , European Urology Focus, vol. 10, no. 1, pp. 123-130. https://doi.org/10.1016/j.euf.2023.08.003

The Association between Serum Albumin and Post-Operative Outcomes among Patients Undergoing Common Surgical Procedures: An Analysis of a Multi-Specialty Surgical Cohort from the National Surgical Quality Improvement Program (NSQIP)
Nipper, CA, Lim, K, Riveros, C, Hsu, E, Ranganathan, S, Xu, J, Brooks, M, Esnaola, N, Klaassen, Z, Jerath, A, Arrington, A, Wallis, CJD & Satkunasivam, R 2022, , Journal of Clinical Medicine, vol. 11, no. 21, 6543. https://doi.org/10.3390/jcm11216543

Association between isolated abnormal coagulation profile on transfusion following major surgery: A NSQIP analysis of individuals without bleeding disorders
Lim, K, Satkunasivam, R, Nipper, C, Xu, J, Hsu, E, Slawin, JR, Roy, T, Allenson, KC, Kim, MP, Barber, SM, Ellis, T, Akinsola, O, Klaassen, Z, Esnaola, N, Ravi, B, Jerath, A & Wallis, CJD 2022, , Transfusion, vol. 62, no. 11, pp. 2223-2234. https://doi.org/10.1111/trf.17146

De-Escalating the Management of In Situ and Invasive Breast Cancer
Angarita, FA, Brumer, R, Castelo, M, Esnaola, NF, Edge, SB & Takabe, K 2022, , Cancers, vol. 14, no. 19, 4545. https://doi.org/10.3390/cancers14194545

A phase II clinical trial of neoadjuvant sasanlimab and stereotactic body radiation therapy as an in situ vaccine for cisplatin-ineligible MIBC: The RAD VACCINE MIBC trial
Satkunasivam, R, Lim, K, Teh, BS, Guzman, J, Zhang, J, Farach, A, Chen, SH, Wallis, CJD, Efstathiou, E, Esnaola, NF & Sonpavde, GP 2022, , Future Oncology, vol. 18, no. 25, pp. 2771-2781. https://doi.org/10.2217/fon-2022-0380

Association between isolated abnormal coagulation profile on transfusion following major surgery: A NSQIP analysis of individuals without bleeding disorders
Lim, K, Satkunasivam, R, Nipper, C, Xu, J, Hsu, E, Slawin, JR, Roy, T, Allenson, KC, Kim, MP, Barber, SM, Ellis, T, Akinsola, O, Klaassen, Z, Esnaola, N, Ravi, B, Jerath, A & Wallis, CJD 2022, , Transfusion, vol. 62, no. 11, pp. 2223-2234. https://doi.org/10.1111/trf.17146

Early prediction of clinical response to checkpoint inhibitor therapy in human solid tumors through mathematical modeling
Butner, JD, Martin, GV, Wang, Z, Corradetti, B, Ferrari, M, Esnaola, N, Chung, C, Hong, DS, Welsh, JW, Hasegawa, N, Mittendorf, EA, Curley, SA, Chen, SH, Pan, PY, Libutti, SK, Ganesan, S, Sidman, RL, Pasqualini, R, Arap, W, Koay, EJ & Cristini, V 2021, , eLife, vol. 10, e70130. https://doi.org/10.7554/eLife.70130, https://doi.org/10.7554/eLife.70130

Early prediction of clinical response to checkpoint inhibitor therapy in human solid tumors through mathematical modeling
Butner, JD, Martin, GV, Wang, Z, Corradetti, B, Ferrari, M, Esnaola, N, Chung, C, Hong, DS, Welsh, JW, Hasegawa, N, Mittendorf, EA, Curley, SA, Chen, SH, Pan, PY, Libutti, SK, Ganesan, S, Sidman, RL, Pasqualini, R, Arap, W, Koay, EJ & Cristini, V 2021, , eLife, vol. 10, e70130. https://doi.org/10.7554/eLife.70130

Obesity affects outcomes of pancreatoduodenectomy
Zorbas, KA, Wu, J, Reddy, SS, Esnaola, NF & Karachristos, A 2021, , Pancreatology, vol. 21, no. 4, pp. 824-832. https://doi.org/10.1016/j.pan.2021.02.019

Atherosclerotic Cardiovascular Disease, Cancer, and Financial Toxicity Among Adults in the United States
Valero-Elizondo, J, Chouairi, F, Khera, R, Grandhi, GR, Saxena, A, Warraich, HJ, Virani, SS, Desai, NR, Sasangohar, F, Krumholz, HM, Esnaola, NF & Nasir, K 2021, , JACC: CardioOncology, vol. 3, no. 2, pp. 236-246. https://doi.org/10.1016/j.jaccao.2021.02.006

Atherosclerotic Cardiovascular Disease, Cancer, and Financial Toxicity Among Adults in the United States
Valero-Elizondo, J, Chouairi, F, Khera, R, Grandhi, GR, Saxena, A, Warraich, HJ, Virani, SS, Desai, NR, Sasangohar, F, Krumholz, HM, Esnaola, NF & Nasir, K 2021, , JACC: CardioOncology, vol. 3, no. 2, pp. 236-246. https://doi.org/10.1016/j.jaccao.2021.02.006

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