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Francesca Taraballi, PhD

Assistant Professor of Orthopedic Surgery, Academic Institute
Assistant Member, Research Institute
Director, Center for Musculoskeletal Regeneration
Houston Methodist


Taraballi Lab


ftaraballi2@houstonmethodist.org
Biography

Dr. Taraballi earned her B.S. in Biological Sciences and her M.S. in Biochemistry at University of Milan - Bicocca, Italy. After another M.S. in Structural Biochemistry, she earned her Ph.D. in Nanostructures and Nanotechnologies from a joint program of the Materials Science Department of University of Milan - Bicocca with the Lawrence National Berkeley Laboratory (LBNL) in 2009.

Dr. Taraballi is currently an Assistant Professor at the Center for Musculoskeletal Regeneration at Houston Methodist Research Institute affiliated to the Department of Orthopedics and Sports Medicine at Houston Methodist Hospital. Dr. Taraballi's research is focused on the development of smart biomaterials, both injectable and implantable, to target the immune system toward tissue restoration. Her main research area of interest is to develop new therapies and devices for articular cartilage repair.

Description of Research

  • Materials fabrication and functionalization to promote cells' survival and differentiation in cartilage repair
  • Materials fabrication and functionalization to enhance immunemodulatories capabilities of mesenchymal stem cells from different sources
  • Development of smart biomaterials to tune the immune system
  • Synthesis and functionalization of micro and nanoparticles for immunemodulation
  • Synthesis and functionalization of nanoparticles for targeted cancer drug delivery

Publications

Mimicking cardiac tissue complexity through physical cues: A review on cardiac tissue engineering approaches
Hendrickson, T, Mancino, C, Whitney, L, Tsao, C, Rahimi, M & Taraballi, F 2021, , Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 33, 102367. https://doi.org/10.1016/j.nano.2021.102367

Biomimetic nano drug delivery carriers for treating cardiovascular diseases
Zinger, A, Cooke, JP & Taraballi, F 2021, , Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 33, pp. 102360. https://doi.org/10.1016/j.nano.2021.102360

Improving the immunosuppressive potential of articular chondroprogenitors in a three-dimensional culture setting
Bauza, G, Pasto, A, Mcculloch, P, Lintner, D, Brozovich, A, Niclot, FB, Khan, I, Francis, LW, Tasciotti, E & Taraballi, F 2020, , Scientific Reports, vol. 10, no. 1, 16610. https://doi.org/10.1038/s41598-020-73188-9

Biomimetic Nanoparticles Potentiate the Anti-Inflammatory Properties of Dexamethasone and Reduce the Cytokine Storm Syndrome: An Additional Weapon against COVID-19?
Molinaro, R, Pasto, A, Taraballi, F, Giordano, F, Azzi, JA, Tasciotti, E & Corbo, C 2020, , Nanomaterials, vol. 10, no. 11, 2301, pp. 1-12. https://doi.org/10.3390/nano10112301

Bioinspired extracellular vesicles: Lessons learned from nature for biomedicine and bioengineering
Zinger, A, Brozovich, A, Pasto, A, Sushnitha, M, Martinez, JO, Evangelopoulos, M, Boada, C, Tasciotti, E & Taraballi, F 2020, , Nanomaterials, vol. 10, no. 11, 2172, pp. 1-23. https://doi.org/10.3390/nano10112172

Bioinspired Extracellular Vesicles: Lessons Learned From Nature for Biomedicine and Bioengineering
Taraballi, F 2020, , Nanomaterials. https://doi.org/doi:10.3390/nano10112172

Reproducible and Characterized Method for Ponatinib Encapsulation into Biomimetic Lipid Nanoparticles as a Platform for Multi-Tyrosine Kinase-Targeted Therapy
Taraballi, F 2020, , ACS Applied Bio Materials. https://doi.org/10.1021/acsabm.0c00685

Mesenchymal Stromal Cell-Mediated Treatment of Local and Systemic Inflammation through the Triggering of an Anti-Inflammatory Response
Taraballi, F 2020, , Advanced Functional Materials. https://doi.org/10.1002/adfm.202002997

Endosomal Escape of Polymer-Coated Silica Nanoparticles in Endothelial Cells
Parodi, A, Evangelopoulos, M, Arrighetti, N, Cevenini, A, Livingston, M, Khaled, SZ, Brown, BS, Yazdi, IK, Paradiso, F, Campa-Carranza, JN, De Vita, A, Taraballi, F & Tasciotti, E 2020, , Small, vol. 16, no. 36, 1907693. https://doi.org/10.1002/smll.201907693

Reproducible and Characterized Method for Ponatinib Encapsulation into Biomimetic Lipid Nanoparticles as a Platform for Multi-Tyrosine Kinase-Targeted Therapy: ACS Applied Bio Materials
Zinger, A, Baudo, G, Naoi, T, Giordano, F, Lenna, S, Massaro, M, Ewing, A, Kim, HR, Tasciotti, E, Yustein, JT & Taraballi, F 2020, , ACS Appl. Bio Mater., vol. 3, no. 10, pp. 6737-6745. https://doi.org/10.1021/acsabm.0c00685

Mimicking the Organic and Inorganic Composition of Anabolic Bone Enhances Human Mesenchymal Stem Cell Osteoinduction and Scaffold Mechanical Properties
Mondragón, E, Cowdin, M, Taraballi, F, Minardi, S, Tasciotti, E, Gregory, CA & Kaunas, R 2020, , Frontiers in Bioengineering and Biotechnology, vol. 8, 753. https://doi.org/10.3389/fbioe.2020.00753

Cell Membrane-Based Biomimetic Nanoparticles and the Immune System: Immunomodulatory Interactions to Therapeutic Applications
Sushnitha, M, Evangelopoulos, M, Tasciotti, E & Taraballi, F 2020, , Frontiers in Bioengineering and Biotechnology, vol. 8, 627. https://doi.org/10.3389/fbioe.2020.00627

Electrospun anti-inflammatory patch loaded with essential oils for wound healing
García-Salinas, S, Evangelopoulos, M, Gámez-Herrera, E, Arruebo, M, Irusta, S, Taraballi, F, Mendoza, G & Tasciotti, E 2020, , International Journal of Pharmaceutics, vol. 577, 119067. https://doi.org/10.1016/j.ijpharm.2020.119067

Acute physiologic effects of performing yoga in the heat on energy expenditure, range of motion, and inflammatory biomarkers
Lambert, BS, Miller, KE, Delgado, DA, Chaliki, K, Lee, J, Bauza, G, Taraballi, F, Dong, D, Tasciotti, E, Harris, JD & McCulloch, P 2020, , International Journal of Exercise Science, vol. 13, no. 3, pp. 802-817.

Enhanced In Vivo Vascularization of 3D-Printed Cell Encapsulation Device Using Platelet-Rich Plasma and Mesenchymal Stem Cells
Paez-Mayorga, J, Capuani, S, Farina, M, Lotito, ML, Niles, JA, Salazar, HF, Rhudy, J, Esnaola, L, Chua, CYX, Taraballi, F, Corradetti, B, Shelton, KA, Nehete, PN, Nichols, JE & Grattoni, A 2020, , Advanced Healthcare Materials, vol. 9, no. 19, 2000670. https://doi.org/10.1002/adhm.202000670

Mesenchymal Stromal Cell-Mediated Treatment of Local and Systemic Inflammation through the Triggering of an Anti-Inflammatory Response
Martinez, JO, Evangelopoulos, M, Brozovich, AA, Bauza, G, Molinaro, R, Corbo, C, Liu, X, Taraballi, F & Tasciotti, E 2020, , Advanced Functional Materials, vol. 31, no. 3, 2002997. https://doi.org/10.1002/adfm.202002997

Cell Encapsulation: Enhanced In Vivo Vascularization of 3D-Printed Cell Encapsulation Device Using Platelet-Rich Plasma and Mesenchymal Stem Cells (Adv. Healthcare Mater. 19/2020)
Paez-Mayorga, J, Capuani, S, Farina, M, Lotito, ML, Niles, JA, Salazar, HF, Rhudy, J, Esnaola, L, Chua, CYX, Taraballi, F, Corradetti, B, Shelton, KA, Nehete, PN, Nichols, JE & Grattoni, A 2020, , Advanced Healthcare Materials, vol. 9, no. 19. https://doi.org/10.1002/adhm.202070071

Marine Collagen Substrates for 2D and 3D Ovarian Cancer Cell Systems
Paradiso, F, Fitzgerald, J, Yao, S, Barry, F, Taraballi, F, Gonzalez, D, Conlan, RS & Francis, L 2019, , Frontiers in Bioengineering and Biotechnology, vol. 7. https://doi.org/10.3389/fbioe.2019.00343

Macrophage-derived nanovesicles exert intrinsic anti-inflammatory properties and prolong survival in sepsis through a direct interaction with macrophages
Molinaro, R, Pastò, A, Corbo, C, Taraballi, F, Giordano, F, Martinez, JO, Zhao, P, Wang, X, Zinger, A, Boada, C, Hartman, KA & Tasciotti, E 2019, , Nanoscale, vol. 11, no. 28, pp. 13576-13586. https://doi.org/10.1039/c9nr04253a

Helix-A peptide prevents gp120-mediated neuronal loss
Avdoshina, V, Taraballi, F, Tasciotti, E, Üren, A & Mocchetti, I 2019, , Molecular Brain, vol. 12, no. 1, 61. https://doi.org/10.1186/s13041-019-0482-z