Francesca Taraballi

Francesca Taraballi, PhD

Assistant Professor of Orthopedic Surgery, Academic Institute
Assistant Member, Research Institute
Director, Center for Musculoskeletal Regeneration
Houston Methodist

Taraballi Lab

Dr. Taraballi earned her B.S. in Biological Sciences and her M.S. in Biochemistry at University of Milan - Bicocca, Italy. After another M.S. in Structural Biochemistry, she earned her Ph.D. in Nanostructures and Nanotechnologies from a joint program of the Materials Science Department of University of Milan - Bicocca with the Lawrence National Berkeley Laboratory (LBNL) in 2009.

Dr. Taraballi is currently an Assistant Professor at the Center for Musculoskeletal Regeneration at Houston Methodist Research Institute affiliated to the Department of Orthopedics and Sports Medicine at Houston Methodist Hospital. Dr. Taraballi's research is focused on the development of smart biomaterials, both injectable and implantable, to target the immune system toward tissue restoration. Her main research area of interest is to develop new therapies and devices for articular cartilage repair.

Description of Research

  • Materials fabrication and functionalization to promote cells' survival and differentiation in cartilage repair
  • Materials fabrication and functionalization to enhance immunemodulatories capabilities of mesenchymal stem cells from different sources
  • Development of smart biomaterials to tune the immune system
  • Synthesis and functionalization of micro and nanoparticles for immunemodulation
  • Synthesis and functionalization of nanoparticles for targeted cancer drug delivery


Lysyl oxidase engineered lipid nanovesicles for the treatment of triple negative breast cancer
De Vita, A, Liverani, C, Molinaro, R, Martinez, JO, Hartman, KA, Spadazzi, C, Miserocchi, G, Taraballi, F, Evangelopoulos, M, Pieri, F, Bongiovanni, A, Mercatali, L, Tasciotti, E & Ibrahim, T 2021, , Scientific Reports, vol. 11, no. 1, 5107.

Long Non-coding RNAs and MicroRNAs Interplay in Osteogenic Differentiation of Mesenchymal Stem Cells
Lanzillotti, C, De Mattei, M, Mazziotta, C, Taraballi, F, Rotondo, JC, Tognon, M & Martini, F 2021, , Frontiers in Cell and Developmental Biology, vol. 9, 646032.

Mimicking cardiac tissue complexity through physical cues: A review on cardiac tissue engineering approaches
Hendrickson, T, Mancino, C, Whitney, L, Tsao, C, Rahimi, M & Taraballi, F 2021, , Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 33, 102367.

The Limitless Future of RNA Therapeutics
Damase, TR, Sukhovershin, R, Boada, C, Taraballi, F, Pettigrew, RI & Cooke, JP 2021, , Frontiers in Bioengineering and Biotechnology, vol. 9, 628137.

Enhancing Inflammation Targeting Using Tunable Leukocyte-Based Biomimetic Nanoparticles
Zinger, A, Sushnitha, M, Naoi, T, Baudo, G, De Rosa, E, Chang, J, Tasciotti, E & Taraballi, F 2021, , ACS Nano.

Micrornas modulate signaling pathways in osteogenic differentiation of mesenchymal stem cells
Mazziotta, C, Lanzillotti, C, Iaquinta, MR, Taraballi, F, Torreggiani, E, Rotondo, JC, Otòn-Gonzalez, L, Mazzoni, E, Frontini, F, Bononi, I, De Mattei, M, Tognon, M & Martini, F 2021, , International journal of molecular sciences, vol. 22, no. 5, 2362, pp. 1-21.

Biomimetic nano drug delivery carriers for treating cardiovascular diseases
Zinger, A, Cooke, JP & Taraballi, F 2021, , Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 33, pp. 102360.

Biomimetic Nanoparticles as a Theranostic Tool for Traumatic Brain Injury
Zinger, A, Soriano, S, Baudo, G, De Rosa, E, Taraballi, F & Villapol, S 2021, , Advanced Functional Materials.

Improving the immunosuppressive potential of articular chondroprogenitors in a three-dimensional culture setting
Bauza, G, Pasto, A, Mcculloch, P, Lintner, D, Brozovich, A, Niclot, FB, Khan, I, Francis, LW, Tasciotti, E & Taraballi, F 2020, , Scientific Reports, vol. 10, no. 1, 16610.

Biomimetic Nanoparticles Potentiate the Anti-Inflammatory Properties of Dexamethasone and Reduce the Cytokine Storm Syndrome: An Additional Weapon against COVID-19?
Molinaro, R, Pasto, A, Taraballi, F, Giordano, F, Azzi, JA, Tasciotti, E & Corbo, C 2020, , Nanomaterials, vol. 10, no. 11, 2301, pp. 1-12.

Bioinspired extracellular vesicles: Lessons learned from nature for biomedicine and bioengineering
Zinger, A, Brozovich, A, Pasto, A, Sushnitha, M, Martinez, JO, Evangelopoulos, M, Boada, C, Tasciotti, E & Taraballi, F 2020, , Nanomaterials, vol. 10, no. 11, 2172, pp. 1-23.

Bioinspired Extracellular Vesicles: Lessons Learned From Nature for Biomedicine and Bioengineering
Taraballi, F 2020, , Nanomaterials.

Reproducible and Characterized Method for Ponatinib Encapsulation into Biomimetic Lipid Nanoparticles as a Platform for Multi-Tyrosine Kinase-Targeted Therapy
Taraballi, F 2020, , ACS Applied Bio Materials.

Mesenchymal Stromal Cell-Mediated Treatment of Local and Systemic Inflammation through the Triggering of an Anti-Inflammatory Response
Taraballi, F 2020, , Advanced Functional Materials.

Endosomal Escape of Polymer-Coated Silica Nanoparticles in Endothelial Cells
Parodi, A, Evangelopoulos, M, Arrighetti, N, Cevenini, A, Livingston, M, Khaled, SZ, Brown, BS, Yazdi, IK, Paradiso, F, Campa-Carranza, JN, De Vita, A, Taraballi, F & Tasciotti, E 2020, , Small, vol. 16, no. 36, 1907693.

Reproducible and Characterized Method for Ponatinib Encapsulation into Biomimetic Lipid Nanoparticles as a Platform for Multi-Tyrosine Kinase-Targeted Therapy: ACS Applied Bio Materials
Zinger, A, Baudo, G, Naoi, T, Giordano, F, Lenna, S, Massaro, M, Ewing, A, Kim, HR, Tasciotti, E, Yustein, JT & Taraballi, F 2020, , ACS Appl. Bio Mater., vol. 3, no. 10, pp. 6737-6745.

Mimicking the Organic and Inorganic Composition of Anabolic Bone Enhances Human Mesenchymal Stem Cell Osteoinduction and Scaffold Mechanical Properties
Mondragón, E, Cowdin, M, Taraballi, F, Minardi, S, Tasciotti, E, Gregory, CA & Kaunas, R 2020, , Frontiers in Bioengineering and Biotechnology, vol. 8, 753.

Cell Membrane-Based Biomimetic Nanoparticles and the Immune System: Immunomodulatory Interactions to Therapeutic Applications
Sushnitha, M, Evangelopoulos, M, Tasciotti, E & Taraballi, F 2020, , Frontiers in Bioengineering and Biotechnology, vol. 8, 627.

Electrospun anti-inflammatory patch loaded with essential oils for wound healing
García-Salinas, S, Evangelopoulos, M, Gámez-Herrera, E, Arruebo, M, Irusta, S, Taraballi, F, Mendoza, G & Tasciotti, E 2020, , International Journal of Pharmaceutics, vol. 577, 119067.

Acute physiologic effects of performing yoga in the heat on energy expenditure, range of motion, and inflammatory biomarkers
Lambert, BS, Miller, KE, Delgado, DA, Chaliki, K, Lee, J, Bauza, G, Taraballi, F, Dong, D, Tasciotti, E, Harris, JD & McCulloch, P 2020, , International Journal of Exercise Science, vol. 13, no. 3, pp. 802-817.