Francesca Taraballi

Francesca Taraballi, PhD

Assistant Professor of Orthopedic Surgery, Academic Institute
Assistant Member, Research Institute
Director, Center for Musculoskeletal Regeneration
Houston Methodist


Taraballi Lab


ftaraballi2@houstonmethodist.org
Biography

Dr. Taraballi earned her B.S. in Biological Sciences and her M.S. in Biochemistry at University of Milan - Bicocca, Italy. After another M.S. in Structural Biochemistry, she earned her Ph.D. in Nanostructures and Nanotechnologies from a joint program of the Materials Science Department of University of Milan - Bicocca with the Lawrence National Berkeley Laboratory (LBNL) in 2009.

Dr. Taraballi is currently an Assistant Professor at the Center for Musculoskeletal Regeneration at Houston Methodist Research Institute affiliated to the Department of Orthopedics and Sports Medicine at Houston Methodist Hospital. Dr. Taraballi's research is focused on the development of smart biomaterials, both injectable and implantable, to target the immune system toward tissue restoration. Her main research area of interest is to develop new therapies and devices for articular cartilage repair.

Description of Research

  • Materials fabrication and functionalization to promote cells' survival and differentiation in cartilage repair
  • Materials fabrication and functionalization to enhance immunemodulatories capabilities of mesenchymal stem cells from different sources
  • Development of smart biomaterials to tune the immune system
  • Synthesis and functionalization of micro and nanoparticles for immunemodulation
  • Synthesis and functionalization of nanoparticles for targeted cancer drug delivery

Publications

Electrospun electroconductive constructs of aligned fibers for cardiac tissue engineering
Mancino, C, Hendrickson, T, Whitney, LV, Paradiso, F, Abasi, S, Tasciotti, E, Taraballi, F & Guiseppi-Elie, A 2022, , Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 44, 102567. https://doi.org/10.1016/j.nano.2022.102567

Biomimetic Collagen Membranes Functionalized with mRNA-loaded Lipid Nanoparticles for Fibroblast Transdifferentiation to Endothelial Cells
Villarreal-Leal, RA, Williams, ME, Taraballi, F, Cooke, JP & Corradetti, B 2022, , FASEB journal : official publication of the Federation of American Societies for Experimental Biology, vol. 36. https://doi.org/10.1096/fasebj.2022.36.S1.L7813

Mechanomimetic 3D Scaffolds as a Humanized In Vitro Model for Ovarian Cancer
Paradiso, F, Lenna, S, Gazze, SA, Parra, JG, Murphy, K, Margarit, L, Gonzalez, D, Francis, L & Taraballi, F 2022, , Cells, vol. 11, no. 5, 824. https://doi.org/10.3390/cells11050824

Thermally responsive hydrogel for atrial fibrillation related stroke prevention
Hendrickson, T, Lupo, C, Bauza, G, Tavares, L, Ingram, S, Wang, S, Moreno, M, Tasciotti, E, Valderrabano, M & Taraballi, F 2022, , Materials Today Bio, vol. 14, 100240. https://doi.org/10.1016/j.mtbio.2022.100240

Vascular Graft Infections: An Overview of Novel Treatments Using Nanoparticles and Nanofibers
He, E, Serpelloni, S, Alvear, P, Rahimi, M & Taraballi, F 2022, , Fibers, vol. 10, no. 2, 12. https://doi.org/10.3390/fib10020012

Studying Activated Fibroblast Phenotypes and Fibrosis-Linked Mechanosensing Using 3D Biomimetic Models
Paradiso, F, Quintela, M, Lenna, S, Serpelloni, S, James, D, Caserta, S, Conlan, S, Francis, L & Taraballi, F 2022, , Macromolecular Bioscience. https://doi.org/10.1002/mabi.202100450

Intraosseous Morphine Decreases Postoperative Pain and Pain Medication Use in Total Knee Arthroplasty: A Double-Blind, Randomized Controlled Trial
Brozovich, AA, Incavo, SJ, Lambert, BS, Sullivan, TC, Wininger, AE, Clyburn, TA, Taraballi, F & Park, KJ 2022, , Journal of Arthroplasty. https://doi.org/10.1016/j.arth.2021.10.009

Evaluation of local tissue peri-implant reaction in total knee arthroplasty failure cases
Brozovich, A, Clyburn, T, Park, K, Harper, KD, Sullivan, T, Incavo, S & Taraballi, F 2022, , Therapeutic Advances in Musculoskeletal Disease, vol. 14. https://doi.org/10.1177/1759720X221092263

High Variability of Mesenchymal Stem Cells Obtained via Bone Marrow Aspirate Concentrate Compared With Traditional Bone Marrow Aspiration Technique
Brozovich, A, Sinicrope, BJ, Bauza, G, Niclot, FB, Lintner, D, Taraballi, F & McCulloch, PC 2021, , Orthopaedic Journal of Sports Medicine, vol. 9, no. 12. https://doi.org/10.1177/23259671211058459

A CNN-based method to reconstruct 3-D spine surfaces from US images in vivo
Tang, S, Yang, X, Shajudeen, P, Sears, C, Taraballi, F, Weiner, B, Tasciotti, E, Dollahon, D, Park, H & Righetti, R 2021, , Medical Image Analysis, vol. 74, 102221. https://doi.org/10.1016/j.media.2021.102221

LDL-Based Lipid Nanoparticle Derived for Blood Plasma Accumulates Preferentially in Atherosclerotic Plaque
Boada, CA, Zinger, A, Rohen, S, Martinez, JO, Evangelopoulos, M, Molinaro, R, Lu, M, Villarreal-Leal, RA, Giordano, F, Sushnitha, M, De Rosa, E, Simonsen, JB, Shevkoplyas, S, Taraballi, F & Tasciotti, E 2021, , Frontiers in Bioengineering and Biotechnology, vol. 9, 794676. https://doi.org/10.3389/fbioe.2021.794676

Polyester Mesh Functionalization with Nitric Oxide-Releasing Silica Nanoparticles Reduces Early Methicillin-Resistant Staphylococcus aureus Contamination
Fernandez-Moure, JS, Van Eps, JL, Scherba, JC, Haddix, S, Livingston, M, Bryan, NS, Cantu, C, Valson, C, Taraballi, F, Kaplan, LJ, Olsen, R & Tasciotti, E 2021, , Surgical Infections, vol. 22, no. 9, pp. 910-922. https://doi.org/10.1089/sur.2020.288

Mechanical studies of the third dimension in cancer: From 2D to 3D model
Paradiso, F, Serpelloni, S, Francis, LW & Taraballi, F 2021, , International journal of molecular sciences, vol. 22, no. 18, 10098. https://doi.org/10.3390/ijms221810098

Improved Posterolateral Lumbar Spinal Fusion Using a Biomimetic, Nanocomposite Scaffold Augmented by Autologous Platelet-Rich Plasma
Van Eps, JL, Fernandez-Moure, JS, Cabrera, FJ, Taraballi, F, Paradiso, F, Minardi, S, Wang, X, Aghdasi, B, Tasciotti, E & Weiner, BK 2021, , Frontiers in Bioengineering and Biotechnology, vol. 9, 622099. https://doi.org/10.3389/fbioe.2021.622099

Biomimetic Nanoparticles as a Theranostic Tool for Traumatic Brain Injury
Zinger, A, Soriano, S, Baudo, G, De Rosa, E, Taraballi, F & Villapol, S 2021, , Advanced Functional Materials, vol. 31, no. 30, pp. 2100722. https://doi.org/10.1002/adfm.202100722

Long Non-coding RNAs and MicroRNAs Interplay in Osteogenic Differentiation of Mesenchymal Stem Cells
Lanzillotti, C, De Mattei, M, Mazziotta, C, Taraballi, F, Rotondo, JC, Tognon, M & Martini, F 2021, , Frontiers in Cell and Developmental Biology, vol. 9, 646032, pp. 646032. https://doi.org/10.3389/fcell.2021.646032

Mimicking cardiac tissue complexity through physical cues: A review on cardiac tissue engineering approaches
Hendrickson, T, Mancino, C, Whitney, L, Tsao, C, Rahimi, M & Taraballi, F 2021, , Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 33, 102367, pp. 102367. https://doi.org/10.1016/j.nano.2021.102367

The Limitless Future of RNA Therapeutics
Damase, TR, Sukhovershin, R, Boada, C, Taraballi, F, Pettigrew, RI & Cooke, JP 2021, , Frontiers in Bioengineering and Biotechnology, vol. 9, 628137. https://doi.org/10.3389/fbioe.2021.628137

Enhancing Inflammation Targeting Using Tunable Leukocyte-Based Biomimetic Nanoparticles
Zinger, A, Sushnitha, M, Naoi, T, Baudo, G, De Rosa, E, Chang, J, Tasciotti, E & Taraballi, F 2021, , ACS Nano, vol. 15, no. 4, pp. 6326-6339. https://doi.org/10.1021/acsnano.0c05792

Lysyl oxidase engineered lipid nanovesicles for the treatment of triple negative breast cancer
De Vita, A, Liverani, C, Molinaro, R, Martinez, JO, Hartman, KA, Spadazzi, C, Miserocchi, G, Taraballi, F, Evangelopoulos, M, Pieri, F, Bongiovanni, A, Mercatali, L, Tasciotti, E & Ibrahim, T 2021, , Scientific Reports, vol. 11, no. 1, 5107, pp. 5107. https://doi.org/10.1038/s41598-021-84492-3