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Francesca Taraballi, PhD

Assistant Professor of Orthopedic Surgery, Institute for Academic Medicine
Assistant Member, Research Institute
Houston Methodist


ftaraballi2@houstonmethodist.org
Biography

Dr. Taraballi earned her B.S. in Biological Sciences and her M.S. in Biochemistry at University of Milan - Bicocca, Italy. After another M.S. in Structural Biochemistry, she earned her Ph.D. in Nanostructures and Nanotechnologies from a joint program of the Materials Science Department of University of Milan - Bicocca with the Lawrence National Berkeley Laboratory (LBNL) in 2009.

Dr. Taraballi is currently an Assistant Professor at the Center for Musculoskeletal Regeneration at Houston Methodist Research Institute affiliated to the Department of Orthopedics and Sports Medicine at Houston Methodist Hospital. Dr. Taraballi's research is focused on the development of smart biomaterials, both injectable and implantable, to target the immune system toward tissue restoration. Her main research area of interest is to develop new therapies and devices for articular cartilage repair.

Description of Research

  • Materials fabrication and functionalization to promote cells' survival and differentiation in cartilage repair
  • Materials fabrication and functionalization to enhance immunemodulatories capabilities of mesenchymal stem cells from different sources
  • Development of smart biomaterials to tune the immune system
  • Synthesis and functionalization of micro and nanoparticles for immunemodulation
  • Synthesis and functionalization of nanoparticles for targeted cancer drug delivery

Publications

Macrophage-derived nanovesicles exert intrinsic anti-inflammatory properties and prolong survival in sepsis through a direct interaction with macrophages
Molinaro, R, Pastò, A, Corbo, C, Taraballi, F, Giordano, F, Martinez, JO, Zhao, P, Wang, X, Zinger, A, Boada, C, Hartman, KA & Tasciotti, E 2019, Nanoscale, vol. 11, no. 28, pp. 13576-13586. https://doi.org/10.1039/c9nr04253a

Helix-A peptide prevents gp120-mediated neuronal loss
Avdoshina, V, Taraballi, F, Tasciotti, E, Üren, A & Mocchetti, I 2019, Molecular Brain, vol. 12, no. 1, 61. https://doi.org/10.1186/s13041-019-0482-z

Immunomodulatory potential of mesenchymal stem cell role in diseases and therapies: A bioengineering prospective
Taraballi, F 2019, Journal of Immunology and Regenerative Medicine.

Biomimetic hydroxyapatite/collagen composite drives bone niche recapitulation in a rabbit orthotopic model
Taraballi, F 2019, Materials Today Bio.

Targeting infiltrating immune cells to improve articular cartilage regeneration
Taraballi, F, Bauza, G, Francis, L, Zhang, A, Hopson, M, Shaikh, S, Cabrera, F, Wang, X, Shi, A, Hamilton, DJ, McCulloch, P & Tasciotti, E 2019, . in Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. vol. 40, Society for Biomaterials, 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence, Seattle, United States, 4/3/19.

Marine collagen substrates for 2D and 3D ovarian cancer cell systems.
Taraballi, F 2019, Front Bioeng Biotechnol.

Thermosensitive Hydrogel Sealing of the Left Atrial Appendage to Prevent Thromboembolism in Atrial Fibrillation".
Taraballi, F 2019, , Patent No. 62/935,084 .

Biomimicry in 3D Nanomaterial Design: Implications for Regenerative Medicine
Taraballi, F 2019, Front Bioeng Biotechnol.

Cell-Instructive Microenvironment to Direct Stem Cell Fate
Taraballi, F 2019, Stem Cell International.

Electrospun Patch Functionalized with Nanoparticles Allows for Spatiotemporal Release of VEGF and PDGF-BB Promoting in Vivo Neovascularization
Tsao, CJ, Pandolfi, L, Wang, X, Minardi, S, Lupo, C, Evangelopoulos, M, Hendrickson, T, Shi, A, Storci, G, Taraballi, F & Tasciotti, E 2018, ACS Applied Materials and Interfaces, vol. 10, no. 51, pp. 44344-44353. https://doi.org/10.1021/acsami.8b19975

Controlled release of small molecules for cardiac differentiation of pluripotent stem cells
Tsao, C, Taraballi, F, Pandolfi, L, Velasquez-Mao, AJ, Ruano, R, Tasciotti, E & Jacot, JG 2018, Tissue Engineering - Part A, vol. 24, no. 23-24, pp. 1798-1807. https://doi.org/10.1089/ten.TEA.2018.0054, https://doi.org/10.1089/ten.tea.2018.0054

Corrigendum: Heparan Sulfate: A Potential Candidate for the Development of Biomimetic Immunomodulatory Membranes
Corradetti, B, Taraballi, F, Giretti, I, Bauza, G, Pistillo, RS, Niclot, FB, Pandolfi, L, Demarchi, D & Tasciotti, E 2018, Frontiers in Bioengineering and Biotechnology, vol. 5, no. JAN, 86, pp. 86. https://doi.org/10.3389/fbioe.2017.00086

Biomimetic Tissue Engineering: Tuning the Immune and Inflammatory Response to Implantable Biomaterials
Taraballi, F, Sushnitha, M, Tsao, C, Bauza, G, Liverani, C, Shi, A & Tasciotti, E 2018, Advanced Healthcare Materials. https://doi.org/10.1002/adhm.201800490

Design and Development of Biomimetic Nanovesicles Using a Microfluidic Approach
Molinaro, R, Evangelopoulos, M, Hoffman, JR, Corbo, C, Taraballi, F, Martinez, JO, Hartman, KA, Cosco, D, Costa, G, Romeo, I, Sherman, M, Paolino, D, Alcaro, S & Tasciotti, E 2018, Advanced Materials. https://doi.org/10.1002/adma.201702749

Implantable drug delivery systems
Taraballi, F 2018, , Patent No. WO2017146819A1.

Immune tuning scaffold for the local induction of a pro-regenerative environment
Corradetti, B, Taraballi, F, Corbo, C, Cabrera, F, Pandolfi, L, Minardi, S, Wang, X, Van Eps, J, Bauza, G, Weiner, B & Tasciotti, E 2017, Scientific Reports, vol. 7, no. 1, 17030. https://doi.org/10.1038/s41598-017-16895-0

Hyaluronic acid coatings as a simple and efficient approach to improve MSC homing toward the site of inflammation
Corradetti, B, Taraballi, F, Martinez, JO, Minardi, S, Basu, N, Bauza, G, Evangelopoulos, M, Powell, S, Corbo, C & Tasciotti, E 2017, Scientific Reports, vol. 7, no. 1, 7991, pp. 7991. https://doi.org/10.1038/s41598-017-08687-3

Concise Review: Biomimetic Functionalization of Biomaterials to Stimulate the Endogenous Healing Process of Cartilage and Bone Tissue
Taraballi, F, Bauza, G, McCulloch, P, Harris, JD & Tasciotti, E 2017, Stem Cells Translational Medicine, vol. 6, no. 12, pp. 2186-2196. https://doi.org/10.1002/sctm.17-0181

Mesoporous silica nanoparticles trigger mitophagy in endothelial cells and perturb neuronal network activity in a size- and time-dependent manner
Orlando, A, Cazzaniga, EM, Tringali, M, Gullo, F, Becchetti, A, Minniti, S, Taraballi, F, Tasciotti, E & Re, F 2017, International journal of nanomedicine, vol. 12, pp. 3547-3559. https://doi.org/10.2147/IJN.S127663

Enhancing Vascularization through the Controlled Release of Platelet-Derived Growth Factor-BB
Minardi, S, Pandolfi, L, Taraballi, F, Wang, X, De Rosa, E, Mills, ZD, Liu, X, Ferrari, M & Tasciotti, E 2017, ACS Applied Materials and Interfaces, vol. 9, no. 17, pp. 14566-14575. https://doi.org/10.1021/acsami.6b13760

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