Francesca Taraballi

Francesca Taraballi, PhD

Assistant Professor of Orthopedic Surgery, Academic Institute
Assistant Member, Research Institute
Director, Center for Musculoskeletal Regeneration
Houston Methodist


Taraballi Lab


ftaraballi2@houstonmethodist.org
Biography

Dr. Taraballi earned her B.S. in Biological Sciences and her M.S. in Biochemistry at University of Milan - Bicocca, Italy. After another M.S. in Structural Biochemistry, she earned her Ph.D. in Nanostructures and Nanotechnologies from a joint program of the Materials Science Department of University of Milan - Bicocca with the Lawrence National Berkeley Laboratory (LBNL) in 2009.

Dr. Taraballi is currently an Assistant Professor at the Center for Musculoskeletal Regeneration at Houston Methodist Research Institute affiliated to the Department of Orthopedics and Sports Medicine at Houston Methodist Hospital. Dr. Taraballi's research is focused on the development of smart biomaterials, both injectable and implantable, to target the immune system toward tissue restoration. Her main research area of interest is to develop new therapies and devices for articular cartilage repair.

Description of Research

  • Materials fabrication and functionalization to promote cells' survival and differentiation in cartilage repair
  • Materials fabrication and functionalization to enhance immunemodulatories capabilities of mesenchymal stem cells from different sources
  • Development of smart biomaterials to tune the immune system
  • Synthesis and functionalization of micro and nanoparticles for immunemodulation
  • Synthesis and functionalization of nanoparticles for targeted cancer drug delivery

Patents

Thermosensitive Hydrogel Sealing of the Left Atrial Appendage to Prevent Thromboembolism in Atrial Fibrillation".

Patent Number: 62/935,084, Jan 01 2019


Implantable drug delivery systems

Patent Number: WO2017146819A1, Jan 01 2018

Publications

Mice deficient for G-protein-coupled receptor 75 display altered presynaptic structural protein expression and disrupted fear conditioning recall
Speidell, A, Walton, S, Campbell, LA, Tomassoni-Ardori, F, Tessarollo, L, Corbo, C, Taraballi, F & Mocchetti, I 2023, , Journal of Neurochemistry. https://doi.org/10.1111/jnc.15818

Tyrosine kinase inhibitor-loaded biomimetic nanoparticles as a treatment for osteosarcoma
Taraballi, F 2022, , Cancer Nanotechnology. https://doi.org/10.1186/s12645-022-00146-7

Tyrosine kinase inhibitor-loaded biomimetic nanoparticles as a treatment for osteosarcoma
Giordano, F, Lenna, S, Baudo, G, Rampado, R, Massaro, M, De Rosa, E, Ewing, A, Kurenbekova, L, Agostini, M, Yustein, JT & Taraballi, F 2022, , Cancer Nanotechnology, vol. 13, no. 1, 40. https://doi.org/10.1186/s12645-022-00146-7, https://doi.org/10.1186/s12645-022-00146-7

Tyrosine kinase inhibitor-loaded biomimetic nanoparticles as a treatment for osteosarcoma
Giordano, F, Lenna, S, Baudo, G, Rampado, R, Massaro, M, De Rosa, E, Ewing, A, Kurenbekova, L, Agostini, M, Yustein, JT & Taraballi, F 2022, , Cancer Nanotechnology, vol. 13, no. 1, 40. https://doi.org/10.1186/s12645-022-00146-7

Osteogenesis in the presence of chemotherapy: A biomimetic approach: Journal of Tissue Engineering
Brozovich, AA, Lenna, S, Paradiso, F, Serpelloni, S, McCulloch, P, Weiner, B, Yustein, JT & Taraballi, F 2022, , Journal of Tissue Engineering, vol. 13, pp. 20417314221138945. https://doi.org/10.1177/20417314221138945

Comparison Between Cancellous Trabecular and Cortical Specimens from Human Lumbar Spine Samples as an Alternative Source of Mesenchymal Stromal Cells
Lenna, S, Brozovich, A, Hirase, T, Paradiso, F, Weiner, BK & Taraballi, F 2022, , Stem Cells and Development, vol. 31, no. 21-22, pp. 672-683. https://doi.org/10.1089/scd.2022.0157

Comparison Between Cancellous Trabecular and Cortical Specimens from Human Lumbar Spine Samples as an Alternative Source of Mesenchymal Stromal Cells
Lenna, S, Brozovich, A, Hirase, T, Paradiso, F, Weiner, BK & Taraballi, F 2022, , Stem Cells and Development, vol. 31, no. 21-22, pp. 672-683. https://doi.org/10.1089/scd.2022.0157

Optimization of a detergent-based protocol for membrane proteins purification from mammalian cells
Rampado, R, Giordano, F, Moracci, L, Crotti, S, Caliceti, P, Agostini, M & Taraballi, F 2022, , Journal of Pharmaceutical and Biomedical Analysis, vol. 219, 114926. https://doi.org/10.1016/j.jpba.2022.114926

Tunable leukocyte-based biomimetic nanoparticles and methods of use
Taraballi, F Sep. 08 2022, , Patent No. 17803152.

TUNABLE LEUKOCYTE-BASED BIOMIMETIC NANOPARTICLES AND METHODS OF USE
Zinger, AY & Taraballi, F Sep. 08 2022, , Patent No. US2022280428.

Mcm for gene therapy to activate wnt pathway
Taraballi, F Sep. 01 2022, , Patent No. 17683699.

Optimization of Biomimetic, Leukocyte-Mimicking Nanovesicles for Drug Delivery Against Colorectal Cancer Using a Design of Experiment Approach
Rampado, R, Biccari, A, D’Angelo, E, Collino, F, Cricrì, G, Caliceti, P, Giordano, F, Taraballi, F, Pucciarelli, S & Agostini, M 2022, , Frontiers in Bioengineering and Biotechnology, vol. 10, 883034. https://doi.org/10.3389/fbioe.2022.883034

Electrospun electroconductive constructs of aligned fibers for cardiac tissue engineering
Mancino, C, Hendrickson, T, Whitney, LV, Paradiso, F, Abasi, S, Tasciotti, E, Taraballi, F & Guiseppi-Elie, A 2022, , Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 44, 102567, pp. 102567. https://doi.org/10.1016/j.nano.2022.102567

Biomimetic Collagen Membranes Functionalized with mRNA-loaded Lipid Nanoparticles for Fibroblast Transdifferentiation to Endothelial Cells
Villarreal-Leal, RA, Williams, ME, Taraballi, F, Cooke, JP & Corradetti, B 2022, , FASEB journal : official publication of the Federation of American Societies for Experimental Biology, vol. 36. https://doi.org/10.1096/fasebj.2022.36.S1.L7813

Mechanomimetic 3D Scaffolds as a Humanized In Vitro Model for Ovarian Cancer
Paradiso, F, Lenna, S, Gazze, SA, Parra, JG, Murphy, K, Margarit, L, Gonzalez, D, Francis, L & Taraballi, F 2022, , Cells, vol. 11, no. 5, 824. https://doi.org/10.3390/cells11050824

Thermally responsive hydrogel for atrial fibrillation related stroke prevention
Hendrickson, T, Lupo, C, Bauza, G, Tavares, L, Ingram, S, Wang, S, Moreno, M, Tasciotti, E, Valderrabano, M & Taraballi, F 2022, , Materials Today Bio, vol. 14, 100240. https://doi.org/10.1016/j.mtbio.2022.100240

Vascular Graft Infections: An Overview of Novel Treatments Using Nanoparticles and Nanofibers
He, E, Serpelloni, S, Alvear, P, Rahimi, M & Taraballi, F 2022, , Fibers, vol. 10, no. 2, 12. https://doi.org/10.3390/fib10020012

Studying Activated Fibroblast Phenotypes and Fibrosis-Linked Mechanosensing Using 3D Biomimetic Models
Paradiso, F, Quintela, M, Lenna, S, Serpelloni, S, James, D, Caserta, S, Conlan, S, Francis, L & Taraballi, F 2022, , Macromolecular Bioscience, vol. 22, no. 4, 2100450. https://doi.org/10.1002/mabi.202100450

Intraosseous Morphine Decreases Postoperative Pain and Pain Medication Use in Total Knee Arthroplasty: A Double-Blind, Randomized Controlled Trial
Brozovich, AA, Incavo, SJ, Lambert, BS, Sullivan, TC, Wininger, AE, Clyburn, TA, Taraballi, F & Park, KJ 2022, , Journal of Arthroplasty, vol. 37, no. 6, pp. S139-S146. https://doi.org/10.1016/j.arth.2021.10.009

Evaluation of local tissue peri-implant reaction in total knee arthroplasty failure cases
Brozovich, A, Clyburn, T, Park, K, Harper, KD, Sullivan, T, Incavo, S & Taraballi, F 2022, , Therapeutic Advances in Musculoskeletal Disease, vol. 14. https://doi.org/10.1177/1759720X221092263

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