Dale J. Hamilton, MD

Elaine and Marvy A. Finger Distinguished Chair for Translational Research in Metabolic Disorders & Professor of Clinical Medicine, Institute for Academic Medicine
Full Clinical Member, Research Institute
Director, Center for Bioenergetics
Houston Methodist
Weill Cornell Medical College


Center for Bioenergetics


Biography

Dr. Hamilton’s professional career tract has provided the expertise, leadership, and experience to direct the Center for Bioenergetics at Houston Methodist Research Institute. His education was in cellular molecular biology and medicine, and post-graduate training in medicine and endocrinology, as well as laboratory research. His early professional career combined clinical practice and graduate medical education. The transition to translational research began in 2002 when he formed collaborations with colleagues involving clinical treatment trials and orthotopic human islet transplantation. By 2006 his research focus had narrowed to translational issues related to mitochondrial substrate oxidation and energy transfer in failing organ systems such as the human heart.

Description of Research

In 2013, Dr. Hamilton established a bioenergetic research initiative at Houston Methodist Research Institute with the objective of identifying mechanisms of altered energy transduction in disease states, especially those involving high energy tissues. Early and ongoing investigations focus on myocardial energetics in the failing heart. Evolving projects now include the mechanistic study of energy strategies in neoplasia and bioenergetic changes associated with estrogen deficiency. A recent novel but growing project addresses the challenge of transferring functional mitochondria into energy altered tissue such as the failing cardiomyocyte or growing neoplastic cell. The investigative methods include the use of pre-clinical models, tissue cultures and human tissue for analysis. Oxygen consumption, respiratory coupling and glycolytic energy transfer using genomics, metabolomic and proteomic methods are also studied. The team includes basic science specialists in biochemistry and cell biology as well as clinical investigators in cardiology, endocrinology and cardiothoracic surgery. These results have been communicated to the local and national scientific community; positive feedback on these results has strengthened the lab’s ability to design a realistic research plan.

Areas Of Expertise

Diabetes Bioenergetics & Molecular Medicine Endocrine disorders Diabetic complications
Education & Training

Residency, Baylor College of Medicine
Clinical Fellowship, Baylor College of Medicine
MD, Saint Louis University
Active Clinical Trials

UX023T-CL201

NCT02304367

Publications

Cholesterol Induces CD8+ T Cell Exhaustion in the Tumor Microenvironment
Ma, X, Bi, E, Lu, Y, Su, P, Huang, C, Liu, L, Wang, Q, Yang, M, Kalady, MF, Qian, J, Zhang, A, Gupte, AA, Hamilton, DJ, Zheng, C & Yi, Q 2019, Cell Metabolism, vol. 30, no. 1, pp. 143-156.e5. https://doi.org/10.1016/j.cmet.2019.04.002

Single-Molecule Force Measurement Guides the Design of Multivalent Ligands with Picomolar Affinity
Yang, Z, Jiang, S, Li, F, Qiu, Y, Gu, J, Pettigrew, RI, Ferrari, M, Hamilton, DJ & Li, Z 2019, Angewandte Chemie - International Edition. https://doi.org/10.1002/anie.201814347

Targeting infiltrating immune cells to improve articular cartilage regeneration
Taraballi, F, Bauza, G, Francis, L, Zhang, A, Hopson, M, Shaikh, S, Cabrera, F, Wang, X, Shi, A, Hamilton, DJ, McCulloch, P & Tasciotti, E 2019, . in Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. vol. 40, Society for Biomaterials, 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence, Seattle, United States, 4/3/19.

Variability in endocrine cell identity in patients with chronic pancreatitis undergoing islet autotransplantation
Beamish, C, Gaber, AO, Afshar, S, Fraga, DW, Hamilton, DJ & Sabek, O 2018, American Journal of Transplantation. https://doi.org/10.1111/ajt.15154

Stage-Based Management of Type 2 Diabetes Mellitus with Heart Failure
Osuna, PM, Brown, SJ, Tabatabai, LS & Hamilton, DJ 2018, Methodist DeBakey cardiovascular journal, vol. 14, no. 4, pp. 257-265. https://doi.org/10.14797/mdcj-14-4-257

Glycolytic Switch Is Required for Transdifferentiation to Endothelial Lineage
Lai, L, Reineke, EL, Hamilton, DJ & Cooke, JP 2019, Circulation, vol. 139, no. 1, pp. 119-133. https://doi.org/10.1161/CIRCULATIONAHA.118.035741, https://doi.org/10.1161/CIRCULATIONAHA.118.035741

Improved Cardiovascular Function in Old Mice After N-Acetyl Cysteine and Glycine Supplemented Diet: Inflammation and Mitochondrial Factors
Cieslik, KA, Sekhar, RV, Granillo, A, Reddy, A, Medrano, G, Heredia, CP, Entman, ML, Hamilton, DJ, Li, S, Reineke, E, Gupte, AA, Zhang, A & Taffet, GE 2018, The journals of gerontology. Series A, Biological sciences and medical sciences, vol. 73, no. 9, pp. 1167-1177. https://doi.org/10.1093/gerona/gly034

Polymer Functionalization of Isolated Mitochondria for Cellular Transplantation and Metabolic Phenotype Alteration
Wu, S, Zhang, A, Li, S, Chatterjee, S, Qi, R, Segura-Ibarra, V, Ferrari, M, Gupte, A, Blanco, E & Hamilton, DJ 2018, Advanced Science, vol. 5, no. 3, 1700530, pp. 1700530-n/a. https://doi.org/10.1002/advs.201700530

Improved cardiovascular function in old mice after N-Acetyl cysteine and glycine supplemented diet: Inflammation and mitochondrial factors
Cieslik, KA, Sekhar, RV, Granillo, A, Reddy, A, Medrano, G, Heredia, CP, Entman, ML, Hamilton, DJ, Li, S, Reineke, EL, Gupte, AA, Zhang, A & Taffet, G 2018, Journals of Gerontology - Series A Biological Sciences and Medical Sciences, vol. 73, no. 9, pp. 1167-1177. https://doi.org/10.1093/gerona/gly034

Coronary Disease Survival with Diabetes
Hamilton, DJ & Gotto, AM 2017, Cardiology (Switzerland), pp. 40-42. https://doi.org/10.1159/000484518

Tead1 is required for maintaining adult cardiomyocyte function, and its loss results in lethal dilated cardiomyopathy
Liu, R, Lee, J, Kim, BS, Wang, Q, Buxton, SK, Balasubramanyam, N, Kim, JJ, Dong, J, Zhang, A, Li, S, Gupte, AA, Hamilton, DJ, Martin, JF, Rodney, GG, Coarfa, C, Wehrens, XH, Yechoor, VK & Moulik, M 2017, JCI Insight, vol. 2, no. 17. https://doi.org/10.1172/jci.insight.93343

Mitochondrial function in non-ischemic heart failure
Gupte, AA & Hamilton, DJ 2017, . in Advances in Experimental Medicine and Biology. vol. 982, Advances in Experimental Medicine and Biology, vol. 982, Springer New York LLC, pp. 113-126. DOI: 10.1007/978-3-319-55330-6_6

The Failing Heart: Energy Supply, Processing, and Transfer
Hamilton, DJ 2017, Methodist DeBakey Cardiovascular Journal, vol. 13, no. 1, pp. 3. https://doi.org/10.14797/mdcj-13-1-3

Guest Editor Dale Hamilton Provides Expert Guidance for Special Issue on Cardiac Metabolism
Hamilton, DJ 2017, Methodist DeBakey Cardiovascular Journal, vol. 13, no. 1, pp. 1. https://doi.org/10.14797/mdcj-13-1-1

Mitochondrial Function in Non-ischemic Heart Failure
Gupte, AA & Hamilton, DJ 2017, . in G Santulli (ed.), Mitochondrial Dynamics in Cardiovascular Medicine. vol. 982, Advances in Experimental Medicine and Biology, no. 1, Springer International Publishing, pp. 113-126. https://doi.org/https://link.springer.com/chapter/10.1007%2F978-3-319-55330-6_6

Metabolic Recovery of the Failing Heart: Emerging Therapeutic Options
Hamilton, DJ 2017, Methodist DeBakey Cardiovascular Journal, vol. 13, no. 1, pp. 25-28. https://doi.org/10.14797/mdcj-13-1-25

Pet Imaging and its Application in Cardiovascular Diseases
Li, Z, Gupte, AA, Zhang, A & Hamilton, DJ 2017, Methodist DeBakey Cardiovascular Journal, vol. 13, no. 1, pp. 29-33. https://doi.org/10.14797/mdcj-13-1-29

Epicardial Fat in the Maintenance of Cardiovascular Health
Wu, Y, Zhang, A, Hamilton, DJ & Deng, T 2017, Methodist DeBakey Cardiovascular Journal, vol. 13, no. 1, pp. 20-24. https://doi.org/10.14797/mdcj-13-1-20

Guest Editor Dale Hamilton Provides Expert Guidance for Special Issue on Cardiac Metabolism
Hamilton, DJ 2017, Methodist DeBakey cardiovascular journal, vol. 13, no. 1. https://doi.org/10.14797/mdcj-13-1-1

Estrogen receptor alpha activation enhances mitochondrial function and systemic metabolism in high fat-fed ovariectomized mice.
Hamilton, DJ, Minze, LJ, Cao, TN, Lyon, CJ, Geiger, PC, Hsueh, WA & Gupte, AA 2016, Physiological Reports, vol. 4, no. 17, pp. e12913.

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