Dale J. Hamilton, MD

Elaine and Marvy A. Finger Distinguished Chair for Translational Research in Metabolic Disorders & Professor of Clinical Medicine, Academic Institute
Full Clinical Member, Research Institute
Director, Center for Bioenergetics
Houston Methodist
Weill Cornell Medical College


Center for Bioenergetics


Biography

Dr. Hamilton’s professional career tract has provided the expertise, leadership, and experience to direct the Center for Bioenergetics at Houston Methodist Research Institute. His education was in cellular molecular biology and medicine, and post-graduate training in medicine and endocrinology, as well as laboratory research. His early professional career combined clinical practice and graduate medical education. The transition to translational research began in 2002 when he formed collaborations with colleagues involving clinical treatment trials and orthotopic human islet transplantation. By 2006 his research focus had narrowed to translational issues related to mitochondrial substrate oxidation and energy transfer in failing organ systems such as the human heart.

Description of Research

In 2013, Dr. Hamilton established a bioenergetic research initiative at Houston Methodist Research Institute with the objective of identifying mechanisms of altered energy transduction in disease states, especially those involving high energy tissues. Early and ongoing investigations focus on myocardial energetics in the failing heart. Evolving projects now include the mechanistic study of energy strategies in neoplasia and bioenergetic changes associated with estrogen deficiency. A recent novel but growing project addresses the challenge of transferring functional mitochondria into energy altered tissue such as the failing cardiomyocyte or growing neoplastic cell. The investigative methods include the use of pre-clinical models, tissue cultures and human tissue for analysis. Oxygen consumption, respiratory coupling and glycolytic energy transfer using genomics, metabolomic and proteomic methods are also studied. The team includes basic science specialists in biochemistry and cell biology as well as clinical investigators in cardiology, endocrinology and cardiothoracic surgery. These results have been communicated to the local and national scientific community; positive feedback on these results has strengthened the lab’s ability to design a realistic research plan.

Areas Of Expertise

Diabetes Bioenergetics & Molecular Medicine Endocrine disorders Diabetic complications
Education & Training

Residency, Baylor College of Medicine
Clinical Fellowship, Baylor College of Medicine
MD, Saint Louis University
Publications

Mitochondrial DNA damage-repair defects in mutant FUS-linked motor neuron diseases and its mitigation via targeted expression of DNA Ligase I
Wang, H, Kodavati, M, Guo, W, Mitra, J, Zhang, A, Mitra, S, Tomkinson, AE, Hamilton, DJ, Van Den Bosch, L & Hegde, M 2022, , 7th US-EU Conference on Endogenous DNA Damage and Repair, Newyork, United States, 11/6/22 - 11/9/22.

AIBP Regulates Metabolism of Ketone and Lipids but Not Mitochondrial Respiration
Kim, J, Zhou, T, Zhang, A, Li, S, Gupte, AA, Hamilton, DJ & Fang, L 2022, , Cells, vol. 11, no. 22, pp. 3643. https://doi.org/10.3390/cells11223643

Enhanced Succinate Oxidation with Mitochondrial Complex II Reactive Oxygen Species Generation in Human Prostate Cancer
Zhang, A, Gupte, AA, Chatterjee, S, Li, S, Ayala, A, Miles, BJ & Hamilton, DJ 2022, , International journal of molecular sciences, vol. 23, no. 20, 12168, pp. 12168. https://doi.org/10.3390/ijms232012168, https://doi.org/10.3390/ijms232012168

Enhanced Succinate Oxidation with Mitochondrial Complex II Reactive Oxygen Species Generation in Human Prostate Cancer
Zhang, A, Gupte, AA, Chatterjee, S, Li, S, Ayala, AG, Miles, BJ & Hamilton, DJ 2022, , International journal of molecular sciences, vol. 23, no. 20. https://doi.org/10.3390/ijms232012168

Enhanced Succinate Oxidation with Mitochondrial Complex II Reactive Oxygen Species Generation in Human Prostate Cancer
Zhang, A, Gupte, AA, Chatterjee, S, Li, S, Ayala, A, Miles, BJ & Hamilton, DJ 2022, , International journal of molecular sciences, vol. 23, no. 20, 12168. https://doi.org/10.3390/ijms232012168

Pretransplant HOMA-ß Is Predictive of Insulin Independence in 7 Patients With Chronic Pancreatitis Undergoing Islet Autotransplantation
Beamish, CA, Gaber, AO, Fraga, DW, Hamilton, DJ & Sabek, OM 2022, , Transplantation Direct, vol. 8, no. 10, pp. E1367. https://doi.org/10.1097/TXD.0000000000001367

The Role of Calcium Signaling in Melanoma
Zhang, H, Chen, Z, Zhang, A, Gupte, AA & Hamilton, DJ 2022, , International journal of molecular sciences, vol. 23, no. 3, 1010. https://doi.org/10.3390/ijms23031010

Polymer-Functionalized Mitochondrial Transplantation to Plaque Macrophages as a Therapeutic Strategy Targeting Atherosclerosis
Liu, H, Wu, S, Lee, H, Baudo, G, Massaro, M, Zhang, A, Hamilton, DJ & Blanco, E 2022, , advanced therapeutics, vol. 5, no. 5, 2100232. https://doi.org/10.1002/adtp.202100232

Suppression of FOXP3 expression by the AP-1 family transcription factor BATF3 requires partnering with IRF4
Arnold, PR, Wen, M, Zhang, L, Ying, Y, Xiao, X, Chu, X, Wang, G, Zhang, X, Mao, Z, Zhang, A, Hamilton, DJ, Chen, W & Li, XC 2022, , Frontiers in immunology, vol. 13, pp. 966364. https://doi.org/10.3389/fimmu.2022.966364

NAD+ depletion-induced vascular senescence via p90RSK-ERK5 S496 phosphorylation
Kotla, S, Zhang, A, Imanishi, M, Lin, SH, Le, N-T, Hamilton, DJ & Abe, JI 2022, , Cell Symposia, Lisbon, Portugal, 4/3/22 - 4/5/22.

Nucleus-mitochondria positive feedback loop formed by ERK5 S496 phosphorylation-mediated poly (ADP-ribose) polymerase activation provokes persistent pro-inflammatory senescent phenotype and accelerates coronary atherosclerosis after chemo-radiation
Kotla, S, Zhang, A, Imanishi, M, Ko, KA, Lin, SH, Gi, YJ, Moczygemba, M, Isgandarova, S, Schadler, KL, Chung, C, Milgrom, SA, Banchs, J, Yusuf, SW, Amaya, DN, Guo, H, Thomas, TN, Shen, YH, Deswal, A, Herrmann, J, Kleinerman, ES, Entman, ML, Cooke, JP, Schifitto, G, Maggirwar, SB, McBeath, E, Gupte, AA, Krishnan, S, Patel, ZS, Yoon, Y, Burks, JK, Fujiwara, K, Brookes, PS, Le, N-T, Hamilton, DJ & Abe, J-I 2021, , Redox Biology, vol. 47, 102132, pp. 102132. https://doi.org/10.1016/j.redox.2021.102132

EpCAM-Targeting Aptamer Radiotracer for Tumor-Specific PET Imaging
Li, F, Zeng, Z, Hamilton, D, Zu, Y & Li, Z 2021, , Bioconjugate chemistry, vol. 32, no. 6, pp. 1139-1145. https://doi.org/10.1021/acs.bioconjchem.1c00188

Plumbagin elicits cell-specific cytotoxic effects and metabolic responses in melanoma cells
Zhang, H, Zhang, A, Gupte, AA & Hamilton, DJ 2021, , Pharmaceutics, vol. 13, no. 5, 706. https://doi.org/10.3390/pharmaceutics13050706

Structure-Based Design of a Selective Class I Histone Deacetylase (HDAC) Near-Infrared (NIR) Probe for Epigenetic Regulation Detection in Triple-Negative Breast Cancer (TNBC)
Zhang, K, Liu, Z, Yao, Y, Qiu, Y, Li, F, Chen, D, Hamilton, DJ, Li, Z & Jiang, S 2021, , Journal of Medicinal Chemistry, vol. 64, no. 7, pp. 4020-4033. https://doi.org/10.1021/acs.jmedchem.0c02161

64Cu/177Lu-DOTA-diZD, a Small-Molecule-Based Theranostic Pair for Triple-Negative Breast Cancer
Huang, Y, Yang, Z, Li, F, Zhao, H, Li, C, Yu, N, Hamilton, DJ & Li, Z 2021, , Journal of Medicinal Chemistry, vol. 64, no. 5, pp. 2705-2713. https://doi.org/10.1021/acs.jmedchem.0c01957

Management of primary cardiac paraganglioma
Chan, EY, Ali, A, Umana, JP, Nguyen, DT, Hamilton, DJ, Graviss, EA, Ravi, V, MacGillivray, TE & Reardon, MJ 2020, , The Journal of thoracic and cardiovascular surgery. https://doi.org/10.1016/j.jtcvs.2020.09.100

Stress-induced premature aging mediated by mitochoindrial hibernation promotes atherosclerosis
Kotla, S, Zhang, A, Imanishi, M, Ae Ko, K, Lin, S, Gi, Y, Fujiwara, K, Burks, JK, Le, N-T, Hamilton, DJ & Abe, JI 2020, , The 21st International Vascular Biology Meeting, 9/9/20 - 9/12/20.

Poly (adp-ribose) Polymerase (parp) Activation and Mitochondrial Hibernation Induced by P90rsk-mediated Erk5 S496 Phosphorylation Promote Mitochondrial Ros Production in Macrophage
Kotla, S, Zhang, A, Ae Ko, K, Imanishi, M, Fujiwara, K, Yoon, Y, Brooks, P, Hamilton, DJ & Abe, JI 2020, , Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 40, no. Sippl_1, 336, pp. A336.

Discovery of class i histone deacetylase inhibitors based on romidpesin with promising selectivity for cancer cells
Zhang, K, Yao, Y, Tu, Z, Liao, C, Wang, Z, Qiu, Y, Chen, D, Hamilton, DJ, Li, Z & Jiang, S 2020, , Future Medicinal Chemistry, vol. 12, no. 4, pp. 311-323. https://doi.org/10.4155/fmc-2019-0290

Time-dependent replicative senescence vs. disturbed flow-induced pre-mature aging in atherosclerosis
Dominic, A, Banerjee, P, Hamilton, DJ, Le, N-T & Abe, JI 2020, , Redox Biology, vol. 37, 101614. https://doi.org/10.1016/j.redox.2020.101614