Unknown

Zhihui Wang, PhD

Associate Research Professor of Mathematics in Medicine, Academic Institute
Associate Research Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Biography

Dr. Wang is an expert at the forefront of research in the fields of computational biology, modeling-aided drug target discovery, biophysical modeling of drug transport, and multiscale cancer modeling. Dr. Wang has developed expertise in both computational and translational research, and has successfully acted as an intermediary, catalyst, and team leader at the intersection of mathematics/engineering and the biology/medical fields. This intermediary role between medical and mathematical fields is of particular importance, facilitating discoveries that are only possible through a joining of these distinct but important research fields.

Description of Research

Dr. Wang’s research spans a broad spectrum of applied mathematics, probability modeling, and systems biology and medicine. Dr. Wang’s research focuses on integrating mathematical, physical, and statistical methods with experimental investigations and patient data analysis to quantitatively study tumor progression and invasion, to help improve prediction of treatment efficacy and optimize treatment planning. Furthermore, he has been developing practical mathematical tools that can potentially be used by doctors in the clinic to predict the outcome for each individual patient prior to actual treatment. 

Publications

Computational approaches for multiscale modeling
Butner, J, Dogra, P, Cristini, V, Deisboeck, TS & Wang, Z 2023, . in RA Bradshaw, PD Stahl & J Hart (eds), Encyclopedia of Cell Biology. 2 edn, Elsevier.

Pharmacokinetic modeling of cancer nanomedicine
Dogra, P, Goel, S, Wang, Z & Cristini, V 2022, . in Cancer Systems Biology and Translational Mathematical Oncology. Oxford University Press.

Mechanistic modeling-guided optimization of microneedle-based skin patch for rapid transdermal delivery of naloxone for opioid overdose treatment
Tijani, A, Dogra, P, Peláez, MJ, Wang, Z, Cristini, V & Puri, A 2022, , Drug Delivery and Translational Research. https://doi.org/10.1007/s13346-022-01202-w

Dedifferentiation-mediated stem cell niche maintenance in early-stage ductal carcinoma in situ progression: insights from a multiscale modeling study
Butner, JD, Dogra, P, Chung, C, Ruiz-Ramírez, J, Nizzero, S, Plodinec, M, Li, X, Pan, P-Y, Chen, S-H, Cristini, V, Ozpolat, B, Calin, GA & Wang, Z 2022, , Cell death & disease, vol. 13, no. 5, pp. 485. https://doi.org/10.1038/s41419-022-04939-x

Genetic and Structural Analysis of SARS-CoV-2 Spike Protein for Universal Epitope Selection
Markosian, C, Staquicini, DI, Dogra, P, Dodero-Rojas, E, Lubin, JH, Tang, FHF, Smith, TL, Contessoto, VG, Libutti, SK, Wang, Z, Cristini, V, Khare, SD, Whitford, PC, Burley, SK, Onuchic, JN, Pasqualini, R & Arap, W 2022, , Molecular Biology and Evolution. https://doi.org/10.1093/molbev/msac091

Dedifferentiation-mediated stem cell niche maintenance in early-stage ductal carcinoma in situ progression: insights from a multiscale modeling study
Butner, JD, Dogra, P, Chung, C, Ruiz-Ramírez, J, Nizzero, S, Plodinec, M, Li, X, Pan, PY, Chen, SH, Cristini, V, Ozpolat, B, Calin, GA & Wang, Z 2022, , Cell Death and Disease, vol. 13, no. 5, 485. https://doi.org/10.1038/s41419-022-04939-x

Translational Modeling Identifies Synergy between Nanoparticle-Delivered miRNA-22 and Standard-of-Care Drugs in Triple-Negative Breast Cancer
Dogra, P, Ramírez, JR, Butner, JD, Peláez, MJ, Chung, C, Hooda-Nehra, A, Pasqualini, R, Arap, W, Cristini, V, Calin, GA, Ozpolat, B & Wang, Z 2022, , Pharmaceutical Research. https://doi.org/10.1007/s11095-022-03176-3

Translational Modeling Identifies Synergy between Nanoparticle-Delivered miRNA-22 and Standard-of-Care Drugs in Triple-Negative Breast Cancer
Dogra, P, Ramírez, JR, Butner, JD, Peláez, MJ, Chung, C, Hooda-Nehra, A, Pasqualini, R, Arap, W, Cristini, V, Calin, GA, Ozpolat, B & Wang, Z 2022, , Pharmaceutical Research. https://doi.org/10.1007/s11095-022-03176-3

Mechanistic modeling-guided optimization of microneedle-based skin patch for rapid transdermal delivery of naloxone for opioid overdose treatment
Tijani, A, Dogra, P, Peláez, MJ, Wang, Z, Cristini, V & Puri, A 2022, , Drug Delivery and Translational Research. https://doi.org/10.1007/s13346-022-01202-w

A Multiscale Model to Identify Limiting Factors in Nanoparticle-based miRNA Delivery for Tumor Inhibition
Dogra, P, Ramírez, JR, Butner, J, Peláez, MJ, Cristini, V & Wang, Z 2021, , Paper presented at 43rd Annual International IEEE Engineering in Medicine and Biology Society Conference, 10/31/21 - 11/4/21. https://doi.org/10.1109/EMBC46164.2021.9630862

Early prediction of clinical response to checkpoint inhibitor therapy in human solid tumors through mathematical modeling
Butner, JD, Martin, GV, Wang, Z, Corradetti, B, Ferrari, M, Esnaola, N, Chung, C, Hong, DS, Welsh, JW, Hasegawa, N, Mittendorf, EA, Curley, SA, Chen, S-H, Pan, P-Y, Libutti, SK, Ganesan, S, Sidman, RL, Pasqualini, R, Arap, W, Koay, EJ & Cristini, V 2021, , eLife, vol. 10. https://doi.org/10.7554/eLife.70130

A Multiscale Model to Identify Limiting Factors in Nanoparticle-Based miRNA Delivery for Tumor Inhibition
Dogra, P, Ramirez, JR, Butner, JD, Pelaez, MJ, Cristini, V & Wang, Z 2021, , Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, vol. 2021, pp. 4230-4233. https://doi.org/10.1109/EMBC46164.2021.9630862

Early prediction of clinical response to checkpoint inhibitor therapy in human solid tumors through mathematical modeling
Butner, JD, Martin, GV, Wang, Z, Corradetti, B, Ferrari, M, Esnaola, N, Chung, C, Hong, DS, Welsh, JW, Hasegawa, N, Mittendorf, EA, Curley, SA, Chen, SH, Pan, PY, Libutti, SK, Ganesan, S, Sidman, RL, Pasqualini, R, Arap, W, Koay, EJ & Cristini, V 2021, , eLife, vol. 10, e70130. https://doi.org/10.7554/eLife.70130

A Multiscale Model to Identify Limiting Factors in Nanoparticle-Based miRNA Delivery for Tumor Inhibition
Dogra, P, Ramirez, JR, Butner, JD, Pelaez, MJ, Cristini, V & Wang, Z 2021, , pp. 4230-4233. https://doi.org/10.1109/EMBC46164.2021.9630862

Translational modeling identifies synergy between nanoparticle-delivered miRNA-22 and standard-of-care drugs in triple negative breast cancer
Dogra, P, Ramírez, JR, Butner, J, Peláez, MJ, Chung, C, Hooda-Nehra, A, Pasqualini, R, Arap, W, Cristini, V, Calin, GA, Ozpolat, B & Wang, Z 2021, , medRxiv. https://doi.org/10.1101/2021.10.19.21265154

Predicting immune checkpoint inhibitor response with mathematical modeling
Butner, JD & Wang, Z 2021, , Immunotherapy, vol. 13, no. 14, pp. 1151-1155. https://doi.org/10.2217/imt-2021-0209

Apropos of Universal Epitope Discovery for COVID-19 Vaccines: A Framework for Targeted Phage Display-Based Delivery and Integration of New Evaluation Tools
Markosian, C, Staquicini, DI, Dogra, P, Dodero-Rojas, E, Tang, FHF, Smith, TL, Contessoto, VG, Libutti, SK, Wang, Z, Cristini, V, Whitford, PC, Burley, SK, Onuchic, JN, Pasqualini, R & Arap, W 2021, , bioRxiv. https://doi.org/10.1101/2021.08.30.458222

Translational mechanistic modeling for treatment optimization of nanoparticle-delivered miRNA-22 therapy in triple negative breast cancer
Dogra, P, Ruiz-Ramirez, J, Peláez, MJ, Butner, J, Cristini, V & Wang, Z 2021, , 9th Annual Houston Methodist Cancer Symposium, 8/27/21.

Targeting a cell surface vitamin d receptor on tumor-associated macrophages in triple-negative breast cancer
Staquicini, FI, Hajitou, A, Driessen, WHP, Proneth, B, Cardó-Vila, M, Staquicini, DI, Markosian, C, Hoh, M, Cortez, M, Hooda-Nehra, A, Jaloudi, M, Silva, IT, Buttura, J, Nunes, D, Dias-Neto, E, Eckhardt, B, Ruiz-Ramírez, J, Dogra, P, Wang, Z, Cristini, V, Trepel, M, Anderson, R, Sidman, RL, Gelovani, JG, Cristofanilli, M, Hortobagy, G, Bhujwalla, ZM, Burley, S, Arap, W & Pasqualini, R 2021, , eLife, vol. 10, e65145. https://doi.org/10.7554/eLife.65145

Conversion of RNA Aptamer into Modified DNA Aptamers Provides for Prolonged Stability and Enhanced Antitumor Activity
Amero, P, Lokesh, GLR, Chaudhari, RR, Cardenas-Zuniga, R, Schubert, T, Attia, YM, Montalvo-Gonzalez, E, Elsayed, AM, Ivan, C, Wang, Z, Cristini, V, Franciscis, VD, Zhang, S, Volk, DE, Mitra, R, Rodriguez-Aguayo, C, Sood, AK & Lopez-Berestein, G 2021, , Journal of the American Chemical Society, vol. 143, no. 20, pp. 7655-7670. https://doi.org/10.1021/jacs.9b10460