Zheng Yin

Zheng Yin, PhD

Assistant Professor of Computational Biology and Mathematics in Radiology, Academic Institute
Assistant Member & Director, Biomedical Informatics Service Core, Research Institute
Houston Methodist
Weill Cornell Medical College


Inhibiting androgen receptor splice variants with cysteine-selective irreversible covalent inhibitors to treat prostate cancer
Thiyagarajan, T, Ponnusamy, S, Huang, D, He, Y, Asemota, S, Young, K, Johnson, D, Bocharova, V, Zhou, W, Jain, A, Petricoin, E, Yin, Z, Pfeffer, L, Miller, D & Narayanan, R 2023, , Proceedings of the National Academy of Sciences of the United States of America, vol. 120, no. 1, 120 (1) e2211832120. https://doi.org/https://www.pnas.org/doi/10.1073/pnas.2211832120

Ryanodine receptor 1-mediated Ca2+ signaling and mitochondrial reprogramming modulate uterine serous cancer malignant phenotypes
Zhang, L, Au-Yeung, CL, Huang, C, Yeung, TL, Ferri-Borgogno, S, Lawson, BC, Kwan, SY, Yin, Z, Wong, ST, Thomas, V, Lu, KH, Yip, KP, Sham, JSK & Mok, SC 2022, , Journal of Experimental and Clinical Cancer Research, vol. 41, no. 1, 242. https://doi.org/10.1186/s13046-022-02419-w

An AI-driven clinical care pathway to reduce 30-day readmission for chronic obstructive pulmonary disease (COPD) patients
Wang, L, Li, G, Ezeana, CF, Ogunti, R, Puppala, M, He, T, Yu, X, Wong, SSY, Yin, Z, Roberts, AW, Nezamabadi, A, Xu, P, Frost, A, Jackson, RE & Wong, STC 2022, , Scientific Reports, vol. 12, no. 1, pp. 20633. https://doi.org/10.1038/s41598-022-22434-3

Ex vivo expanded human regulatory T cells modify neuroinflammation in a preclinical model of Alzheimer’s disease
Faridar, A, Vasquez, M, Thome, AD, Yin, Z, Xuan, H, Wang, JH, Wen, S, Li, X, Thonhoff, JR, Zhao, W, Zhao, H, Beers, DR, Wong, STC, Masdeu, JC & Appel, SH 2022, , Acta Neuropathologica Communications, vol. 10, no. 1, 144. https://doi.org/10.1186/s40478-022-01447-z

Risk factors and machine learning model for predicting hospitalization outcomes in geriatric patients with dementia
Wang, X, Ezeana, CF, Wang, L, Puppala, M, Huang, Y-S, He, Y, Yu, X, Yin, Z, Zhao, H, Lai, EC & Wong, STC 2022, , Alzheimers and Dementia: Translational Research and Clinical Interventions, vol. 8, no. 1, pp. e12351. https://doi.org/10.1002/trc2.12351

Artificial Intelligence Unifies Knowledge and Actions in Drug Repositioning
Yin, Z & Wong, ST 2021, , Emerging topics in life sciences. https://doi.org/10.1042/ETLS20210223

Artificial intelligence unifies knowledge and actions in drug repositioning
Yin, Z & Wong, STC 2021, , Emerging Topics in Life Sciences, vol. 5, no. 6, pp. 803-813. https://doi.org/10.1042/ETLS20210223

Converging Multi-Modality Datasets to Build Efficient Drug Repositioning Pipelines against Alzheimer's Disease and Related Dementias
Yin, Z & Wong, ST 2021, , Medical Review.

Acetyl-CoA Synthetase 2: A Critical Linkage in Obesity-Induced Tumorigenesis in Myeloma
Li, Z, Liu, H, He, J, Wang, Z, Yin, Z, You, G, Wang, Z, Davis, RE, Lin, P, Bergsagel, PL, Manasanch, EE, Wong, STC, Esnaola, NF, Chang, JC, Orlowski, RZ, Yi, Q & Yang, J 2021, , Cell Metabolism, vol. 33, no. 1, pp. 78-93.e7. https://doi.org/10.1016/j.cmet.2020.12.011

A Time-Series Feature-Based Recursive Classification Model to Optimize Treatment Strategies for Improving Outcomes and Resource Allocations of COVID-19 Patients
Wang, L, Yin, Z, Puppala, M, Ezeana, C, Wong, K, He, T, Gotur, D & Wong, S 2022, , IEEE Journal of Biomedical and Health Informatics, vol. 26, no. 7, pp. 3323-3329. https://doi.org/10.1109/JBHI.2021.3139773

Imatinib revives the therapeutic potential of metformin on ewing sarcoma by attenuating tumor hypoxic response and inhibiting convergent signaling pathways
Nan, X, Wang, J, Cheng, H, Yin, Z, Sheng, J, Qiu, B, Lau, CC, Yustein, JT, Zhao, H & Wong, STC 2019, , Cancer Letters. https://doi.org/10.1016/j.canlet.2019.10.034

A Deep Learning-Based Decision Support Tool for Precision Risk Assessment of Breast Cancer
He, T, Puppala, M, Ezeana, CF, Huang, Y-S, Chou, P-H, Yu, X, Chen, S, Wang, L, Yin, Z, Danforth, RL, Ensor, J, Chang, J, Patel, T & Wong, STC 2020, , JCO Clinical Cancer Informatics, vol. 3, pp. 1-12. https://doi.org/10.1200/CCI.18.00121

Clusterin impairs hepatic insulin sensitivity and adipocyte clusterin associates with cardiometabolic risk
Bradley, D, Blaszczak, A, Yin, Z, Liu, J, Joseph, JJ, Wright, V, Anandani, K, Needleman, B, Noria, S, Renton, D, Yearsley, M, Wong, STC & Hsueh, WA 2019, , Diabetes care, vol. 42, no. 3, pp. 466-475. https://doi.org/10.2337/dc18-0870

Two birds, one stone: Hesperetin alleviates chemotherapyinduced diarrhea and potentiates tumor inhibition
Yu, Y, Kong, R, Cao, H, Yin, Z, Liu, J, Nan, X, Phan, AT, Ding, T, Zhao, H & Wong, STC 2018, , Oncotarget, vol. 9, no. 46, pp. 27958-27973. https://doi.org/10.18632/oncotarget.24563

KAT2A coupled with the a-KGDH complex acts as a histone H3 succinyltransferase
Wang, Y, Guo, YR, Liu, K, Yin, Z, Liu, R, Xia, Y, Tan, L, Yang, P, Lee, J-H, Li, X-J, Hawke, D, Zheng, Y, Qian, X, Lyu, J, He, J, Xing, D, Tao, YJ & Lu, Z 2017, , Nature, vol. 552, no. 7684, pp. 273-277. https://doi.org/10.1038/nature25003

C-reactive protein promotes bone destruction in human myeloma through the CD32-p38 MAPK-Twist axis
Yang, J, Liu, Z, Liu, H, He, J, Yang, J, Lin, P, Wang, Q, Du, J, Ma, W, Yin, Z, Davis, E, Orlowski, RZ, Hou, J & Yi, Q 2017, , Science signaling, vol. 10, no. 509. https://doi.org/10.1126/scisignal.aan6282

KAT2A coupled with the a-KGDH complex acts as a histone H3 succinyltransferase
Yin, Z 2017, Nature.

Current Computational Models for Prediction of the Varied Interactions Related to Noncoding RNAs
Chen, X, Peng, H & Yin, Z 2016, , BioMed Research International, vol. 2016, 4183574. https://doi.org/10.1155/2016/4183574

How cells explore shape space: A quantitative statistical perspective of cellular morphogenesis
Yin, Z, Sailem, H, Sero, J, Ardy, R, Wong, STC & Bakal, C 2014, , BioEssays, vol. 36, no. 12, pp. 1195-1203. https://doi.org/10.1002/bies.201400011

Integration of multiscale dendritic spine structure and function data into systems biology models
Mancuso, JJ, Cheng, J, Yin, Z, Gilliam, JC, Xia, X, Li, X & Wong, STC 2014, , Frontiers in Neuroanatomy, vol. 8, no. November, 130. https://doi.org/10.3389/fnana.2014.00130