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Zheng Yin, PhD

Assistant Professor of Computational Biology and Mathematics in Oncology, Academic Institute
Assistant Member & Director, Biomedical Informatics Service Core, Research Institute
Houston Methodist

A Deep Learning-Based Decision Support Tool for Precision Risk Assessment of Breast Cancer
He, T, Puppala, M, Ezeana, CF, Huang, Y-S, Chou, P-H, Yu, X, Chen, S, Wang, L, Yin, Z, Danforth, RL, Ensor, J, Chang, J, Patel, T & Wong, STC 2020, JCO Clinical Cancer Informatics, vol. 3, pp. 1-12.

Clusterin impairs hepatic insulin sensitivity and adipocyte clusterin associates with cardiometabolic risk
Bradley, D, Blaszczak, A, Yin, Z, Liu, J, Joseph, JJ, Wright, V, Anandani, K, Needleman, B, Noria, S, Renton, D, Yearsley, M, Wong, ST & Hsueh, WA 2019, Diabetes Care, vol. 42, no. 3, pp. 466-475.

Imatinib revives the therapeutic potential of metformin on ewing sarcoma by attenuating tumor hypoxic response and inhibiting convergent signaling pathways
Nan, X, Wang, J, Cheng, H, Yin, Z, Sheng, J, Qiu, B, Lau, CC, Yustein, JT, Zhao, H & Wong, STC 2019, Cancer Letters.

Two birds, one stone: Hesperetin alleviates chemotherapyinduced diarrhea and potentiates tumor inhibition
Yu, Y, Kong, R, Cao, H, Yin, Z, Liu, J, Nan, X, Phan, AT, Ding, T, Zhao, H & Wong, ST 2018, Oncotarget, vol. 9, no. 46, pp. 27958-27973.

KAT2A coupled with the a-KGDH complex acts as a histone H3 succinyltransferase
Wang, Y, Guo, YR, Liu, K, Yin, Z, Liu, R, Xia, Y, Tan, L, Yang, P, Lee, J-H, Li, X-J, Hawke, D, Zheng, Y, Qian, X, Lyu, J, He, J, Xing, D, Tao, YJ & Lu, Z 2017, Nature, vol. 552, no. 7684, pp. 273-277.

C-reactive protein promotes bone destruction in human myeloma through the CD32-p38 MAPK-Twist axis
Yang, J, Liu, Z, Liu, H, He, J, Yang, J, Lin, P, Wang, Q, Du, J, Ma, W, Yin, Z, Davis, E, Orlowski, RZ, Hou, J & Yi, Q 2017, Science signaling, vol. 10, no. 509.

KAT2A coupled with the a-KGDH complex acts as a histone H3 succinyltransferase
Yin, Z 2017, Nature.

Current Computational Models for Prediction of the Varied Interactions Related to Noncoding RNAs
Chen, X, Peng, H & Yin, Z 2016, BioMed Research International, vol. 2016, 4183574.

How cells explore shape space: A quantitative statistical perspective of cellular morphogenesis
Yin, Z, Sailem, H, Sero, J, Ardy, R, Wong, ST & Bakal, C 2015, BioEssays, vol. 36, no. 12, pp. 1195-1203.

Integration of multiscale dendritic spine structure and function data into systems biology models
Mancuso, JJ, Cheng, J, Yin, Z, Gilliam, JC, Xia, X, Li, X & Wong, STC 2014, Frontiers in Neuroanatomy, vol. 8, no. November, 130.

Transcriptome analysis of human adipocytes implicates the NOD-like receptor pathway in obesity-induced adipose inflammation
Yin, Z, Deng, T, Peterson, LE, Yu, R, Lin, J, Hamilton, DJ, Reardon, PR, Sherman, V, Winnier, GE, Zhan, M, Lyon, CJ, Wong, ST & Hsueh, WA 2014, Molecular and cellular endocrinology, vol. 394, no. 1-2, pp. 80-87.

An integrated analytic pipeline for identifying and predicting genetic interactions based on perturbation data from high content double RNAi screening
Yin, Z, Li, F & Wong, ST 2014, . in Proceedings of the XSEDE 2014 Conference: Engaging Communities., 7, Association for Computing Machinery, 2014 Annual Conference on Extreme Science and Engineering Discovery Environment, XSEDE 2014, Atlanta, GA, United States, 7/13/14.

Genomics-Based Cancer Theranostics
Yin, Z, Mancuso, J, Li, F & Wong, ST 2014, . in Cancer Theranostics. Elsevier, pp. 9-20.

Mechanical unloading promotes myocardial energy recovery in human heart failure
Gupte, AA, Hamilton, DJ, Cordero-Reyes, AM, Youker, KA, Yin, Z, Estep, JD, Stevens, RD, Wenner, B, Ilkayeva, O, Loebe, M, Peterson, LE, Lyon, CJ, Wong, ST, Newgard, CB, Torre, G, Taegtmeyer, H & Hsueh, WA 2014, Circulation: Cardiovascular Genetics, vol. 7, no. 3, pp. 266-276.

Transcriptional signaling pathways inversely regulated in Alzheimer's disease and glioblastoma multiform
Liu, T, Ren, D, Zhu, X, Yin, Z, Jin, G, Zhao, Z, Robinson, D, Li, X, Wong, K, Cui, K, Zhao, H & Wong, STC 2013, Scientific reports, vol. 3, 3467.

The miR-223/nuclear factor I-A axis regulates glial precursor proliferation and tumorigenesis in the CNS
Glasgow, SM, Laug, D, Brawley, VS, Zhang, Z, Corder, A, Yin, Z, Wong, ST, Li, XN, Foster, AE, Ahmed, N & Deneen, B 2013, Journal of Neuroscience, vol. 33, no. 33, pp. 13560-13568.

A screen for morphological complexity identifies regulators of switch-like transitions between discrete cell shapes
Yin, Z, Sadok, A, Sailem, H, McCarthy, A, Xia, X, Li, F, Garcia, MA, Evans, L, Barr, AR, Perrimon, N, Marshall, CJ, Wong, ST & Bakal, C 2013, Nature Cell Biology, vol. 15, no. 7, pp. 860-871.

Chapter 17: Bioimage Informatics for Systems Pharmacology
Li, F, Yin, Z, Jin, G, Zhao, H & Wong, ST 2013, PLoS Computational Biology, vol. 9, no. 4, e1003043.

Class II major histocompatibility complex plays an essential role in obesity-induced adipose inflammation
Deng, T, Lyon, CJ, Minze, LJ, Lin, J, Zou, J, Liu, JZ, Ren, Y, Yin, Z, Hamilton, DJ, Reardon, PR, Sherman, V, Wang, HY, Phillips, KJ, Webb, P, Wong, ST, Wang, R & Hsueh, WA 2013, Cell Metabolism, vol. 17, no. 3, pp. 411-422.

A semi-supervised learning approach to predict synthetic genetic interactions by combining functional and topological properties of functional gene network
You, ZH, Yin, Z, Han, K, Huang, DS & Zhou, X 2010, BMC bioinformatics, vol. 11, 343.

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