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Yulin Li, MD, PhD

Assistant Professor of Immunotherapy in Oncology, Academic Institute
Assistant Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Dr. Li finished his medical school at Beijing Medical University and his graduate school at Penn State. He had his postdoctoral training at Stanford University before joining the Research Institute in late 2017.

Description of Research

Dr. Li's research interests includes 1) Roles of oncogenes in tumorigenesis, and 2) Rational combination therapy.  Dr. Li's lab utilizes both experimental and computational approaches to study cancer and rare diseases.

Areas Of Expertise

Proteomics in oncology Combination therapy Differentiation

XPO1-dependent nuclear export as a target for cancer therapy
Azizian, NG, Azizian, NG, Li, Y & Li, Y 2020, , Journal of Hematology and Oncology, vol. 13, no. 1, 61.

Simultaneous targeting of XPO1 and BCL2 as an effective treatment strategy for double-hit lymphoma
Liu, Y, Azizian, NG, Dou, Y, Pham, LV & Li, Y 2019, , Journal of Hematology and Oncology, vol. 12, no. 1.

Mebendazole for Differentiation Therapy of Acute Myeloid Leukemia Identified by a Lineage Maturation Index
Li, Y, Thomas, D, Deutzmann, A, Majeti, R, Felsher, DW & Dill, DL 2019, , Scientific Reports, vol. 9, no. 1, pp. 16775.

Rational Targeted Therapeutics for Double-Hit Lymphoma
Li, Y 2019, International Journal of Hematologic Oncology.

BIM-mediated apoptosis and oncogene addiction
Li, Y, Deutzmann, A & Felsher, DW 2016, Aging, vol. 8, no. 9, pp. 1834-1835.

BIM mediates oncogene inactivation-induced apoptosis in multiple transgenic mouse models of acute lymphoblastic leukemia
Li, Y, Deutzmann, A, Choi, PS, Fan, AC & Felsher, DW 2016, , Oncotarget, vol. 7, no. 19, pp. 26926-26934.

MYC regulates the antitumor immune response through CD47 and PD-L1
Casey, SC, Tong, L, Li, Y, Do, R, Walz, S, Fitzgerald, KN, Gouw, AM, Baylot, V, Gütgemann, I, Eilers, M & Felsher, DW 2016, , Science, vol. 352, no. 6282, pp. 227-231.

MYC oncogene overexpression drives renal cell carcinoma in a mouse model through glutamine metabolism
Shroff, EH, Eberlin, LS, Dang, VM, Gouw, AM, Gabay, M, Adam, SJ, Bellovin, DI, Trand, PT, Philbrick, WM, Garcia-Ocana, A, Casey, SC, Li, Y, Dang, CV, Zare, RN & Felsher, DW 2015, , Proceedings of the National Academy of Sciences of the United States of America, vol. 112, no. 21, pp. 6539-6544.

miR-17–92 explains MYC oncogene addiction
Li, Y, Casey, SC, Choi, PS & Felsher, DW 2014, , Molecular and Cellular Oncology, vol. 1, no. 4, e970092.

Activation of cre recombinase alone can induce complete tumor regression
Li, Y, Choi, PS, Casey, SC & Felsher, DW 2014, , PLoS ONE, vol. 9, no. 9, e0107589.

Addiction to multiple oncogenes can be exploited to prevent the emergence of therapeutic resistance
Choi, PS, Li, Y & Felsher, DW 2014, , Proceedings of the National Academy of Sciences of the United States of America, vol. 111, no. 32, pp. E3316-E3324.

MYC through miR-17-92 suppresses specific target genes to maintain survival, autonomous proliferation, and a Neoplastic state
Li, Y, Choi, PS, Casey, SC, Dill, DL & Felsher, DW 2014, , Cancer Cell, vol. 26, no. 2, pp. 262-272.

Oncogene withdrawal engages the immune system to induce sustained cancer regression
Casey, SC, Li, Y, Fan, AC & Felsher, DW 2014, , Journal for immunotherapy of cancer, vol. 2, no. 1, 24.

Inactivation of MYC reverses tumorigenesis
Li, Y, Casey, SC & Felsher, DW 2014, , Journal of Internal Medicine, vol. 276, no. 1, pp. 52-60.

An essential role for the immune system in the mechanism of tumor regression following targeted oncogene inactivation
Casey, SC, Li, Y & Felsher, DW 2014, , Immunologic Research, vol. 58, no. 2-3, pp. 282-291.

Oncogene addiction: Resetting the safety switch?
Li, Y, Choi, PS & Felsher, DW 2014, , Oncotarget, vol. 5, no. 18, pp. 7986-7987.

MYC activation is a hallmark of cancer initiation and maintenance
Gabay, M, Li, Y & Felsher, DW 2014, , Cold Spring Harbor Perspectives in Medicine, vol. 4, no. 6.

PERK eIF2 alpha kinase is required to regulate the viability of the exocrine pancreas in mice
Iida, K, Li, Y, McGrath, BC, Frank, A & Cavener, DR 2007, , BMC Cell Biology, vol. 8, 38.

PERK EIF2AK3 control of pancreatic ß cell differentiation and proliferation is required for postnatal glucose homeostasis
Zhang, W, Feng, D, Li, Y, Iida, K, McGrath, B & Cavener, DR 2006, , Cell Metabolism, vol. 4, no. 6, pp. 491-497.

Proinsulin disulfide maturation and misfolding in the endoplasmic reticulum
Liu, M, Li, Y, Cavener, D & Arvan, P 2005, , Journal of Biological Chemistry, vol. 280, no. 14, pp. 13209-13212.