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Yuliang Zhao, PhD

Full Affiliate Member, Research Institute
Houston Methodist


Dr. Yuliang Zhao earned his Ph.D. in Chemical Science from the Tokyo Metropolitan University in 1999. He held faculty appointments at the Chinese Academy of Sciences in Beijing before becoming a member of Houston Methodist Research Institute in 2011. Dr. Zhao also holds adjunct faculty appointments at Peking University (Beijing), the Medical School of Jilin University (Changchun), and Sichuan University (Chengdu).

As the the founder and Director of CAS Key Lab for Biomedical Effects of Nanomaterials & Nanosafety, he directs a research program that is developing a new generation of cancer chemotherapeutics using low-toxic nanoparticles. Dr. Zhao has also been a member of nine study sections and review boards in China and Europe. He is the founder and Director of Research Center for Cancer Nanotechnology at Tianjin Cancer Hospital in China. He has served as the Associate Editor and editorial board member of seven scientific research journals since 2006.

Description of Research

Dr. Zhao's research program focuses on nanotoxicology, cancer nanotechnology, and nanochemistry. He is developing molecular dynamics modeling for designing low-toxic nanosurfaces for cancer nanotechnology applications, and for lowering the toxicity of nanomaterials in living systems. A major aim of his research is to understand the mechanisms of nanotoxicity of engineered nanoparticles in vivo. In addition, a major research goal is to characterize the structure-function relationships between the tumor microenvironment (like extracellular matrices) and engineered nanoparticles that inhibit tumor growth and metastasis. Dr. Zhao's research team at CAS collaborates with Dr. Mauro Ferrari, Dr. Ye "Tony" Hu and other faculty members of the Department of Nanomedicine at the Research Institute in the research of cancer nanotechnology and nanotechnology based biomarker identification.

Areas Of Expertise

Nanotoxicology Cancer nanotechnology Chemistry Nanoscale molecular dynamics modeling
Education & Training

Postdoctoral Fellowship, Japan Society for the Promotion of Science, Tokyo Metropolitan University, Tokyo
PhD, Tokyo Metropolitan University

Walking the line: The fate of nanomaterials at biological barriers
Meng, H, Leong, W, Leong, KW, Chen, C & Zhao, Y 2018, Biomaterials, vol 174, pp. 41-53. DOI: 10.1016/j.biomaterials.2018.04.056

Intelligent testing strategy and analytical techniques for the safety assessment of nanomaterials
Chen, R, Qiao, J, Bai, R, Zhao, Y & Chen, C 2018, Analytical and Bioanalytical Chemistry, pp. 1-16. DOI: 10.1007/s00216-018-0940-y

Imparting Designer Biorecognition Functionality to Metal–Organic Frameworks by a DNA-Mediated Surface Engineering Strategy
Ning, W, Di, Z, Yu, Y, Zeng, P, Di, C, Chen, D, Kong, X, Nie, G, Zhao, Y & Li, L 2018, Small, vol 14, no. 11, 1703812. DOI: 10.1002/smll.201703812

Acute Oral Administration of Single-Walled Carbon Nanotubes Increases Intestinal Permeability and Inflammatory Responses: Association with the Changes in Gut Microbiota in Mice
Chen, H, Zhao, R, Wang, B, Zheng, L, Ouyang, H, Wang, H, Zhou, X, Zhang, D, Chai, Z, Zhao, Y & Feng, W 2018, Advanced Healthcare Materials. DOI: 10.1002/adhm.201701313

A DNA nanorobot functions as a cancer therapeutic in response to a molecular trigger in vivo
Li, S, Jiang, Q, Liu, S, Zhang, Y, Tian, Y, Song, C, Wang, J, Zou, Y, Anderson, GJ, Han, JY, Chang, Y, Liu, Y, Zhang, C, Chen, L, Zhou, G, Nie, G, Yan, H, Ding, B & Zhao, Y 2018, Nature Biotechnology, vol 36, no. 3, pp. 258-264. DOI: 10.1038/nbt.4071

Intelligent MoS2 Nanotheranostic for Targeted and Enzyme-/pH-/NIR-Responsive Drug Delivery to Overcome Cancer Chemotherapy Resistance Guided by PET Imaging
Dong, X, Yin, W, Zhang, X, Zhu, S, He, X, Yu, J, Xie, J, Guo, Z, Yan, L, Liu, X, Wang, Q, Gu, Z & Zhao, Y 2018, ACS Applied Materials and Interfaces, vol 10, no. 4, pp. 4271-4284. DOI: 10.1021/acsami.7b17506

Biodegradable MoOx nanoparticles with efficient near-infrared photothermal and photodynamic synergetic cancer therapy at the second biological window
Yin, W, Bao, T, Zhang, X, Gao, Q, Yu, J, Dong, X, Yan, L, Gu, Z & Zhao, Y 2018, Nanoscale, vol 10, no. 3, pp. 1517-1531. DOI: 10.1039/c7nr07927c

Quantification of Nanomaterial/Nanomedicine Trafficking in Vivo
Wang, L, Yan, L, Liu, J, Chen, C & Zhao, Y 2018, Analytical Chemistry, vol 90, no. 1, pp. 589-614. DOI: 10.1021/acs.analchem.7b04765

Molecular mechanism of Gd@C82(OH)22 increasing collagen expression: Implication for encaging tumor
Liu, J, Kang, SG, Wang, P, Wang, Y, Lv, X, Liu, Y, Wang, F, Gu, Z, Yang, Z, Weber, JK, Tao, N, Qin, Z, Miao, Q, Chen, C, Zhou, R & Zhao, Y 2018, Biomaterials, vol 152, pp. 24-36. DOI: 10.1016/j.biomaterials.2017.10.027

Application of multifunctional nanomaterials in tumor radiosensitization
Gong, L, Xie, J, Zhu, S, Gu, Z & Zhao, Y 2018, Wuli Huaxue Xuebao/ Acta Physico - Chimica Sinica, vol 34, no. 2, pp. 140-167. DOI: 10.3866/PKU.WHXB201707174

Peroxidase-like activity of MoS2 nanoflakes with different modifications and their application for H2O2 and glucose detection
Yu, J, Ma, D, Mei, L, Gao, Q, Yin, W, Zhang, X, Yan, L, Gu, Z, Ma, X & Zhao, Y 2018, Journal of Materials Chemistry B, vol 6, no. 3, pp. 487-498. DOI: 10.1039/c7tb02676e

Synthesis of BSA-Coated BiOI@Bi2S3 Semiconductor Heterojunction Nanoparticles and Their Applications for Radio/Photodynamic/Photothermal Synergistic Therapy of Tumor
Guo, Z, Zhu, S, Yong, Y, Zhang, X, Dong, X, Du, J, Xie, J, Wang, Q, Gu, Z & Zhao, Y 2017, Advanced Materials. DOI: 10.1002/adma.201704136

Bifunctional Tellurium Nanodots for Photo-Induced Synergistic Cancer Therapy
Yang, T, Ke, H, Wang, Q, Tang, YA, Deng, Y, Yang, H, Yang, X, Yang, P, Ling, D, Chen, C, Zhao, Y, Wu, H & Chen, H 2017, ACS Nano, vol 11, no. 10, pp. 10012-10024. DOI: 10.1021/acsnano.7b04230

Metallofullerenol Inhibits Cellular Iron Uptake by Inducing Transferrin Tetramerization
Li, J, Xing, X, Sun, B, Zhao, Y & Wu, Z 2017, Chemistry - An Asian Journal, vol 12, no. 20, pp. 2646-2651. DOI: 10.1002/asia.201700910

The effects of orally administered Ag, TiO2 and SiO2 nanoparticles on gut microbiota composition and colitis induction in mice
Chen, H, Zhao, R, Wang, B, Cai, C, Zheng, L, Wang, H, Wang, M, Ouyang, H, Zhou, X, Chai, Z, Zhao, Y & Feng, W 2017, NanoImpact, vol 8, pp. 80-88. DOI: 10.1016/j.impact.2017.07.005

Ultrasmall Superparamagnetic Iron Oxide Nanoparticle for T2-Weighted Magnetic Resonance Imaging
Wang, Y, Xu, C, Chang, Y, Zhao, L, Zhang, K, Zhao, Y, Gao, F & Gao, X 2017, ACS Applied Materials and Interfaces, vol 9, no. 34, pp. 28959-28966. DOI: 10.1021/acsami.7b10030

Photothermal Effect Enhanced Cascade-Targeting Strategy for Improved Pancreatic Cancer Therapy by Gold Nanoshell@Mesoporous Silica Nanorod
Zhao, R, Han, X, Li, Y, Wang, H, Ji, T, Zhao, Y & Nie, G 2017, ACS Nano, vol 11, no. 8, pp. 8103-8113. DOI: 10.1021/acsnano.7b02918

Fullerenol inhibits the cross-talk between bone marrow-derived mesenchymal stem cells and tumor cells by regulating MAPK signaling
Nie, X, Tang, J, Liu, Y, Cai, R, Miao, Q, Zhao, Y & Chen, C 2017, Nanomedicine: Nanotechnology, Biology, and Medicine, vol 13, no. 6, pp. 1879-1890. DOI: 10.1016/j.nano.2017.03.013

Polyoxometalate-Based Radiosensitization Platform for Treating Hypoxic Tumors by Attenuating Radioresistance and Enhancing Radiation Response
Yong, Y, Zhang, C, Gu, Z, Du, J, Guo, Z, Dong, X, Xie, J, Zhang, G, Liu, X & Zhao, Y 2017, ACS Nano, vol 11, no. 7, pp. 7164-7176. DOI: 10.1021/acsnano.7b03037

MoS2-Nanosheet-Assisted Coordination of Metal Ions with Porphyrin for Rapid Detection and Removal of Cadmium Ions in Aqueous Media
Yin, W, Dong, X, Yu, J, Pan, J, Yao, Z, Gu, Z & Zhao, Y 2017, ACS Applied Materials and Interfaces, vol 9, no. 25, pp. 21362-21370. DOI: 10.1021/acsami.7b04185