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Yuliang Zhao, PhD

Full Affiliate Member, Research Institute
Houston Methodist


Biography

Dr. Yuliang Zhao earned his Ph.D. in Chemical Science from the Tokyo Metropolitan University in 1999. He held faculty appointments at the Chinese Academy of Sciences in Beijing before becoming a member of Houston Methodist Research Institute in 2011. Dr. Zhao also holds adjunct faculty appointments at Peking University (Beijing), the Medical School of Jilin University (Changchun), and Sichuan University (Chengdu).

As the the founder and Director of CAS Key Lab for Biomedical Effects of Nanomaterials & Nanosafety, he directs a research program that is developing a new generation of cancer chemotherapeutics using low-toxic nanoparticles. Dr. Zhao has also been a member of nine study sections and review boards in China and Europe. He is the founder and Director of Research Center for Cancer Nanotechnology at Tianjin Cancer Hospital in China. He has served as the Associate Editor and editorial board member of seven scientific research journals since 2006.

Description of Research

Dr. Zhao's research program focuses on nanotoxicology, cancer nanotechnology, and nanochemistry. He is developing molecular dynamics modeling for designing low-toxic nanosurfaces for cancer nanotechnology applications, and for lowering the toxicity of nanomaterials in living systems. A major aim of his research is to understand the mechanisms of nanotoxicity of engineered nanoparticles in vivo. In addition, a major research goal is to characterize the structure-function relationships between the tumor microenvironment (like extracellular matrices) and engineered nanoparticles that inhibit tumor growth and metastasis. Dr. Zhao's research team at CAS collaborates with Dr. Mauro Ferrari, Dr. Ye "Tony" Hu and other faculty members of the Department of Nanomedicine at the Research Institute in the research of cancer nanotechnology and nanotechnology based biomarker identification.

Areas Of Expertise

Nanotoxicology Cancer nanotechnology Chemistry Nanoscale molecular dynamics modeling
Education & Training

Postdoctoral Fellowship, Japan Society for the Promotion of Science, Tokyo Metropolitan University, Tokyo
PhD, Tokyo Metropolitan University
Publications

A tumour-selective cascade activatable self-detained system for drug delivery and cancer imaging
An, HW, Li, LL, Wang, Y, Wang, Z, Hou, D, Lin, YX, Qiao, SL, Wang, MD, Yang, C, Cong, Y, Ma, Y, Zhao, XX, Cai, Q, Chen, WT, Lu, CQ, Xu, W, Wang, H & Zhao, Y 2019, Nature Communications, vol. 10, no. 1, 4861. https://doi.org/10.1038/s41467-019-12848-5

Research Activities in Advanced Materials at National Center for Nanoscience and Technology of China
Tang, Z, Liu, M & Zhao, Y 2019, Advanced Materials, vol. 31, no. 45, 1901327. https://doi.org/10.1002/adma.201901327

Nano as a rosetta stone: The global roles and opportunities for nanoscience and nanotechnology
Zhao, Y, Bai, C, Brinker, CJ, Chi, L, Dawson, KA, Gogotsi, Y, Halas, NJ, Lee, ST, Lee, T, Liz-Marzán, L, Miller, JF, Mitra, S, Nel, AE, Nordlander, P, Parak, WJ, Rowan, A, Rogach, AL, Rotello, VM, Tang, BZ, Wee, ATS & Weiss, PS 2019, ACS Nano, vol. 13, no. 10, pp. 10853-10855. https://doi.org/10.1021/acsnano.9b08042

Near-Infrared Light-Initiated Hybridization Chain Reaction for Spatially and Temporally Resolved Signal Amplification
Chu, H, Zhao, J, Mi, Y, Zhao, Y & Li, L 2019, Angewandte Chemie - International Edition, vol. 58, no. 42, pp. 14877-14881. https://doi.org/10.1002/anie.201906224

Boron and Nitrogen Co-Doping of Graphynes without Inducing Empty or Doubly Filled States in p-Conjugated Systems
Liu, H, Gao, X & Zhao, Y 2019, Journal of Physical Chemistry C, vol. 123, no. 1, pp. 625-630. https://doi.org/10.1021/acs.jpcc.8b10684

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Zhang, Y, Li, S, Jiang, Q, Di, C, Zhao, Y, Ding, B & Nie, G 2019, Kexue Tongbao/Chinese Science Bulletin, vol. 64, no. 25, pp. 2625-2632. https://doi.org/10.1360/N972019-00257

Cellular Responses to Exposure to Outdoor Air from the Chinese Spring Festival at the Air-Liquid Interface
Ding, J, Guo, J, Wang, L, Chen, Y, Hu, B, Li, Y, Huang, R, Cao, J, Zhao, Y, Geiser, M, Miao, Q, Liu, Y & Chen, C 2019, Environmental Science and Technology, vol. 53, no. 15, pp. 9128-9138. https://doi.org/10.1021/acs.est.9b00399

Precision Nanomedicine Development Based on Specific Opsonization of Human Cancer Patient-Personalized Protein Coronas
Ren, J, Cai, R, Wang, J, Daniyal, M, Baimanov, D, Liu, Y, Yin, D, Liu, Y, Miao, Q, Zhao, Y & Chen, C 2019, Nano Letters, vol. 19, no. 7, pp. 4692-4701. https://doi.org/10.1021/acs.nanolett.9b01774

Exploring the Interaction of Fullerenol with Key Digestive Proteases Using Raman-Based Frequency-Shift Sensing and Molecular Simulation Analysis
Xie, D, Chang, YN, Xing, G, Zhao, L, Li, M & Zhao, Y 2019, ACS Applied Bio Materials, vol. 2, no. 7, pp. 2946-2954. https://doi.org/10.1021/acsabm.9b00304

Correction to: Rational Design of Conjugated Photosensitizers with Controllable Photoconversion for Dually Cooperative Phototherapy (Advanced Materials, (2018), 30, 29, (1801216), 10.1002/adma.201801216)
Ye, S, Rao, J, Qiu, S, Zhao, J, He, H, Yan, Z, Yang, T, Deng, Y, Ke, H, Yang, H, Zhao, Y, Guo, Z & Chen, H 2019, Advanced Materials, vol. 31, no. 21, 1806346. https://doi.org/10.1002/adma.201806346

Ultrasensitive Detection of Circulating Tumor DNA of Lung Cancer via an Enzymatically Amplified SERS-Based Frequency Shift Assay
Zhang, J, Dong, Y, Zhu, W, Xie, D, Zhao, Y, Yang, D & Li, M 2019, ACS Applied Materials and Interfaces, vol. 11, no. 20, pp. 18145-18152. https://doi.org/10.1021/acsami.9b02953

Influence of Surface Charge on the Phytotoxicity, Transformation, and Translocation of CeO 2 Nanoparticles in Cucumber Plants
Liu, M, Feng, S, Ma, Y, Xie, C, He, X, Ding, Y, Zhang, J, Luo, W, Zheng, L, Chen, D, Yang, F, Chai, Z, Zhao, Y & Zhang, Z 2019, ACS Applied Materials and Interfaces, vol. 11, no. 18, pp. 16905-16913. https://doi.org/10.1021/acsami.9b01627

An Extendable Star-Like Nanoplatform for Functional and Anatomical Imaging-Guided Photothermal Oncotherapy
Han, X, Xu, Y, Li, Y, Zhao, X, Zhang, Y, Min, H, Qi, Y, Anderson, GJ, You, L, Zhao, Y & Nie, G 2019, ACS Nano, vol. 13, no. 4, pp. 4379-4391. https://doi.org/10.1021/acsnano.8b09607

Surface-Functionalized Modified Copper Sulfide Nanoparticles Enhance Checkpoint Blockade Tumor Immunotherapy by Photothermal Therapy and Antigen Capturing
Wang, R, He, Z, Cai, P, Zhao, Y, Gao, L, Yang, W, Zhao, Y, Gao, X & Gao, F 2019, ACS Applied Materials and Interfaces, vol. 11, no. 15, pp. 13964-13972. https://doi.org/10.1021/acsami.9b01107

Translocation, biotransformation-related degradation, and toxicity assessment of polyvinylpyrrolidone-modified 2H-phase nano-MoS 2
Mei, L, Zhang, X, Yin, W, Dong, X, Guo, Z, Fu, W, Su, C, Gu, Z & Zhao, Y 2019, Nanoscale, vol. 11, no. 11, pp. 4767-4780. https://doi.org/10.1039/c8nr10319d

Tumor microenvironment-responsive cu 2 (oh)po 4 nanocrystals for selective and controllable radiosentization via the x-ray-triggered fenton-like reaction
Zhang, C, Yan, L, Wang, X, Dong, X, Zhou, R, Gu, Z & Zhao, Y 2019, Nano Letters, vol. 19, no. 3, pp. 1749-1757. https://doi.org/10.1021/acs.nanolett.8b04763

Graphene-Based Smart Platforms for Combined Cancer Therapy
Gu, Z, Zhu, S, Yan, L, Zhao, F & Zhao, Y 2019, Advanced Materials, vol. 31, no. 9, 1800662. https://doi.org/10.1002/adma.201800662

Generalized Preparation of Two-Dimensional Quasi-nanosheets via Self-assembly of Nanoparticles
Cai, R, Yang, D, Lin, KT, Lyu, Y, Zhu, B, He, Z, Zhang, L, Kitamura, Y, Qiu, L, Chen, X, Zhao, Y, Chen, Z & Tan, W 2019, Journal of the American Chemical Society, vol. 141, no. 4, pp. 1725-1734. https://doi.org/10.1021/jacs.8b12415

Engineering Multifunctional DNA Hybrid Nanospheres through Coordination-Driven Self-Assembly
Li, M, Wang, C, Di, Z, Li, H, Zhang, J, Xue, W, Zhao, M, Zhang, K, Zhao, Y & Li, L 2019, Angewandte Chemie - International Edition, vol. 58, no. 5, pp. 1350-1354. https://doi.org/10.1002/anie.201810735

Graphdiyne Nanoparticles with High Free Radical Scavenging Activity for Radiation Protection
Xie, J, Wang, N, Dong, X, Wang, C, Du, Z, Mei, L, Yong, Y, Huang, C, Li, Y, Gu, Z & Zhao, Y 2019, ACS Applied Materials and Interfaces, vol. 11, no. 3, pp. 2579-2590. https://doi.org/10.1021/acsami.8b00949

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