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Yuliang Zhao, PhD

Full Affiliate Member, Research Institute
Houston Methodist


Dr. Yuliang Zhao earned his Ph.D. in Chemical Science from the Tokyo Metropolitan University in 1999. He held faculty appointments at the Chinese Academy of Sciences in Beijing before becoming a member of Houston Methodist Research Institute in 2011. Dr. Zhao also holds adjunct faculty appointments at Peking University (Beijing), the Medical School of Jilin University (Changchun), and Sichuan University (Chengdu).

As the the founder and Director of CAS Key Lab for Biomedical Effects of Nanomaterials & Nanosafety, he directs a research program that is developing a new generation of cancer chemotherapeutics using low-toxic nanoparticles. Dr. Zhao has also been a member of nine study sections and review boards in China and Europe. He is the founder and Director of Research Center for Cancer Nanotechnology at Tianjin Cancer Hospital in China. He has served as the Associate Editor and editorial board member of seven scientific research journals since 2006.

Description of Research

Dr. Zhao's research program focuses on nanotoxicology, cancer nanotechnology, and nanochemistry. He is developing molecular dynamics modeling for designing low-toxic nanosurfaces for cancer nanotechnology applications, and for lowering the toxicity of nanomaterials in living systems. A major aim of his research is to understand the mechanisms of nanotoxicity of engineered nanoparticles in vivo. In addition, a major research goal is to characterize the structure-function relationships between the tumor microenvironment (like extracellular matrices) and engineered nanoparticles that inhibit tumor growth and metastasis. Dr. Zhao's research team at CAS collaborates with Dr. Mauro Ferrari, Dr. Ye "Tony" Hu and other faculty members of the Department of Nanomedicine at the Research Institute in the research of cancer nanotechnology and nanotechnology based biomarker identification.

Areas Of Expertise

Nanotoxicology Cancer nanotechnology Chemistry Nanoscale molecular dynamics modeling
Education & Training

Postdoctoral Fellowship, Japan Society for the Promotion of Science, Tokyo Metropolitan University, Tokyo
PhD, Tokyo Metropolitan University

Tumor microenvironment-manipulated radiocatalytic sensitizer based on bismuth heteropolytungstate for radiotherapy enhancement
Zhou, R, Wang, H, Yang, Y, Zhang, C, Dong, X, Du, J, Yan, L, Zhang, G, Gu, Z & Zhao, Y 2019, Biomaterials, vol. 189, pp. 11-22. DOI: 10.1016/j.biomaterials.2018.10.016

Reversal of pancreatic desmoplasia by re-educating stellate cells with a tumour microenvironment-activated nanosystem
Han, X, Li, Y, Xu, Y, Zhao, X, Zhang, Y, Yang, X, Wang, Y, Zhao, R, Anderson, GJ, Zhao, Y & Nie, G 2018, Nature communications, vol. 9, no. 1, 3390. DOI: 10.1038/s41467-018-05906-x

Nanomedicine in China
Zhao, Y 2018, Advanced Healthcare Materials, vol. 7, no. 20, 1801051. DOI: 10.1002/adhm.201801051

Mechanisms of Antioxidant Activities of Fullerenols from First-Principles Calculation
Wang, Z, Gao, X & Zhao, Y 2018, Journal of Physical Chemistry A, vol. 122, no. 41, pp. 8183-8190. DOI: 10.1021/acs.jpca.8b06340

Ultrasensitive Detection of Serum MicroRNA Using Branched DNA-Based SERS Platform Combining Simultaneous Detection of a-Fetoprotein for Early Diagnosis of Liver Cancer
Cheng, L, Zhang, Z, Zuo, D, Zhu, W, Zhang, J, Zeng, Q, Yang, D, Li, M & Zhao, Y 2018, ACS Applied Materials and Interfaces, vol. 10, no. 41, pp. 34869-34877. DOI: 10.1021/acsami.8b10252

Simultaneous Quantification of Multiple Cancer Biomarkers in Blood Samples through DNA-Assisted Nanopore Sensing
Liu, L, Li, T, Zhang, S, Song, P, Guo, B, Zhao, Y & Wu, HC 2018, Angewandte Chemie - International Edition, vol. 57, no. 37, pp. 11882-11887. DOI: 10.1002/anie.201803324

Walking the line: The fate of nanomaterials at biological barriers
Meng, H, Leong, W, Leong, KW, Chen, C & Zhao, Y 2018, Biomaterials, vol. 174, pp. 41-53. DOI: 10.1016/j.biomaterials.2018.04.056

One Second Formation of Large Area Graphene on a Conical Tip Surface via Direct Transformation of Surface Carbide
Ge, Y, Xu, L, Lu, X, Xu, J, Liang, J & Zhao, Y 2018, Small, vol. 14, no. 29, 1801288. DOI: 10.1002/smll.201801288

Turning On/Off the Anti-Tumor Effect of the Au Cluster via Atomically Controlling Its Molecular Size
Zhai, J, Jia, Y, Zhao, L, Yuan, Q, Gao, F, Zhang, X, Cai, P, Gao, L, Guo, J, Yi, S, Chai, Z, Zhao, Y & Gao, X 2018, ACS Nano, vol. 12, no. 5, pp. 4378-4386. DOI: 10.1021/acsnano.8b00027

Specific detection and effective inhibition of a single bacterial species in situ using peptide mineralized Au cluster probes
Zhang, X, Liu, L, Liu, R, Wang, J, Hu, X, Yuan, Q, Guo, J, Xing, G, Zhao, Y & Gao, X 2018, Science China Chemistry, vol. 61, no. 5, pp. 627-634. DOI: 10.1007/s11426-017-9206-y

Nanomaterial libraries and model organisms for rapid high-content analysis of nanosafety
Li, Y, Wang, J, Zhao, F, Bai, B, Nie, G, Nel, AE & Zhao, Y 2018, National Science Review, vol. 5, no. 3, pp. 365-388. DOI: 10.1093/nsr/nwx120

Intelligent testing strategy and analytical techniques for the safety assessment of nanomaterials
Chen, R, Qiao, J, Bai, R, Zhao, Y & Chen, C 2018, Analytical and Bioanalytical Chemistry, pp. 1-16. DOI: 10.1007/s00216-018-0940-y

Imparting Designer Biorecognition Functionality to Metal–Organic Frameworks by a DNA-Mediated Surface Engineering Strategy
Ning, W, Di, Z, Yu, Y, Zeng, P, Di, C, Chen, D, Kong, X, Nie, G, Zhao, Y & Li, L 2018, Small, vol. 14, no. 11, 1703812. DOI: 10.1002/smll.201703812

Graphdiyne Nanosheet-Based Drug Delivery Platform for Photothermal/Chemotherapy Combination Treatment of Cancer
Jin, J, Guo, M, Liu, J, Liu, J, Zhou, H, Li, J, Wang, L, Liu, H, Li, Y, Zhao, Y & Chen, C 2018, ACS Applied Materials and Interfaces, vol. 10, no. 10, pp. 8436-8442. DOI: 10.1021/acsami.7b17219

A DNA nanorobot functions as a cancer therapeutic in response to a molecular trigger in vivo
Li, S, Jiang, Q, Liu, S, Zhang, Y, Tian, Y, Song, C, Wang, J, Zou, Y, Anderson, GJ, Han, JY, Chang, Y, Liu, Y, Zhang, C, Chen, L, Zhou, G, Nie, G, Yan, H, Ding, B & Zhao, Y 2018, Nature Biotechnology, vol. 36, no. 3, pp. 258-264. DOI: 10.1038/nbt.4071

Intelligent MoS2 Nanotheranostic for Targeted and Enzyme-/pH-/NIR-Responsive Drug Delivery to Overcome Cancer Chemotherapy Resistance Guided by PET Imaging
Dong, X, Yin, W, Zhang, X, Zhu, S, He, X, Yu, J, Xie, J, Guo, Z, Yan, L, Liu, X, Wang, Q, Gu, Z & Zhao, Y 2018, ACS Applied Materials and Interfaces, vol. 10, no. 4, pp. 4271-4284. DOI: 10.1021/acsami.7b17506

Biodegradable MoOx nanoparticles with efficient near-infrared photothermal and photodynamic synergetic cancer therapy at the second biological window
Yin, W, Bao, T, Zhang, X, Gao, Q, Yu, J, Dong, X, Yan, L, Gu, Z & Zhao, Y 2018, Nanoscale, vol. 10, no. 3, pp. 1517-1531. DOI: 10.1039/c7nr07927c

Quantification of Nanomaterial/Nanomedicine Trafficking in Vivo
Wang, L, Yan, L, Liu, J, Chen, C & Zhao, Y 2018, Analytical Chemistry, vol. 90, no. 1, pp. 589-614. DOI: 10.1021/acs.analchem.7b04765

Molecular mechanism of Gd@C82(OH)22 increasing collagen expression: Implication for encaging tumor
Liu, J, Kang, SG, Wang, P, Wang, Y, Lv, X, Liu, Y, Wang, F, Gu, Z, Yang, Z, Weber, JK, Tao, N, Qin, Z, Miao, Q, Chen, C, Zhou, R & Zhao, Y 2018, Biomaterials, vol. 152, pp. 24-36. DOI: 10.1016/j.biomaterials.2017.10.027

Application of multifunctional nanomaterials in tumor radiosensitization
Gong, L, Xie, J, Zhu, S, Gu, Z & Zhao, Y 2018, Wuli Huaxue Xuebao/ Acta Physico - Chimica Sinica, vol. 34, no. 2, pp. 140-167. DOI: 10.3866/PKU.WHXB201707174