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Yuliang Zhao, PhD

Full Affiliate Member, Research Institute
Houston Methodist


Biography

Dr. Yuliang Zhao earned his Ph.D. in Chemical Science from the Tokyo Metropolitan University in 1999. He held faculty appointments at the Chinese Academy of Sciences in Beijing before becoming a member of Houston Methodist Research Institute in 2011. Dr. Zhao also holds adjunct faculty appointments at Peking University (Beijing), the Medical School of Jilin University (Changchun), and Sichuan University (Chengdu).

As the the founder and Director of CAS Key Lab for Biomedical Effects of Nanomaterials & Nanosafety, he directs a research program that is developing a new generation of cancer chemotherapeutics using low-toxic nanoparticles. Dr. Zhao has also been a member of nine study sections and review boards in China and Europe. He is the founder and Director of Research Center for Cancer Nanotechnology at Tianjin Cancer Hospital in China. He has served as the Associate Editor and editorial board member of seven scientific research journals since 2006.

Description of Research

Dr. Zhao's research program focuses on nanotoxicology, cancer nanotechnology, and nanochemistry. He is developing molecular dynamics modeling for designing low-toxic nanosurfaces for cancer nanotechnology applications, and for lowering the toxicity of nanomaterials in living systems. A major aim of his research is to understand the mechanisms of nanotoxicity of engineered nanoparticles in vivo. In addition, a major research goal is to characterize the structure-function relationships between the tumor microenvironment (like extracellular matrices) and engineered nanoparticles that inhibit tumor growth and metastasis. Dr. Zhao's research team at CAS collaborates with Dr. Mauro Ferrari, Dr. Ye "Tony" Hu and other faculty members of the Department of Nanomedicine at the Research Institute in the research of cancer nanotechnology and nanotechnology based biomarker identification.

Areas Of Expertise

Nanotoxicology Cancer nanotechnology Chemistry Nanoscale molecular dynamics modeling
Education & Training

Postdoctoral Fellowship, Japan Society for the Promotion of Science, Tokyo Metropolitan University, Tokyo
PhD, Tokyo Metropolitan University
Publications

15 Years of Small: Research Trends in Nanosafety
Zhu, S, Li, L, Gu, Z, Chen, C & Zhao, Y 2020, , Small, vol. 16, no. 36, 2000980. https://doi.org/10.1002/smll.202000980

Nano-bio interactions: the implication of size-dependent biological effects of nanomaterials
Wang, X, Cui, X, Zhao, Y & Chen, C 2020, , Science China Life Sciences, vol. 63, no. 8, pp. 1168-1182. https://doi.org/10.1007/s11427-020-1725-0

A Heterojunction Structured WO2.9-WSe2Nanoradiosensitizer Increases Local Tumor Ablation and Checkpoint Blockade Immunotherapy upon Low Radiation Dose
Dong, X, Dong, X, Cheng, R, Cheng, R, Zhu, S, Liu, H, Liu, H, Zhou, R, Zhou, R, Zhang, C, Zhang, C, Chen, K, Chen, K, Mei, L, Mei, L, Wang, C, Wang, C, Su, C, Liu, X, Gu, Z, Gu, Z, Zhao, Y & Zhao, Y 2020, , ACS Nano, vol. 14, no. 5, pp. 5400-5416. https://doi.org/10.1021/acsnano.9b08962

Cell-Penetrating Nanoparticles Activate the Inflammasome to Enhance Antibody Production by Targeting Microtubule-Associated Protein 1-Light Chain 3 for Degradation
Zhu, M, Du, L, Zhao, R, Wang, HY, Zhao, Y, Nie, G & Wang, RF 2020, , ACS Nano, vol. 14, no. 3, pp. 3703-3717. https://doi.org/10.1021/acsnano.0c00962

Ultrasmall BiOI Quantum Dots with Efficient Renal Clearance for Enhanced Radiotherapy of Cancer
Wang, X, Guo, Z, Zhang, C, Zhu, S, Li, L, Gu, Z & Zhao, Y 2020, , Advanced Science, vol. 7, no. 6, 1902561. https://doi.org/10.1002/advs.201902561

Nd3+-Sensitized Upconversion Metal–Organic Frameworks for Mitochondria-Targeted Amplified Photodynamic Therapy
Liu, C, Liu, B, Zhao, J, Di, Z, Chen, D, Gu, Z, Li, L & Zhao, Y 2020, , Angewandte Chemie - International Edition, vol. 59, no. 7, pp. 2634-2638. https://doi.org/10.1002/anie.201911508

Single-particle analysis for structure and iron chemistry of atmospheric particulate matter
Ding, J, Guan, Y, Cong, Y, Chen, L, Li, YF, Zhang, L, Zhang, L, Wang, J, Bai, R, Zhao, Y, Chen, C & Wang, L 2020, , Analytical Chemistry, vol. 92, no. 1, pp. 975-982. https://doi.org/10.1021/acs.analchem.9b03913

Two-dimensional nanomaterials beyond graphene for antibacterial applications: Current progress and future perspectives
Mei, L, Zhu, S, Yin, W, Chen, C, Nie, G, Gu, Z & Zhao, Y 2020, , Theranostics, vol. 10, no. 2, pp. 757-781. https://doi.org/10.7150/thno.39701

Nanomedicine-Based Immunotherapy for the Treatment of Cancer Metastasis
Zhang, P, Zhai, Y, Cai, Y, Zhao, Y & Li, Y 2019, , Advanced Materials, vol. 31, no. 49, 1904156. https://doi.org/10.1002/adma.201904156

Emerging Delivery Strategies of Carbon Monoxide for Therapeutic Applications: from CO Gas to CO Releasing Nanomaterials
Yan, H, Du, J, Zhu, S, Nie, G, Zhang, H, Gu, Z & Zhao, Y 2019, , Small, vol. 15, no. 49, 1904382. https://doi.org/10.1002/smll.201904382

A tumour-selective cascade activatable self-detained system for drug delivery and cancer imaging
An, HW, Li, LL, Wang, Y, Wang, Z, Hou, D, Lin, YX, Qiao, SL, Wang, MD, Yang, C, Cong, Y, Ma, Y, Zhao, XX, Cai, Q, Chen, WT, Lu, CQ, Xu, W, Wang, H & Zhao, Y 2019, , Nature Communications, vol. 10, no. 1, 4861. https://doi.org/10.1038/s41467-019-12848-5

3D halos assembled from Fe3O4/Au NPs with enhanced catalytic and optical properties
Cai, R, Yang, D, Lin, KT, Cao, TS, Lyv, Y, Chen, K, Yang, Y, Ge, J, Xia, L, Christou, G, Zhao, Y, Chen, Z & Tan, W 2019, , Nanoscale, vol. 11, no. 43, pp. 20968-20976. https://doi.org/10.1039/c9nr05874e

A Safe-by-Design Strategy towards Safer Nanomaterials in Nanomedicines
Yan, L, Zhao, F, Wang, J, Zu, Y, Gu, Z & Zhao, Y 2019, , Advanced Materials, vol. 31, no. 45, 1805391. https://doi.org/10.1002/adma.201805391

Research Activities in Advanced Materials at National Center for Nanoscience and Technology of China
Tang, Z, Liu, M & Zhao, Y 2019, , Advanced Materials, vol. 31, no. 45, 1901327. https://doi.org/10.1002/adma.201901327

Engineered Graphene Oxide Nanocomposite Capable of Preventing the Evolution of Antimicrobial Resistance
Zheng, H, Ji, Z, Roy, KR, Gao, M, Pan, Y, Cai, X, Wang, L, Li, W, Chang, CH, Kaweeteerawat, C, Chen, C, Xia, T, Zhao, Y & Li, R 2019, , ACS Nano, vol. 13, no. 10, pp. 11488-11499. https://doi.org/10.1021/acsnano.9b04970

Nano as a rosetta stone: The global roles and opportunities for nanoscience and nanotechnology
Zhao, Y, Bai, C, Brinker, CJ, Chi, L, Dawson, KA, Gogotsi, Y, Halas, NJ, Lee, ST, Lee, T, Liz-Marzán, L, Miller, JF, Mitra, S, Nel, AE, Nordlander, P, Parak, WJ, Rowan, A, Rogach, AL, Rotello, VM, Tang, BZ, Wee, ATS & Weiss, PS 2019, , ACS Nano, vol. 13, no. 10, pp. 10853-10855. https://doi.org/10.1021/acsnano.9b08042

A Dual-Response DNA Probe for Simultaneously Monitoring Enzymatic Activity and Environmental pH Using a Nanopore
Liu, L, You, Y, Zhou, K, Guo, B, Cao, Z, Zhao, Y & Wu, HC 2019, , Angewandte Chemie - International Edition, vol. 58, no. 42, pp. 14929-14934. https://doi.org/10.1002/anie.201907816

Near-Infrared Light-Initiated Hybridization Chain Reaction for Spatially and Temporally Resolved Signal Amplification
Chu, H, Zhao, J, Mi, Y, Zhao, Y & Li, L 2019, , Angewandte Chemie - International Edition, vol. 58, no. 42, pp. 14877-14881. https://doi.org/10.1002/anie.201906224

Boron and Nitrogen Co-Doping of Graphynes without Inducing Empty or Doubly Filled States in p-Conjugated Systems
Liu, H, Gao, X & Zhao, Y 2019, , Journal of Physical Chemistry C, vol. 123, no. 1, pp. 625-630. https://doi.org/10.1021/acs.jpcc.8b10684

Graphdiyne: The Fundamentals and Application of an Emerging Carbon Material
Huang, C, Zhao, Y & Zhao, Y 2019, , Advanced Materials, vol. 31, no. 42, 1904885. https://doi.org/10.1002/adma.201904885