Yuliang Zhao

Yuliang Zhao, PhD

Full Affiliate Member, Research Institute
Houston Methodist


Dr. Yuliang Zhao earned his Ph.D. in Chemical Science from the Tokyo Metropolitan University in 1999. He held faculty appointments at the Chinese Academy of Sciences in Beijing before becoming a member of Houston Methodist Research Institute in 2011. Dr. Zhao also holds adjunct faculty appointments at Peking University (Beijing), the Medical School of Jilin University (Changchun), and Sichuan University (Chengdu).

As the the founder and Director of CAS Key Lab for Biomedical Effects of Nanomaterials & Nanosafety, he directs a research program that is developing a new generation of cancer chemotherapeutics using low-toxic nanoparticles. Dr. Zhao has also been a member of nine study sections and review boards in China and Europe. He is the founder and Director of Research Center for Cancer Nanotechnology at Tianjin Cancer Hospital in China. He has served as the Associate Editor and editorial board member of seven scientific research journals since 2006.

Description of Research

Dr. Zhao's research program focuses on nanotoxicology, cancer nanotechnology, and nanochemistry. He is developing molecular dynamics modeling for designing low-toxic nanosurfaces for cancer nanotechnology applications, and for lowering the toxicity of nanomaterials in living systems. A major aim of his research is to understand the mechanisms of nanotoxicity of engineered nanoparticles in vivo. In addition, a major research goal is to characterize the structure-function relationships between the tumor microenvironment (like extracellular matrices) and engineered nanoparticles that inhibit tumor growth and metastasis. Dr. Zhao's research team at CAS collaborates with Dr. Mauro Ferrari, Dr. Ye "Tony" Hu and other faculty members of the Department of Nanomedicine at the Research Institute in the research of cancer nanotechnology and nanotechnology based biomarker identification.

Areas Of Expertise

Nanotoxicology Cancer nanotechnology Chemistry Nanoscale molecular dynamics modeling
Education & Training

Postdoctoral Fellowship, Japan Society for the Promotion of Science, Tokyo Metropolitan University, Tokyo
PhD, Tokyo Metropolitan University

Correction: Durable and enhanced immunity against SARS-CoV-2 elicited by manganese nanoadjuvant formulated subunit vaccine (Signal Transduction and Targeted Therapy, (2023), 8, 1, (462), 10.1038/s41392-023-01718-8)
Guo, M, Cao, M, Sun, J, Chen, Z, Wang, X, Dai, L, Gao, GF, Zhao, Y, Wang, Y & Chen, C 2024, , Signal Transduction and Targeted Therapy, vol. 9, no. 1, 22. https://doi.org/10.1038/s41392-024-01739-x

Modular Weaving DNAzyme in Skeleton of DNA Nanocages for Photoactivatable Catalytic Activity Regulation
Zhao, H, Yi, D, Li, L, Zhao, Y & Li, M 2024, , Angewandte Chemie - International Edition, vol. 63, no. 18, e202404064. https://doi.org/10.1002/anie.202404064

Protein Corona-Mediated Inhibition of Nanozyme Activity: Impact of Protein Shape
Cong, Y, Qiao, R, Wang, X, Ji, Y, Yang, J, Baimanov, D, Yu, S, Cai, R, Zhao, Y, Wu, X, Chen, C & Wang, L 2024, , Journal of the American Chemical Society, vol. 146, no. 15, pp. 10478-10488. https://doi.org/10.1021/jacs.3c14046

Nanotechnology in Bioanalytical Chemistry
Chen, C & Zhao, Y 2024, , Chemical Research in Chinese Universities, vol. 40, no. 2, pp. 159-161. https://doi.org/10.1007/s40242-024-4059-8

Celebrating the 20th anniversary of the National Center for Nanoscience and Technology, China (NCNST)
Liu, X, Dai, Q, Wei, Z, Chen, C & Zhao, Y 2024, , Nanoscale, vol. 16, no. 6, pp. 2691-2694. https://doi.org/10.1039/d3nr90228e

The dynamic role of platelets in cancer progression and their therapeutic implications
Li, S, Lu, Z, Wu, S, Chu, T, Li, B, Qi, F, Zhao, Y & Nie, G 2024, , Nature Reviews Cancer, vol. 24, no. 1, pp. 72-87. https://doi.org/10.1038/s41568-023-00639-6

Highly Efficient Growth of Large-Sized Uniform Graphene Glass in Air by Scanning Electromagnetic Induction Quenching Method
Wang, J, Chang, Z, Lu, M, Li, M, Gao, X, Xu, J & Zhao, Y 2024, , Advanced Functional Materials. https://doi.org/10.1002/adfm.202402188

A Two-Decade Journey of Continuous Innovation at the National Center for Nanoscience and Technology of China (NCNST)
Dai, Q, Wei, Z, Tang, Z & Zhao, Y 2024, , Advanced Materials, vol. 36, no. 22, 2313657. https://doi.org/10.1002/adma.202313657

Octadecyl Gallate and Lipid-Modified MnSe2 Nanoparticles Enhance Radiosensitivity in Esophageal Squamous Cell Carcinoma and Promote Radioprotection in Normal Tissues
Li, X, Liu, H, Gao, W, Yang, Q, Li, X, Zhou, X, Wang, L, Lu, Z, Liu, J, Luo, A, Chen, C, Liu, Z & Zhao, YL 2024, , Advanced Materials, vol. 36, no. 23, 2311291. https://doi.org/10.1002/adma.202311291

Programming conformational cooperativity to regulate allosteric protein-oligonucleotide signal transduction
Liang, Y, Qie, Y, Yang, J, Wu, R, Cui, S, Zhao, Y, Anderson, GJ, Nie, G, Li, S & Zhang, C 2023, , Nature Communications, vol. 14, no. 1, 4898. https://doi.org/10.1038/s41467-023-40589-z

Durable and enhanced immunity against SARS-CoV-2 elicited by manganese nanoadjuvant formulated subunit vaccine
Guo, M, Cao, M, Sun, J, Chen, Z, Wang, X, Dai, L, Gao, GF, Zhao, Y, Wang, Y & Chen, C 2023, , Signal Transduction and Targeted Therapy, vol. 8, no. 1, 462. https://doi.org/10.1038/s41392-023-01718-8

STING and TLR9 agonists synergistically enhance the immunogenicity of SARS-CoV-2 subunit vaccine
Li, Y, Chen, Z, Lu, X, Sun, J, Guo, M, Zhou, H, Bai, R, Zhao, Y, Chen, C & Wang, Y 2023, , Nano Research, vol. 16, no. 12, pp. 13322-13334. https://doi.org/10.1007/s12274-023-6295-5

A special issue for the 20th anniversary of National Center for Nanoscience and Technology
Dai, Q, Nie, G, Tang, Z & Zhao, Y 2023, , Nano Research, vol. 16, no. 12, pp. 12881-12882. https://doi.org/10.1007/s12274-023-6377-4

Recent advances in nanoantibiotics against multidrug-resistant bacteria
Li, M, Liu, Y, Gong, Y, Yan, X, Wang, L, Zheng, W, Ai, H & Zhao, Y 2023, , Nanoscale Advances, vol. 5, no. 23, pp. 6278-6317. https://doi.org/10.1039/d3na00530e

Entangling of Peptide Nanofibers Reduces the Invasiveness of SARS-CoV-2
Yang, PP, Ye, XW, Liu, MQ, Yang, JX, Feng, XL, Li, YJ, Zhang, K, Liang, HW, Yi, Y, Wang, L, Liu, YX, Yang, XL, Shi, ZL, Feng, LQ, Chen, L, Xue, Y, Pan-Hammarström, Q, Wang, H & Zhao, Y 2023, , Advanced Healthcare Materials, vol. 12, no. 24, 2300673. https://doi.org/10.1002/adhm.202300673

He, H, Wu, S, Xin, J, Zhao, H, Wang, Y, Yan, D, Shan, L, Wang, X & Zhao, Y 2023, , Bulletin of Chinese Academy of Sciences, vol. 38, no. 9, pp. 1315-1324. https://doi.org/10.16418/j.issn.1000-3045.20230815001

Catalytic Signal Transduction Theory Enabled Virtual Screening of Nanomaterials for Medical Functions
Gao, XJ, Zhao, Y & Gao, X 2023, , Accounts of Chemical Research, vol. 56, no. 17, pp. 2366-2377. https://doi.org/10.1021/acs.accounts.3c00339

Enzyme and MicroRNA Dual-Regulated Photodynamic Molecular Beacons for Cell-Selective Amplification of Antitumor Efficacy
Feng, X, Li, L, Zhao, Y & Li, M 2023, , Nano Letters, vol. 23, no. 16, pp. 7743-7749. https://doi.org/10.1021/acs.nanolett.3c01814

Two-Dimensional Carbon Graphdiyne: Advances in Fundamental and Application Research
Zheng, X, Chen, S, Li, J, Wu, H, Zhang, C, Zhang, D, Chen, X, Gao, Y, He, F, Hui, L, Liu, H, Jiu, T, Wang, N, Li, G, Xu, J, Xue, Y, Huang, C, Chen, C, Guo, Y, Lu, TB, Wang, D, Mao, L, Zhang, J, Zhang, Y, Chi, L, Guo, W, Bu, XH, Zhang, H, Dai, L, Zhao, Y & Li, Y 2023, , ACS Nano, vol. 17, no. 15, pp. 14309-14346. https://doi.org/10.1021/acsnano.3c03849

Fabrication of AuPt heterostructured nanorings for enhanced synergistic radio-photothermal therapy
Luo, M, Zhu, X, Yang, H, Yan, L, Cai, R, Zhao, Y & Tan, W 2023, , Nano Today, vol. 51, 101919. https://doi.org/10.1016/j.nantod.2023.101919