Ying Xuan Chua

Ying Xuan Chua, PhD

Assistant Professor of Nanomedicine, Academic Institute
Assistant Member, Research Institute
Houston Methodist
Weill Cornell Medical College


ychua@houstonmethodist.org
Biography

Dr. Corrine Ying Xuan Chua obtained her Bachelor of Science degree in Microbiology magna cum laude in 2006 from the University of Louisiana at Lafayette in Lafayette, LA. In 2009, she received her master's degree in Cellular and Structural Biology from the University of Texas Health Science Center at San Antonio in San Antonio, TX. Her master's thesis was focused on studying mechanisms of therapeutic resistance in alveolar rhabdomyosarcoma, a rare childhood muscle cancer. She researched different preclinical therapeutics in genetically engineered murine cancer models of alveolar rhabdomyosarcoma.

In 2015, she received her Ph.D. degree in Cancer Biology summa cum laude from the University of Texas MD Anderson Cancer Center, Houston, TX. She focused on investigating oncogenic pathways and identifying therapeutically targetable factors for glioma treatment. There she achieved several accomplishments for this work, including publications as first- or co-author in a peer-reviewed journals (Oncogene, PNAS, Journal of Pathology) and awards such as the Caroline Ross Endowed Fellowship Award, Professor Alexander Wang Memorial Scholarship Award and UT Graduate School-related awards.

Dr. Chua joined the Department of Nanomedicine at Houston Methodist Research Institute as a postdoctoral fellow the under the mentorship of Dr. Alessandro Grattoni in 2016. Her research activities as a postdoctoral fellow involved drug delivery using nanotechnology-based implants for a variety of therapeutic indications including cancer and HIV.

She is currently a Research Assistant Professor in the Department of Nanomedicine at Houston Methodist Research Institute and an Assistant Professor of Nanomedicine Research in Medicine at Weill Cornell Medical College, New York, NY.

Description of Research

Dr. Chua’s research interest is to develop alternative strategies for cancer treatment, with a primary focus on nanofluidics-based intratumoral delivery of immunotherapy to improve therapeutic efficacy and minimize adverse effects of systemic treatment. She is also working on developing a therapeutic cancer vaccine via an implantable platform for continuous antigen-specific immune activation against tumors.

Areas Of Expertise

Immunotherapy Implantable devices Intratumoral immunotherapy Therapeutic cancer vaccine
Publications

Intratumoral nanofluidic system enhanced tumor biodistribution of PD-L1 antibody in triple-negative breast cancer
Liu, H-C, Capuani, S, Badachhape, AA, Di Trani, N, Davila Gonzalez, D, Vander Pol, RS, Viswanath, DI, Saunders, S, Hernandez, N, Ghaghada, KB, Chen, S-H, Nance, E, Annapragada, AV, Chua, CYX & Grattoni, A 2023, , Bioengineering and Translational Medicine, vol. 8, no. 6, e10594, pp. e10594. https://doi.org/10.1002/btm2.10594

Local Delivery of Drugs in a 3D Bioengineered Subcutaneous Niche: Biodistribution and Pharmacokinetics.
Capuani, S, Hernandez, N, Paez-Mayorga, J, Dogra, P, Wang, Z, Cristini, V, Chua, CYX, Nichols, J & Grattoni, A 2023, , 8th Nano Today Conference, San Diego, United States, 4/22/23 - 4/25/23.

Implantable niche with local immunosuppression for islet allotransplantation achieves type 1 diabetes reversal in rats
Paez-Mayorga, J, Campa-Carranza, JN, Capuani, S, Hernandez, N, Liu, H-C, Chua, CYX, Pons-Faudoa, FP, Malgir, G, Alvarez, B, Niles, JA, Argueta, LB, Shelton, KA, Kezar, S, Nehete, PN, Berman, DM, Willman, MA, Li, XC, Ricordi, C, Nichols, JE, Gaber, AO, Kenyon, NS & Grattoni, A 2022, , Nature Communications, vol. 13, no. 1, 7951. https://doi.org/10.1038/s41467-022-35629-z, https://doi.org/10.1038/s41467-022-35629-z

Localization of drug biodistribution in a 3D-bioengineered subcutaneous neovascularized microenvironment
Capuani, S, Hernandez, N, Paez-Mayorga, J, Dogra, P, Wang, Z, Cristini, V, Chua, CYX, Nichols, JE & Grattoni, A 2022, , Materials Today Bio, vol. 16, pp. 100390. https://doi.org/10.1016/j.mtbio.2022.100390

Localization of drug biodistribution in a 3D-bioengineered subcutaneous neovascularized microenvironment
Capuani, S, Hernandez, N, Paez-Mayorga, J, Dogra, P, Wang, Z, Cristini, V, Chua, CYX, Nichols, JE & Grattoni, A 2022, , Materials Today Bio, vol. 16, 100390, pp. 100390. https://doi.org/10.1016/j.mtbio.2022.100390

Biodistribution of locally delivered drugs in a 3d bioengineered subcutaneous niche.
Capuani, S, Hernandez, N, Paez-Mayorga, J, Dogra, P, Wang, Z, Cristini, V, Chua, CYX, Nichols, J & Grattoni, A 2022, , 7th Bioengineering & Translational Medicine Conference, Boston, United States, 12/14/22 - 12/16/22.

Engineered implantable vaccine platform for continuous antigen-specific immunomodulation
Viswanath, DI, Liu, HC, Capuani, S, Vander Pol, RS, Saunders, SZ, Chua, CYX & Grattoni, A 2022, , Biomaterials, vol. 281, 121374, pp. 121374. https://doi.org/10.1016/j.biomaterials.2022.121374

Emerging biomaterial-based strategies for personalized therapeutic in situ cancer vaccines
Viswanath, DI, Liu, HC, Huston, DP, Chua, CYX & Grattoni, A 2022, , Biomaterials, vol. 280, 121297, pp. 121297. https://doi.org/10.1016/j.biomaterials.2021.121297

Advanced strategies to thwart foreign body response to implantable devices
Capuani, S, Malgir, G, Chua, CYX & Grattoni, A 2022, , Bioengineering and Translational Medicine, vol. 7, no. 3, e10300, pp. e10300. https://doi.org/10.1002/btm2.10300

Emerging local immunomodulatory strategies to circumvent systemic immunosuppression in cell transplantation
Campa-Carranza, JN, Paez-Mayorga, J, Chua, CYX, Nichols, JE & Grattoni, A 2022, , Expert Opinion on Drug Delivery, vol. 19, no. 5, pp. 595-610. https://doi.org/10.1080/17425247.2022.2076834

Emerging immunomodulatory strategies for cell therapeutics
Chua, CYX, Jiang, AY, Eufrásio-da-Silva, T, Dolatshahi-Pirouz, A, Langer, R, Orive, G & Grattoni, A 2023, , Trends in Biotechnology, vol. 41, no. 3, pp. 358-373. https://doi.org/10.1016/j.tibtech.2022.11.008, https://doi.org/10.1016/j.tibtech.2022.11.008

Long-acting tunable release of amlodipine loaded PEG-PCL micelles for tailored treatment of chronic hypertension
Di Trani, N, Liu, HC, Qi, R, Viswanath, DI, Liu, X, Chua, CYX & Grattoni, A 2021, , Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 37, 102417. https://doi.org/10.1016/j.nano.2021.102417

Carbon fiber reinforced polymers for implantable medical devices
Chua, CYX, Liu, HC, Di Trani, N, Susnjar, A, Ho, J, Scorrano, G, Rhudy, J, Sizovs, A, Lolli, G, Hernandez, N, Nucci, MC, Cicalo, R, Ferrari, M & Grattoni, A 2021, , Biomaterials, vol. 271, 120719, pp. 120719. https://doi.org/10.1016/j.biomaterials.2021.120719

Preventive Efficacy of a Tenofovir Alafenamide Fumarate Nanofluidic Implant in SHIV-Challenged Nonhuman Primates
Pons-Faudoa, FP, Sizovs, A, Shelton, KA, Momin, Z, Niles, JA, Bushman, LR, Xu, J, Chua, CYX, Nichols, JE, Demaria, S, Ittmann, MM, Hawkins, T, Rooney, JF, Marzinke, MA, Kimata, JT, Anderson, PL, Nehete, PN, Arduino, RC, Ferrari, M, Sastry, KJ & Grattoni, A 2021, , advanced therapeutics, vol. 4, no. 3, 2000163. https://doi.org/10.1002/adtp.202000163

Preventive efficacy of a tenofovir alafenamide fumarate nanofluidic implant in SHIV-challenged nonhuman primates
Pons-Faudoa, FP, Sizovs, A, Shelton, KA, Momin, Z, Niles, JA, Bushman, LR, Xu, J, Chua, CYX, Nichols, JE, Demaria, S, Ittmann, MM, Hawkins, T, Rooney, JF, Marzinke, MA, Kimata, JT, Anderson, PL, Nehete, PN, Arduino, RC, Ferrari, M, Sastry, KJ & Grattoni, A 2021, , Advanced Therapeutics, vol. 4, no. 3. https://doi.org/10.1002/adtp.202000163

Preventive Efficacy of a Tenofovir Alafenamide Fumarate Nanofluidic Implant in SHIV-Challenged Nonhuman Primates
Pons-Faudoa, FP, Sizovs, A, Shelton, KA, Momin, Z, Niles, JA, Bushman, LR, Xu, J, Chua, CYX, Nichols, JE, Demaria, S, Ittmann, MM, Hawkins, T, Rooney, JF, Marzinke, MA, Kimata, JT, Anderson, PL, Nehete, PN, Arduino, RC, Ferrari, M, Sastry, KJ & Grattoni, A 2021, , advanced therapeutics, vol. 4, no. 3, 2000163, pp. 2000163. https://doi.org/10.1002/adtp.202000163, https://doi.org/10.1002/adtp.202000163

Neovascularized implantable cell homing encapsulation platform with tunable local immunosuppressant delivery for allogeneic cell transplantation
Paez-Mayorga, J, Capuani, S, Hernandez, N, Farina, M, Chua, YX, Blanchard, R, Sizovs, A, Liu, HC, Fraga, DW, Niles, JA, Salazar, HF, Corradetti, B, Sikora, AG, Kloc, M, Li, XC, Gaber, AO, Nichols, J & Grattoni, A 2020, , Biomaterials, vol. 257, 120232. https://doi.org/10.1016/j.biomaterials.2020.120232

Intratumoral Nanofluidic System for Enhancing Tumor Biodistribution of Agonist CD40 Antibody
Chua, CYX, Ho, J, Susnjar, A, Lolli, G, Di Trani, N, Pesaresi, F, Zhang, M, Nance, E & Grattoni, A 2020, , advanced therapeutics, vol. 3, no. 10, 2000055. https://doi.org/10.1002/adtp.202000055

Emerging Technologies for Local Cancer Treatment
Chua, CYX, Ho, J, Demaria, S, Ferrari, M & Grattoni, A 2020, , Advanced Therapeutics, vol. 3, no. 9, 2000027. https://doi.org/10.1002/adtp.202000027

Emerging technologies for local cancer treatment
Chua, CYX, Ho, J, Demaria, S, Ferrari, M & Grattoni, A 2020, , Advanced Therapeutics, vol. 3, no. 9. https://doi.org/10.1002/adtp.202000027

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