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Yi-Lan Weng, PhD

Assistant Professor of Neurosurgery, Institute for Academic Medicine
Assistant Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Neuroepigenetics Lab


Biography

I am interested in understanding how the regenerative capacity is governed in the nervous system. In the lab, we use combinatorial approaches including next-generation sequencing, molecular biology and fluorescence imaging to study the epitranscriptomic mechanisms in neural repair and human pathologies at different stages of development. In particular, we are interested in the m6A RNA methylation in regulating RNA trafficking, localization and translation, as well as how dysfunction of these mechanisms could be linked to brain disorders. The long-term goal is to use knowledge obtained from these analyses to guide therapeutic approaches for treatment of injuries, stroke and neurodegenerative diseases.

Publications

m6A facilitates hippocampus-dependent learning and memory through YTHDF1
Shi, H, Zhang, X, Weng, YL, Lu, Z, Liu, Y, Lu, Z, Li, J, Hao, P, Zhang, Y, Zhang, F, Wu, Y, Delgado, JY, Su, Y, Patel, MJ, Cao, X, Shen, B, Huang, X, Ming, GL, Zhuang, X, Song, H, He, C & Zhou, T 2018, Nature, vol. 563, no. 7730, pp. 249-253. https://doi.org/10.1038/s41586-018-0666-1

Epitranscriptomic m6A Regulation of Axon Regeneration in the Adult Mammalian Nervous System
Weng, Y-L, Wang, X, An, R, Cassin, J, Vissers, C, Liu, Y, Liu, Y, Xu, T, Wang, X, Wong, SZH, Joseph, J, Dore, LC, Dong, Q, Zheng, W, Jin, P, Wu, H, Shen, B, Zhuang, X, He, C, Liu, K, Song, H & Ming, G-L 2018, Neuron, vol. 97, no. 2, pp. 313-325.e6. https://doi.org/10.1016/j.neuron.2017.12.036

An Intrinsic Epigenetic Barrier for Functional Axon Regeneration
Weng, Y-L, An, R, Cassin, J, Joseph, J, Mi, R, Wang, C, Zhong, C, Jin, S-G, Pfeifer, GP, Bellacosa, A, Dong, X, Hoke, A, He, Z, Song, H & Ming, G-L 2017, Neuron, vol. 94, no. 2, pp. 337-346.e6. https://doi.org/10.1016/j.neuron.2017.03.034

Epigenetic regulation of axonal regenerative capacity
Weng, YL, Joseph, J, An, R, Song, H & Ming, GL 2016, Epigenomics, vol. 8, no. 10, pp. 1429-1442. https://doi.org/10.2217/epi-2016-0058

Modulation of the proteoglycan receptor PTPs promotes recovery after spinal cord injury
Lang, BT, Cregg, JM, Depaul, MA, Tran, AP, Xu, K, Dyck, SM, Madalena, KM, Brown, BP, Weng, YL, Li, S, Karimi-Abdolrezaee, S, Busch, SA, Shen, Y & Silver, J 2015, Nature, vol. 518, no. 7539, pp. 404-408. https://doi.org/10.1038/nature13974

Tet3 regulates synaptic transmission and homeostatic plasticity via DNA oxidation and repair
Yu, H, Su, Y, Shin, J, Zhong, C, Guo, JU, Weng, YL, Gao, F, Geschwind, DH, Coppola, G, Ming, GL & Song, H 2015, Nature Neuroscience, vol. 18, no. 6, pp. 836-843. https://doi.org/10.1038/nn.4008

DNA Modifications and Neurological Disorders
Weng, YL, An, R, Shin, J, Song, H & Ming, GL 2013, Neurotherapeutics, vol. 10, no. 4, pp. 556-567. https://doi.org/10.1007/s13311-013-0223-4

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