Yi-Lan Weng

Yi-Lan Weng, PhD

Assistant Professor of Neurosurgery, Academic Institute
Assistant Member, Research Institute
Houston Methodist
Weill Cornell Medical College

Neuroepigenetics Lab

Description of Research

I am interested in understanding how the regenerative capacity is governed in the nervous system. In the lab, we use combinatorial approaches including next-generation sequencing, molecular biology and fluorescence imaging to study the epitranscriptomic mechanisms in neural repair and human pathologies at different stages of development. In particular, we are interested in the m6A RNA methylation in regulating RNA trafficking, localization and translation, as well as how dysfunction of these mechanisms could be linked to brain disorders. The long-term goal is to use knowledge obtained from these analyses to guide therapeutic approaches for treatment of injuries, stroke and neurodegenerative diseases.


An EGFR signature predicts cell line and patient sensitivity to multiple tyrosine kinase inhibitors
Cheng, C, Zhao, Y, Schaafsma, E, Weng, YL & Amos, C 2020, , International Journal of Cancer, vol. 147, no. 9, pp. 2621-2633. https://doi.org/10.1002/ijc.33053

Knocking Out Non-muscle Myosin II in Retinal Ganglion Cells Promotes Long-Distance Optic Nerve Regeneration
Wang, XW, Yang, SG, Zhang, C, Hu, MW, Qian, J, Ma, JJ, Zhang, Y, Yang, BB, Weng, YL, Ming, GL, Kosanam, AR, Saijilafu & Zhou, FQ 2020, , Cell Reports, vol. 31, no. 3, 107537. https://doi.org/10.1016/j.celrep.2020.107537

m6A mRNA Methylation Is Essential for Oligodendrocyte Maturation and CNS Myelination
Xu, H, Dzhashiashvili, Y, Shah, A, Kunjamma, RB, Weng, YL, Elbaz, B, Fei, Q, Jones, JS, Li, YI, Zhuang, X, Ming, GL, He, C & Popko, B 2020, , Neuron, vol. 105, no. 2, pp. 293-309.e5. https://doi.org/10.1016/j.neuron.2019.12.013

Knocking out non-muscle myosin II in retinal ganglion cells promotes long-distance optic nerve regeneration
Wang, XW, Yang, SG, Zhang, C, Ma, JJ, Zhang, Y, Yang, BB, Weng, YL, Ming, GL, Kosanam, AR, Saijilafu & Zhou, FQ 2019, , Unknown Journal. https://doi.org/10.1101/625707

m6A facilitates hippocampus-dependent learning and memory through YTHDF1
Shi, H, Zhang, X, Weng, YL, Lu, Z, Liu, Y, Lu, Z, Li, J, Hao, P, Zhang, Y, Zhang, F, Wu, Y, Delgado, JY, Su, Y, Patel, MJ, Cao, X, Shen, B, Huang, X, Ming, GL, Zhuang, X, Song, H, He, C & Zhou, T 2018, , Nature, vol. 563, no. 7730, pp. 249-253. https://doi.org/10.1038/s41586-018-0666-1

Epitranscriptomic m6A Regulation of Axon Regeneration in the Adult Mammalian Nervous System
Weng, Y-L, Wang, X, An, R, Cassin, J, Vissers, C, Liu, Y, Liu, Y, Xu, T, Wang, X, Wong, SZH, Joseph, J, Dore, LC, Dong, Q, Zheng, W, Jin, P, Wu, H, Shen, B, Zhuang, X, He, C, Liu, K, Song, H & Ming, G-L 2018, , Neuron, vol. 97, no. 2, pp. 313-325.e6. https://doi.org/10.1016/j.neuron.2017.12.036

An Intrinsic Epigenetic Barrier for Functional Axon Regeneration
Weng, Y-L, An, R, Cassin, J, Joseph, J, Mi, R, Wang, C, Zhong, C, Jin, S-G, Pfeifer, GP, Bellacosa, A, Dong, X, Hoke, A, He, Z, Song, H & Ming, G-L 2017, , Neuron, vol. 94, no. 2, pp. 337-346.e6. https://doi.org/10.1016/j.neuron.2017.03.034

Epigenetic regulation of axonal regenerative capacity
Weng, YL, Joseph, J, An, R, Song, H & Ming, GL 2016, , Epigenomics, vol. 8, no. 10, pp. 1429-1442. https://doi.org/10.2217/epi-2016-0058

Modulation of the proteoglycan receptor PTPs promotes recovery after spinal cord injury
Lang, BT, Cregg, JM, Depaul, MA, Tran, AP, Xu, K, Dyck, SM, Madalena, KM, Brown, BP, Weng, YL, Li, S, Karimi-Abdolrezaee, S, Busch, SA, Shen, Y & Silver, J 2015, , Nature, vol. 518, no. 7539, pp. 404-408. https://doi.org/10.1038/nature13974

Tet3 regulates synaptic transmission and homeostatic plasticity via DNA oxidation and repair
Yu, H, Su, Y, Shin, J, Zhong, C, Guo, JU, Weng, YL, Gao, F, Geschwind, DH, Coppola, G, Ming, GL & Song, H 2015, , Nature Neuroscience, vol. 18, no. 6, pp. 836-843. https://doi.org/10.1038/nn.4008

DNA Modifications and Neurological Disorders
Weng, YL, An, R, Shin, J, Song, H & Ming, GL 2013, , Neurotherapeutics, vol. 10, no. 4, pp. 556-567. https://doi.org/10.1007/s13311-013-0223-4

The cytoplasmic adaptor protein caskin mediates Lar signal transduction during Drosophila motor axon guidance
Weng, YL, Liu, N, DiAntonio, A & Broihier, HT 2011, , Journal of Neuroscience, vol. 31, no. 12, pp. 4421-4433. https://doi.org/10.1523/JNEUROSCI.5230-10.2011