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Xuewu Liu, PhD

Research Professor of Nanomedicine, Institute for Academic Medicine
Full Research Member, Research Institute
Houston Methodist


Dr. Xuewu Liu worked as an engineer in the optics industry for two years before undertaking postdoctoral training at the Indiana Center for Biological Microscopy at IUPUI Indianapolis. He then joined Ohio State University as a senior research associate in nanomedicine. He was appointed assistant professor of nanomedicine and biomedical engineering at the University of Texas Health Science Center in Houston in 2006. In 2010, Dr. Liu joined to The Methodist Hospital Research Institute, to direct the nanoengineering core.

Dr. Xuewu Liu is a leading scientist in silicon nanotechnology, with extensive experience in materials science, optics, microfabrication and nanomedicine. He directs research and development of silicon based biomedical nanotechnology, and coordinates a nanoengineering team to support biomedical research at the institute levels. The nanomedicine platforms he has developed include porous silicon particles, nanowire barcodes, an implantable nanochannel delivery system, nanowire enhanced nanofluidic devices, and nanoporous proteomic chips. Dr. Liu had been issued 8 US patents, and published over 100 peer-reviewed journal papers, of which >20 were highlighted as journal cover articles.

Description of Research

Dr. Liu’s research focus is the development of silicon based nanotechnology platforms for prevention, diagnosis and treatment of human disease. His current interests include mass production of porous silicon particles, surface chemistry of porous silicon, nanowire theranostic platforms, multifunctional nanoparticles, and microfluidics devices for isolation and analysis of exosomes.

Areas Of Expertise

Silicon nanotechnology Drug delivery nanoparticles Theranostics Biological microfluidics
Education & Training

MS, Jilin University
Postdoctoral Associate, Heart and Lung Research Institute
Postdoctoral Associate, Indiana Center for Biological Microscopy, Indianapolis, IN
PhD, Kent State University

Chemotherapy sensitizes therapy-resistant cells to mild hyperthermia by suppressing heat shock protein 27 expression in triple-negative breast cancer
Mu, C, Wu, X, Zhou, X, Wolfram, J, Shen, J, Zhang, D, Mai, J, Xia, X, Holder, AM, Ferrari, M, Liu, X & Shen, H 2018, Clinical Cancer Research, vol. 24, no. 19, pp. 4900-4912. DOI: 10.1158/1078-0432.CCR-17-3872

Production and transplantation of bioengineered lung into a large-animal model
Nichols, JE, La Francesca, S, Niles, JA, Vega, SP, Argueta, LB, Frank, L, Christiani, DC, Pyles, RB, Himes, BE, Zhang, R, Li, S, Sakamoto, J, Rhudy, J, Hendricks, G, Begarani, F, Liu, X, Patrikeev, I, Pal, R, Usheva, E, Vargas, G, Miller, A, Woodson, L, Wacher, A, Grimaldo, M, Weaver, D, Mlcak, R & Cortiella, J 2018, Science Translational Medicine, vol. 10, no. 452. DOI: 10.1126/scitranslmed.aao3926

Co-delivery of tumor antigen and dual toll-like receptor ligands into dendritic cell by silicon microparticle enables efficient immunotherapy against melanoma
Zhu, M, Ding, X, Zhao, R, Liu, X, Shen, H, Cai, C, Ferrari, M, Wang, HY & Wang, RF 2018, Journal of Controlled Release, vol. 272, pp. 72-82. DOI: 10.1016/j.jconrel.2018.01.004

Highly biocompatible BSA-MnO2 nanoparticles as an efficient near-infrared photothermal agent for cancer therapy
Wang, Y, Song, Y, Zhu, G, Zhang, D & Liu, X 2018, Chinese Chemical Letters. DOI: 10.1016/j.cclet.2017.12.004

Thioaptamer targeted discoidal microparticles increase self immunity and reduce Mycobacterium tuberculosis burden in mice
Leonard, F, Ha, NP, Sule, P, Alexander, JF, Volk, DE, Lokesh, GLR, Liu, X, Cirillo, JD, Gorenstein, DG, Yuan, J, Chatterjee, S, Graviss, EA & Godin, B 2017, Journal of Controlled Release, vol. 266, pp. 238-247. DOI: 10.1016/j.jconrel.2017.09.038

Gemcitabine enhances the transport of nanovector-albumin-bound paclitaxel in gemcitabine-resistant pancreatic ductal adenocarcinoma
Borsoi, C, Leonard, F, Lee, Y, Zaid, M, Elganainy, D, Alexander, JF, Kai, M, Liu, YT, Kang, Y, Liu, X, Koay, EJ, Ferrari, M, Godin, B & Yokoi, K 2017, Cancer Letters, vol. 403, pp. 296-304. DOI: 10.1016/j.canlet.2017.06.026

Macrophage polarization contributes to the anti-tumoral efficacy of mesoporous nanovectors loaded with albumin-bound paclitaxel
Leonard, F, Curtis, LT, Ware, MJ, Nosrat, T, Liu, X, Yokoi, K, Frieboes, HB & Godin, B 2017, Frontiers in Immunology, vol. 8, no. JUN, 693. DOI: 10.3389/fimmu.2017.00693

Highly efficient genome editing of human hematopoietic stem cells via a nano-silicon-blade delivery approach
Ma, Y, Han, X, Quintana Bustamante, O, Bessa De Castro, R, Zhang, K, Zhang, P, Li, Y, Liu, Z, Liu, X, Ferrari, M, Hu, Z, Carlos Segovia, J & Qin, L 2017, Integrative Biology (United Kingdom), vol. 9, no. 6, pp. 548-554. DOI: 10.1039/c7ib00060j

Enhancing Vascularization through the Controlled Release of Platelet-Derived Growth Factor-BB
Minardi, S, Pandolfi, L, Taraballi, F, Wang, X, De Rosa, E, Mills, ZD, Liu, X, Ferrari, M & Tasciotti, E 2017, ACS Applied Materials and Interfaces, vol. 9, no. 17, pp. 14566-14575. DOI: 10.1021/acsami.6b13760

Multi-step encapsulation of chemotherapy and gene silencing agents in functionalized mesoporous silica nanoparticles
Shen, J, Liu, H, Mu, C, Wolfram, J, Zhang, W, Kim, HC, Zhu, G, Hu, Z, Ji, LN, Liu, X, Ferrari, M, Mao, ZW & Shen, H 2017, Nanoscale, vol. 9, no. 16, pp. 5329-5341. DOI: 10.1039/c7nr00377c

The active modulation of drug release by an ionic field effect transistor for an ultra-low power implantable nanofluidic system
Bruno, G, Canavese, G, Liu, X, Filgueira, CS, Sacco, A, Demarchi, D, Ferrari, M & Grattoni, A 2016, Nanoscale, vol. 8, no. 44, pp. 18718-18725. DOI: 10.1039/c6nr06235k

Enzyme-responsive multistage vector for drug delivery to tumor tissue
Mi, Y, Wolfram, J, Mu, C, Liu, X, Blanco, E, Shen, H & Ferrari, M 2016, Pharmacological Research, vol. 113, pp. 92-99. DOI: 10.1016/j.phrs.2016.08.024

Correction: In situ growth of fluorescent silicon nanocrystals in a monolithic microcapsule as a photostable, versatile platform
Zhu, G, Huang, Y, Bhave, G, Wang, Y, Hu, Z & Liu, X 2016, Nanoscale, vol. 8, no. 37, pp. 16786. DOI: 10.1039/c6nr90194h

In situ growth of fluorescent silicon nanocrystals in a monolithic microcapsule as a photostable, versatile platform
Zhu, G, Huang, Y, Bhave, G, Wang, Y, Hu, Z & Liu, X 2016, Nanoscale, vol. 8, no. 34, pp. 15645-15657. DOI: 10.1039/c6nr03829h

A pyruvate decarboxylase-mediated therapeutic strategy for mimicking yeast metabolism in cancer cells
Scott, B, Shen, J, Nizzero, S, Boom, K, Persano, S, Mi, Y, Liu, X, Zhao, Y, Blanco, E, Shen, H, Ferrari, M & Wolfram, J 2016, Pharmacological Research, vol. 111, pp. 413-421. DOI: 10.1016/j.phrs.2016.07.005

Enhanced performance of macrophage-encapsulated nanoparticle albumin-bound-paclitaxel in hypo-perfused cancer lesions
Leonard, F, Curtis, LT, Yesantharao, P, Tanei, T, Alexander, JF, Wu, M, Lowengrub, J, Liu, X, Ferrari, M, Yokoi, K, Frieboes, HB & Godin, B 2016, Nanoscale, vol. 8, no. 25, pp. 12544-12552. DOI: 10.1039/c5nr07796f

In Situ Reductive Synthesis of Structural Supported Gold Nanorods in Porous Silicon Particles for Multifunctional Nanovectors
Zhu, G, Liu, JT, Wang, Y, Zhang, D, Guo, Y, Tasciotti, E, Hu, Z & Liu, X 2016, ACS Applied Materials and Interfaces, vol. 8, no. 18, pp. 11881-11891. DOI: 10.1021/acsami.6b03008

An injectable nanoparticle generator enhances delivery of cancer therapeutics
Xu, R, Zhang, G, Mai, J, Deng, X, Segura-Ibarra, V, Wu, S, Shen, J, Liu, H, Hu, Z, Chen, L, Huang, Y, Koay, E, Huang, Y, Liu, J, Ensor, JE, Blanco, E, Liu, X, Ferrari, M & Shen, H 2016, Nature Biotechnology, vol. 34, no. 4, pp. 414-418. DOI: 10.1038/nbt.3506

IL-4 Release from a Biomimetic Scaffold for the Temporally Controlled Modulation of Macrophage Response
Minardi, S, Corradetti, B, Taraballi, F, Byun, JH, Cabrera, F, Liu, X, Ferrari, M, Weiner, BK & Tasciotti, E 2016, Annals of Biomedical Engineering, vol. 44, no. 6, pp. 2008-19. DOI: 10.1007/s10439-016-1580-z

Cell source determines the immunological impact of biomimetic nanoparticles
Evangelopoulos, M, Parodi, A, Martinez, JO, Yazdi, IK, Cevenini, A, van de Ven, AL, Quattrocchi, N, Boada, C, Taghipour, N, Corbo, C, Brown, BS, Scaria, S, Liu, X, Ferrari, M & Tasciotti, E 2016, Biomaterials, vol. 82, pp. 168-177. DOI: 10.1016/j.biomaterials.2015.11.054