Xuewu Liu

Xuewu Liu, PhD

Research Professor of Nanomedicine, Academic Institute
Full Research Member, Research Institute
Houston Methodist


Dr. Xuewu Liu worked as an engineer in the optics industry for two years before undertaking postdoctoral training at the Indiana Center for Biological Microscopy at IUPUI Indianapolis. He then joined Ohio State University as a senior research associate in nanomedicine. He was appointed assistant professor of nanomedicine and biomedical engineering at the University of Texas Health Science Center in Houston in 2006. In 2010, Dr. Liu joined to The Methodist Hospital Research Institute, to direct the nanoengineering core.

Dr. Xuewu Liu is a leading scientist in silicon nanotechnology, with extensive experience in materials science, optics, microfabrication and nanomedicine. He directs research and development of silicon based biomedical nanotechnology, and coordinates a nanoengineering team to support biomedical research at the institute levels. The nanomedicine platforms he has developed include porous silicon particles, nanowire barcodes, an implantable nanochannel delivery system, nanowire enhanced nanofluidic devices, and nanoporous proteomic chips. Dr. Liu had been issued 8 US patents, and published over 100 peer-reviewed journal papers, of which >20 were highlighted as journal cover articles.

Description of Research

Dr. Liu’s research focus is the development of silicon based nanotechnology platforms for prevention, diagnosis and treatment of human disease. His current interests include mass production of porous silicon particles, surface chemistry of porous silicon, nanowire theranostic platforms, multifunctional nanoparticles, and microfluidics devices for isolation and analysis of exosomes.

Areas Of Expertise

Silicon nanotechnology Drug delivery nanoparticles Theranostics Biological microfluidics
Education & Training

MS, Jilin University
Postdoctoral Associate, Heart and Lung Research Institute
Postdoctoral Associate, Indiana Center for Biological Microscopy, Indianapolis, IN
PhD, Kent State University


Patent Number: EP3027264, Jun 08 2016

Nanochanneled device with electrodes and related methods

Patent Number: CN105530988, Apr 27 2016


Patent Number: US2015246174, Sep 03 2015


Patent Number: US2015088102, Mar 26 2015


Patent Number: WO2015017777, Feb 05 2015


Long-acting tunable release of amlodipine loaded PEG-PCL micelles for tailored treatment of chronic hypertension
Di Trani, N, Liu, HC, Qi, R, Viswanath, DI, Liu, X, Chua, CYX & Grattoni, A 2021, , Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 37, 102417. https://doi.org/10.1016/j.nano.2021.102417

Platforms to test the temporospatial capabilities of carrier systems in delivering growth factors to benefit vascular bioengineering
Argueta, LB, Niles, JA, Sakamoto, J, Liu, X, Vega, SP, Frank, L, Paessler, M, Cortiella, J & Nichols, JE 2021, , Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 36, 102419. https://doi.org/10.1016/j.nano.2021.102419

Silicon carbide-gated nanofluidic membrane for active control of electrokinetic ionic transport
Silvestri, A, Di Trani, N, Canavese, G, Ros, PM, Iannucci, L, Grassini, S, Wang, Y, Liu, X, Demarchi, D & Grattoni, A 2021, , Membranes, vol. 11, no. 7, 535. https://doi.org/10.3390/membranes11070535

Long-acting tunable release of amlodipine loaded PEG-PCL micelles for tailored treatment of chronic hypertension
Di Trani, N, Liu, HC, Qi, R, Viswanath, DI, Liu, X, Chua, CYX & Grattoni, A 2021, , Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 37, 102417. https://doi.org/10.1016/j.nano.2021.102417

Synergistic Activation of Antitumor Immunity by a Particulate Therapeutic Vaccine
Mai, J, Li, Z, Xia, X, Zhang, J, Li, J, Liu, H, Shen, J, Ramirez, M, Li, F, Li, Z, Yokoi, K, Liu, X, Mittendorf, EA, Ferrari, M & Shen, H 2021, , Advanced Science. https://doi.org/10.1002/advs.202100166

Enhanced thermal effect of plasmonic nanostructures confined in discoidal porous silicon particles
Zhang, D, Wu, HJ, Zhou, X, Qi, R, Xu, L, Guo, Y & Liu, X 2020, , RSC Advances, vol. 10, no. 51, pp. 30840-30847. https://doi.org/10.1039/d0ra03379k

Silicon nanofluidic membrane for electrostatic control of drugs and analytes elution
Di Trani, N, Silvestri, A, Wang, Y, Demarchi, D, Liu, X & Grattoni, A 2020, , Pharmaceutics, vol. 12, no. 7, 679, pp. 1-16. https://doi.org/10.3390/pharmaceutics12070679

Liposome-embedding silicon microparticle for oxaliplatin delivery in tumor chemotherapy
Cevenini, A, Celia, C, Orrù, S, Sarnataro, D, Raia, M, Mollo, V, Locatelli, M, Imperlini, E, Peluso, N, Peltrini, R, De Rosa, E, Parodi, A, Del Vecchio, L, Di Marzio, L, Fresta, M, Netti, PA, Shen, H, Liu, X, Tasciotti, E & Salvatore, F 2020, , Pharmaceutics, vol. 12, no. 6, 559, pp. 1-28. https://doi.org/10.3390/pharmaceutics12060559

Sequential deconstruction of composite drug transport in metastatic breast cancer
Goel, S, Zhang, G, Dogra, P, Nizzero, S, Cristini, V, Wang, Z, Hu, Z, Li, Z, Liu, X, Shen, H & Ferrari, M 2020, , Science advances, vol. 6, no. 26, eaba4498, pp. eaba4498. https://doi.org/10.1126/sciadv.aba4498

Electrostatically gated nanofluidic membrane for ultra-low power controlled drug delivery
Di Trani, N, Silvestri, A, Sizovs, A, Wang, Y, Erm, DR, Demarchi, D, Liu, X & Grattoni, A 2020, , Lab on a Chip, vol. 20, no. 9, pp. 1562-1576. https://doi.org/10.1039/d0lc00121j

Design and in vitro characterization of multistage silicon-PLGA budesonide particles for inflammatory bowel disease
Leonard, F, Srinivasan, S, Liu, X, Collnot, EM, Ferrari, M, Lehr, CM & Godin, B 2020, , European Journal of Pharmaceutics and Biopharmaceutics, vol. 151, pp. 61-72. https://doi.org/10.1016/j.ejpb.2020.03.020

Hollow Mesoporous Metal-Organic Framework Microdisks via a Solid Template-Based Approach and Post-Synthetic Wet-Chemical Etching for Protein Loading
Zhu, G, Cheng, L, Qi, R & Liu, X 2020, , ChemNanoMat, vol. 6, no. 4, pp. 589-597. https://doi.org/10.1002/cnma.202000061

Biocompatible PLGA-mesoporous silicon microspheres for the controlled release of bmp-2 for bone augmentation
Minardi, S, Fernandez-Moure, JS, Fan, D, Murphy, MB, Yazdi, IK, Liu, X, Weiner, BK & Tasciotti, E 2020, , Pharmaceutics, vol. 12, no. 2, 118. https://doi.org/10.3390/pharmaceutics12020118

Potentiating Antitumor Efficacy Through Radiation and Sustained Intratumoral Delivery of Anti-CD40 and Anti-PDL1
Liu, HC, Viswanath, DI, Pesaresi, F, Xu, Y, Zhang, L, Di Trani, N, Paez-Mayorga, J, Hernandez, N, Wang, Y, Erm, DR, Ho, J, Susnjar, A, Liu, X, Demaria, S, Chen, SH, Teh, BS, Butler, EB, Xuan Chua, CY & Grattoni, A 2021, , International Journal of Radiation Oncology Biology Physics, vol. 110, no. 2, pp. 492-506. https://doi.org/10.1016/j.ijrobp.2020.07.2326

Mesenchymal Stromal Cell-Mediated Treatment of Local and Systemic Inflammation through the Triggering of an Anti-Inflammatory Response
Martinez, JO, Evangelopoulos, M, Brozovich, AA, Bauza, G, Molinaro, R, Corbo, C, Liu, X, Taraballi, F & Tasciotti, E 2020, , Advanced Functional Materials, vol. 31, no. 3, 2002997. https://doi.org/10.1002/adfm.202002997

Investigation of parameters that determine Nano-DC vaccine transport
Zhang, J, Mai, J, Li, F, Shen, J, Zhang, G, Li, J, Hinkle, LE, Lin, D, Liu, X, Li, Z, Wang, RF, Mittendorf, EA, Ferrari, M & Shen, H 2019, , Biomedical Microdevices, vol. 21, no. 2, 39. https://doi.org/10.1007/s10544-019-0397-6

Microfluidic device for the analysis of MDR cancerous cell-derived exosomes’ response to nanotherapy
Qi, R, Zhu, G, Wang, Y, Wu, S, Li, S, Zhang, D, Bu, Y, Bhave, G, Han, R & Liu, X 2019, , Biomedical Microdevices, vol. 21, no. 2, 35. https://doi.org/10.1007/s10544-019-0381-1

Chemotherapy sensitizes therapy-resistant cells to mild hyperthermia by suppressing heat shock protein 27 expression in triple-negative breast cancer
Mu, C, Wu, X, Zhou, X, Wolfram, J, Shen, J, Zhang, D, Mai, J, Xia, X, Holder, AM, Ferrari, M, Liu, X & Shen, H 2018, , Clinical Cancer Research, vol. 24, no. 19, pp. 4900-4912. https://doi.org/10.1158/1078-0432.CCR-17-3872

Production and transplantation of bioengineered lung into a large-animal model
Nichols, JE, La Francesca, S, Niles, JA, Vega, SP, Argueta, LB, Frank, L, Christiani, DC, Pyles, RB, Himes, BE, Zhang, R, Li, S, Sakamoto, J, Rhudy, J, Hendricks, G, Begarani, F, Liu, X, Patrikeev, I, Pal, R, Usheva, E, Vargas, G, Miller, A, Woodson, L, Wacher, A, Grimaldo, M, Weaver, D, Mlcak, R & Cortiella, J 2018, , Science translational medicine, vol. 10, no. 452. https://doi.org/10.1126/scitranslmed.aao3926

Co-delivery of tumor antigen and dual toll-like receptor ligands into dendritic cell by silicon microparticle enables efficient immunotherapy against melanoma
Zhu, M, Ding, X, Zhao, R, Liu, X, Shen, H, Cai, C, Ferrari, M, Wang, HY & Wang, RF 2018, , Journal of Controlled Release, vol. 272, pp. 72-82. https://doi.org/10.1016/j.jconrel.2018.01.004