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Xuewu Liu, PhD

Research Professor of Nanomedicine, Institute for Academic Medicine
Full Research Member, Research Institute
Houston Methodist


Dr. Xuewu Liu worked as an engineer in the optics industry for two years before undertaking postdoctoral training at the Indiana Center for Biological Microscopy at IUPUI Indianapolis. He then joined Ohio State University as a senior research associate in nanomedicine. He was appointed assistant professor of nanomedicine and biomedical engineering at the University of Texas Health Science Center in Houston in 2006. In 2010, Dr. Liu joined to The Methodist Hospital Research Institute, to direct the nanoengineering core.

Dr. Xuewu Liu is a leading scientist in silicon nanotechnology, with extensive experience in materials science, optics, microfabrication and nanomedicine. He directs research and development of silicon based biomedical nanotechnology, and coordinates a nanoengineering team to support biomedical research at the institute levels. The nanomedicine platforms he has developed include porous silicon particles, nanowire barcodes, an implantable nanochannel delivery system, nanowire enhanced nanofluidic devices, and nanoporous proteomic chips. Dr. Liu had been issued 8 US patents, and published over 100 peer-reviewed journal papers, of which >20 were highlighted as journal cover articles.

Description of Research

Dr. Liu’s research focus is the development of silicon based nanotechnology platforms for prevention, diagnosis and treatment of human disease. His current interests include mass production of porous silicon particles, surface chemistry of porous silicon, nanowire theranostic platforms, multifunctional nanoparticles, and microfluidics devices for isolation and analysis of exosomes.

Areas Of Expertise

Silicon nanotechnology Drug delivery nanoparticles Theranostics Biological microfluidics
Education & Training

MS, Jilin University
Postdoctoral Associate, Heart and Lung Research Institute
Postdoctoral Associate, Indiana Center for Biological Microscopy, Indianapolis, IN
PhD, Kent State University


Patent Number: EP3027264, Jun 08 2016

Nanochanneled device with electrodes and related methods

Patent Number: CN105530988, Apr 27 2016


Patent Number: US2015246174, Sep 03 2015


Patent Number: US2015088102, Mar 26 2015


Patent Number: WO2015017777, Feb 05 2015

View All

Microfluidic device for the analysis of MDR cancerous cell-derived exosomes’ response to nanotherapy
Qi, R, Zhu, G, Wang, Y, Wu, S, Li, S, Zhang, D, Bu, Y, Bhave, G, Han, R & Liu, X 2019, Biomedical Microdevices, vol. 21, no. 2, 35.

Investigation of parameters that determine Nano-DC vaccine transport
Zhang, J, Mai, J, Li, F, Shen, J, Zhang, G, Li, J, Hinkle, LE, Lin, D, Liu, X, Li, Z, Wang, R, Mittendorf, EA, Ferrari, M & Shen, H 2019, Biomedical Microdevices, vol. 21, no. 2, 39.

Chemotherapy sensitizes therapy-resistant cells to mild hyperthermia by suppressing heat shock protein 27 expression in triple-negative breast cancer
Mu, C, Wu, X, Zhou, X, Wolfram, J, Shen, J, Zhang, D, Mai, J, Xia, X, Holder, AM, Ferrari, M, Liu, X & Shen, H 2018, Clinical Cancer Research, vol. 24, no. 19, pp. 4900-4912.

Production and transplantation of bioengineered lung into a large-animal model
Nichols, JE, La Francesca, S, Niles, JA, Vega, SP, Argueta, LB, Frank, L, Christiani, DC, Pyles, RB, Himes, BE, Zhang, R, Li, S, Sakamoto, J, Rhudy, J, Hendricks, G, Begarani, F, Liu, X, Patrikeev, I, Pal, R, Usheva, E, Vargas, G, Miller, A, Woodson, L, Wacher, A, Grimaldo, M, Weaver, D, Mlcak, R & Cortiella, J 2018, Science Translational Medicine, vol. 10, no. 452.

Co-delivery of tumor antigen and dual toll-like receptor ligands into dendritic cell by silicon microparticle enables efficient immunotherapy against melanoma
Zhu, M, Ding, X, Zhao, R, Liu, X, Shen, H, Cai, C, Ferrari, M, Wang, HY & Wang, RF 2018, Journal of Controlled Release, vol. 272, pp. 72-82.

Silver-Nanoparticle-Embedded Porous Silicon Disks Enabled SERS Signal Amplification for Selective Glutathione Detection
Bu, Y, Zhu, G, Li, S, Qi, R, Bhave, G, Zhang, D, Han, R, Sun, D, Liu, X, Hu, Z & Liu, X 2018, ACS Applied Nano Materials, vol. 1, no. 1, pp. 410-417.

Highly biocompatible BSA-MnO2 nanoparticles as an efficient near-infrared photothermal agent for cancer therapy
Wang, Y, Song, Y, Zhu, G, Zhang, D & Liu, X 2018, Chinese Chemical Letters.

Thioaptamer targeted discoidal microparticles increase self immunity and reduce Mycobacterium tuberculosis burden in mice
Leonard, F, Ha, NP, Sule, P, Alexander, JF, Volk, DE, Lokesh, GLR, Liu, X, Cirillo, JD, Gorenstein, DG, Yuan, J, Chatterjee, S, Graviss, EA & Godin, B 2017, Journal of Controlled Release, vol. 266, pp. 238-247.

Gemcitabine enhances the transport of nanovector-albumin-bound paclitaxel in gemcitabine-resistant pancreatic ductal adenocarcinoma
Borsoi, C, Leonard, F, Lee, Y, Zaid, M, Elganainy, D, Alexander, JF, Kai, M, Liu, YT, Kang, Y, Liu, X, Koay, EJ, Ferrari, M, Godin, B & Yokoi, K 2017, Cancer Letters, vol. 403, pp. 296-304.

Macrophage polarization contributes to the anti-tumoral efficacy of mesoporous nanovectors loaded with albumin-bound paclitaxel
Leonard, F, Curtis, LT, Ware, MJ, Nosrat, T, Liu, X, Yokoi, K, Frieboes, HB & Godin, B 2017, Frontiers in Immunology, vol. 8, no. JUN, 693.

Highly efficient genome editing of human hematopoietic stem cells via a nano-silicon-blade delivery approach
Ma, Y, Han, X, Quintana Bustamante, O, Bessa De Castro, R, Zhang, K, Zhang, P, Li, Y, Liu, Z, Liu, X, Ferrari, M, Hu, Z, Carlos Segovia, J & Qin, L 2017, Integrative Biology (United Kingdom), vol. 9, no. 6, pp. 548-554.

Enhancing Vascularization through the Controlled Release of Platelet-Derived Growth Factor-BB
Minardi, S, Pandolfi, L, Taraballi, F, Wang, X, De Rosa, E, Mills, ZD, Liu, X, Ferrari, M & Tasciotti, E 2017, ACS Applied Materials and Interfaces, vol. 9, no. 17, pp. 14566-14575.

Multi-step encapsulation of chemotherapy and gene silencing agents in functionalized mesoporous silica nanoparticles
Shen, J, Liu, H, Mu, C, Wolfram, J, Zhang, W, Kim, HC, Zhu, G, Hu, Z, Ji, LN, Liu, X, Ferrari, M, Mao, ZW & Shen, H 2017, Nanoscale, vol. 9, no. 16, pp. 5329-5341.

The active modulation of drug release by an ionic field effect transistor for an ultra-low power implantable nanofluidic system
Bruno, G, Canavese, G, Liu, X, Filgueira, CS, Sacco, A, Demarchi, D, Ferrari, M & Grattoni, A 2016, Nanoscale, vol. 8, no. 44, pp. 18718-18725.

Enzyme-responsive multistage vector for drug delivery to tumor tissue
Mi, Y, Wolfram, J, Mu, C, Liu, X, Blanco, E, Shen, H & Ferrari, M 2016, Pharmacological Research, vol. 113, pp. 92-99.

Correction: In situ growth of fluorescent silicon nanocrystals in a monolithic microcapsule as a photostable, versatile platform
Zhu, G, Huang, Y, Bhave, G, Wang, Y, Hu, Z & Liu, X 2016, Nanoscale, vol. 8, no. 37, pp. 16786.

In situ growth of fluorescent silicon nanocrystals in a monolithic microcapsule as a photostable, versatile platform
Zhu, G, Huang, Y, Bhave, G, Wang, Y, Hu, Z & Liu, X 2016, Nanoscale, vol. 8, no. 34, pp. 15645-15657.

A pyruvate decarboxylase-mediated therapeutic strategy for mimicking yeast metabolism in cancer cells
Scott, B, Shen, J, Nizzero, S, Boom, K, Persano, S, Mi, Y, Liu, X, Zhao, Y, Blanco, E, Shen, H, Ferrari, M & Wolfram, J 2016, Pharmacological Research, vol. 111, pp. 413-421.

Enhanced performance of macrophage-encapsulated nanoparticle albumin-bound-paclitaxel in hypo-perfused cancer lesions
Leonard, F, Curtis, LT, Yesantharao, P, Tanei, T, Alexander, JF, Wu, M, Lowengrub, J, Liu, X, Ferrari, M, Yokoi, K, Frieboes, HB & Godin, B 2016, Nanoscale, vol. 8, no. 25, pp. 12544-12552.

Fine, D, Grattoni, A, Ferrari, M, Liu, X, Goodall, R, Hosali, S, Fine, D, Grattoni, A, Ferrari, M, Liu, X, Goodall, R & Hosali, S 2016, , Patent No. EP3027264, IPC No. B82Y 5/ 00 A I.

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