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Xin Yi, PhD

Assistant Professor of Clinical Pathology and Genomic Medicine, Academic Institute
Houston Methodist
Weill Cornell Medical College

Clinical Chemistry Fellowship


Dr. Xin Yi is a board-certified clinical chemist (DABCC) with broad expertise in clinical chemistry, endocrinology testing, therapeutic drug monitoring, toxicology, and clinical pharmacogenetics. She is a fellow of the AACC’s National Academy of Clinical Biochemistry (NACB), and the Co-director of the ComACC postdoctoral fellowship program at Houston Methodist Hospital. Her clinical services include supervising the professional activities in the sections of general and special chemistry, point of care, and diagnostic immunology. Prior to her current position, she completed her postdoctoral fellowship training in clinical chemistry at the University of Chicago after completing her PhD in clinical-bioanalytical chemistry at Cleveland State University.

Description of Research

Dr. Yi is interested in the application of new technologies, especially mass spectrometry and genetic analysis, in broader clinical diagnostic use. Her past research activities focused on developing novel diagnostic assays for hormone measurements using mass spectrometry, such as high-sensitive estradiol measurement to assist clinical management in pediatrics, men and postmenopausal women. Her studies in pharmacogenetics involved understanding the impact of genetic variations on therapeutic responses, such as responses to anticoagulant and antiplatelet agents, Warfarin and Clopidogrel. Her current research activities are focused on studying the expression of onco-proteins in tumor tissues using mass spectrometry, and utilizing this approach to aid cancer differential diagnoses and personalized cancer therapies.


Development of a Nonradioactive Platelet Serotonin Uptake and Release Assay by Micro-Liquid Chromatography Tandem Mass Spectrometry Using Minimal Blood Volume
Chan, SL, Yi, X, Wysocki, E, Bridgman, R, Gutierrez, J, Mikrut, K, Leung, EKY, Yeo, KTJ & Miller, JL 2019, American Journal of Clinical Pathology, vol. 152, no. 6, pp. 718-724.

Quality control practices for chemistry and immunochemistry in a cohort of 21 large academic medical centers
Rosenbaum, MW, Flood, JG, Melanson, SEF, Baumann, NA, Marzinke, MA, Rai, AJ, Hayden, J, Wu, AHB, Ladror, M, Lifshitz, MS, Scott, MG, Peck-Palmer, OM, Bowen, R, Babic, N, Sobhani, K, Giacherio, D, Bocsi, GT, Herman, DS, Wang, P, Toffaletti, J, Handel, E, Kelly, KA, Albeiroti, S, Wang, S, Zimmer, M, Driver, B, Yi, X, Wilburn, C & Lewandrowski, KB 2018, American Journal of Clinical Pathology, vol. 150, no. 2, pp. 96-104.

Diiodothyropropionic acid (DITPA) cross-reacts with thyroid function assays on different immunoassay platforms
Leung, EKY, Yi, X, Refetoff, S & Yeo, KTJ 2016, Clinica Chimica Acta, vol. 453, pp. 203-204.

Clinical evaluation of the QMS® Tacrolimus Immunoassay
Leung, EKY, Yi, X, Gloria, C & Yeo, KTJ 2014, Clinica Chimica Acta, vol. 431, pp. 270-275.

RNase L contributes to experimentally induced type 1 diabetes onset in mice
Zeng, C, Yi, X, Zipris, D, Liu, H, Zhang, L, Zheng, Q, Malathi, K, Jin, G & Zhou, A 2014, Journal of Endocrinology, vol. 223, no. 3, pp. 277-287.

Lack of RNase L attenuates macrophage functions
Yi, X, Zeng, C, Liu, H, Chen, X, Zhang, P, Yun, BS, Jin, G & Zhou, A 2013, PloS one, vol. 8, no. 12, e81269.

Synthesis and anticancer mechanism investigation of dual Hsp27 and tubulin inhibitors
Zhong, B, Chennamaneni, S, Lama, R, Yi, X, Geldenhuys, WJ, Pink, JJ, Dowlati, A, Xu, Y, Zhou, A & Su, B 2013, Journal of Medicinal Chemistry, vol. 56, no. 13, pp. 5306-5320.

Identification of a class of novel tubulin inhibitors
Yi, X, Zhong, B, Smith, KM, Geldenhuys, WJ, Feng, Y, Pink, JJ, Dowlati, A, Xu, Y, Zhou, A & Su, B 2012, Journal of Medicinal Chemistry, vol. 55, no. 7, pp. 3425-3435.

From COX-2 inhibitor nimesulide to potent anti-cancer agent: Synthesis, in vitro, in vivo and pharmacokinetic evaluation
Zhong, B, Cai, X, Chennamaneni, S, Yi, X, Liu, L, Pink, JJ, Dowlati, A, Xu, Y, Zhou, A & Su, B 2012, European Journal of Medicinal Chemistry, vol. 47, no. 1, pp. 432-444.

In vitro and in vivo effects of a cyclooxygenase-2 inhibitor nimesulide analog JCC76 in aromatase inhibitors-insensitive breast cancer cells
Zhong, B, Cai, X, Yi, X, Zhou, A, Chen, S & Su, B 2011, Journal of Steroid Biochemistry and Molecular Biology, vol. 126, no. 1-2, pp. 10-18.

Synthesis and evaluation of some steroidal oximes as cytotoxic agents: Structure/activity studies (II)
Cui, J, Fan, L, Huang, Y, Yi, X & Zhou, A 2009, Steroids, vol. 74, no. 12, pp. 989-995.

Synthesis and cytotoxic analysis of some disodium 3ß,6ß-dihydroxysterol disulfates
Cui, J, Wang, H, Huang, Y, Yi, X & Zhou, A 2009, Steroids, vol. 74, no. 13-14, pp. 1057-1060.

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