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Xiang Xiao, PhD

Associate Research Professor of Transplant Immunology in Surgery, Academic Institute
Associate Research Member, Research Institute
Houston Methodist

Dr. Xiao’s research interests are related to how the immune system responds to allotransplants, with specific emphasis on the fundamental mechanisms that control various T cell programs involved in transplant rejection and tolerance. One of the key aspects of his recent research focuses on the role of costimulatory molecules in T helper cells differentiation, functions, and fate decisions.

Description of Research

Dr. Xiang Xiao earned his Ph.D. in cell biology from University of Science and Technology of China in Heifei, China in 2005. He completed his postdoctoral fellowship training at Beth Israel Deaconess Medical Center and Harvard Medical School in Boston in 2013. After that, he joined Houston Methodist Research Institute as a research scientist. Dr. Xiao is now an assistant research professor of transplant immunology in surgery. Dr. Xiao studies the cellular and molecular mechanisms T cell functions relevant to transplant tolerance. He has published more than 20 original papers and review articles in high-impact scientific journals.

Education & Training

PhD, University of Science and Technology of China
Postdoctoral Fellowship, Harvard Medical School
Postdoctoral Fellowship, Beth Israel Deaconess Medical Center

Epigenetically modifying the Foxp3 locus for generation of stable antigen-specific Tregs as cellular therapeutics
Chen, S, Zhang, L, Ying, Y, Wang, Y, Arnold, PR, Wang, G, Li, J, Ghobrial, RM, Chen, W, Xiao, X & Li, XC 2020, American Journal of Transplantation, vol. 20, no. 9, pp. 2366-2379.

T cell exhaustion is associated with antigen abundance and promotes transplant acceptance
Zou, D, Dai, Y, Zhang, X, Wang, G, Xiao, X, Jia, P, Li, XC, Guo, Z & Chen, W 2020, American Journal of Transplantation, vol. 20, no. 9, pp. 2540-2550.

T follicular helper and memory cell responses and the mTOR pathway in murine heart transplantation
Xie, A, Yan, H, Fu, J, He, A, Xiao, X, Li, XC & Chen, W 2020, , Journal of Heart and Lung Transplantation, vol. 39, no. 2, pp. 134-144.

The transcription factor RelB restrains group 2 innate lymphoid cells and type 2 immune pathology in vivo
Zhang, L, Ying, Y, Chen, S, Arnold, PR, Tian, F, Minze, LJ, Xiao, X & Li, XC 2020, Cellular and Molecular Immunology.

Identification of the E3 ligase TRIM29 as a critical checkpoint regulator of NK cell functions
Dou, Y, Xing, J, Kong, G, Wang, G, Lou, X, Xiao, X, Vivier, E, Li, XC & Zhang, Z 2019, Journal of immunology (Baltimore, Md. : 1950), vol. 203, no. 4, pp. 873-880.

Transcriptional and epigenetic regulation of immune tolerance: roles of the NF-?B family members
Zhang, L, Xiao, X, Arnold, PR & Li, XC 2019, , Cellular and Molecular Immunology, vol. 16, no. 4, pp. 315-323.

OX40 Costimulation Inhibits Foxp3 Expression and Treg Induction via BATF3-Dependent and Independent Mechanisms
Zhang, X, Xiao, X, Lan, P, Li, J, Dou, Y, Chen, W, Ishii, N, Chen, S, Xia, B, Chen, K, Taparowsky, E & Li, XC 2018, , Cell Reports, vol. 24, no. 3, pp. 607-618.

Role of the NF-kB family member RelB in regulation of Foxp3+ regulatory t cells in vivo
Li, J, Chen, S, Chen, W, Ye, Q, Dou, Y, Xiao, Y, Zhang, L, Minze, LJ, Li, XC & Xiao, X 2018, , Journal of Immunology, vol. 200, no. 4, pp. 1325-1334.

Guidance of super-enhancers in regulation of IL-9 induction and airway inflammation
Xiao, X, Fan, Y, Li, J, Zhang, X, Lou, X, Dou, Y, Shi, X, Lan, P, Xiao, Y, Minze, L & Li, XC 2018, , Journal of Experimental Medicine, vol. 215, no. 2, pp. 559-574.

Ablation of interferon regulatory factor 4 in T cells induces “memory” of transplant tolerance that is irreversible by immune checkpoint blockade
Zhang, H, Wu, J, Zou, D, Xiao, X, Yan, H, Li, XC & Chen, W 2019, , American Journal of Transplantation, vol. 19, no. 3, pp. 884-893.

Macrophage subpopulations and their impact on chronic allograft rejection versus graft acceptance in a mouse heart transplant model
Zhao, Y, Chen, S, Lan, P, Wu, C, Dou, Y, Xiao, X, Zhang, Z, Minze, L, He, X, Chen, W & Li, XC 2017, , American Journal of Transplantation.

IL-9 and Th9 cells in health and diseases—From tolerance to immunopathology
Li, J, Chen, S, Xiao, X, Zhao, Y, Ding, W & Li, XC 2017, , Cytokine and Growth Factor Reviews, vol. 37, pp. 47-55.

Adipocyte adaptive immunity mediates diet-induced adipose inflammation and insulin resistance by decreasing adipose Treg cells
Deng, T, Liu, J, Deng, Y, Minze, LJ, Xiao, X, Wright, V, Yu, R, Li, XC, Blaszczak, A, Bergin, S, DiSilvestro, D, Judd, R, Bradley, D, Caligiuri, M, Lyon, CJ & Hsueh, WA 2017, , Nature Communications, vol. 8, 15725.

TNF superfamily receptor OX40 triggers invariant NKT cell pyroptosis and liver injury
Lan, P, Fan, Y, Zhao, Y, Lou, X, Monsour, HP, Zhang, X, Choi, Y, Dou, Y, Ishii, N, Ghobrial, RM, Xiao, X & Li, XC 2017, The Journal of clinical investigation.

Ablation of Transcription Factor IRF4 Promotes Transplant Acceptance by Driving Allogenic CD4+ T Cell Dysfunction
Wu, J, Zhang, H, Shi, X, Xiao, X, Fan, Y, Minze, LJ, Wang, J, Ghobrial, RM, Xia, J, Sciammas, R, Li, XC & Chen, W 2017, , Immunity.

Graft-Infiltrating Macrophages Adopt an M2 Phenotype and Are Inhibited by Purinergic Receptor P2X7 Antagonist in Chronic Rejection
Wu, C, Zhao, Y, Xiao, X, Fan, Y, Kloc, M, Liu, W, Ghobrial, RM, Lan, P, He, X & Li, XC 2016, , American Journal of Transplantation, vol. 16, no. 9, pp. 2563-2573.

The Costimulatory Receptor OX40 Inhibits Interleukin-17 Expression through Activation of Repressive Chromatin Remodeling Pathways
Xiao, X, Shi, X, Fan, Y, Wu, C, Zhang, X, Minze, L, Liu, W, Ghobrial, RM, Lan, P & Li, XC 2016, , Immunity, vol. 44, no. 6, pp. 1271-1283.

GITR subverts Foxp3(+) Tregs to boost Th9 immunity through regulation of histone acetylation
Xiao, X, Shi, X, Fan, Y, Zhang, X, Wu, M, Lan, P, Minze, L, Fu, Y-X, Ghobrial, RM, Liu, W & Li, XC 2015, , Nature Communications, vol. 6, pp. 8266.

CD4+CD62L+ Central Memory T Cells Can Be Converted to Foxp3+ T Cells
Zhang, X, Chang Li, X, Xiao, X, Sun, R, Tian, Z & Wei, H 2013, , PLoS ONE, vol. 8, no. 10, e77322.

IL-9 and Th9 cells: Progress and challenges
Zhao, P, Xiao, X, Ghobrial, RM & Li, XC 2013, , International Immunology, vol. 25, no. 10, pp. 547-551.