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Xiang Xiao, PhD

Associate Research Professor of Transplant Immunology in Surgery, Institute for Academic Medicine
Associate Research Member, Research Institute
Houston Methodist


XXIAO@HoustonMethodist.org
Biography

Dr. Xiao’s research interests are related to how the immune system responds to allotransplants, with specific emphasis on the fundamental mechanisms that control various T cell programs involved in transplant rejection and tolerance. One of the key aspects of his recent research focuses on the role of costimulatory molecules in T helper cells differentiation, functions, and fate decisions.

Description of Research

Dr. Xiang Xiao earned his Ph.D. in cell biology from University of Science and Technology of China in Heifei, China in 2005. He completed his postdoctoral fellowship training at Beth Israel Deaconess Medical Center and Harvard Medical School in Boston in 2013. After that, he joined Houston Methodist Research Institute as a research scientist. Dr. Xiao is now an assistant research professor of transplant immunology in surgery. Dr. Xiao studies the cellular and molecular mechanisms T cell functions relevant to transplant tolerance. He has published more than 20 original papers and review articles in high-impact scientific journals.

Education & Training

PhD, University of Science and Technology of China
Postdoctoral Fellowship, Harvard Medical School
Postdoctoral Fellowship, Beth Israel Deaconess Medical Center
Publications

OX40 Costimulation Inhibits Foxp3 Expression and Treg Induction via BATF3-Dependent and Independent Mechanisms
Zhang, X, Xiao, X, Lan, P, Li, J, Dou, Y, Chen, W, Ishii, N, Chen, S, Xia, B, Chen, K, Taparowsky, E & Li, XC 2018, Cell Reports, vol. 24, no. 3, pp. 607-618. https://doi.org/10.1016/j.celrep.2018.06.052

Role of the NF-kB family member RelB in regulation of Foxp3+ regulatory t cells in vivo
Li, J, Chen, S, Chen, W, Ye, Q, Dou, Y, Xiao, Y, Zhang, L, Minze, LJ, Li, XC & Xiao, X 2018, Journal of Immunology, vol. 200, no. 4, pp. 1325-1334. https://doi.org/10.4049/jimmunol.1701310

Guidance of super-enhancers in regulation of IL-9 induction and airway inflammation
Xiao, X, Fan, Y, Li, J, Zhang, X, Lou, X, Dou, Y, Shi, X, Lan, P, Xiao, Y, Minze, L & Li, XC 2018, Journal of Experimental Medicine, vol. 215, no. 2, pp. 559-574. https://doi.org/10.1084/jem.20170928

Ablation of interferon regulatory factor 4 in T cells induces “memory” of transplant tolerance that is irreversible by immune checkpoint blockade
Zhang, H, Wu, J, Zou, D, Xiao, X, Yan, H, Li, XC & Chen, W 2018, American Journal of Transplantation. https://doi.org/10.1111/ajt.15196

Macrophage subpopulations and their impact on chronic allograft rejection versus graft acceptance in a mouse heart transplant model
Zhao, Y, Chen, S, Lan, P, Wu, C, Dou, Y, Xiao, X, Zhang, Z, Minze, L, He, X, Chen, W & Li, XC 2017, American Journal of Transplantation. https://doi.org/10.1111/ajt.14543

IL-9 and Th9 cells in health and diseases—From tolerance to immunopathology
Li, J, Chen, S, Xiao, X, Zhao, Y, Ding, W & Li, XC 2017, Cytokine and Growth Factor Reviews, vol. 37, pp. 47-55. https://doi.org/10.1016/j.cytogfr.2017.07.004

Adipocyte adaptive immunity mediates diet-induced adipose inflammation and insulin resistance by decreasing adipose Treg cells
Deng, T, Liu, J, Deng, Y, Minze, LJ, Xiao, X, Wright, V, Yu, R, Li, XC, Blaszczak, A, Bergin, S, DiSilvestro, D, Judd, R, Bradley, D, Caligiuri, M, Lyon, CJ & Hsueh, WA 2017, Nature communications, vol. 8, 15725. https://doi.org/10.1038/ncomms15725

TNF superfamily receptor OX40 triggers invariant NKT cell pyroptosis and liver injury
Lan, P, Fan, Y, Zhao, Y, Lou, X, Monsour, HP, Zhang, X, Choi, Y, Dou, Y, Ishii, N, Ghobrial, RM, Xiao, X & Li, XC 2017, The Journal of clinical investigation. https://doi.org/10.1172/JCI91075

Ablation of Transcription Factor IRF4 Promotes Transplant Acceptance by Driving Allogenic CD4+ T Cell Dysfunction
Wu, J, Zhang, H, Shi, X, Xiao, X, Fan, Y, Minze, LJ, Wang, J, Ghobrial, RM, Xia, J, Sciammas, R, Li, XC & Chen, W 2017, Immunity. https://doi.org/10.1016/j.immuni.2017.11.003

Graft-Infiltrating Macrophages Adopt an M2 Phenotype and Are Inhibited by Purinergic Receptor P2X7 Antagonist in Chronic Rejection
Wu, C, Zhao, Y, Xiao, X, Fan, Y, Kloc, M, Liu, W, Ghobrial, RM, Lan, P, He, X & Li, XC 2016, American Journal of Transplantation, vol. 16, no. 9, pp. 2563-2573. https://doi.org/10.1111/ajt.13808

The Costimulatory Receptor OX40 Inhibits Interleukin-17 Expression through Activation of Repressive Chromatin Remodeling Pathways
Xiao, X, Shi, X, Fan, Y, Wu, C, Zhang, X, Minze, L, Liu, W, Ghobrial, RM, Lan, P & Li, XC 2016, Immunity, vol. 44, no. 6, pp. 1271-1283. https://doi.org/10.1016/j.immuni.2016.05.013

GITR subverts Foxp3(+) Tregs to boost Th9 immunity through regulation of histone acetylation
Xiao, X, Shi, X, Fan, Y, Zhang, X, Wu, M, Lan, P, Minze, L, Fu, Y-X, Ghobrial, RM, Liu, W & Li, XC 2015, Nature communications, vol. 6, pp. 8266. https://doi.org/10.1038/ncomms9266

CD4+CD62L+ Central Memory T Cells Can Be Converted to Foxp3+ T Cells
Zhang, X, Chang Li, X, Xiao, X, Sun, R, Tian, Z & Wei, H 2013, PLoS ONE, vol. 8, no. 10, e77322. https://doi.org/10.1371/journal.pone.0077322

IL-9 and Th9 cells: Progress and challenges
Zhao, P, Xiao, X, Ghobrial, RM & Li, XC 2013, International Immunology, vol. 25, no. 10, pp. 547-551. https://doi.org/10.1093/intimm/dxt039

OX40 signaling favors the induction of TH9 cells and airway inflammation
Xiao, X, Balasubramanian, S, Liu, W, Chu, X, Wang, H, Taparowsky, EJ, Fu, YX, Choi, Y, Walsh, MC & Li, XC 2012, Nature Immunology, vol. 13, no. 10, pp. 981-990. https://doi.org/10.1038/ni.2390

Biomarkers for monitoring therapeutic side effects or various supratherapeutic confounders after kidney transplantation
Gong, W, Whitcher, GH, Townamchai, N, Xiao, X & Ge, F 2012, Transplantation proceedings, vol. 44, no. 5, pp. 1265-1269. https://doi.org/10.1016/j.transproceed.2011.11.069

Deleterious effect of CTLA4-Ig on a treg-dependent transplant model
Riella, LV, Liu, T, Yang, J, Chock, S, Shimizu, T, Mfarrej, B, Batal, I, Xiao, X, Sayegh, MH & Chandraker, A 2012, American Journal of Transplantation, vol. 12, no. 4, pp. 846-856. https://doi.org/10.1111/j.1600-6143.2011.03929.x

Innate NK cells and macrophages recognize and reject allogeneic nonself in vivo via different mechanisms
Liu, W, Xiao, X, Demirci, G, Madsen, J & Li, XC 2012, Journal of Immunology, vol. 188, no. 6, pp. 2703-2711. https://doi.org/10.4049/jimmunol.1102997

New insights on OX40 in the control of T cell immunity and immune tolerance in vivo
Xiao, X, Gong, W, Demirci, G, Liu, W, Spoerl, S, Chu, X, Bishop, DK, Turka, LA & Li, XC 2012, Journal of Immunology, vol. 188, no. 2, pp. 892-901. https://doi.org/10.4049/jimmunol.1101373

Islet allograft tolerance in the absence of invariant natural killer T cells
Chu, X, Kilpatrick, E, Xiao, X, Liu, W, Demirci, G, Exley, M & Li, XC 2011, Clinical Immunology, vol. 141, no. 3, pp. 268-272. https://doi.org/10.1016/j.clim.2011.09.003