William A. Zoghbi, MD, FASE, FAHA, MACC

Elkins Family Distinguished Chair in Cardiac Health, DeBakey Heart & Vascular Center
Chair, Department of Cardiology
Professor of Cardiology, Academic Institute
Full Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Biography

William A. Zoghbi, a renowned cardiology, echocardiography and cardiac imaging expert, has developed noninvasive heart function and valve disorder evaluation techniques. As a result, Dr. Zoghbi has overseen national and international heart valve evaluation guideline development.

He built his reputation on his ischemic heart disease, myocardial function and hibernation research, as well as his development of echocardiographic techniques to evaluate valvular dynamics and measure valvular regurgitation. Dr. Zoghbi has authored more than 300 publications and lectured at every major cardiology conference worldwide.

Dr. Zoghbi has served:

  • The American College of Cardiology (ACC); president in 2012, honored as a master in 2013 and Board of Trustee member from 2002 to 2015
  • The American Heart Association
  • The American Society of Echocardiography (ASE); president in 2008
  • The World Heart Federation; board member from 2014 to 2015 and Global Cardiovascular Disease Taskforce co-chair

Since 2008, Dr. Zoghbi’s professional activities have included:

  • Implementing the ACC’s international mission and working with many international chapters he helped build
  • Representing the ACC and the global cardiovascular community at the United Nations and World Health Organization, advocating for a 25 percent reduction of the world’s noncommunicable disease mortality rate by 2025, known as the 25 x 25 Initiative
  • Focusing on patient-centered care and spearheading the CardioSmart.org relaunch while ACC president

Dr. Zoghbi’s scholarly contributions include service as:

  • A senior editor of JACC Cardiovascular Imaging
  • Global health section editor for the Journal of the American College of Cardiology
  • An editorial board member of Global Heart
  • Former associate editor of Circulation

A dedicated educator, Dr. Zoghbi has trained more than 100 cardiology fellows in advanced cardiovascular imaging. In 2004, he received the American Society of Echocardiography’s Richard Popp Excellence in Teaching Award.  He also co-chaired the American College of Cardiology committee responsible for a monograph advising cardiovascular imaging training best practices.

In 2005, Dr. Zoghbi joined the Houston Methodist Specialty Physician Group following his 20-year tenure at Baylor College of Medicine, where he was the John S. Dunn Professor of Medicine and served as Houston Methodist’s echocardiography laboratory director. In 2005, he established Houston Methodist’s Cardiovascular Imaging Institute, integrating all cardiovascular imaging modalities to enhance patient care, education and research. He became the William L. Winters Endowed Chair in Cardiovascular Imaging in 2005. In 2016, Dr. Zoghbi was appointed chairman of the Department of Cardiology at Houston Methodist and holds the Elkins Family Distinguished Chair in Cardiology, established in his honor.  

Description of Research

Dr. Zoghbi´s research focuses on cardiovascular imaging, emphasizing echocardiography. He has developed methods for evaluation of valvular function, ventricular function quantitation and myocardial viability detection in patients with ischemic ventricular dysfunction. More recently, Dr. Zoghbi has collaborated with University of Houston mathematicians and led his laboratory’s efforts to better understand cardiac valve structure and function and improve quantitation of artificial valve function using in vitro modeling and multimodality imaging.

Areas Of Expertise

Echocardiography Valvular function Ventricular function Myocardial hibernation
Education & Training

Residency, Baylor College of Medicine
Clinical Fellowship, Baylor College of Medicine
Internship, University of Texas, Medical Branch
MD, Meharry Medical College School of Medicine
Publications

Sex differences in machine learning computed tomography-derived fractional flow reserve
Al Rifai, M, Ahmed, AI, Han, Y, Saad, JM, Alnabelsi, T, Nabi, F, Chang, SM, Cocker, M, Schwemmer, C, Ramirez-Giraldo, JC, Zoghbi, WA, Mahmarian, JJ & Al-Mallah, MH 2022, , Scientific Reports, vol. 12, no. 1, 13861. https://doi.org/10.1038/s41598-022-17875-9

Atrial Functional Mitral Regurgitation: A JACC: Cardiovascular Imaging Expert Panel Viewpoint
Zoghbi, WA, Levine, RA, Flachskampf, F, Grayburn, P, Gillam, L, Leipsic, J, Thomas, JD, Kwong, RY, Vandervoort, P & Chandrashekhar, Y 2022, , JACC: Cardiovascular Imaging, vol. 15, no. 11, pp. 1870-1882. https://doi.org/10.1016/j.jcmg.2022.08.016

An Integrative, Multiparametric Approach to Mitral Regurgitation Evaluation: A Case-Based Illustration
Faza, NN, Chebrolu, LB, El-Tallawi, KC & Zoghbi, WA 2022, , JACC: Case Reports, vol. 4, no. 19, pp. 1231-1241. https://doi.org/10.1016/j.jaccas.2022.07.013

Differences in Cardiac Remodeling in Left-Sided Valvular Regurgitation: Implications for Optimal Definition of Significant Aortic Regurgitation
Vejpongsa, P, Xu, J, Quinones, MA, Shah, DJ & Zoghbi, WA 2022, , JACC: Cardiovascular Imaging, vol. 15, no. 10, pp. 1730-1741. https://doi.org/10.1016/j.jcmg.2022.05.006

Myocardial Contractile Mechanics in Ischemic Mitral Regurgitation: Multicenter Data Using Stress Perfusion Cardiovascular Magnetic Resonance
Kochav, JD, Kim, J, Judd, R, Tak, KA, Janjua, E, Maciejewski, AJ, Kim, HW, Klem, I, Heitner, J, Shah, D, Zoghbi, WA, Shenoy, C, Farzaneh-Far, A, Polsani, V, Villar-Calle, P, Parker, M, Judd, KM, Khalique, OK, Leon, MB, Devereux, RB, Levine, RA, Kim, RJ & Weinsaft, JW 2022, , JACC: Cardiovascular Imaging, vol. 15, no. 7, pp. 1212-1226. https://doi.org/10.1016/j.jcmg.2022.03.014

Prognostic Interplay Between Coronary Artery Calcium Scoring and Cardiorespiratory FItness: The CAC-FIT Study
Ahmed, AI, Saad, JM, Han, Y, Alfawara, MS, Soliman, A, Nabi, F, Zoghbi, WA & Al-Mallah, MH 2022, , Mayo Clinic Proceedings, vol. 97, no. 7, pp. 1269-1281. https://doi.org/10.1016/j.mayocp.2022.03.032

Challenges and Opportunities in Evaluating Severity of Degenerative Mitral Regurgitation: Details Matter
Zoghbi, WA 2022, , JACC: Cardiovascular Imaging, vol. 15, no. 5, pp. 761-765. https://doi.org/10.1016/j.jcmg.2022.01.011

Prognostic Value of Computed Tomography-Derived Fractional Flow Reserve Comparison With Myocardial Perfusion Imaging
Ahmed, AI, Han, Y, Al Rifai, M, Alnabelsi, T, Nabi, F, Chang, SM, Cocker, M, Schwemmer, C, Ramirez-Giraldo, JC, Kleiman, NS, Zoghbi, WA, Mahmarian, JJ & Al-Mallah, MH 2022, , JACC: Cardiovascular Imaging, vol. 15, no. 2, pp. 284-295. https://doi.org/10.1016/j.jcmg.2021.09.007

Coronary microvascular dysfunction and COVID-19: implications for long COVID patients
Malahfji, M, Crudo, V, Ahmed, AI, Saeed, M, Saad, JM, Zoghbi, WA & Al-Mallah, MH 2022, , Journal of Nuclear Cardiology. https://doi.org/10.1007/s12350-022-03073-7

Cardiac involvement in hospitalized patients with COVID-19 and its incremental value in outcomes prediction
Pournazari, P, Spangler, AL, Ameer, F, Hagan, KK, Tano, ME, Chamsi-Pasha, M, Chebrolu, LH, Zoghbi, WA, Nasir, K & Nagueh, SF 2021, , Scientific Reports, vol. 11, no. 1, 19450. https://doi.org/10.1038/s41598-021-98773-4

Next Frontier in Functional Mitral Regurgitation: Defining Severity Beyond Which Interventions Can Alter Remodeling and Prognosis
Zoghbi, WA & Chandrashekhar, Y 2021, , JACC: Cardiovascular Imaging, vol. 14, no. 12, pp. 2486-2488. https://doi.org/10.1016/j.jcmg.2021.11.005

Valve Strain Quantitation in Normal Mitral Valves and Mitral Prolapse With Variable Degrees of Regurgitation
El-Tallawi, KC, Zhang, P, Azencott, R, He, J, Herrera, EL, Xu, J, Chamsi-Pasha, M, Jacob, J, Lawrie, GM & Zoghbi, WA 2021, , JACC: Cardiovascular Imaging, vol. 14, no. 6, pp. 1099-1109. https://doi.org/10.1016/j.jcmg.2021.01.006

Mitral Valve Remodeling and Strain in Secondary Mitral Regurgitation: Comparison With Primary Regurgitation and Normal Valves
El-Tallawi, KC, Zhang, P, Azencott, R, He, J, Xu, J, Herrera, EL, Jacob, J, Chamsi-Pasha, M, Lawrie, GM & Zoghbi, WA 2021, , JACC: Cardiovascular Imaging, vol. 14, no. 4, pp. 782-793. https://doi.org/10.1016/j.jcmg.2021.02.004

Ischemia-Mediated Dysfunction in Subpapillary Myocardium as a Marker of Functional Mitral Regurgitation
Kochav, JD, Kim, J, Judd, R, Kim, HW, Klem, I, Heitner, J, Shah, D, Shenoy, C, Farzaneh-Far, A, Polsani, V, Kalil, R, Villar-Calle, P, Nambiar, L, Sultana, R, Parker, M, Cargile, P, Khalique, OK, Leon, MB, Karmpaliotis, D, Ratcliffe, M, Levine, R, Zoghbi, WA, Devereux, RB, Moskowitz, CS, Kim, R & Weinsaft, JW 2021, , JACC: Cardiovascular Imaging, vol. 14, no. 4, pp. 826-839. https://doi.org/10.1016/j.jcmg.2021.01.007

Projecting the Transmitral Mean Gradient in Degenerative Mitral Stenosis for Heart Rate and Stroke Volume
Grayburn, PA, Marwick, TH & Zoghbi, WA 2021, , JACC: Cardiovascular Imaging, vol. 14, no. 3, pp. 571-572. https://doi.org/10.1016/j.jcmg.2021.01.009

Diffeomorphic Shape Matching by Operator Splitting in 3D Cardiology Imaging
Zhang, P, Mang, A, He, J, Azencott, R, El-Tallawi, KC & Zoghbi, WA 2021, , Journal of Optimization Theory and Applications, vol. 188, no. 1, pp. 143-168. https://doi.org/10.1007/s10957-020-01789-5

Extracellular Volume in Primary Mitral Regurgitation
Kitkungvan, D, Yang, EY, El Tallawi, KC, Nagueh, SF, Nabi, F, Khan, MA, Nguyen, DT, Graviss, EA, Lawrie, GM, Zoghbi, WA, Bonow, RO, Quinones, MA & Shah, DJ 2021, , JACC: Cardiovascular Imaging, vol. 14, no. 6, pp. 1146-1160. https://doi.org/10.1016/j.jcmg.2020.10.010

Impact of Myocardial Scar on Prognostic Implication of Secondary Mitral Regurgitation in Heart Failure
Tayal, B, Debs, D, Nabi, F, Malahfji, M, Little, SH, Reardon, M, Zoghbi, W, Kleiman, N & Shah, DJ 2021, , JACC: Cardiovascular Imaging, vol. 14, no. 4, pp. 812-822. https://doi.org/10.1016/j.jcmg.2020.11.004

One Hundred Percent Reparability of Mitral Prolapse: Results of a Dynamic Nonresectional Technique
Lawrie, G, Zoghbi, W, Little, S, Shah, D, Earle, N & Earle, E 2021, , Annals of Thoracic Surgery, vol. 112, no. 6, pp. 1921-1928. https://doi.org/10.1016/j.athoracsur.2020.09.090

Outcomes of patients with moderate-to-severe Ischemia excluded from the ischemia trial
Al-Mallah, MH, Ahmed, AI, Nabi, F, Chang, SM, Kleiman, NS, Chamsi-Pasha, MA, Shah, A, Han, Y, Zoghbi, WA & Mahmarian, JJ 2022, , Journal of Nuclear Cardiology, vol. 29, no. 3, pp. 1100-1105. https://doi.org/10.1007/s12350-021-02679-7