William G. Ondo, MD

Professor of Neurology, Institute for Academic Medicine
Full Clinical Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Dr. William G. Ondo is the director of the Movement Disorders Clinic at the Houston Methodist Neurological Institute. Dr. Ondo has been in practice for nearly 20 years and specializes in diagnosis, treatment and research of Parkinson’s disease, essential tremors, the use of botulinum toxins in treating movement disorders, and restless legs syndrome.

Dr. Ondo earned his medical degree from the Medical College of Virginia before completing an internship at the University of North Carolina Hospital, a neurology residency at Duke University, and a movement disorders fellowship at the Baylor College of Medicine. He is board certified by the American Board of Psychiatry and Neurology in adult neurology and sleep medicine. He has authored more than 250 original articles and book chapters as well as edited two books on movement disorders. He currently serves as the president of the Tremor Research Group.

Areas Of Expertise

Ataxia Parkinson's disease Dystonia Essential tremor Restless legs

In Reply—Additional Safety Considerations Before Prescribing Opioids to Manage Restless Legs Syndrome
Silber, MH, Becker, PM, Buchfuhrer, MJ, Earley, CJ, Ondo, WG, Walters, AS & Winkelman, JW 2018, Mayo Clinic proceedings, vol. 93, no. 7, pp. 955-956. DOI: 10.1016/j.mayocp.2018.03.021

Restless Legs Syndrome “Patient Odyssey” survey of disease burden on patient and spouses/partners
Ondo, W 2018, Sleep Medicine, vol. 47, pp. 51-53. DOI: 10.1016/j.sleep.2017.12.003

Onabotulinum toxin-A injections for sleep bruxism
Ondo, WG, Simmons, JH, Shahid, MH, Hashem, V, Hunter, C & Jankovic, J 2018, Neurology, vol. 90, no. 7, pp. e559-e564. DOI: 10.1212/WNL.0000000000004951

Non-VMAT2 inhibitor treatments for the treatment of tardive dyskinesia
Lin, CC & Ondo, WG 2018, Journal of the neurological sciences. DOI: 10.1016/j.jns.2018.02.014

Treating Hallucinations and Delusions Associated With Parkinson’s Disease Psychosis
Panchal, SC & Ondo, WG 2018, Current Psychiatry Reports, vol. 20, no. 1, 3. DOI: 10.1007/s11920-018-0869-z

The Appropriate Use of Opioids in the Treatment of Refractory Restless Legs Syndrome
for the 2018, Mayo Clinic proceedings, vol. 93, no. 1, pp. 59-67. DOI: 10.1016/j.mayocp.2017.11.007

Evidence-based and consensus clinical practice guidelines for the iron treatment of restless legs syndrome/Willis-Ekbom disease in adults and children: an IRLSSG task force report
on behalf of the & International Restless Legs Syndrome Study Group (IRLSSG) 2018, Sleep Medicine, vol. 41, pp. 27-44. DOI: 10.1016/j.sleep.2017.11.1126

Clinical features of Parkinson's disease with and without rapid eye movement sleep behavior disorder
Liu, Y, Zhu, XY, Zhang, XJ, Kuo, SH, Ondo, WG & Wu, YC 2017, Translational Neurodegeneration, vol. 6, no. 1, 35. DOI: 10.1186/s40035-017-0105-5

A 500 U/2 mL dilution of abobotulinumtoxinA vs. placebo: randomized study in cervical dystonia
Lew, MF, Brashear, A, Dashtipour, K, Isaacson, S, Hauser, RA, Maisonobe, P, Snyder, D & Ondo, W 2017, International Journal of Neuroscience, pp. 1-8. DOI: 10.1080/00207454.2017.1406935

Restless Legs Syndrome: Clinical features, diagnosis and a practical approach to management
Wijemanne, S & Ondo, W 2017, Practical Neurology, vol. 17, no. 6, pp. 444-452. DOI: 10.1136/practneurol-2017-001762

Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry: a meta-analysis
23andMe Research Team 2017, The Lancet Neurology, vol. 16, no. 11, pp. 898-907. DOI: 10.1016/S1474-4422(17)30327-7

Psychiatric associations of adult-onset focal dystonia phenotypes
Berman, BD, Junker, J, Shelton, E, Sillau, SH, Jinnah, HA, Perlmutter, JS, Espay, AJ, Jankovic, J, Vidailhet, M, Bonnet, C, Ondo, W, Malaty, IA, Rodríguez, R, McDonald, WM, Marsh, L, Zurowski, M, Bäumer, T & Brüggemann, N 2017, Journal of neurology, neurosurgery, and psychiatry, vol. 88, no. 7, pp. 595-602. DOI: 10.1136/jnnp-2016-315461

Randomized controlled trial of deutetrabenazine for tardive dyskinesia the ARM-TD study
Fernandez, HH, Factor, SA, Hauser, RA, Jimenez-Shahed, J, Ondo, WG, Jarskog, LF, Meltzer, HY, Woods, SW, Bega, D, LeDoux, MS, Shprecher, DR, Davis, C, Davis, MD, Stamler, D & Anderson, KE 2017, Neurology, vol. 88, no. 21, pp. 2003-2010. DOI: 10.1212/WNL.0000000000003960

Optimizing extended-release carbidopa/levodopa in Parkinson disease
Espay, AJ, Pagan, FL, Walter, BL, Morgan, JC, Elmer, LW, Waters, CH, Agarwal, P, Dhall, R, Ondo, WG, Klos, KJ & Silver, DE 2017, Neurology: Clinical Practice, vol. 7, no. 1, pp. 86-93. DOI: 10.1212/CPJ.0000000000000316

Thalamic deep brain stimulation for orthostatic tremor: A multicenter international registry
Merola, A, Fasano, A, Hassan, A, Ostrem, JL, Contarino, MF, Lyons, M, Krauss, JK, Wolf, ME, Klassen, BT, van Rootselaar, AF, Regidor, I, Duker, AP, Ondo, W, Guridi, J, Volkmann, J, Shukla, AW, Mandybur, GT, Okun, MS, Witt, K, Starr, PA, Deuschl, G & Espay, AJ 2017, Movement Disorders. DOI: 10.1002/mds.27082

Deutetrabenazine for treatment of involuntary movements in patients with tardive dyskinesia (AIM-TD): A double-blind, randomised, placebo-controlled, phase 3 trial
Anderson, KE, Stamler, D, Davis, MD, Factor, SA, Hauser, RA, Isojärvi, J, Jarskog, LF, Jimenez-Shahed, J, Kumar, R, McEvoy, JP, Ochudlo, S, Ondo, WG & Fernandez, HH 2017, The Lancet Psychiatry. DOI: 10.1016/S2215-0366(17)30236-5

Clinical and demographic characteristics related to onset site and spread of cervical dystonia
Norris, SA, Jinnah, HA, Espay, AJ, Klein, C, Brüggemann, N, Barbano, RL, Malaty, IAC, Rodriguez, RL, Vidailhet, M, Roze, E, Reich, SG, Berman, BD, LeDoux, MS, Richardson, SP, Agarwal, P, Mari, Z, Ondo, WG, Shih, LC, Fox, SH, Berardelli, A, Testa, CM, Cheng, FCF, Truong, D, Nahab, FB, Xie, T, Hallett, M, Rosen, AR, Wright, LJ & Perlmutter, JS 2016, Movement Disorders, vol. 31, no. 12, pp. 1874-1882. DOI: 10.1002/mds.26817

Knowledge gaps and research recommendations for essential tremor
Hopfner, F, Haubenberger, D, Galpern, WR, Gwinn, K, Vant Veer, A, White, S, Bhatia, K, Adler, CH, Eidelberg, D, Ondo, W, Stebbins, GT, Tanner, CM, Helmich, RC, Lenz, FA, Sillitoe, RV, Vaillancourt, D, Vitek, JL, Louis, ED, Shill, HA, Frosch, MP, Foroud, T, Kuhlenbäumer, G, Singleton, A, Testa, CM, Hallett, M, Elble, R & Deuschl, G 2016, Parkinsonism and Related Disorders, vol. 33, pp. 27-35. DOI: 10.1016/j.parkreldis.2016.10.002

Practice guideline summary: Treatment of restless legs syndrome in adults: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology
Winkelman, JW, Armstrong, MJ, Allen, RP, Chaudhuri, KR, Ondo, W, Trenkwalder, C, Zee, PC, Gronseth, GS, Gloss, D & Zesiewicz, T 2016, Neurology. DOI: 10.1212/WNL.0000000000003388

A randomized trial of focused ultrasound thalamotomy for essential tremor
Elias, WJ, Lipsman, N, Ondo, WG, Ghanouni, P, Kim, YG, Lee, W, Schwartz, M, Hynynen, K, Lozano, AM, Shah, BB, Huss, D, Dallapiazza, RF, Gwinn, R, Witt, J, Ro, S, Eisenberg, HM, Fishman, PS, Gandhi, D, Halpern, CH, Chuang, R, Pauly, KB, Tierney, TS, Hayes, MT, Cosgrove, GR, Yamaguchi, T, Abe, K, Taira, T & Chang, JW 2016, New England Journal of Medicine, vol. 375, no. 8, pp. 730-739. DOI: 10.1056/NEJMoa1600159