William G. Ondo, MD

Professor of Neurology, Academic Institute
Full Clinical Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Dr. William G. Ondo is the director of the Movement Disorders Clinic at the Houston Methodist Neurological Institute. Dr. Ondo has been in practice for nearly 20 years and specializes in diagnosis, treatment and research of Parkinson’s disease, essential tremors, the use of botulinum toxins in treating movement disorders, and restless legs syndrome.

Dr. Ondo earned his medical degree from the Medical College of Virginia before completing an internship at the University of North Carolina Hospital, a neurology residency at Duke University, and a movement disorders fellowship at the Baylor College of Medicine. He is board certified by the American Board of Psychiatry and Neurology in adult neurology and sleep medicine. He has authored more than 250 original articles and book chapters as well as edited two books on movement disorders. He currently serves as the president of the Tremor Research Group.

Areas Of Expertise

Ataxia Parkinson's disease Dystonia Essential tremor Restless legs

Essential tremor-plus: a controversial new concept
Louis, ED, Bares, M, Benito-Leon, J, Fahn, S, Frucht, SJ, Jankovic, J, Ondo, WG, Pal, PK & Tan, EK 2020, The Lancet Neurology, vol. 19, no. 3, pp. 266-270. https://doi.org/10.1016/S1474-4422(19)30398-9

Safety and Efficacy of RimabotulinumtoxinB for Treatment of Sialorrhea in Adults: A Randomized Clinical Trial
Isaacson, SH, Ondo, WG, Jackson, CE, Trosch, RM, Molho, E, Pagan, F, Lew, M, Dashtipour, K, Clinch, T & Espay, AJ 2020, JAMA Neurology. https://doi.org/10.1001/jamaneurol.2019.4565

Current and Emerging Treatments of Essential Tremor
Ondo, WG 2020, Neurologic Clinics. https://doi.org/10.1016/j.ncl.2020.01.002

Clinical features and subtypes of restless legs syndrome in Chinese population: a study of 359 patients
Zhu, XY, Wu, TT, Wang, HM, Ni, LY, Li, X, Liu, Y, Zhang, XJ, Chen, YJ, Cui, XX, Ondo, WG & Wu, YC 2019, Sleep Medicine, vol. 59, pp. 15-23. https://doi.org/10.1016/j.sleep.2019.01.053

Systematic literature review of quetiapine for the treatment of psychosis in patients with Parkinsonism
Chen, JJ, Hua, H, Massihi, L, Portillo, I, Alipour, A, Ondo, WG & Dashtipour, K 2019, Journal of Neuropsychiatry and Clinical Neurosciences, vol. 31, no. 3, pp. 188-195. https://doi.org/10.1176/appi.neuropsych.18080180

Restless legs syndrome in end stage renal disease patients undergoing hemodialysis
Lin, XW, Zhang, JF, Qiu, MY, Ni, LY, Yu, HL, Kuo, SH, Ondo, WG, Yu, Q & Wu, YC 2019, BMC neurology, vol. 19, no. 1, 47. https://doi.org/10.1186/s12883-019-1265-y

45 Long-term Treatment with Deutetrabenazine Is Associated with Continued Improvement in Tardive Dyskinesia: Results from an Open-label Extension Study
Hauser, RA, Fernandez, HH, Stamler, D, Davis, MD, Factor, SA, Jimenez-Shahed, J, Ondo, WG, Jarskog, LF, Woods, SW, LeDoux, MS, Shprecher, DR & Anderson, KE 2019, CNS spectrums, vol. 24, no. 1, pp. 200-201. https://doi.org/10.1017/S1092852919000385

46 Confirmed Safety of Deutetrabenazine for Tardive Dyskinesia in a 2-Year Open-label Extension Study
Fernandez, HH, Stamler, D, Davis, MD, Factor, SA, Hauser, RA, Jimenez-Shahed, J, Ondo, WG, Jarskog, LF, Woods, SW, LeDoux, MS, Shprecher, DR & Anderson, KE 2019, CNS spectrums, vol. 24, no. 1. https://doi.org/10.1017/S1092852919000397

Clinical and radiological characteristics of restless legs syndrome following acute lacunar infarction
Tuo, H, Tian, Z, Ma, X, Cui, Y, Xue, Y, Che, J, Xu, C, Chen, K, Zhang, Y, Zhang, L, Bi, H, Le, W & Ondo, WG 2019, Sleep Medicine, vol. 53, pp. 81-87. https://doi.org/10.1016/j.sleep.2018.06.004

Treatment of restless legs syndrome and periodic limb movements
Ondo, WG 2019, . in Current Clinical Neurology. Current Clinical Neurology, Humana Press, pp. 329-331. https://doi.org/10.1007/978-3-319-97897-0_76

Long-term safety and efficacy of deutetrabenazine for the treatment of tardive dyskinesia
Fernandez, HH, Stamler, D, Davis, MD, Factor, SA, Hauser, RA, Jimenez-Shahed, J, Ondo, WG, Jarskog, LF, Woods, SW, Bega, D, Ledoux, MS, Shprecher, DR & Anderson, KE 2019, Journal of Neurology, Neurosurgery and Psychiatry. https://doi.org/10.1136/jnnp-2018-319918

Comparison of the Fahn-Tolosa-Marin Clinical Rating Scale and the Essential Tremor Rating Assessment Scale
Ondo, WG, Hashem, V, LeWitt, PA, Pahwa, R, Shih, L, Tarsy, D, Zesiewicz, T & Elble, R 2018, Movement Disorders Clinical Practice, vol. 5, no. 1, pp. 60-65. https://doi.org/10.1002/mdc3.12560

In Reply—Additional Safety Considerations Before Prescribing Opioids to Manage Restless Legs Syndrome
Silber, MH, Becker, PM, Buchfuhrer, MJ, Earley, CJ, Ondo, WG, Walters, AS & Winkelman, JW 2018, Mayo Clinic proceedings, vol. 93, no. 7, pp. 955-956. https://doi.org/10.1016/j.mayocp.2018.03.021

Restless Legs Syndrome “Patient Odyssey” survey of disease burden on patient and spouses/partners
Ondo, WG 2018, Sleep Medicine, vol. 47, pp. 51-53. https://doi.org/10.1016/j.sleep.2017.12.003

Onabotulinum toxin-A injections for sleep bruxism: A double-blind, placebo-controlled study
Ondo, WG, Simmons, JH, Shahid, MH, Hashem, V, Hunter, C & Jankovic, J 2018, Neurology, vol. 90, no. 7, pp. e559-e564. https://doi.org/10.1212/WNL.0000000000004951

The Appropriate Use of Opioids in the Treatment of Refractory Restless Legs Syndrome
for the 2018, Mayo Clinic proceedings, vol. 93, no. 1, pp. 59-67. https://doi.org/10.1016/j.mayocp.2017.11.007

Non-VMAT2 inhibitor treatments for the treatment of tardive dyskinesia
Lin, CC & Ondo, WG 2018, Journal of the neurological sciences. https://doi.org/10.1016/j.jns.2018.02.014

Treating Hallucinations and Delusions Associated With Parkinson’s Disease Psychosis
Panchal, SC & Ondo, WG 2018, Current Psychiatry Reports, vol. 20, no. 1, 3. https://doi.org/10.1007/s11920-018-0869-z

Evidence-based and consensus clinical practice guidelines for the iron treatment of restless legs syndrome/Willis-Ekbom disease in adults and children: an IRLSSG task force report
International Restless Legs Syndrome Study Group (IRLSSG) 2018, Sleep Medicine, vol. 41, pp. 27-44. https://doi.org/10.1016/j.sleep.2017.11.1126

Clinical features of Parkinson's disease with and without rapid eye movement sleep behavior disorder
Liu, Y, Zhu, XY, Zhang, XJ, Kuo, SH, Ondo, WG & Wu, YC 2017, Translational Neurodegeneration, vol. 6, no. 1, 35. https://doi.org/10.1186/s40035-017-0105-5

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