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Weihua Zhao, MD, PhD

Assistant Research Professor of Neurology, Institute for Academic Medicine
Assistant Research Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Biography

During her postdoctoral training, Dr. Zhao conducted research on amyotrophic lateral sclerosis (ALS) or Lou Gehrig’s disease. She investigated the roles of glutamate-mediated cytotoxicity, immune-mediated injury, and oxidative stress in motor neuron death. She also investigated the potential for a new phospholipid agent, VP025, to inhibit immune activation and protect motor neurons from injury. After completing her postdoctoral fellowship, Dr. Zhao joined the Methodist Hospital Research Institute as a scientist in the Department of Neurology.

Areas Of Expertise

Inflammation ALS Lou Gehrig’s disease Immune Suppression Neuroprotection Neurocytotoxicity
Education & Training

Postdoctoral Fellowship, Baylor College of Medicine
MD, Beijing Medical University, Beijing
PhD, Peking University
Publications

Functional alterations of myeloid cells during the course of Alzheimer’s disease
Thome, AD, Faridar, A, Beers, DR, Thonhoff, JR, Zhao, W, Wen, S, Pascual, B, Masdeu, JC & Appel, SH 2018, Molecular Neurodegeneration, vol. 13, no. 1, pp. 61. DOI: 10.1186/s13024-018-0293-1

Expanded autologous regulatory T-lymphocyte infusions in ALS
Thonhoff, JR, Beers, DR, Zhao, W, Pleitez, M, Simpson, EP, Berry, JD, Cudkowicz, ME & Appel, SH 2018, Neurology - Neuroimmunology Neuroinflammation, vol. 5, no. 4.

Expanded autologous regulatory T-lymphocyte infusions in ALS A phase I, first-in-human study
Thonhoff, JR, Beers, DR, Zhao, W, Pleitez, M, Simpson, EP, Berry, JD, Cudkowicz, ME & Appel, SH 2018, Neurology: Neuroimmunology and NeuroInflammation, vol. 5, no. 4, e465. DOI: 10.1212/NXI.0000000000000465

The role of regulatory T lymphocytes in amyotrophic lateral sclerosis
Beers, DR, Zhao, W & Appel, SH 2018, JAMA Neurology, vol. 75, no. 6, pp. 656-658. DOI: 10.1001/jamaneurol.2018.0043

Characterization of Gene Expression Phenotype in Amyotrophic Lateral Sclerosis Monocytes
Zhao, W, Beers, DR, Hooten, KG, Sieglaff, DH, Zhang, A, Kalyana-Sundaram, S, Traini, CM, Halsey, WS, Hughes, AM, Sathe, GM, Livi, GP, Fan, GH & Appel, SH 2017, JAMA Neurology, vol. 74, no. 6, pp. 677-685. DOI: 10.1001/jamaneurol.2017.0357

ALS patients' regulatory T lymphocytes are dysfunctional, and correlate with disease progression rate and severity
Beers, DR, Zhao, W, Wang, J, Zhang, X, Wen, S, Neal, D, Thonhoff, JR, Alsuliman, AS, Shpall, EJ, Rezvani, K & Appel, SH 2017, JCI Insight, vol. 2, no. 5, pp. e89530. DOI: 10.1172/jci.insight.89530

TDP-43 activates microglia through NF-?B and NLRP3 inflammasome
Zhao, W, Beers, DR, Bell, S, Wang, J, Wen, S, Baloh, RH & Appel, SH 2015, Experimental Neurology, vol. 273, pp. 24-35. DOI: 10.1016/j.expneurol.2015.07.019

Protective and Toxic Neuroinflammation in Amyotrophic Lateral Sclerosis
Hooten, KG, Beers, DR, Zhao, W & Appel, SH 2015, Neurotherapeutics, vol. 12, no. 2, pp. 364-375. DOI: 10.1007/s13311-014-0329-3

The Role of Regulatory T Cells and Microglia in Amyotrophic Lateral Sclerosis
Beers, DR, Zhao, W, Hooten, KG & Appel, SH 2015, . in S David (ed.), Neuroinflammation: New Insights into Beneficial and Detrimental Functions. Wiley, pp. 235-249. DOI: 10.1002/9781118732748.ch15

Role of Inflammation in Neurodegenerative Diseases
Appel, SH, Beers, DR & Zhao, W 2014, . in Neurobiology of Brain Disorders: Biological Basis of Neurological and Psychiatric Disorders. Elsevier, pp. 380-395. DOI: 10.1016/B978-0-12-398270-4.00025-2

Neuroimmunology of Amyotrophic Lateral Sclerosis
Henkel, JS, Beers, DR, Zhao, W & Appel, SH 2014, . in Neuroinflammation and CNS Disorders. Wiley, pp. 185-209. DOI: 10.1002/9781118406557.ch8

Immune-mediated mechanisms in the pathoprogression of amyotrophic lateral sclerosis
Zhao, W, Beers, DR & Appel, SH 2013, Journal of Neuroimmune Pharmacology, vol. 8, no. 4, pp. 888-899. DOI: 10.1007/s11481-013-9489-x

Erratum: Regulatory T-lymphocytes mediate amyotrophic lateral sclerosis progression and survival [EMBO Mol Med 5, 1] DOI: 10.1002/emmm.201201544
Henkel, JS, Beers, DR, Wen, S, Rivera, AL, Toennis, KM, Appel, JE, Zhao, W, Moore, DH, Powell, SZ & Appel, SH 2013, EMBO Molecular Medicine, vol. 5, no. 2. DOI: 10.1002/emmm.201390002

Regulatory T-lymphocytes mediate amyotrophic lateral sclerosis progression and survival
Henkel, JS, Beers, DR, Wen, S, Rivera, AL, Toennis, KM, Appel, JE, Zhao, W, Moore, DH, Powell, SZ & Appel, SH 2013, EMBO Molecular Medicine, vol. 5, no. 1, pp. 64-79. DOI: 10.1002/emmm.201201544

Regulatory T lymphocytes from ALS mice suppress microglia and effector T lymphocytes through different cytokine-mediated mechanisms
Zhao, W, Beers, DR, Liao, B, Henkel, JS & Appel, SH 2012, Neurobiology of Disease, vol. 48, no. 3, pp. 418-428. DOI: 10.1016/j.nbd.2012.07.008

Transformation from a neuroprotective to a neurotoxic microglial phenotype in a mouse model of ALS
Liao, B, Zhao, W, Beers, DR, Henkel, JS & Appel, SH 2012, Experimental Neurology, vol. 237, no. 1, pp. 147-152. DOI: 10.1016/j.expneurol.2012.06.011

Reactive oxygen and nitrogen species - A driving force in amyotrophic lateral sclerosis
Henkel, JS, Beers, DR, Zhao, W & Appel, SH 2012, . in Systems Biology of Free Radicals and Antioxidants. Springer-Verlag Berlin Heidelberg, pp. 3141-3165. DOI: 10.1007/978-3-642-30018-9_131

Neuroinflammation modulates distinct regional and temporal clinical responses in ALS mice
Beers, DR, Zhao, W, Liao, B, Kano, O, Wang, J, Huang, A, Appel, SH & Henkel, JS 2011, Brain, Behavior, and Immunity, vol. 25, no. 5, pp. 1025-1035. DOI: 10.1016/j.bbi.2010.12.008

The microglial-motoneuron dialogue in ALS
Appel, SH, Zhao, W, Beers, DR & Henkel, JS 2011, Acta Myologica, vol. 30, no. JUNE, pp. 4-8.

Endogenous regulatory T lymphocytes ameliorate amyotrophic lateral sclerosis in mice and correlate with disease progression in patients with amyotrophic lateral sclerosis
Beers, DR, Henkel, JS, Zhao, W, Wang, J, Huang, A, Wen, S, Liao, B & Appel, SH 2011, Brain, vol. 134, no. 5, pp. 1293-1314. DOI: 10.1093/brain/awr074