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Weidong Le, MD, PhD

Full Affiliate Member, Research Institute
Houston Methodist


Biography

Dr. Le received his Bachelor’s degree from Suzhou Medical College in 1978, and his doctoral degree from Shanghai 2nd Medical University in 1988. He did postdoctoral training at Baylor College of Medicine starting in 1989. He was promoted to Assistant Professor in 1993, Associate Professor in 2000 and Professor in 2005 at Baylor College of Medicine. He has published over 185 SCI papers in peer review journals and 7 scientific books. He has been awarded 26 research grants including 3 NIH R0-1 awards, grants from Michael Fox Foundation, APDA, PDF and NPA. Recently, he received two grant awards from the Helis Foundation to support Parkinson’s disease research. He is a reviewer committee member of NIH, VA, INSERM, Singapore Academy of Science, and the Chinese Nature Science Foundation. He is an editorial board member of six international journals including Autophagy, Neurodegenerative Disease, and is the Academic Editor of Plos One and J Alzheimer’s Disease.

Description of Research

Dr. Le is a neurologist/neuroscientist with research interest in the cellular and molecular basis of neuronal injury in these neurodegenerative diseases. Dr. Le’s research program focuses on defining the molecular mechanisms and pathological pathways of three major neurodegenerative diseases (Parkinson’s disease [PD], Alzheimers’s disease, and ALS). Recently he pioneered a linkage study of transcription factors regulating CNS development and neurodegenerative disorders.

Areas Of Expertise

Neurodegenerative diseases ALS Parkinson’s Disease Alzheimer
Education & Training

Postdoctoral Fellowship, Baylor College of Medicine
MS, Shanghai 2nd Medical University
PhD, Shanghai 2nd Medical University
Publications

Activation of dopamine receptor D1 inhibits glioblastoma tumorigenicity by regulating autophagic activity
Yang, K, Wei, M, Yang, Z, Fu, Z, Xu, R, Cheng, C, Chen, X, Chen, S, Dammer, E & Le, W 2020, , Cellular Oncology, vol. 43, no. 6, pp. 1175-1190. https://doi.org/10.1007/s13402-020-00550-4

Alteration of metabolic profile and potential biomarkers in the plasma of Alzheimer?s disease
Shao, Y, Ouyang, Y, Li, T, Liu, X, Xu, X, Li, S, Xu, G & Le, W 2020, , Aging and Disease, vol. 11, no. 6, pp. 1459-1470. https://doi.org/10.14336/AD.2020.0217

Profiling Non-motor Symptoms in Monogenic Parkinson’s Disease
Liu, X & Le, W 2020, , Frontiers in Aging Neuroscience, vol. 12, 591183. https://doi.org/10.3389/fnagi.2020.591183

Extended Study of NUS1 Gene Variants in Parkinson's Disease
Yuan, L, Chen, X, Song, Z, Le, W, Zheng, W, Liu, X & Deng, H 2020, , Frontiers in Neurology, vol. 11, 583182. https://doi.org/10.3389/fneur.2020.583182

Neurogranin: A Potential Biomarker of Neurological and Mental Diseases
Xiang, Y, Xin, J, Le, W & Yang, Y 2020, , Frontiers in Aging Neuroscience, vol. 12, 584743. https://doi.org/10.3389/fnagi.2020.584743

Nurr1Cd11bcre conditional knockout mice display inflammatory injury to nigrostriatal dopaminergic neurons
Dong, J, Liu, X, Wang, Y, Cai, H & Le, W 2020, , GLIA, vol. 68, no. 10, pp. 2057-2069. https://doi.org/10.1002/glia.23826

Research advances on L-DOPA-induced dyskinesia: from animal models to human disease
Chen, X, Wang, Y, Wu, H, Cheng, C & Le, W 2020, , Neurological Sciences, vol. 41, no. 8, pp. 2055-2065. https://doi.org/10.1007/s10072-020-04333-5

a-Synuclein Negatively Regulates Nurr1 Expression Through NF-?B-Related Mechanism
Jia, C, Qi, H, Cheng, C, Wu, X, Yang, Z, Cai, H, Chen, S & Le, W 2020, , Frontiers in Molecular Neuroscience, vol. 13, 64. https://doi.org/10.3389/fnmol.2020.00064

Whole exome sequencing identified a new compound heterozygous PRKN mutation in a Chinese family with early-onset Parkinson’s disease
Li, T, Kou, D, Cui, Y & Le, W 2020, , Bioscience Reports, vol. 40, no. 5, BSR20200534. https://doi.org/10.1042/BSR20200534

B-Cell Receptor-Associated Protein 31 Negatively Regulates the Expression of Monoamine Oxidase A Via R1
Jia, CC, Li, G, Jiang, R, Liu, X, Yuan, Q, Le, W, Hou, Y & Wang, B 2020, Frontiers in Molecular Biosciences, vol. 7, 64. https://doi.org/10.3389/fmolb.2020.00064

Roles of VMP1 in Autophagy and ER–Membrane Contact: Potential Implications in Neurodegenerative Disorders
Wang, P, Kou, D & Le, W 2020, , Frontiers in Molecular Neuroscience, vol. 13, 42. https://doi.org/10.3389/fnmol.2020.00042

Correction to: Parkinson's disease-related Leucine-rich repeat kinase 2 modulates nuclear morphology and genomic stability in striatal projection neurons during aging
Chen, X, Xie, C, Tian, W, Sun, L, Zheng, W, Hawes, S, Chang, L, Kung, J, Ding, J, Chen, S, Le, W & Cai, H 2020, , Molecular Neurodegeneration, vol. 15, no. 1, 22. https://doi.org/10.1186/s13024-020-00371-x

Rapid eye movement sleep behavior disorder and neurodegenerative diseases: An update
Zhang, F, Niu, L, Liu, X, Liu, Y, Li, S, Yu, H & Le, W 2020, Aging and Disease, vol. 11, no. 2, pp. 315-326. https://doi.org/10.14336/AD.2019.0324

Parkinson's disease-related Leucine-rich repeat kinase 2 modulates nuclear morphology and genomic stability in striatal projection neurons during aging
Chen, X, Xie, C, Tian, W, Sun, L, Wang, Z, Hawes, S, Chang, L, Kung, J, Ding, J, Chen, S, Le, W & Cai, H 2020, , Molecular Neurodegeneration, vol. 15, no. 1, 12. https://doi.org/10.1186/s13024-020-00360-0

Biomarkers for Parkinson’s Disease: How Good Are They?
Li, T & Le, W 2020, , Neuroscience Bulletin, vol. 36, no. 2, pp. 183-194. https://doi.org/10.1007/s12264-019-00433-1

Parkinson's disease in traditional Chinese medicine
Li, S & Le, W 2020, , The Lancet Neurology. https://doi.org/10.1016/S1474-4422(19)30224-8

Therapeutic effects of hirsutella sinensis on the disease onset and progression of amyotrophic lateral sclerosis in SOD1G93A transgenic mouse model
Shang, HY, Zhang, JJ, Fu, ZF, Liu, YF, Li, S, Chen, S & Le, WD 2020, , CNS Neuroscience and Therapeutics, vol. 26, no. 1, pp. 90-100. https://doi.org/10.1111/cns.13182

Preface
Le, W 2020, , Advances in experimental medicine and biology, vol. 1207, pp. vii-viii.

Autophagy and motor neuron diseases
Zhang, X, Yang, K & Le, W 2020, . in Advances in Experimental Medicine and Biology. Advances in Experimental Medicine and Biology, vol. 1207, Springer, pp. 53-74. https://doi.org/10.1007/978-981-15-4272-5_3

Autophagy and alzheimer’s disease
Chen, S, Zhou, Q, Ni, Y & Le, W 2020, . in Advances in Experimental Medicine and Biology. Advances in Experimental Medicine and Biology, vol. 1207, Springer, pp. 3-19. https://doi.org/10.1007/978-981-15-4272-5_1