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Weidong Le, MD, PhD

Full Affiliate Member, Research Institute
Houston Methodist


Biography

Dr. Le received his Bachelor’s degree from Suzhou Medical College in 1978, and his doctoral degree from Shanghai 2nd Medical University in 1988. He did postdoctoral training at Baylor College of Medicine starting in 1989. He was promoted to Assistant Professor in 1993, Associate Professor in 2000 and Professor in 2005 at Baylor College of Medicine. He has published over 185 SCI papers in peer review journals and 7 scientific books. He has been awarded 26 research grants including 3 NIH R0-1 awards, grants from Michael Fox Foundation, APDA, PDF and NPA. Recently, he received two grant awards from the Helis Foundation to support Parkinson’s disease research. He is a reviewer committee member of NIH, VA, INSERM, Singapore Academy of Science, and the Chinese Nature Science Foundation. He is an editorial board member of six international journals including Autophagy, Neurodegenerative Disease, and is the Academic Editor of Plos One and J Alzheimer’s Disease.

Description of Research

Dr. Le is a neurologist/neuroscientist with research interest in the cellular and molecular basis of neuronal injury in these neurodegenerative diseases. Dr. Le’s research program focuses on defining the molecular mechanisms and pathological pathways of three major neurodegenerative diseases (Parkinson’s disease [PD], Alzheimers’s disease, and ALS). Recently he pioneered a linkage study of transcription factors regulating CNS development and neurodegenerative disorders.

Areas Of Expertise

Neurodegenerative diseases ALS Parkinson’s Disease Alzheimer
Education & Training

Postdoctoral Fellowship, Baylor College of Medicine
MS, Shanghai 2nd Medical University
PhD, Shanghai 2nd Medical University
Publications

Piperine attenuates cognitive impairment in an experimental mouse model of sporadic Alzheimer's disease
Wang, C, Cai, Z, Wang, W, Wei, M, Kou, D, Li, T, Yang, Z, Guo, H, Le, W & Li, S 2019, Journal of Nutritional Biochemistry, vol. 70, pp. 147-155. https://doi.org/10.1016/j.jnutbio.2019.05.009

Distinct Connectivity and Functionality of Aldehyde Dehydrogenase 1a1-Positive Nigrostriatal Dopaminergic Neurons in Motor Learning
Wu, J, Kung, J, Dong, J, Chang, L, Xie, C, Habib, A, Hawes, S, Yang, N, Chen, V, Liu, Z, Evans, R, Liang, B, Sun, L, Ding, J, Yu, J, Saez-Atienzar, S, Tang, B, Khaliq, Z, Lin, DT, Le, W & Cai, H 2019, Cell Reports, vol. 28, no. 5, pp. 1167-1181.e7. https://doi.org/10.1016/j.celrep.2019.06.095

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Yang, Z, Sun, L, Kou, D, Li, T, Sun, Z & Le, W 2019, Chinese Journal of Neurology, vol. 52, no. 5, pp. 387-393. https://doi.org/10.3760/cma.j.issn.1006-7876.2019.05.005

ALDH1A1 regulates postsynaptic µ–opioid receptor expression in dorsal striatal projection neurons and mitigates dyskinesia through transsynaptic retinoic acid signaling
Pan, J, Yu, J, Sun, L, Xie, C, Chang, L, Wu, J, Hawes, S, Saez–Atienzar, S, Zheng, W, Kung, J, Ding, J, Le, W, Chen, S & Cai, H 2019, Scientific Reports, vol. 9, no. 1, 3602. https://doi.org/10.1038/s41598-019-40326-x

Altered Expression Levels of MicroRNA-132 and Nurr1 in Peripheral Blood of Parkinson's Disease: Potential Disease Biomarkers
Yang, Z, Li, T, Li, S, Wei, M, Qi, H, Shen, B, Chang, RCC, Le, W & Piao, F 2019, ACS Chemical Neuroscience. https://doi.org/10.1021/acschemneuro.8b00460

Graphene oxide nanocolloids induce autophagy-lysosome dysfunction in mouse embryonic stem cells
Wei, M, Fu, Z, Wang, C, Zheng, W, Li, S & Le, W 2019, Journal of Biomedical Nanotechnology, vol. 15, no. 2, pp. 340-351. https://doi.org/10.1166/jbn.2019.2684

Recent advances and perspectives of metabolomics-based investigations in Parkinson's disease
Shao, Y & Le, W 2019, Molecular neurodegeneration, vol. 14, no. 1, 3. https://doi.org/10.1186/s13024-018-0304-2

Clinical and radiological characteristics of restless legs syndrome following acute lacunar infarction
Tuo, H, Tian, Z, Ma, X, Cui, Y, Xue, Y, Che, J, Xu, C, Chen, K, Zhang, Y, Zhang, L, Bi, H, Le, W & Ondo, WG 2019, Sleep Medicine, vol. 53, pp. 81-87. https://doi.org/10.1016/j.sleep.2018.06.004

Alteration in sleep architecture and electroencephalogram as an early sign of Alzheimer's disease preceding the disease pathology and cognitive decline
Zhang, F, Zhong, R, Li, S, Fu, Z, Wang, R, Wang, T, Huang, Z & Le, W 2019, Alzheimers and Dementia. https://doi.org/10.1016/j.jalz.2018.12.004

Exercise and Parkinson's disease
Xu, X, Fu, Z & Le, W 2019, . in International Review of Neurobiology. International Review of Neurobiology, Academic Press. https://doi.org/10.1016/bs.irn.2019.06.003

Therapeutic effects of hirsutella sinensis on the disease onset and progression of amyotrophic lateral sclerosis in SOD1G93A transgenic mouse model
Shang, HY, Zhang, JJ, Fu, ZF, Liu, YF, Li, S, Chen, S & Le, W 2019, CNS Neuroscience and Therapeutics. https://doi.org/10.1111/cns.13182

Dynamic changes of CX3CL1/CX3CR1 axis during microglial activation and motor neuron loss in the spinal cord of ALS mouse model
Zhang, J, Liu, Y, Liu, X, Li, S, Cheng, C, Chen, S & Le, W 2018, Translational Neurodegeneration, vol. 7, no. 1, 35. https://doi.org/10.1186/s40035-018-0138-4

Fingerprint analysis of Huolingshengji Formula and its neuroprotective effects in SOD1G93A mouse model of amyotrophic lateral sclerosis
Zhou, Q, Wang, Y, Zhang, J, Shao, Y, Li, S, Wang, Y, Cai, H, Feng, Y & Le, W 2018, Scientific Reports, vol. 8, no. 1, 1668. https://doi.org/10.1038/s41598-018-19923-9

Recent advances in microfluidic models for cancer metastasis research
Xu, H, Liu, X & Le, W 2018, TrAC - Trends in Analytical Chemistry, vol. 105, pp. 1-6. https://doi.org/10.1016/j.trac.2018.04.007

Impacts of acute hypoxia on Alzheimer's disease-like pathologies in APPswe/PS1dE9 mice and their wild type littermates
Zhang, F, Zhong, R, Qi, H, Li, S, Cheng, C, Liu, X, Liu, Y & Le, W 2018, Frontiers in Neuroscience, vol. 12, no. MAY, 314. https://doi.org/10.3389/fnins.2018.00314

Potential biomarkers of Parkinson's disease revealed by plasma metabolic profiling
Zhao, H, Wang, C, Zhao, N, Li, W, Yang, Z, Liu, X, Le, W & Zhang, X 2018, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, vol. 1081-1082, pp. 101-108. https://doi.org/10.1016/j.jchromb.2018.01.025

Targeting the MIR-665-3p-ATG4B-Autophagy axis relieves inflammation and apoptosis in intestinal ischemia/reperfusion
Li, Z, Wang, G, Feng, D, Zu, G, Li, Y, Shi, X, Zhao, Y, Jing, H, Ning, S, Le, W, Yao, J & Tian, X 2018, Cell Death and Disease, vol. 9, no. 5, 483. https://doi.org/10.1038/s41419-018-0518-9

Distinct disruptions in Land's cycle remodeling of glycerophosphocholines in murine cortex mark symptomatic onset and progression in two Alzheimer's disease mouse models
Granger, MW, Liu, H, Fowler, CF, Blanchard, AP, Taylor, MW, Sherman, SPM, Xu, H, Le, W & Bennett, SAL 2018, Journal of Neurochemistry. https://doi.org/10.1111/jnc.14560

Pathological Impacts of Chronic Hypoxia on Alzheimer's Disease
Zhang, F, Niu, L, Li, S & Le, W 2018, ACS Chemical Neuroscience. https://doi.org/10.1021/acschemneuro.8b00442

Repurposing carbamazepine for the treatment of amyotrophic lateral sclerosis in SOD1-G93A mouse model
Zhang, JJ, Zhou, QM, Chen, S & Le, W 2018, CNS Neuroscience and Therapeutics. https://doi.org/10.1111/cns.12855

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