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Weidong Le, MD, PhD

Full Affiliate Member, Research Institute
Houston Methodist


Dr. Le received his Bachelor’s degree from Suzhou Medical College in 1978, and his doctoral degree from Shanghai 2nd Medical University in 1988. He did postdoctoral training at Baylor College of Medicine starting in 1989. He was promoted to Assistant Professor in 1993, Associate Professor in 2000 and Professor in 2005 at Baylor College of Medicine. He has published over 185 SCI papers in peer review journals and 7 scientific books. He has been awarded 26 research grants including 3 NIH R0-1 awards, grants from Michael Fox Foundation, APDA, PDF and NPA. Recently, he received two grant awards from the Helis Foundation to support Parkinson’s disease research. He is a reviewer committee member of NIH, VA, INSERM, Singapore Academy of Science, and the Chinese Nature Science Foundation. He is an editorial board member of six international journals including Autophagy, Neurodegenerative Disease, and is the Academic Editor of Plos One and J Alzheimer’s Disease.

Description of Research

Dr. Le is a neurologist/neuroscientist with research interest in the cellular and molecular basis of neuronal injury in these neurodegenerative diseases. Dr. Le’s research program focuses on defining the molecular mechanisms and pathological pathways of three major neurodegenerative diseases (Parkinson’s disease [PD], Alzheimers’s disease, and ALS). Recently he pioneered a linkage study of transcription factors regulating CNS development and neurodegenerative disorders.

Areas Of Expertise

Neurodegenerative diseases ALS Parkinson’s Disease Alzheimer
Education & Training

Postdoctoral Fellowship, Baylor College of Medicine
MS, Shanghai 2nd Medical University
PhD, Shanghai 2nd Medical University

Fingerprint analysis of Huolingshengji Formula and its neuroprotective effects in SOD1G93A mouse model of amyotrophic lateral sclerosis
Zhou, Q, Wang, Y, Zhang, J, Shao, Y, Li, S, Wang, Y, Cai, H, Feng, Y & Le, W 2018, Scientific Reports, vol. 8, no. 1, 1668. DOI: 10.1038/s41598-018-19923-9

Recent advances in microfluidic models for cancer metastasis research
Xu, H, Liu, X & Le, W 2018, TrAC - Trends in Analytical Chemistry, vol. 105, pp. 1-6. DOI: 10.1016/j.trac.2018.04.007

Impacts of acute hypoxia on Alzheimer's disease-like pathologies in APPswe/PS1dE9 mice and their wild type littermates
Zhang, F, Zhong, R, Qi, H, Li, S, Cheng, C, Liu, X, Liu, Y & Le, W 2018, Frontiers in Neuroscience, vol. 12, no. MAY, 314. DOI: 10.3389/fnins.2018.00314

Potential biomarkers of Parkinson's disease revealed by plasma metabolic profiling
Zhao, H, Wang, C, Zhao, N, Li, W, Yang, Z, Liu, X, Le, W & Zhang, X 2018, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, vol. 1081-1082, pp. 101-108. DOI: 10.1016/j.jchromb.2018.01.025

Repurposing carbamazepine for the treatment of amyotrophic lateral sclerosis in SOD1-G93A mouse model
Zhang, JJ, Zhou, QM, Chen, S & Le, WD 2018, CNS Neuroscience and Therapeutics. DOI: 10.1111/cns.12855

Targeting the MIR-665-3p-ATG4B-Autophagy axis relieves inflammation and apoptosis in intestinal ischemia/reperfusion
Li, Z, Wang, G, Feng, D, Zu, G, Li, Y, Shi, X, Zhao, Y, Jing, H, Ning, S, Le, W, Yao, J & Tian, X 2018, Cell Death and Disease, vol. 9, no. 5, 483. DOI: 10.1038/s41419-018-0518-9

An insight review of autophagy biology and neurodegenerative diseases: machinery, mechanisms and regulation
Li, S & Le, W 2017, Science China Life Sciences, pp. 1-3. DOI: 10.1007/s11427-017-9214-7

Nanomaterials modulate stem cell differentiation: biological interaction and underlying mechanisms
Wei, M, Li, S & Le, W 2017, Journal of nanobiotechnology, vol. 15, no. 1. DOI: 10.1186/s12951-017-0310-5

Biomarker Discovery in Parkinson’s Disease: Present Challenges and Future Opportunities
Li, S & Le, W 2017, Neuroscience Bulletin, pp. 1-2. DOI: 10.1007/s12264-017-0184-4

Milestones of Parkinson’s Disease Research: 200 Years of History and Beyond
Li, S & Le, W 2017, Neuroscience Bulletin, pp. 1-5. DOI: 10.1007/s12264-017-0178-2

Can Biomarkers Help the Early Diagnosis of Parkinson’s Disease?
Le, W, Dong, J, Li, S & Korczyn, AD 2017, Neuroscience Bulletin, pp. 1-8. DOI: 10.1007/s12264-017-0174-6

Acute hypoxia induced an imbalanced M1/M2 activation of microglia through NF-?B signaling in Alzheimer's disease mice and wild-type littermates
Zhang, F, Zhong, R, Li, S, Fu, Z, Cheng, C, Cai, H & Le, W 2017, Frontiers in Aging Neuroscience, vol. 9, no. AUG, 282. DOI: 10.3389/fnagi.2017.00282

Activation of DRD5 (dopamine receptor D5) inhibits tumor growth by autophagic cell death
Leng, ZG, Lin, SJ, Wu, ZR, Guo, YH, Cai, L, Shang, HB, Tang, H, Xue, YJ, Lou, MQ, Zhao, W, Le, WD, Zhao, WG, Zhang, X & Wu, ZB 2017, Autophagy, pp. 1-16. DOI: 10.1080/15548627.2017.1328347

Tiny But Mighty: Promising Roles of MicroRNAs in the Diagnosis and Treatment of Parkinson’s Disease
Wang, Y, Yang, Z & Le, W 2017, Neuroscience Bulletin, pp. 1-9. DOI: 10.1007/s12264-017-0160-z

Diagnostic accuracy of tablet-based software for the detection of concussion
Yang, S, Flores, B, Magal, R, Harris, K, Gross, J, Ewbank, A, Davenport, S, Ormachea, P, Nasser, W, Le, W, Peacock, WF, Katz, Y & Eagleman, DM 2017, PLoS ONE, vol. 12, no. 7, e0179352. DOI: 10.1371/journal.pone.0179352

Gold nanoparticles enhance the differentiation of embryonic stem cells into dopaminergic neurons via mTOR/p70S6K pathway
Wei, M, Li, S, Yang, Z, Zheng, W & Le, W 2017, Nanomedicine, vol 12, no. 11, pp. 1305-1317. DOI: 10.2217/nnm-2017-0001

Gold nanoparticles enhance the differentiation of embryonic stem cells into dopaminergic neurons via mTOR/p70S6K pathway
Wei, M, Li, S, Yang, Z, Zheng, W & Le, W 2017, Nanomedicine, vol. 12, no. 11, pp. 1305-1317. DOI: 10.2217/nnm-2017-0001

The missing link between sleep disorders and age-related dementia: recent evidence and plausible mechanisms
Zhang, F, Zhong, R, Li, S, Chang, RCC & Le, W 2017, Journal of Neural Transmission, pp. 1-10. DOI: 10.1007/s00702-017-1696-9

Early pathogenic event of Alzheimer's disease documented in iPSCs from patients with PSEN1 mutations
Yang, J, Zhao, H, Ma, Y, Shi, G, Song, J, Tang, Y, Li, S, Li, T, Liu, N, Tang, F, Gu, J, Zhang, L, Zhang, Z, Zhang, X, Jin, Y & Le, W 2017, Oncotarget, vol. 8, no. 5, pp. 7900-7913. DOI: 10.18632/oncotarget.13776

n-butylidenephthalide treatment prolongs life span and attenuates motor neuron loss in SOD1G93A mouse model of amyotrophic lateral sclerosis
Zhou, QM, Zhang, JJ, Li, S, Chen, S & Le, WD 2017, CNS Neuroscience and Therapeutics. DOI: 10.1111/cns.12681