Not found

Vittorio Cristini, PhD

Director, Mathematics in Medicine Program
Houston Methodist


Mathematics in Medicine Program


Biography

Dr. Cristini is a leading expert and researcher in the fields of mathematical and computational biology, applied and computational mathematics, physical oncology, complex fluids and microfluidics, multidisciplinary (bio)materials science, and systems biology and medicine.

He was included in the 2014 ISI Highly-Cited Researchers in Mathematics, a total of less than one hundred mathematicians worldwide named “most influential scientific minds.” He served as editor for Cancer Research and several biomedical journals including NeuroImage and PloS Computational Biology. He has published two book monographs with Cambridge University Press in 2010 and with CRC Press in 2017, and over 90 peer-reviewed journal articles.

Dr. Cristini was the first recipient of the “Andreas Acrivos Dissertation Award in Fluid Dynamics” by the American Physical Society in 2000. His 2005 paper in the Bulletin of Mathematical Biology was in the top 0.1% of citations in the field of Mathematics and has been designated as a “New Hot Paper in the field of Mathematics” by the Institute for Scientific Information (ISI) Web of Knowledge; two articles have been featured in the Cancer Research Highlights of the American Association for Cancer Research. His research has been highly recognized internationally and by the media and several science museums in the US, and has been supported by the Cullen Trust for Health Care, the National Science Foundation, the National Institutes of Health, the Department of Defense, the States of California, Texas and New Mexico among the others.

For more than 15 years, Dr. Cristini has continually served in PI roles on several NSF, NIH, and DoD grants focused on the development of predictive multi-scale patient-specific computational models of tumor growth and mechanistic mathematical models of tumor response to chemo/immunotherapy, targeted therapy, and nano-therapeutics, most notably as part of multinstitutional grants including two NSF and joint NSF/NIGMS grants (funded in September 2017 and 2013, respectively), two R01s beginning in April and July 2018, two U01 NCI grants on pancreatic and gynecological cancers (funded in August 2015 and July 2017, respectively), two NCI Physical Sciences in Oncology Centers (PS-OC), one NCI Center for Excellence in Cancer Nanotechnology (CCNE), of which he served as the overall PI in 2015-2016, one NCI Integrative Cancer Biology Program (ICBP) center grant, and one NIGMS P50 grant in systems biology.

Dr. Cristini has developed and taught novel courses in Computational and Precision Biomedicine, and has mentored and trained graduate students, postdocs, and junior faculty, including the NIGMS Spatio-Temporal Modeling Center (STMC UNM) and the NIGMS-IRACDA Academic Science Education and Research Training (ASERT) program mentees.

Areas Of Expertise

Mathematical modeling
Publications

Biophysical Modeling of Cancer In Silico
Cristini, V, Lowengrub, J & Wang, Z 2019, .

Establishing the effects of mesoporous silica nanoparticle properties on in vivo disposition using imaging-based pharmacokinetics
Dogra, P, Adolphi, NL, Wang, Z, Lin, YS, Butler, KS, Durfee, PN, Croissant, JG, Noureddine, A, Coker, EN, Bearer, EL, Cristini, V & Brinker, CJ 2018, Nature Communications, vol. 9, no. 1, 4551. https://doi.org/10.1038/s41467-018-06730-z

Understanding Ductal Carcinoma in Situ Invasion using a Multiscale Agent-Based Model*
Joseph Butner, D, Cristini, V & Wang, Z 2018, in 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018. vol. 2018-July, 8513542, Institute of Electrical and Electronics Engineers Inc. pp. 5846-5849, 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018, Honolulu, United States, 7/18/18. https://doi.org/10.1109/EMBC.2018.8513542

Regenerative Medicine to Trump Cancer
Corradetti, B, Dogra, P, Ferrari, M & Cristini, V 2018, Open Access Government.

A visually apparent and quantifiable CT imaging feature identifies biophysical subtypes of pancreatic ductal adenocarcinoma
Koay, EJ, Lee, Y, Cristini, V, Lowengrub, JS, Kang, Y, San Lucas, FA, Hobbs, BP, Ye, R, Elganainy, D, Almahariq, M, Amer, AM, Yu, S, Chatterjee, D, Yan, H, Park, PC, Rios Perez, MV, Li, D, Garg, N, Reiss, K, Chauhan, A, Zaid, MM, Nikzad, N, Wolff, RA, Javle, M, Varadhachary, GR, Shroff, RT, Das, P, Lee, JE, Ferrari, M, Maitra, A, Taniguchi, CM, Kim, MP, Crane, CH, Katz, MHG, Wang, H, Bhosale, P, Tamm, EP & Fleming, JB 2018, Clinical Cancer Research, vol. 24, no. 23, pp. 5883-5894. https://doi.org/10.1158/1078-0432.CCR-17-3668

Understanding the Connection between Nanoparticle Uptake and Cancer Treatment Efficacy using Mathematical Modeling
Brocato, TA, Coker, EN, Durfee, PN, Lin, YS, Townson, J, Wyckoff, EF, Cristini, V, Brinker, CJ & Wang, Z 2018, Scientific Reports, vol. 8, no. 1, 7538, pp. 7538. https://doi.org/10.1038/s41598-018-25878-8

Understanding the Connection between Nanoparticle Uptake and Cancer Treatment Efficacy using Mathematical Modeling
Brocato, TA, Coker, EN, Durfee, PN, Lin, YS, Townson, J, Wyckoff, EF, Cristini, V, Brinker, CJ & Wang, Z 2018, Scientific Reports, vol. 8, no. 1, 7538, pp. 7538. https://doi.org/10.1038/s41598-018-25878-8

Development of a three dimensional, multiscale agent-based model of ductal carcinoma in situ
Butner, JD, Cristini, V & Wang, Z 2017, . in 2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Smarter Technology for a Healthier World, EMBC 2017 - Proceedings., 8036769, Institute of Electrical and Electronics Engineers Inc. pp. 86-89, 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2017, Jeju Island, Korea, Republic of, 7/11/17. https://doi.org/10.1109/EMBC.2017.8036769

Development of a three dimensional, multiscale agent-based model of ductal carcinoma in situ
Butner, JD, Cristini, V & Wang, Z 2017, . in 2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Smarter Technology for a Healthier World, EMBC 2017 - Proceedings., 8036769, Institute of Electrical and Electronics Engineers Inc. pp. 86-89, 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2017, Jeju Island, Korea, Republic of, 7/11/17. https://doi.org/10.1109/EMBC.2017.8036769

An introduction to physical oncology: How mechanistic mathematical modeling can improve cancer therapy outcomes
Cristini, V, Koay, EJ & Wang, Z 2017, . CRC Press. https://doi.org/10.4324/9781315374499

A hybrid agent-based model of the developing mammary terminal end bud
Butner, JD, Chuang, Y-L, Simbawa, E, Al-Fhaid, AS, Mahmoud, SR, Cristini, V & Wang, Z 2016, Journal of Theoretical Biology, vol. 407, pp. 259-70. https://doi.org/10.1016/j.jtbi.2016.07.040

A hybrid agent-based model of the developing mammary terminal end bud
Butner, JD, Chuang, Y-L, Simbawa, E, Al-Fhaid, AS, Mahmoud, SR, Cristini, V & Wang, Z 2016, Journal of Theoretical Biology, vol. 407, pp. 259-70. https://doi.org/10.1016/j.jtbi.2016.07.040

Development of a three dimensional, lattice-free multiscale model of the mammary terminal end bud
Butner, JD, Cristini, V & Zhihui Wang 2016, Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, vol. 2016, pp. 6134-6137. https://doi.org/10.1109/EMBC.2016.7592128

Development of a three dimensional, lattice-free multiscale model of the mammary terminal end bud
Butner, JD, Cristini, V & Zhihui Wang 2016, Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, vol. 2016, pp. 6134-6137. https://doi.org/10.1109/EMBC.2016.7592128

Theory and Experimental Validation of a Spatio-temporal Model of Chemotherapy Transport to Enhance Tumor Cell Kill
Wang, Z, Kerketta, R, Chuang, YL, Dogra, P, Butner, JD, Brocato, TA, Day, A, Xu, R, Shen, H, Simbawa, E, AL-Fhaid, AS, Mahmoud, SR, Curley, SA, Ferrari, M, Koay, EJ & Cristini, V 2016, PLoS Computational Biology, vol. 12, no. 6, e1004969. https://doi.org/10.1371/journal.pcbi.1004969

Theory and Experimental Validation of a Spatio-temporal Model of Chemotherapy Transport to Enhance Tumor Cell Kill
Wang, Z, Kerketta, R, Chuang, YL, Dogra, P, Butner, JD, Brocato, TA, Day, A, Xu, R, Shen, H, Simbawa, E, AL-Fhaid, AS, Mahmoud, SR, Curley, SA, Ferrari, M, Koay, EJ & Cristini, V 2016, PLoS Computational Biology, vol. 12, no. 6, e1004969. https://doi.org/10.1371/journal.pcbi.1004969

A Geometrically-Constrained Mathematical Model of Mammary Gland Ductal Elongation Reveals Novel Cellular Dynamics within the Terminal End Bud
Paine, I, Chauviere, A, Landua, J, Sreekumar, A, Cristini, V, Rosen, J & Lewis, MT 2016, PLoS Computational Biology, vol. 12, no. 4, pp. e1004839. https://doi.org/10.1371/journal.pcbi.1004839

A Geometrically-Constrained Mathematical Model of Mammary Gland Ductal Elongation Reveals Novel Cellular Dynamics within the Terminal End Bud
Paine, I, Chauviere, A, Landua, J, Sreekumar, A, Cristini, V, Rosen, J & Lewis, MT 2016, PLoS Computational Biology, vol. 12, no. 4, pp. e1004839. https://doi.org/10.1371/journal.pcbi.1004839

Integrated nanotechnology platform for tumor-targeted multimodal imaging and therapeutic cargo release
Hosoya, H, Dobroff, AS, Driessen, WHP, Cristini, V, Brinker, LM, Staquicini, FI, Cardó-Vila, M, DAngelo, S, Ferrara, F, Proneth, B, Lin, Y-S, Dunphy, DR, Dogra, P, Melancon, MP, Stafford, RJ, Miyazono, K, Gelovani, JG, Kataoka, K, Brinker, CJ, Sidman, RL, Arap, W & Pasqualini, R 2016, Proceedings of the National Academy of Sciences of the United States of America, vol. 113, no. 7, pp. 1877-82. https://doi.org/10.1073/pnas.1525796113

Integrated nanotechnology platform for tumor-targeted multimodal imaging and therapeutic cargo release
Hosoya, H, Dobroff, AS, Driessen, WHP, Cristini, V, Brinker, LM, Staquicini, FI, Cardó-Vila, M, DAngelo, S, Ferrara, F, Proneth, B, Lin, Y-S, Dunphy, DR, Dogra, P, Melancon, MP, Stafford, RJ, Miyazono, K, Gelovani, JG, Kataoka, K, Brinker, CJ, Sidman, RL, Arap, W & Pasqualini, R 2016, Proceedings of the National Academy of Sciences of the United States of America, vol. 113, no. 7, pp. 1877-82. https://doi.org/10.1073/pnas.1525796113