Todd N. Eagar

Todd N. Eagar, PhD

Associate Professor of Clinical Pathology and Genomic Medicine, Academic Institute
Houston Methodist
Weill Cornell Medical College


HLA Fellowship


Biography

Dr. Eagar received his PhD in immunology and molecular pathogenesis from the Northwestern University Medical School in Chicago in 2001. He then completed an immunology fellowship at the University of California at San Francisco and an HLA fellowship at Houston Methodist Hospital. Dr. Eagar was an assistant professor in the Department of Pathology and Immunology at The University of Texas Southwestern Medical Center in Dallas before joining the Department of Pathology and Genomic Medicine here in 2013.

Description of Research

Dr. Eagar is board certified in histocompatibility by the American Board of Histocompatibility and Immunogenetics. His research interests include identifying immune processes involved in the pathogenesis of multiple sclerosis and transplant rejection, with a focus on finding novel regulatory pathways involved in T cell activation that might be harnessed for therapeutic intervention.

Publications

Effectiveness of combined plasma cell therapy and costimulation blockade based desensitization regimen in heart transplant candidates
Fida, N, Eagar, TN, Yun, AN, Rogers, AW, Nguyen, DT, Graviss, EA, Ishaq, F, DiPaola, NR, Kim, J, Janardhana, G, Kassi, M, Yousefzai, R, Suarez, EE, Bhimaraj, A, Krisl, JC & Guha, A 2024, , Clinical Transplantation, vol. 38, no. 2, e15249, pp. e15249. https://doi.org/10.1111/ctr.15249

Exome Sequencing Implicates DGKZ , ESRRA , and GXYLT1 for Modulating Granuloma Formation in Crohn Disease
Harris, RA, Bush, AH, Eagar, TN, Qian, J, Greenwood, MP, Opekun, AR, Baldassano, R, Guthery, SL, Noe, JD, Otley, A, Rosh, JR, Kugathasan, S & Kellermayer, R 2023, , Journal of pediatric gastroenterology and nutrition, vol. 77, no. 3, pp. 354-357. https://doi.org/10.1097/MPG.0000000000003873

Allogeneic, off-the-shelf, SARS-CoV-2-specific T cells (ALVR109) for the treatment of COVID-19 in high-risk patients
Vasileiou, S, Hill, LQ, Kuvalekar, M, Workineh, AG, Watanabe, A, Velazquez, Y, Lulla, S, Mooney, K, Lapteva, N, Grilley, BJ, Heslop, HE, Rooney, CM, Brenner, MK, Eagar, TN, Carrum, G, Grimes, KA, Leen, AM & Lulla, P 2023, , Haematologica, vol. 108, no. 7, pp. 1840-1850. https://doi.org/10.3324/haematol.2022.281946

COVID-19 infection and vaccination rarely impact HLA antibody profile in waitlisted renal transplant candidates- a multicenter cohort
Roll, GR, Bray, RA, Cooper, M, Eagar, TN, Gebel, HM, Vranic, GM, Hitchman, KMK, Houp, J, Kamoun, M, Killian, J, Kim, J, Kumar, V, Levine, M, Lovasik, BP, Lunow-Luke, T, Parsons, RF, Pattanayak, V, Ranch, D, Shah, A, Stock, PG, Timofeeva, OA, Trofe-Clark, J, Wongjirad, C, Yeh, H, Yi, S & Rajalingam, R 2023, , Human Immunology, vol. 84, no. 4, pp. 278-285. https://doi.org/10.1016/j.humimm.2023.02.005

Deceased donor vein extension grafts for right living donor kidney transplantation
Meinders, AM, Knight, R, Eagar, TN, Hobeika, M, Podder, H, Gaber, AO & Yi, SG 2023, , Clinical Transplantation, vol. 37, no. 8, e14963. https://doi.org/10.1111/ctr.14963

Risk Factors Associated with an Impaired Antibody Response in Kidney Transplant Recipients following 2 Doses of the SARS-CoV-2 mRNA Vaccine
Yi, SG, Moore, LW, Eagar, T, Graviss, EA, Nguyen, DT, Ibrahim, H, Huang, HJ, Hobeika, M, McMillan, R, Saharia, A, Mobley, C, Podder, H, Drews, A, Ghobrial, RM, Gaber, AO & Knight, RJ 2022, , Transplantation Direct, vol. 8, no. 1, e1257, pp. e1257. https://doi.org/10.1097/TXD.0000000000001257, https://doi.org/10.1097/TXD.0000000000001257

Early humoral immune response to two doses of severe acute respiratory syndrome coronavirus 2 vaccine in a diverse group of solid organ transplant candidates and recipients
Huang, HJ, Yi, SG, Mobley, CM, Saharia, A, Bhimaraj, A, Moore, LW, Kloc, M, Adrogue, HE, Graviss, EA, Nguyen, DT, Eagar, TN, Jones, SL, Ankoma-Sey, V, MacGillivray, TE, Knight, RJ, Gaber, AO & Ghobrial, RM 2022, , Clinical Transplantation, vol. 36, no. 5, e14600. https://doi.org/10.1111/ctr.14600, https://doi.org/10.1111/ctr.14600

Early humoral immune response to two doses of severe acute respiratory syndrome coronavirus 2 vaccine in a diverse group of solid organ transplant candidates and recipients
Huang, HJ, Yi, SG, Mobley, CM, Saharia, A, Bhimaraj, A, Moore, LW, Kloc, M, Adrogue, HE, Graviss, EA, Nguyen, DT, Eagar, TN, Jones, SL, Ankoma-Sey, V, MacGillivray, TE, Knight, RJ, Gaber, AO & Ghobrial, RM 2022, , Clinical Transplantation, vol. 36, no. 5, e14600. https://doi.org/10.1111/ctr.14600

Helper T-Cell Subsets and Control of the Inflammatory Response
Eagar, TN & Miller, SD 2022, . in Clinical Immunology: Principles and Practice, Sixth Edition. Elsevier, pp. 151-161. https://doi.org/10.1016/B978-0-7020-8165-1.00011-3

Long-Term Follow-Up of Renal Transplant Recipients Treated With IVIG for De Novo Donor-Specific Antibodies
Knight, RJ, Loucks-Devos, J, Khan, NA, Nguyen, DT, Graviss, EA, Eagar, TN, Patel, SJ & Osama Gaber, A 2021, , Transplantation Proceedings, vol. 53, no. 6, pp. 1865-1871. https://doi.org/10.1016/j.transproceed.2021.05.011

CD11c+CD88+CD317+ myeloid cells are critical mediators of persistent CNS autoimmunity
Manouchehri, N, Hussain, RZ, Cravens, PD, Esaulova, E, Artyomov, MN, Edelson, BT, Wu, GF, Cross, AH, Doelger, R, Loof, N, Eagar, TN, Forsthuber, TG, Calvier, L, Herz, J & Stüve, O 2021, , Proceedings of the National Academy of Sciences of the United States of America, vol. 118, no. 14, e2014492118. https://doi.org/10.1073/pnas.2014492118

Limited window for donation of convalescent plasma with high live-virus neutralizing antibody titers for COVID-19 immunotherapy
Gontu, A, Srinivasan, S, Salazar, E, Nair, MS, Nissly, RH, Greenawalt, D, Bird, IM, Herzog, CM, Ferrari, MJ, Poojary, I, Katani, R, Lindner, SE, Minns, AM, Rossi, R, Christensen, PA, Castillo, B, Chen, J, Eagar, TN, Yi, X, Zhao, P, Leveque, C, Olsen, RJ, Bernard, DW, Gollihar, J, Kuchipudi, SV, Musser, JM & Kapur, V 2021, , Communications Biology, vol. 4, no. 1, 267. https://doi.org/10.1038/s42003-021-01813-y

Significantly Decreased Mortality in a Large Cohort of Coronavirus Disease 2019 (COVID-19) Patients Transfused Early with Convalescent Plasma Containing High-Titer Anti–Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike Protein IgG
Salazar, E, Christensen, PA, Graviss, EA, Nguyen, DT, Castillo, B, Chen, J, Lopez, BV, Eagar, TN, Yi, X, Zhao, P, Rogers, J, Shehabeldin, A, Joseph, D, Masud, F, Leveque, C, Olsen, RJ, Bernard, DW, Gollihar, J & Musser, JM 2021, , American Journal of Pathology, vol. 191, no. 1, pp. 90-107. https://doi.org/10.1016/j.ajpath.2020.10.008

Persistent Immunogenicity of the mRNA COVID-19 Vaccine in Patients Vaccinated Before Kidney Transplant
Yi, SG, Eagar, T, Moore, L, Huang, HJ, Ibrahim, H, Hobeika, MJ, McMillan, R, Podder, H, Ghobrial, RM, Gaber, AO & Knight, RJ 2021, , Transplantation, vol. 105, no. 10, pp. E133-E134. https://doi.org/10.1097/TP.0000000000003872

Convalescent plasma anti–SARS-CoV-2 spike protein ectodomain and receptor-binding domain IgG correlate with virus neutralization
Salazar, E, Kuchipudi, SV, Christensen, PA, Eagar, T, Yi, X, Zhao, P, Jin, Z, Long, SW, Olsen, RJ, Chen, J, Castillo, B, Leveque, C, Towers, D, Lavinder, J, Gollihar, J, Cardona, J, Ippolito, G, Nissly, R, Bird, I, Greenawalt, D, Rossi, RM, Gontu, A, Srinivasan, S, Poojary, I, Cattadori, IM, Hudson, PJ, Josleyn, NM, Prugar, L, Huie, K, Herbert, A, Bernard, DW, Dye, JM, Kapur, V & Musser, JM 2020, , Journal of Clinical Investigation, vol. 130, no. 12, pp. 6728-6738. https://doi.org/10.1172/JCI141206

Significantly Decreased Mortality in a Large Cohort of Coronavirus Disease 2019 (COVID-19) Patients Transfused Early with Convalescent Plasma Containing High-Titer Anti–Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike Protein IgG
Salazar, E, Christensen, PA, Graviss, EA, Nguyen, DT, Castillo, B, Chen, J, Lopez, BV, Eagar, TN, Yi, X, Zhao, P, Rogers, J, Shehabeldin, A, Joseph, D, Masud, F, Leveque, C, Olsen, RJ, Bernard, DW, Gollihar, J & Musser, JM 2021, , American Journal of Pathology, vol. 191, no. 1, pp. 90-107. https://doi.org/10.1016/j.ajpath.2020.10.008, https://doi.org/10.1016/j.ajpath.2020.10.008

Treatment of Coronavirus Disease 2019 Patients with Convalescent Plasma Reveals a Signal of Significantly Decreased Mortality
Salazar, E, Christensen, PA, Graviss, EA, Nguyen, DT, Castillo, B, Chen, J, Lopez, BV, Eagar, TN, Yi, X, Zhao, P, Rogers, J, Shehabeldin, A, Joseph, D, Leveque, C, Olsen, RJ, Bernard, DW, Gollihar, J & Musser, JM 2020, , American Journal of Pathology, vol. 190, no. 11, pp. 2290-2303. https://doi.org/10.1016/j.ajpath.2020.08.001

Early transfusion of a large cohort of COVID-19 patients with high titer anti-SARS-CoV-2 spike protein IgG convalescent plasma confirms a signal of significantly decreased mortality
Salazar, E, Christensen, PA, Graviss, EA, Nguyen, DT, Castillo, B, Chen, J, Lopez, BV, Eagar, TN, Yi, X, Zhao, P, Rogers, J, Shehabeldin, A, Joseph, D, Masud, FN, Leveque, C, Olsen, RJ, Bernard, DW, Gollihar, JD & Musser, JM 2020, , Unknown Journal. https://doi.org/10.1101/2020.10.02.20206029

Convalescent plasma anti-SARS-CoV-2 spike protein ectodomain and receptor binding domain IgG correlate with virus neutralization
Salazar, E, Kuchipudi, SV, Christensen, PA, Eagar, T, Yi, X, Zhao, P, Jin, Z, Long, SW, Olsen, RJ, Chen, J, Castillo, B, Leveque, C, Towers, D, Lavinder, JJ, Gollihar, J, Cardona, JA, Ippolito, GC, Nissly, RH, Bird, I, Greenawalt, D, Rossi, RM, Gontu, A, Srinivasan, S, Poojary, I, Cattadori, IM, Hudson, P, Josleyn, NM, Prugar, L, Huie, KE, Herbert, AS, Bernard, DW, Dye, JM, Kapur, V & Musser, JM 2020, , The Journal of clinical investigation, vol. 130, no. 12, pp. 6728-6738. https://doi.org/10.1172/JCI141206

Treatment of Coronavirus Disease 2019 (COVID-19) Patients with Convalescent Plasma
Salazar, E, Perez, KK, Ashraf, M, Chen, J, Castillo, B, Christensen, PA, Eubank, T, Bernard, DW, Eagar, TN, Long, SW, Subedi, S, Olsen, RJ, Leveque, C, Schwartz, MR, Dey, M, Chavez-East, C, Rogers, J, Shehabeldin, A, Joseph, D, Williams, G, Thomas, K, Masud, F, Talley, C, Dlouhy, KG, Lopez, BV, Hampton, C, Lavinder, J, Gollihar, JD, Maranhao, AC, Ippolito, GC, Saavedra, MO, Cantu, CC, Yerramilli, P, Pruitt, L & Musser, JM 2020, , American Journal of Pathology, vol. 190, no. 8, pp. 1680-1690. https://doi.org/10.1016/j.ajpath.2020.05.014

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