Todd N. Eagar

Todd N. Eagar, PhD

Assistant Professor of Pathology and Genomic Medicine, Academic Institute
Assistant Member, Research Institute
Houston Methodist
Weill Cornell Medical College


HLA Fellowship


Biography

Dr. Eagar received his PhD in immunology and molecular pathogenesis from the Northwestern University Medical School in Chicago in 2001. He then completed an immunology fellowship at the University of California at San Francisco and an HLA fellowship at Houston Methodist Hospital. Dr. Eagar was an assistant professor in the Department of Pathology and Immunology at The University of Texas Southwestern Medical Center in Dallas before joining the Department of Pathology and Genomic Medicine here in 2013.

Description of Research

Dr. Eagar is board certified in histocompatibility by the American Board of Histocompatibility and Immunogenetics. His research interests include identifying immune processes involved in the pathogenesis of multiple sclerosis and transplant rejection, with a focus on finding novel regulatory pathways involved in T cell activation that might be harnessed for therapeutic intervention.

Publications

CD11c+CD88+CD317+ myeloid cells are critical mediators of persistent CNS autoimmunity
Manouchehri, N, Hussain, RZ, Cravens, PD, Esaulova, E, Artyomov, MN, Edelson, BT, Wu, GF, Cross, AH, Doelger, R, Loof, N, Eagar, TN, Forsthuber, TG, Calvier, L, Herz, J & Stüve, O 2021, , Proceedings of the National Academy of Sciences of the United States of America, vol. 118, no. 14, e2014492118. https://doi.org/10.1073/pnas.2014492118

Limited window for donation of convalescent plasma with high live-virus neutralizing antibody titers for COVID-19 immunotherapy
Gontu, A, Srinivasan, S, Salazar, E, Nair, MS, Nissly, RH, Greenawalt, D, Bird, IM, Herzog, CM, Ferrari, MJ, Poojary, I, Katani, R, Lindner, SE, Minns, AM, Rossi, R, Christensen, PA, Castillo, B, Chen, J, Eagar, TN, Yi, X, Zhao, P, Leveque, C, Olsen, RJ, Bernard, DW, Gollihar, J, Kuchipudi, SV, Musser, JM & Kapur, V 2021, , Communications Biology, vol. 4, no. 1, 267. https://doi.org/10.1038/s42003-021-01813-y

Significantly Decreased Mortality in a Large Cohort of Coronavirus Disease 2019 (COVID-19) Patients Transfused Early with Convalescent Plasma Containing High-Titer Anti–Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike Protein IgG
Salazar, E, Christensen, PA, Graviss, EA, Nguyen, DT, Castillo, B, Chen, J, Lopez, BV, Eagar, TN, Yi, X, Zhao, P, Rogers, J, Shehabeldin, A, Joseph, D, Masud, F, Leveque, C, Olsen, RJ, Bernard, DW, Gollihar, J & Musser, JM 2021, , American Journal of Pathology, vol. 191, no. 1, pp. 90-107. https://doi.org/10.1016/j.ajpath.2020.10.008

Convalescent plasma anti–SARS-CoV-2 spike protein ectodomain and receptor-binding domain IgG correlate with virus neutralization
Salazar, E, Kuchipudi, SV, Christensen, PA, Eagar, T, Yi, X, Zhao, P, Jin, Z, Long, SW, Olsen, RJ, Chen, J, Castillo, B, Leveque, C, Towers, D, Lavinder, J, Gollihar, J, Cardona, J, Ippolito, G, Nissly, R, Bird, I, Greenawalt, D, Rossi, RM, Gontu, A, Srinivasan, S, Poojary, I, Cattadori, IM, Hudson, PJ, Josleyn, NM, Prugar, L, Huie, K, Herbert, A, Bernard, DW, Dye, JM, Kapur, V & Musser, JM 2020, , Journal of Clinical Investigation, vol. 130, no. 12, pp. 6728-6738. https://doi.org/10.1172/JCI141206

Significantly Decreased Mortality in a Large Cohort of Coronavirus Disease 2019 (COVID-19) Patients Transfused Early with Convalescent Plasma Containing High-Titer Anti–Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike Protein IgG
Salazar, E, Christensen, PA, Graviss, EA, Nguyen, DT, Castillo, B, Chen, J, Lopez, BV, Eagar, TN, Yi, X, Zhao, P, Rogers, J, Shehabeldin, A, Joseph, D, Masud, F, Leveque, C, Olsen, RJ, Bernard, DW, Gollihar, J & Musser, JM 2021, , American Journal of Pathology, vol. 191, no. 1, pp. 90-107. https://doi.org/10.1016/j.ajpath.2020.10.008, https://doi.org/10.1016/j.ajpath.2020.10.008

Treatment of Coronavirus Disease 2019 Patients with Convalescent Plasma Reveals a Signal of Significantly Decreased Mortality
Salazar, E, Christensen, PA, Graviss, EA, Nguyen, DT, Castillo, B, Chen, J, Lopez, BV, Eagar, TN, Yi, X, Zhao, P, Rogers, J, Shehabeldin, A, Joseph, D, Leveque, C, Olsen, RJ, Bernard, DW, Gollihar, J & Musser, JM 2020, , American Journal of Pathology, vol. 190, no. 11, pp. 2290-2303. https://doi.org/10.1016/j.ajpath.2020.08.001

Early transfusion of a large cohort of COVID-19 patients with high titer anti-SARS-CoV-2 spike protein IgG convalescent plasma confirms a signal of significantly decreased mortality
Salazar, E, Christensen, PA, Graviss, EA, Nguyen, DT, Castillo, B, Chen, J, Lopez, BV, Eagar, TN, Yi, X, Zhao, P, Rogers, J, Shehabeldin, A, Joseph, D, Masud, FN, Leveque, C, Olsen, RJ, Bernard, DW, Gollihar, JD & Musser, JM 2020, , Unknown Journal. https://doi.org/10.1101/2020.10.02.20206029

Convalescent plasma anti-SARS-CoV-2 spike protein ectodomain and receptor binding domain IgG correlate with virus neutralization
Salazar, E, Kuchipudi, SV, Christensen, PA, Eagar, T, Yi, X, Zhao, P, Jin, Z, Long, SW, Olsen, RJ, Chen, J, Castillo, B, Leveque, C, Towers, D, Lavinder, JJ, Gollihar, J, Cardona, JA, Ippolito, GC, Nissly, RH, Bird, I, Greenawalt, D, Rossi, RM, Gontu, A, Srinivasan, S, Poojary, I, Cattadori, IM, Hudson, P, Josleyn, NM, Prugar, L, Huie, KE, Herbert, AS, Bernard, DW, Dye, JM, Kapur, V & Musser, JM 2020, , The Journal of clinical investigation, vol. 130, no. 12, pp. 6728-6738. https://doi.org/10.1172/JCI141206

Treatment of Coronavirus Disease 2019 (COVID-19) Patients with Convalescent Plasma
Salazar, E, Perez, KK, Ashraf, M, Chen, J, Castillo, B, Christensen, PA, Eubank, T, Bernard, DW, Eagar, TN, Long, SW, Subedi, S, Olsen, RJ, Leveque, C, Schwartz, MR, Dey, M, Chavez-East, C, Rogers, J, Shehabeldin, A, Joseph, D, Williams, G, Thomas, K, Masud, F, Talley, C, Dlouhy, KG, Lopez, BV, Hampton, C, Lavinder, J, Gollihar, JD, Maranhao, AC, Ippolito, GC, Saavedra, MO, Cantu, CC, Yerramilli, P, Pruitt, L & Musser, JM 2020, , American Journal of Pathology, vol. 190, no. 8, pp. 1680-1690. https://doi.org/10.1016/j.ajpath.2020.05.014

Limitations of cell-lineage-specific non-dynamic gene recombination in CD11c.Cre+ITGA4fl/fl mice
Manouchehri, N, Hussain, RZ, Cravens, PD, Doelger, R, Greenberg, BM, Okuda, DT, Forsthuber, TG, Eagar, TN & Stüve, O 2020, , Journal of Neuroimmunology, vol. 344, 577245. https://doi.org/10.1016/j.jneuroim.2020.577245

a4-integrin deficiency in B cells does not affect disease in a T-cell-mediated EAE disease model
Hussain, RZ, Cravens, PD, Miller-Little, WA, Doelger, R, Granados, V, Herndon, E, Okuda, DT, Eagar, TN & Stüve, O 2019, , Neurology: Neuroimmunology and NeuroInflammation, vol. 6, no. 4, e563. https://doi.org/10.1212/NXI.0000000000000563

Presenilin1 regulates Th1 and Th17 effector responses but is not required for experimental autoimmune encephalomyelitis
Cummings, M, Arumanayagam, ACS, Zhao, P, Kannanganat, S, Stuve, O, Karandikar, NJ & Eagar, TN 2018, , PLoS ONE, vol. 13, no. 8, e0200752. https://doi.org/10.1371/journal.pone.0200752

Early clearance vs persistence of de novo donor-specific antibodies following lung transplantation
Islam, AK, Sinha, N, DeVos, JM, Kaleekal, TS, Jyothula, SS, Teeter, LD, Nguyen, DTM, Eagar, TN, Moore, LW, Puppala, M, Wong, STC, Knight, RJ, Frost, AE, Graviss, EA & Osama Gaber, A 2017, , Clinical Transplantation. https://doi.org/10.1111/ctr.13028

The detrimental impact of persistent vs an isolated occurrence of de novo donor-specific antibodies on intermediate-term renal transplant outcomes
Loucks-DeVos, JM, Eagar, TN, Gaber, AO, Patel, SJ, Teeter, LD, Graviss, EA & Knight, RJ 2017, , Clinical Transplantation, vol. 31, no. 8, e13025. https://doi.org/10.1111/ctr.13025

Population genomic analysis of 1,777 extended-spectrum beta-lactamase-producing Klebsiella pneumoniae isolates, Houston, Texas: Unexpected abundance of clonal group 307
Long, SW, Olsen, RJ, Eagar, TN, Beres, SB, Zhao, P, Davis, JJ, Brettin, T, Xia, F & Musser, JM 2017, , mBio, vol. 8, no. 3, e00489-17. https://doi.org/10.1128/mBio.00489-17

A single amino acid substitution prevents recognition of a dominant human aquaporin-4 determinant in the context of HLA-DRB1-03:01 by a murine TCR
Arellano, B, Hussain, R, Miller-Little, WA, Herndon, E, Lambracht-Washington, D, Eagar, TN, Lewis, R, Healey, D, Vernino, S, Greenberg, BM & Stüve, O 2016, , PLoS ONE, vol. 11, no. 4, e0152720. https://doi.org/10.1371/journal.pone.0152720

T cell subsets and their signature cytokines in autoimmune and inflammatory diseases
Raphael, I, Nalawade, S, Eagar, TN & Forsthuber, TG 2015, , Cytokine, vol. 74, no. 1, pp. 5-17. https://doi.org/10.1016/j.cyto.2014.09.011

Immune surveillance of the central nervous system in multiple sclerosis - Relevance for therapy and experimental models
Hussain, RZ, Hayardeny, L, Cravens, PC, Yarovinsky, F, Eagar, TN, Arellano, B, Deason, K, Castro-Rojas, C & Stüve, O 2014, , Journal of Neuroimmunology, vol. 276, no. 1-2, pp. 9-17. https://doi.org/10.1016/j.jneuroim.2014.08.622

Testing effects of glatiramer acetate and fingolimod in an infectious model of CNS immune surveillance
Castro-Rojas, C, Deason, K, Hussain, RZ, Hayardeny, L, Cravens, PC, Yarovinsky, F, Eagar, TN, Arellano, B & Stüve, O 2014, , Journal of Neuroimmunology, vol. 276, no. 1-2, pp. 232-235. https://doi.org/10.1016/j.jneuroim.2014.08.624

A peptide prime-DNA boost immunization protocol provides significant benefits as a new generation Aß42 DNA vaccine for Alzheimer disease
Lambracht-Washington, D, Qu, BX, Fu, M, Anderson, LD, Eagar, TN, Stüve, O & Rosenberg, RN 2013, , Journal of Neuroimmunology, vol. 254, no. 1-2, pp. 63-68. https://doi.org/10.1016/j.jneuroim.2012.09.008