Timothy B. Boone, MD, PhD

Chair, Department of Urology
Professor of Urology, Academic Institute
Chief Education Officer, Academic Institute
Full Member, Research Institute
Director, Regenerative Medicine Program
Craig C. Brown and Suzanne H. Smith Centennial Chair in Medical Education, Houston Methodist
Weill Cornell Medical College


Dr. Timothy B. Boone is the Chair of the Urology Department, Director of Education for the Houston Methodist Academic Institute, and a member of the Neurological Institute at Houston Methodist Hospital. He is Professor of Urology at Weill Cornell Medical College and holds appointments as Professor of Urology at Texas A&M College of Medicine and Baylor College of Medicine where he is a Clinical Professor of Urology. In 2014, Dr. Boone was appointed Associate Dean, Texas A&M University College of Medicine at the Houston campus.

Dr. Boone earned his Master of Science in physiology and Ph.D. in neuroscience at the University of Texas Graduate School of Biomedical Sciences at Houston. He completed his M.D./Ph.D. at the University of Texas Medical School at Houston and urology residency training at the University of Texas Southwestern Medical School in Dallas. In 1991 he joined the faculty in the Department of Urology at UT Southwestern for two years and then moved to Baylor College of Medicine where he joined the Scott Department of Urology. In 2000 Dr. Boone was named Professor and Chair of the Scott Department of Urology where he served until 2008. For over 20 years he actively participated in the care of spinal cord injured veterans with neurogenic bladder dysfunction at the VA Spinal Cord Injury Unit in Dallas and in Houston.

Boone specializes in the treatment of patients with incontinence following prostatectomy, women with complex voiding disorders, and bladder problems related to neurologic disease including spinal cord injury, stroke, multiple sclerosis, and Parkinson's disease. He maintains active participation in research, focusing on mechanisms of sensory control and dysfunction in the bladder and urethra that are related to spinal cord injury, diabetes or obstruction. Dr. Boone is the primary investigator for the Neuroregeneration and Bladder Sensory Science Laboratory at the Houston Methodist Research Institute.

Throughout his career Dr. Boone has written over 200 publications and given hundreds of lectures regionally and nationally while serving as a visiting professor for many departments of urology. He is a member of the American Association of Genitourinary Surgeons, Clinical Society of GU Surgeons, American Urological Association, Texas Urological Society, Society for Neuroscience, Society for Urodynamics, Female Pelvic Medicine and Urogenital Reconstruction, and the AOA Honor Medical Society. He serves as consultant reviewer for several scientific journals including Neurourology and Urodynamics, Journal of Urology, British Journal of Urology, Urology, Spinal Cord, and the New England Journal of Medicine. He is on the editorial board of Nature Reviews in Urology. Dr. Boone was elected as a Trustee to the American Board of Urology in 2006 and served as President of the American Board of Urology from 2011 - 2012.

Description of Research

Incontinence, Neurourology, Neurogenic Bladder, Urinary Diversion and Urinary Reconstruction

Areas Of Expertise

Incontinence Neurourology Neurogenic Bladder Regenerative Medicine Urinary Diversion and Urinary Reconstruction
Education & Training

Residency, UT Southwestern Medical Center
PhD, University of Texas Graduate School of Biomedical Science - Houston
Internship, University of Texas Health Science Center at Houston
MD, University of Texas Health Science Center at Houston

High spatial correlation in brain connectivity between micturition and resting states within bladder-related networks using 7 T MRI in multiple sclerosis women with voiding dysfunction
Shi, Z, Tran, K, Karmonik, C, Boone, T & Khavari, R 2021, , World Journal of Urology. https://doi.org/10.1007/s00345-021-03599-4

Voiding dysfunction in old male rats associated with enlarged prostate and irregular afferent-triggered reflex responses
Zhang, C, Li, X, Boone, TB, Cruz, Y, Zhang, Y & Munoz, A 2020, , International Neurourology Journal, vol. 24, no. 3, pp. 258-269. https://doi.org/10.5213/inj.2040114.057

Refractory bladder dysfunction: A multi-institutional experience with intravesical botulinum toxin-a injection in adult patients who underwent previous augmentation cystoplasty
Martinez, L, Tubre, R, Roberts, R, Boone, TB, Griebling, TL, Padmanabhan, P & Khavari, R 2020, , Turkish Journal of Urology, vol. 46, no. 4, pp. 309-313. https://doi.org/10.5152/tud.2020.19259

Are White Matter Tract Integrities Different in Multiple Sclerosis Women With Voiding Dysfunction?
Tran, K, Karmonik, C, Boone, TB & Khavari, R 2020, , Female pelvic medicine & reconstructive surgery. https://doi.org/10.1097/SPV.0000000000000830

Brain activation patterns of female multiple sclerosis patients with voiding dysfunction
Khavari, R, Chen, J, Boone, TB & Karmonik, C 2020, , Neurourology and Urodynamics, vol. 39, no. 3, pp. 969-977. https://doi.org/10.1002/nau.24304

The Patient Beyond the Sphincter–Cognitive and Functional Considerations Affecting the Natural History of Artificial Urinary Sphincters
Lavi, A, Boone, TB, Cohen, M & Gross, M 2020, , Urology, vol. 137, pp. 14-18. https://doi.org/10.1016/j.urology.2019.11.031

Low Interrater Reliability of Videourodynamic Diagnosis of Detrusor External Sphincter Dyssynergia
Miller, BD, Tallman, CT, Boone, TB & Khavari, R 2019, Female pelvic medicine & reconstructive surgery. https://doi.org/10.1097/SPV.0000000000000754

Surveillance urodynamics for neurogenic lower urinary tract dysfunction: A systematic review
Kavanagh, A, Akhavizadegan, H, Walter, M, Stothers, L, Welk, B & Boone, TB 2019, , Canadian Urological Association Journal, vol. 13, no. 4, pp. 133-141. https://doi.org/10.5489/cuaj.5563

Functional Brain Imaging in Voiding Dysfunction
Khavari, R & Boone, TB 2019, , Current Bladder Dysfunction Reports, vol. 14, no. 1, pp. 24-30. https://doi.org/10.1007/s11884-019-00503-0

Outcomes of Intradetrusor OnabotulinumtoxinA Injection in Adults with Congenital Spinal Dysraphism at a Tertiary Transitional Urology Clinic
Kaviani, A, Pande, R, Boone, TB & Khavari, R 2019, , Urology Practice, vol. 6, no. 2, pp. 112-116. https://doi.org/10.1016/j.urpr.2018.06.002

Data-driven machine-learning quantifies differences in the voiding initiation network in neurogenic voiding dysfunction in women with multiple sclerosis
Karmonik, C, Boone, T & Khavari, R 2019, , International Neurourology Journal, vol. 23, no. 3, pp. 195-204. https://doi.org/10.5213/inj.1938058.029

Similarity of functional connectivity patterns in patients with multiple sclerosis who void spontaneously versus patients with voiding dysfunction
Khavari, R, Elias, SN, Boone, T & Karmonik, C 2018, Neurourology and Urodynamics. DOI: 10.1002/nau.23837

A cross-sectional study of sexual function and fertility status in adults with congenital genitourinary abnormalities in a US tertiary care centre
Mccloskey, H, Kaviani, A, Pande, R, Boone, T & Khavari, R 2018, , Journal of the Canadian Urological Association. https://doi.org/10.5489/cuaj.5374

Trainee responses to hurricane harvey: Correlating volunteerism with burnout
Yeo, CJJ, Román, GC, Kusnerik, D, Burt, T, Mersinger, D, Thomas, S, Boone, T & Powell, SZ 2018, , Frontiers in Public Health, vol. 6, no. AUG, 224. https://doi.org/10.3389/fpubh.2018.00224

Higher Neural Correlates in Patients with Multiple Sclerosis and Neurogenic Overactive Bladder Following Treatment with Intradetrusor Injection of OnabotulinumtoxinA
Khavari, R, Elias, SN, Pande, R, Wu, KM, Boone, TB & Karmonik, C 2019, , The Journal of urology, vol. 201, no. 1, pp. 135-140. https://doi.org/10.1016/j.juro.2018.07.066

Synergistic activities of abdominal muscles are required for efficient micturition in anesthetized female mice
Zhang, C, Zhang, Y, Cruz, Y, Boone, TB & Munoz, A 2018, , International Neurourology Journal, vol. 22, no. 1, pp. 9-19. https://doi.org/10.5213/inj.1835052.526

Similarity of functional connectivity patterns in patients with multiple sclerosis who void spontaneously versus patients with voiding dysfunction
Khavari, R, Elias, SN, Boone, T & Karmonik, C 2018, , Neurourology and Urodynamics, vol. 38, no. 1, pp. 239-247. https://doi.org/10.1002/nau.23837

Modern Theories of Pelvic Floor Support: A Topical Review of Modern Studies on Structural and Functional Pelvic Floor Support from Medical Imaging, Computational Modeling, and Electromyographic Perspectives
Peng, Y, Miller, BD, Boone, TB & Zhang, Y 2018, , Current Urology Reports, vol. 19, no. 1, 9. https://doi.org/10.1007/s11934-018-0752-9

Comparison of Adjuvant Radiation Therapy Before or After Artificial Urinary Sphincter Placement: A Multi-Institutional, Retrospective Analysis
DeLay, KJ, Haney, NM, Chiang, J, Stewart, C, Yafi, FA, Angermeier, K, Wood, H, Boone, T, Kavanagh, AG, Gretzer, M, Boyd, S, Loh-Doyle, JC & Hellstrom, WJG 2018, , Urology, vol. 113, pp. 160-165. https://doi.org/10.1016/j.urology.2017.11.041

Modulatory effects of intravesical P2X2/3 purinergic receptor inhibition on lower urinary tract electromyographic properties and voiding function of female rats with moderate or severe spinal cord injury
Salazar, BH, Hoffman, KA, Zhang, C, Zhang, Y, Cruz, Y, Boone, TB & Munoz, A 2019, , BJU International, vol. 123, no. 3, pp. 538-547. https://doi.org/10.1111/bju.14561