Thomas Segall-Shapiro, PhD

Assistant Research Professor of Pathology and Genomic Medicine, Academic Institute
Assistant Research Member, Research Institute
Houston Methodist


SARS-COV-2 Omicron variants conformationally escape a rare quaternary antibody binding mode
Goike, J, Hsieh, CL, Horton, AP, Gardner, EC, Zhou, L, Bartzoka, F, Wang, N, Javanmardi, K, Hebert, A, Abbasi, SA, Xie, X, Xia, H, Shi, PY, Renberg, R, Segall-Shapiro, T, Terrace, CI, Wu, W, Shroff, R, Byrom, M, Ellington, AD, Marcotte, EM, Musser, JM, Kuchipudi, SV, Kapur, V, Georgiou, G, Weaver, S, Dye, JM, Boutz, DR, McLellan, JS & Gollihar, JD 2023, , Communications Biology, vol. 6, 1250, pp. 1250. https://doi.org/10.1038/s42003-023-05649-6

Author Correction: Engineered promoters enable constant gene expression at any copy number in bacteria
Segall-Shapiro, TH, Sontag, ED & Voigt, CA 2022, , Nature Biotechnology, vol. 40, no. 5, pp. 799. https://doi.org/10.1038/s41587-022-01300-7

Antibody escape and cryptic cross-domain stabilization in the SARS-CoV-2 Omicron spike protein
Javanmardi, K, Segall-Shapiro, TH, Chou, CW, Boutz, DR, Olsen, RJ, Xie, X, Xia, H, Shi, PY, Johnson, CD, Annapareddy, A, Weaver, S, Musser, JM, Ellington, AD, Finkelstein, IJ & Gollihar, JD 2022, , Cell Host and Microbe, vol. 30, no. 9, pp. 1242-1254.e6. https://doi.org/10.1016/j.chom.2022.07.016

Selection for constrained peptides that bind to a single target protein
King, AM, Anderson, DA, Glassey, E, Segall-Shapiro, TH, Zhang, Z, Niquille, DL, Embree, AC, Pratt, K, Williams, TL, Gordon, DB & Voigt, CA 2021, , Nature Communications, vol. 12, no. 1, 6343. https://doi.org/10.1038/s41467-021-26350-4

Escherichia coli “Marionette” strains with 12 highly optimized small-molecule sensors
Meyer, AJ, Segall-Shapiro, TH, Glassey, E, Zhang, J & Voigt, CA 2019, , Nature Chemical Biology, vol. 15, no. 2, pp. 196-204. https://doi.org/10.1038/s41589-018-0168-3

Engineered promoters enable constant gene expression at any copy number in bacteria
Segall-Shapiro, TH, Sontag, ED & Voigt, CA 2018, , Nature Biotechnology, vol. 36, no. 4, pp. 352-358. https://doi.org/10.1038/nbt.4111

The Structure of a Thermophilic Kinase Shapes Fitness upon Random Circular Permutation
Jones, AM, Mehta, MM, Thomas, EE, Atkinson, JT, Segall-Shapiro, TH, Liu, S & Silberg, JJ 2016, , ACS Synthetic Biology, vol. 5, no. 5, pp. 415-425. https://doi.org/10.1021/acssynbio.5b00305

TREC-IN: Gene knock-in genetic tool for genomes cloned in yeast
Chandran, S, Noskov, VN, Segall-Shapiro, TH, Ma, L, Whiteis, C, Lartigue, C, Jores, J, Vashee, S & Chuang, RY 2014, , BMC genomics, vol. 15, no. 1, 1180. https://doi.org/10.1186/1471-2164-15-1180

A 'resource allocator' for transcription based on a highly fragmented T7 RNA polymerase
Segall-Shapiro, TH, Meyer, AJ, Ellington, AD, Sontag, ED & Voigt, CA 2014, , Molecular Systems Biology, vol. 10, no. 7, 742. https://doi.org/10.15252/msb.20145299

Advances in genetic circuit design: Novel biochemistries, deep part mining, and precision gene expression
Nielsen, AAK, Segall-Shapiro, TH & Voigt, CA 2013, , Current Opinion in Chemical Biology, vol. 17, no. 6, pp. 878-892. https://doi.org/10.1016/j.cbpa.2013.10.003

Design of orthogonal genetic switches based on a crosstalk map of ss, anti-ss, and promoters
Rhodius, VA, Segall-Shapiro, TH, Sharon, BD, Ghodasara, A, Orlova, E, Tabakh, H, Burkhardt, DH, Clancy, K, Peterson, TC, Gross, CA & Voigt, CA 2013, , Molecular Systems Biology, vol. 9, 702. https://doi.org/10.1038/msb.2013.58

A genetically encoded and gate for cell-targeted metabolic labeling of proteins
Mahdavi, A, Segall-Shapiro, TH, Kou, S, Jindal, GA, Hoff, KG, Liu, S, Chitsaz, M, Ismagilov, RF, Silberg, JJ & Tirrell, DA 2013, , Journal of the American Chemical Society, vol. 135, no. 8, pp. 2979-2982. https://doi.org/10.1021/ja400448f

An adaptor from translational to transcriptional control enables predictable assembly of complex regulation
Liu, CC, Qi, L, Lucks, JB, Segall-Shapiro, TH, Wang, D, Mutalik, VK & Arkin, AP 2012, , Nature Methods, vol. 9, no. 11, pp. 1088-1094. https://doi.org/10.1038/nmeth.2184

Modular control of multiple pathways using engineered orthogonal T7 polymerases
Temme, K, Hill, R, Segall-Shapiro, TH, Moser, F & Voigt, CA 2012, , Nucleic Acids Research, vol. 40, no. 17, pp. 8773-8781. https://doi.org/10.1093/nar/gks597

Mesophilic and hyperthermophilic adenylate kinases differ in their tolerance to random fragmentation
Segall-Shapiro, TH, Nguyen, PQ, Dos Santos, ED, Subedi, S, Judd, J, Suh, J & Silberg, JJ 2011, , Journal of Molecular Biology, vol. 406, no. 1, pp. 135-148. https://doi.org/10.1016/j.jmb.2010.11.057

Creation of a bacterial cell controlled by a chemically synthesized genome
Gibson, DG, Glass, JI, Lartigue, C, Noskov, VN, Chuang, RY, Algire, MA, Benders, GA, Montague, MG, Ma, L, Moodie, MM, Merryman, C, Vashee, S, Krishnakumar, R, Assad-Garcia, N, Andrews-Pfannkoch, C, Denisova, EA, Young, L, Qi, ZN, Segall-Shapiro, TH, Calvey, CH, Parmar, PP, Hutchison, CA, Smith, HO & Venter, JC 2010, , Science, vol. 329, no. 5987, pp. 52-56. https://doi.org/10.1126/science.1190719

Tandem repeat coupled with endonuclease cleavage (TREC): A seamless modification tool for genome engineering in yeast
Noskov, VN, Segall-Shapiro, TH & Chuang, RY 2010, , Nucleic Acids Research, vol. 38, no. 8, gkq099, pp. 2570-2576. https://doi.org/10.1093/nar/gkq099