Thomas A. Kent VIEW CLINICAL PROFILE

Thomas A. Kent, MD

Adjunct Professor of Neurology, Academic Institute
Adjunct Professor of Radiology, Academic Institute
Full Affiliate Member, Research Institute
Houston Methodist


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Biography

Dr. Thomas Kent is a neurologist and clinician scientist with a basic, translational and clinical research program, focused mostly on stroke and other brain injuries. He currently works at the Texas A&M Health Science Center-Houston Campus in the Institute of Biosciences and Technology and as Associate Dean for the Engineering Medical School. 

Areas Of Expertise

Stroke Neurology Neurological disease Brain
Publications

The Effects of Antioxidant Nutraceuticals on Cellular Sulfur Metabolism and Signaling
Olson, KR, Derry, PJ, Kent, TA & Straub, KD 2023, , Antioxidants and Redox Signaling, vol. 38, no. 1-3, pp. 68-94. https://doi.org/10.1089/ars.2022.0077

Oxidized Activated Charcoal Nanozymes: Synthesis, and Optimization for In Vitro and In Vivo Bioactivity for Traumatic Brain Injury
McHugh, EA, Liopo, AV, Mendoza, K, Robertson, CS, Wu, G, Wang, Z, Chen, W, Beckham, JL, Derry, PJ, Kent, TA & Tour, JM 2023, , Advanced Materials, vol. 36, no. 10, 2211239, pp. e2211239. https://doi.org/10.1002/adma.202211239

Oxidation of Hydrogen Sulfide to Polysulfide and Thiosulfate by a Carbon Nanozyme: Therapeutic Implications with an Emphasis on Down Syndrome
Derry, PJ, Liopo, AV, Mouli, K, McHugh, EA, Vo, ATT, McKelvey, A, Suva, LJ, Wu, G, Gao, Y, Olson, KR, Tour, JM & Kent, TA 2023, , Advanced Materials, vol. 36, no. 10, 2211241, pp. e2211241. https://doi.org/10.1002/adma.202211241

Naphthoquinones Oxidize H2S to Polysulfides and Thiosulfate, Implications for Therapeutic Applications
Olson, KR, Clear, KJ, Derry, PJ, Gao, Y, Ma, Z, Cieplik, NM, Fiume, A, Gaziano, DJ, Kasko, SM, Narloch, K, Velander, CL, Nwebube, I, Pallissery, CJ, Pfaff, E, Villa, BP, Kent, TA, Wu, G & Straub, KD 2022, , International journal of molecular sciences, vol. 23, no. 21, 13293. https://doi.org/10.3390/ijms232113293

SARS-CoV-2 and the central nervous system: Emerging insights into hemorrhage-associated neurological consequences and therapeutic considerations
Mitra, J, Kodavati, M, Provasek, VE, Rao, KS, Mitra, S, Hamilton, DJ, Horner, PJ, Vahidy, FS, Britz, GW, Kent, TA & Hegde, ML 2022, , Ageing Research Reviews, vol. 80, 101687. https://doi.org/10.1016/j.arr.2022.101687

Using Mobile Video-Teleconferencing to Deliver Secondary Stroke Prevention Interventions: A Pilot Study
Anderson, JA, Kimmel, B, Sansgiry, S, Venkatasubba Rao, CP, Ovalle, AP, Cerra-Stewart, CA & Kent, TA 2022, , Telemedicine Reports, vol. 3, no. 1, pp. 175-183. https://doi.org/10.1089/tmr.2022.0026

Thrombolysis experience in Costa Rica compared against individual patient data from two randomized controlled trials
Torrealba-Acosta, G, Barboza-Elizondo, M, Fernández-Morales, H, Qasim, M, Litvak, P, Rothlisberger, T, Tsivgoulis, G, Alexandrov, AV, Kent, TA & Mandava, P 2022, , Journal of Stroke and Cerebrovascular Diseases, vol. 31, no. 8, 106599, pp. 106599. https://doi.org/10.1016/j.jstrokecerebrovasdis.2022.106599

Coenzyme Q10 and related quinones oxidize H2S to polysulfides and thiosulfate
Olson, KR, Clear, KJ, Derry, PJ, Gao, Y, Ma, Z, Wu, G, Kent, TA & Straub, KD 2022, , Free Radical Biology and Medicine, vol. 182, pp. 119-131. https://doi.org/10.1016/j.freeradbiomed.2022.02.018

Sonothrombolysis in patients with acute ischemic stroke with large vessel occlusion: An individual patient data meta-analysis
Tsivgoulis, G, Katsanos, AH, Eggers, J, Larrue, V, Thomassen, L, Grotta, JC, Seitidis, G, Schellinger, PD, Mavridis, D, Demchuk, A, Novotny, V, Molina, CA, Veroniki, AA, Köhrmann, M, Soinne, L, Khanevski, AN, Barreto, AD, Saqqur, M, Psaltopoulou, T, Muir, KW, Fiebach, JB, Rothlisberger, T, Kent, TA, Mandava, P, Alexandrov, AW & Alexandrov, AV 2021, , Stroke, vol. 52, no. 12, pp. 3786-3795. https://doi.org/10.1161/STROKEAHA.120.030960

Blood pressure excursions in acute ischemic stroke patients treatedwith intravenous thrombolysis
Tsivgoulis, G, Katsanos, AH, Mandava, P, Kohrmann, M, Soinne, L, Barreto, AD, Sharma, VK, Mikulik, R, Muir, KW, Rothlisberger, T, Grotta, JC, Levi, CR, Molina, CA, Saqqur, M, Mavridis, D, Psaltopoulou, T, Vosko, MR, Fiebach, JB, Sandset, EC, Kent, TA, Alexandrov, AW, Schellinger, PD & Alexandrov, AV 2021, , Journal of Hypertension, vol. 39, no. 2, pp. 266-272. https://doi.org/10.1097/HJH.0000000000002628

The Key Regulator of Necroptosis, RIP1 Kinase, Contributes to the Formation of Astrogliosis and Glial Scar in Ischemic Stroke
Zhu, YM, Lin, L, Wei, C, Guo, Y, Qin, Y, Li, ZS, Kent, TA, McCoy, CE, Wang, ZX, Ni, Y, Zhou, XY & Zhang, HL 2021, , Translational Stroke Research, vol. 12, no. 6, pp. 991-1017. https://doi.org/10.1007/s12975-021-00888-3

The Chemical Basis of Intracerebral Hemorrhage and Cell Toxicity With Contributions From Eryptosis and Ferroptosis
Derry, PJ, Vo, ATT, Gnanansekaran, A, Mitra, J, Liopo, AV, Hegde, ML, Tsai, AL, Tour, JM & Kent, TA 2020, , Frontiers in Cellular Neuroscience, vol. 14, 603043. https://doi.org/10.3389/fncel.2020.603043

Manage Emotions to Reduce Aggression: A Pilot Study of a Brief Treatment to Help Veterans Reduce Impulsive Aggression
Miles, SR, Kent, TA, Stanley, M, Thompson, KE, Sharp, C, Niles, BL, Young-Mccaughan, S, Mintz, J, Roache, JD, Litz, BT, Hale, WJ, Stanford, MS, Keane, TM & Peterson, AL 2020, , Journal of Nervous and Mental Disease, vol. 208, no. 11, pp. 897-903. https://doi.org/10.1097/NMD.0000000000001229

Oxidized Activated Charcoal Nanoparticles as Catalytic Superoxide Dismutase Mimetics: Evidence for Direct Participation of an Intrinsic Radical
Wu, G, McHugh, EA, Berka, V, Chen, W, Wang, Z, Beckham, JL, Derry, PJ, Roy, T, Kent, TA, Tour, JM & Tsai, AL 2020, , ACS Applied Nano Materials, vol. 3, no. 7, pp. 6962-6971. https://doi.org/10.1021/acsanm.0c01285

Pervasive Genomic Damage in Experimental Intracerebral Hemorrhage: Therapeutic Potential of a Mechanistic-Based Carbon Nanoparticle
Dharmalingam, P, Talakatta, G, Mitra, J, Wang, H, Derry, PJ, Nilewski, LG, McHugh, EA, Fabian, RH, Mendoza, K, Vasquez, V, Hegde, PM, Kakadiaris, E, Roy, T, Boldogh, I, Hegde, VL, Mitra, S, Tour, JM, Kent, TA & Hegde, M 2020, , ACS Nano, vol. 14, no. 3, pp. 2827-2846. https://doi.org/10.1021/acsnano.9b05821

Use of a bioengineered antioxidant in mouse models of metabolic syndrome
Griffin, DM, Bitner, BR, Criss, Z, Marcano, D, Berlin, JM, Kent, TA, Tour, JM, Samson, SL & Pautler, RG 2020, , Expert Opinion on Investigational Drugs, vol. 29, no. 2, pp. 209-219. https://doi.org/10.1080/13543784.2020.1716216

Pulse pressure variability is associated with unfavorable outcomes in acute ischaemic stroke patients treated with intravenous thrombolysis
Katsanos, AH, Alexandrov, AV, Mandava, P, Köhrmann, M, Soinne, L, Barreto, AD, Sharma, VK, Mikulik, R, Muir, KW, Rothlisberger, T, Grotta, JC, Levi, CR, Molina, CA, Saqqur, M, Palaiodimou, L, Psaltopoulou, T, Vosko, MR, Moreira, T, Fiebach, JB, Rubiera, M, Sandset, EC, de Havenon, A, Kent, TA, Alexandrov, AW, Schellinger, PD & Tsivgoulis, G 2020, , European Journal of Neurology, vol. 27, no. 12, pp. 2453-2462. https://doi.org/10.1111/ene.14447

Acute and chronic mitochondrial electron transport chain dysfunction treatments and Graphenic materials for use thereof
Hegde, M, Hegde, PM, Mitra, J, Dharmalingam, P, Kent, TA, M. Tour, J & Derry, PJ, , Patent No. 18730149.4-1112.

Lone Star Stroke Consortium: A Collaborative State-Funded Model for Research
Grotta, JC, Anderson, JA, Brey, RL, Kent, TA, Hurn, PD, Goldberg, MP, Savitz, SI, Cruz-Flores, S & Warach, SJ 2020, , Stroke, vol. 51, no. 12, pp. 3778-3786. https://doi.org/10.1161/STROKEAHA.120.031547

Critical Comparison of the Superoxide Dismutase-like Activity of Carbon Antioxidant Nanozymes by Direct Superoxide Consumption Kinetic Measurements
Wu, G, Berka, V, Derry, PJ, Mendoza, K, Kakadiaris, E, Roy, T, Kent, TA, Tour, JM & Tsai, AL 2019, , ACS Nano, vol. 13, no. 10, pp. 11203-11213. https://doi.org/10.1021/acsnano.9b04229

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