Tetsuo Ashizawa, MD

Harriet and Joe B. Foster Distinguished Chair in Neurosciences, Stanley H. Appel Department of Neurology
Professor of Neurology, Academic Institute
Full Member, Research Institute
Director, Neurosciences Research Program
Houston Methodist
Weill Cornell Medical College


Tetsuo Ashizawa, MD, formerly the executive director of the McKnight Brain Institute at the University of Florida, organized and developed interdisciplinary neuroscience research programs involving multiple colleges and departments. He also chaired the neurology department at the University of Texas Medical Branch and at the University of Florida, where he supervised the clinical care of and research in a variety of neurological disorders.

As a physician-scientist, some of Dr. Ashizawa’s current research is funded by the National Institutes of Health, the Muscular Dystrophy Association and the Myotonic Dystrophy Foundation. He is studying neurogenetic disorders caused by expansions of DNA sequences that are connected end-to-end and abnormally repeated, such as myotonic dystrophies, spinocerebellar ataxias, Friedreich’s ataxia, and Huntington’s disease.

Dr. Ashizawa received his medical degree from the Keio University School of Medicine in Tokyo. After moving to the U.S., he completed his neurology residency and Muscular Dystrophy Association fellowships in neurochemistry and clinical neuromuscular disorders at Baylor College of Medicine. 

Dr. Ashizawa is board certified in neurology by the American Board of Psychiatry and Neurology. He serves on multiple grant review panels, including NIH study sections, and on the scientific advisory boards of the Myotonic Dystrophy Foundation, the National Ataxia Foundation, and the Association Française contre les Myopathies.

Areas Of Expertise

Hereditary cerebellar ataxias Multiple system atrophy - cerebellar type Friedreich’s ataxia Myotonic dystrophy Facioscapulohumeral muscular dystrophy Limb girdle muscular dystrophy Huntington’s disease Fragile X associated tremor ataxia syndrome Charcot-Marie-Tooth disease
Education & Training

Fellow, Baylor College of Medicine
Residency, Baylor College of Medicine
MD, Keio University School of Medicine

ATTCT and ATTCC repeat expansions in the ATXN10 gene affect disease penetrance of spinocerebellar ataxia type 10
Morato Torres, CA, Zafar, F, Tsai, YC, Vazquez, JP, Gallagher, MD, McLaughlin, I, Hong, K, Lai, J, Lee, J, Chirino-Perez, A, Romero-Molina, AO, Torres, F, Fernandez-Ruiz, J, Ashizawa, T, Ziegle, J, Jiménez Gil, FJ & Schüle, B 2022, , Human Genetics and Genomics Advances, vol. 3, no. 4, 100137. https://doi.org/10.1016/j.xhgg.2022.100137

The genetic and molecular features of the intronic pentanucleotide repeat expansion in spinocerebellar ataxia type 10
Kurosaki, T & Ashizawa, T 2022, , Frontiers in Genetics, vol. 13, 936869. https://doi.org/10.3389/fgene.2022.936869

Paving the Way Toward Meaningful Trials in Ataxias: An Ataxia Global Initiative Perspective
Ataxia Global Initiative (AGI) 2022, , Movement Disorders, vol. 37, no. 6, pp. 1125-1130. https://doi.org/10.1002/mds.29032

Brief assessment of cognitive function in myotonic dystrophy: Multicenter longitudinal study using computer-assisted evaluation
Myotonic Dystrophy Clinical Research Network 2022, , Muscle and Nerve, vol. 65, no. 5, pp. 560-567. https://doi.org/10.1002/mus.27520

Mechanistic and Therapeutic Insights into Ataxic Disorders with Pentanucleotide Expansions
Zhang, N & Ashizawa, T 2022, , Cells, vol. 11, no. 9, 1567. https://doi.org/10.3390/cells11091567

Comparing loss of balance and functional capacity among patients with SCA2, SCA3 and SCA10
Zonta, MB, Teive, HAG, Camargo, CHF, Meira, AT, Lopes Neto, FDN, Tensini, FS, Braga, CB, Ashizawa, T & Munhoz, RP 2022, , Clinical Neurology and Neurosurgery, vol. 214, 107150. https://doi.org/10.1016/j.clineuro.2022.107150

Neurodegenerative diseases associated with non-coding CGG tandem repeat expansions
Zhou, ZD, Jankovic, J, Ashizawa, T & Tan, EK 2022, , Nature Reviews Neurology, vol. 18, no. 3, pp. 145-157. https://doi.org/10.1038/s41582-021-00612-7

The S-Factor, a New Measure of Disease Severity in Spinocerebellar Ataxia: Findings and Implications
Selvadurai, LP, Perlman, SL, Wilmot, GR, Subramony, SH, Gomez, CM, Ashizawa, T, Paulson, HL, Onyike, CU, Rosenthal, LS, Sair, HI, Kuo, SH, Ratai, EM, Zesiewicz, TA, Bushara, KO, Öz, G, Dietiker, C, Geschwind, MD, Nelson, AB, Opal, P, Yacoubian, TA, Nopoulos, PC, Shakkottai, VG, Figueroa, KP, Pulst, SM, Morrison, PE & Schmahmann, JD 2022, , Cerebellum. https://doi.org/10.1007/s12311-022-01424-1

Reply to: “Cognitive Impairments in Spinocerebellar Ataxia Type 10 and Their Relation to Cortical Thickness”
Meira, AT, Arruda, WO, Franklin, GL, Coutinho, L, Strobel, G, Ono, SE, de Carvalho Neto, A, Camargo, CHF, Munhoz, RP, Ashizawa, T & Teive, HAG 2021, , Movement Disorders, vol. 36, no. 12, pp. 2977. https://doi.org/10.1002/mds.28832

Huntingtin Maintains Mitochondrial Genome Integrity and Function
Pradhan, S, Gao, R, Bush, K, Zhang, N, Smith-Geater, C, Chakraborty, A, Morozko, E, Dickey, A, Yuan, S, Snowden, J, Sikdar, N, Choudhary, S, Keene, C, Ellerby, L, Ashizawa, T, Hazra, T, La Spada, A, Wairkar, Y, Thompson, L & Sarkar, P 2021, , SSRN Electronic Journal.

Clinical and genomic analysis of a large Chinese family with familial cortical myoclonic tremor with epilepsy and SAMD12 intronic repeat expansion
Zhou, Y, Sood, R, Wang, Q, Carrington, B, Park, M, Young, AC, Birnbaum, D, Liu, Z, Ashizawa, T, Mullikin, JC, Koubeissi, MZ & Liu, P 2021, , Epilepsia Open, vol. 6, no. 1, pp. 102-111. https://doi.org/10.1002/epi4.12450

Response to ATXN10 Microsatellite Distribution in a Peruvian Amerindian Population
Véliz-Otani, D, Cubas-Montecino, D, Milla-Neyra, K, Ashizawa, T, Saraiva-Pereira, ML, Jardim, LB & Cornejo-Olivas, M 2021, , Cerebellum, vol. 20, no. 6, pp. 946-947. https://doi.org/10.1007/s12311-021-01258-3

DNAzyme Cleavage of CAG Repeat RNA in Polyglutamine Diseases
Zhang, N, Bewick, B, Schultz, J, Tiwari, A, Krencik, R, Zhang, A, Adachi, K, Xia, G, Yun, K, Sarkar, P & Ashizawa, T 2021, , Neurotherapeutics, vol. 18, no. 3, pp. 1710-1728. https://doi.org/10.1007/s13311-021-01075-w

Blood Neurofilament Light Chain in Genetic Ataxia: A Meta-Analysis
Peng, L, Wang, S, Chen, Z, Peng, Y, Wang, C, Long, Z, Peng, H, Shi, Y, Hou, X, Lei, L, Wan, L, Liu, M, Zou, G, Shen, L, Xia, K, Qiu, R, Tang, B, Ashizawa, T, Klockgether, T & Jiang, H 2022, , Movement Disorders, vol. 37, no. 1, pp. 171-181. https://doi.org/10.1002/mds.28783

CCG•CGG interruptions in high-penetrance SCA8 families increase RAN translation and protein toxicity
Perez, BA, Shorrock, HK, Banez-Coronel, M, Zu, T, Romano, LEL, Laboissonniere, LA, Reid, T, Ikeda, Y, Reddy, K, Gomez, CM, Bird, T, Ashizawa, T, Schut, LJ, Brusco, A, Berglund, JA, Hasholt, LF, Nielsen, JE, Subramony, SH & Ranum, LPW 2021, , EMBO Molecular Medicine, vol. 13, no. 11, e14095. https://doi.org/10.15252/emmm.202114095

A CRISPR-Cas13a Based Strategy That Tracks and Degrades Toxic RNA in Myotonic Dystrophy Type 1
Zhang, N, Bewick, B, Xia, G, Furling, D & Ashizawa, T 2020, , Frontiers in Genetics, vol. 11, 594576. https://doi.org/10.3389/fgene.2020.594576

A CRISPR-Cas13a Based Strategy That Tracks and Degrades Toxic RNA in Myotonic Dystrophy Type 1
Zhang, N, Bewick, B, Xia, G, Furling, D & Ashizawa, T 2020, , Frontiers in Genetics, vol. 11, 594576. https://doi.org/10.3389/fgene.2020.594576

Biallelic Intronic AAGGG Expansion of RFC1 is Related to Multiple System Atrophy
Wan, L, Chen, Z, Wan, N, Liu, M, Xue, J, Chen, H, Zhang, Y, Peng, Y, Tang, Z, Gong, Y, Yuan, H, Wang, S, Deng, Q, Hou, X, Wang, C, Peng, H, Shi, Y, Peng, L, Lei, L, Duan, R, Xia, K, Qiu, R, Shen, L, Tang, B, Ashizawa, T & Jiang, H 2020, , Annals of Neurology, vol. 88, no. 6, pp. 1132-1143. https://doi.org/10.1002/ana.25902

Balance and physical functioning in Spinocerebellar ataxias 3 and 10
Konno, KM, Zonta, MB, Guimarães, ATB, Camargo, CHF, Munhoz, RP, Raskin, S, Ashizawa, T & Teive, HAG 2020, , Acta Neurologica Scandinavica, vol. 143, no. 4, pp. 458-463. https://doi.org/10.1111/ane.13384

Analysis of diffusion tensor parameters in spinocerebellar ataxia type 3 and type 10 patients
Meira, AT, Arruda, WO, Ono, SE, Franklin, GL, de Carvalho Neto, A, Raskin, S, Ashizawa, T, Camargo, CHF & Teive, HAG 2020, , Parkinsonism and Related Disorders, vol. 78, pp. 73-78. https://doi.org/10.1016/j.parkreldis.2020.06.460