Tetsuo Ashizawa, MD

Harriet and Joe B. Foster Distinguished Chair in Neurosciences, Stanley H. Appel Department of Neurology
Professor of Neurology, Academic Institute
Full Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Biography

Tetsuo Ashizawa, MD, formerly the executive director of the McKnight Brain Institute at the University of Florida, organized and developed interdisciplinary neuroscience research programs involving multiple colleges and departments. He also chaired the neurology department at the University of Texas Medical Branch and at the University of Florida, where he supervised the clinical care of and research in a variety of neurological disorders.

As a physician-scientist, some of Dr. Ashizawa’s current research is funded by the National Institutes of Health, the Muscular Dystrophy Association and the Myotonic Dystrophy Foundation. He is studying neurogenetic disorders caused by expansions of DNA sequences that are connected end-to-end and abnormally repeated, such as myotonic dystrophies, spinocerebellar ataxias, Friedreich’s ataxia, and Huntington’s disease.

Dr. Ashizawa received his medical degree from the Keio University School of Medicine in Tokyo. After moving to the U.S., he completed his neurology residency and Muscular Dystrophy Association fellowships in neurochemistry and clinical neuromuscular disorders at Baylor College of Medicine. 

Dr. Ashizawa is board certified in neurology by the American Board of Psychiatry and Neurology. He serves on multiple grant review panels, including NIH study sections, and on the scientific advisory boards of the Myotonic Dystrophy Foundation, the National Ataxia Foundation, and the Association Française contre les Myopathies.

Areas Of Expertise

Hereditary cerebellar ataxias Multiple system atrophy - cerebellar type Friedreich’s ataxia Myotonic dystrophy Facioscapulohumeral muscular dystrophy Limb girdle muscular dystrophy Huntington’s disease Fragile X associated tremor ataxia syndrome Charcot-Marie-Tooth disease
Education & Training

Fellow, Baylor College of Medicine
Residency, Baylor College of Medicine
MD, Keio University School of Medicine
Publications

Getting on the Right Foot: Using Observational and Quantitative Methods to Evaluate Movement Disorders
Spann, J, Chen, SA, Ashizawa, T & Hoque, E 2024, . in Proceedings of 2024 29th Annual Conference on Intelligent User Interfaces, IUI 2024. ACM International Conference Proceeding Series, Association for Computing Machinery, pp. 742-749, 29th Annual Conference on Intelligent User Interfaces, IUI 2024, Greenville, United States, 3/18/24. https://doi.org/10.1145/3640543.3645160

Erratum: Correction: The Role of the Mammalian DNA End-processing Enzyme Polynucleotide Kinase 3'-Phosphatase in Spinocerebellar Ataxia Type 3 Pathogenesis (PLoS genetics (2015) 11 1 (e1004749))
Chatterjee, A, Saha, S, Chakraborty, A, Silva-Fernandes, A, Mandal, SM, Neves-Carvalho, A, Liu, Y, Pandita, RK, Hegde, M, Hegde, PM, Boldogh, I, Ashizawa, T, Koeppen, AH, Pandita, TK, Maciel, P, Sarkar, PS & Hazra, TK 2024, , PLoS Genetics, vol. 20, no. 1, pp. e1011124. https://doi.org/10.1371/journal.pgen.1011124

The Cerebellar Cognitive Affective/Schmahmann Syndrome Scale in Spinocerebellar Ataxias
Selvadurai, LP, Perlman, SL, Ashizawa, T, Wilmot, GR, Onyike, CU, Rosenthal, LS, Shakkottai, VG, Paulson, HL, Subramony, SH, Bushara, KO, Kuo, SH, Dietiker, C, Geschwind, MD, Nelson, AB, Gomez, CM, Opal, P, Zesiewicz, TA, Hawkins, T, Yacoubian, TA, Nopoulos, PC, Sha, SJ, Morrison, PE, Figueroa, KP, Pulst, SM & Schmahmann, JD 2024, , Cerebellum. https://doi.org/10.1007/s12311-023-01651-0

Fatigue Impacts Quality of Life in People with Spinocerebellar Ataxias
Lai, RY, Rummey, C, Amlang, CJ, Lin, CYR, Chen, TX, Perlman, S, Wilmot, G, Gomez, CM, Schmahmann, JD, Paulson, H, Ying, SH, Onyike, CU, Zesiewicz, TA, Bushara, KO, Geschwind, MD, Figueroa, KP, Pulst, SM, Subramony, SH, Burns, MR, Opal, P, Duquette, A, Ashizawa, T, Hamedani, AG, Davis, MY, Srinivasan, SR, Moore, LR, Shakkottai, VG, Rosenthal, LS & Kuo, SH 2024, , Movement Disorders Clinical Practice, vol. 11, no. 5, pp. 496-503. https://doi.org/10.1002/mdc3.14006

Comparison of Live and Remote Video Ratings of the Scale for Assessment and Rating of Ataxia
Taheri Amin, A, Faber, J, Önder, D, Kimmich, O, Synofzik, M, Ashizawa, T, Klockgether, T & Grobe-Einsler, M 2023, , Movement Disorders Clinical Practice, vol. 10, no. 9, pp. 1404-1407. https://doi.org/10.1002/mdc3.13843

Baseline Clinical and Blood Biomarkers in Patients With Preataxic and Early-Stage Disease Spinocerebellar Ataxia 1 and 3
READISCA Consortium Collaborators 2023, , Neurology, vol. 100, no. 17, pp. E1836-E1848. https://doi.org/10.1212/WNL.0000000000207088

Auto-Gait: Automatic Ataxia Risk Assessment with Computer Vision from Gait Task Videos
Rahman, W, Hasan, M, Islam, MS, Olubajo, T, Thaker, J, Abdelkader, AR, Yang, P, Paulson, H, Oz, G, Durr, A, Klockgether, T, Ashizawa, T, Investigators, R & Hoque, E 2023, , Proceedings of the ACM on Interactive, Mobile, Wearable and Ubiquitous Technologies, vol. 7, no. 1, 26. https://doi.org/10.1145/3580845

Antisense oligonucleotide targeting DMPK in patients with myotonic dystrophy type 1: a multicentre, randomised, dose-escalation, placebo-controlled, phase 1/2a trial
Thornton, CA, Moxley, RT, Eichinger, K, Heatwole, C, Mignon, L, Arnold, WD, Ashizawa, T, Day, JW, Dent, G, Tanner, MK, Duong, T, Greene, EP, Herbelin, L, Johnson, NE, King, W, Kissel, JT, Leung, DG, Lott, DJ, Norris, DA, Pucillo, EM, Schell, W, Statland, JM, Stinson, N, Subramony, SH, Xia, S, Bishop, KM & Bennett, CF 2023, , The Lancet Neurology, vol. 22, no. 3, pp. 218-228. https://doi.org/10.1016/S1474-4422(23)00001-7

Synaptic Loss in Spinocerebellar Ataxia Type 3 Revealed by SV2A Positron Emission Tomography
Chen, Z, Liao, G, Wan, N, He, Z, Chen, D, Tang, Z, Long, Z, Zou, G, Peng, L, Wan, L, Wang, C, Peng, H, Shi, Y, Tang, Y, Li, J, Li, Y, Long, T, Hou, X, He, L, Qiu, R, Chen, D, Wang, J, Guo, J, Shen, L, Huang, Y, Ashizawa, T, Klockgether, T, Tang, B, Zhou, M, Hu, S & Jiang, H 2023, , Movement Disorders, vol. 38, no. 6, pp. 978-989. https://doi.org/10.1002/mds.29395

SCAview: an Intuitive Visual Approach to the Integrative Analysis of Clinical Data in Spinocerebellar Ataxias
EUROSCA study group, ESMI study group, RISCA study group, CRC-SCA study group & SCA Registry study group 2023, , Cerebellum. https://doi.org/10.1007/s12311-023-01546-0

State of the Art and History of Therapeutics in Ataxias
Kingsbury, C, Ghanekar, S, Huang, Y, Zhao, Y, Ashizawa, T, Kuo, SH, Gooch, CL & Zesiewicz, TA 2023, . in Contemporary Clinical Neuroscience. Contemporary Clinical Neuroscience, vol. Part F6, Springer, pp. 691-722. https://doi.org/10.1007/978-3-031-24345-5_29

Clinically Meaningful Magnetic Resonance Endpoints Sensitive to Preataxic Spinocerebellar Ataxia Types 1 and 3
for the READISCA Consortium 2023, , Annals of Neurology, vol. 93, no. 4, pp. 686-701. https://doi.org/10.1002/ana.26573

ATTCT and ATTCC repeat expansions in the ATXN10 gene affect disease penetrance of spinocerebellar ataxia type 10
Morato Torres, CA, Zafar, F, Tsai, YC, Vazquez, JP, Gallagher, MD, McLaughlin, I, Hong, K, Lai, J, Lee, J, Chirino-Perez, A, Romero-Molina, AO, Torres, F, Fernandez-Ruiz, J, Ashizawa, T, Ziegle, J, Jiménez Gil, FJ & Schüle, B 2022, , Human Genetics and Genomics Advances, vol. 3, no. 4, 100137, pp. 100137. https://doi.org/10.1016/j.xhgg.2022.100137

The genetic and molecular features of the intronic pentanucleotide repeat expansion in spinocerebellar ataxia type 10
Kurosaki, T & Ashizawa, T 2022, , Frontiers in Genetics, vol. 13, 936869, pp. 936869. https://doi.org/10.3389/fgene.2022.936869

Paving the Way Toward Meaningful Trials in Ataxias: An Ataxia Global Initiative Perspective
Ataxia Global Initiative (AGI) 2022, , Movement Disorders, vol. 37, no. 6, pp. 1125-1130. https://doi.org/10.1002/mds.29032

Mechanistic and Therapeutic Insights into Ataxic Disorders with Pentanucleotide Expansions
Zhang, N & Ashizawa, T 2022, , Cells, vol. 11, no. 9, 1567. https://doi.org/10.3390/cells11091567

Brief assessment of cognitive function in myotonic dystrophy: Multicenter longitudinal study using computer-assisted evaluation
Myotonic Dystrophy Clinical Research Network 2022, , Muscle and Nerve, vol. 65, no. 5, pp. 560-567. https://doi.org/10.1002/mus.27520

Comparing loss of balance and functional capacity among patients with SCA2, SCA3 and SCA10
Zonta, MB, Teive, HAG, Camargo, CHF, Meira, AT, Lopes Neto, FDN, Tensini, FS, Braga, CB, Ashizawa, T & Munhoz, RP 2022, , Clinical Neurology and Neurosurgery, vol. 214, 107150, pp. 107150. https://doi.org/10.1016/j.clineuro.2022.107150

Neurodegenerative diseases associated with non-coding CGG tandem repeat expansions
Zhou, ZD, Jankovic, J, Ashizawa, T & Tan, EK 2022, , Nature Reviews Neurology, vol. 18, no. 3, pp. 145-157. https://doi.org/10.1038/s41582-021-00612-7

The S-Factor, a New Measure of Disease Severity in Spinocerebellar Ataxia: Findings and Implications
Selvadurai, LP, Perlman, SL, Wilmot, GR, Subramony, SH, Gomez, CM, Ashizawa, T, Paulson, HL, Onyike, CU, Rosenthal, LS, Sair, HI, Kuo, SH, Ratai, EM, Zesiewicz, TA, Bushara, KO, Öz, G, Dietiker, C, Geschwind, MD, Nelson, AB, Opal, P, Yacoubian, TA, Nopoulos, PC, Shakkottai, VG, Figueroa, KP, Pulst, SM, Morrison, PE & Schmahmann, JD 2023, , Cerebellum, vol. 22, no. 5, pp. 790-809. https://doi.org/10.1007/s12311-022-01424-1