Tetsuo Ashizawa, MD

Harriet and Joe B. Foster Distinguished Chair in Neurosciences, Stanley H. Appel Department of Neurology
Professor of Neurology, Institute for Academic Medicine
Full Member, Research Institute
Director, Neurosciences Research Program
Houston Methodist
Weill Cornell Medical College


Biography

Tetsuo Ashizawa, MD, formerly the executive director of the McKnight Brain Institute at the University of Florida, organized and developed interdisciplinary neuroscience research programs involving multiple colleges and departments. He also chaired the neurology department at the University of Texas Medical Branch and at the University of Florida, where he supervised the clinical care of and research in a variety of neurological disorders.

As a physician-scientist, some of Dr. Ashizawa’s current research is funded by the National Institutes of Health, the Muscular Dystrophy Association and the Myotonic Dystrophy Foundation. He is studying neurogenetic disorders caused by expansions of DNA sequences that are connected end-to-end and abnormally repeated, such as myotonic dystrophies, spinocerebellar ataxias, Friedreich’s ataxia, and Huntington’s disease.

Dr. Ashizawa received his medical degree from the Keio University School of Medicine in Tokyo. After moving to the U.S., he completed his neurology residency and Muscular Dystrophy Association fellowships in neurochemistry and clinical neuromuscular disorders at Baylor College of Medicine. 

Dr. Ashizawa is board certified in neurology by the American Board of Psychiatry and Neurology. He serves on multiple grant review panels, including NIH study sections, and on the scientific advisory boards of the Myotonic Dystrophy Foundation, the National Ataxia Foundation, and the Association Française contre les Myopathies.

Areas Of Expertise

Hereditary cerebellar ataxias Multiple system atrophy - cerebellar type Friedreich’s ataxia Myotonic dystrophy Facioscapulohumeral muscular dystrophy Limb girdle muscular dystrophy Huntington’s disease Fragile X associated tremor ataxia syndrome Charcot-Marie-Tooth disease
Education & Training

Fellow, Baylor College of Medicine
Residency, Baylor College of Medicine
MD, Keio University School of Medicine
Publications

Intravenously Administered Novel Liposomes, DCL64, Deliver Oligonucleotides to Cerebellar Purkinje Cells
Ashizawa, AT, Holt, J, Faust, K, Liu, W, Tiwari, A, Zhang, N & Ashizawa, T 2018, Cerebellum, pp. 1-10. DOI: 10.1007/s12311-018-0961-2

Spinocerebellar ataxias type 3 and 10: Onset and progression of ataxia during pregnancy and puerperium
Silva, GV, Bonilha, P, Moro, A, Munhoz, R, Raskin, S, Ashizawa, T, Nascimento, FA & Teive, HAG 2018, Parkinsonism and Related Disorders, vol. 52, pp. 119-120. DOI: 10.1016/j.parkreldis.2018.03.025

Olfactory Function in SCA10
Moscovich, M, Munhoz, RP, Moro, A, Raskin, S, McFarland, K, Ashizawa, T, Teive, HAG & Silveira-Moriyama, L 2018, Cerebellum, pp. 1-6. DOI: 10.1007/s12311-018-0954-1

Body composition in Spinocerebellar ataxia type 3 and 10 patients: Comparative study with control group
Leite, CDMBA, Schieferdecker, MEM, Frehner, C, Munhoz, RP, Ashizawa, T & Teive, HAG 2018, Nutritional Neuroscience, pp. 1-6. DOI: 10.1080/1028415X.2018.1469282

Intron retention induced by microsatellite expansions as a disease biomarker
Sznajder, LJ, Thomas, JD, Carrell, EM, Reid, T, McFarland, KN, Cleary, JD, Oliveira, R, Nutter, CA, Bhatt, K, Sobczak, K, Ashizawa, T, Thornton, CA, Ranum, LPW & Swanson, MS 2018, Proceedings of the National Academy of Sciences of the United States of America, vol. 115, no. 16, pp. 4234-4239. DOI: 10.1073/pnas.1716617115

A crystal ball for survival for spinocerebellar ataxias?
Ashizawa, T 2018, The Lancet Neurology, vol. 17, no. 4, pp. 292-294. DOI: 10.1016/S1474-4422(18)30088-7

C9orf72 repeat expansions as genetic modifiers for depression in spinocerebellar ataxias
Figueroa, KP, Gan, SR, Perlman, S, Wilmot, G, Gomez, CM, Schmahmann, J, Paulson, H, Shakkottai, VG, Ying, SH, Zesiewicz, T, Bushara, K, Geschwind, M, Xia, G, Subramony, SH, Ashizawa, T, Pulst, SM & Kuo, SH 2018, Movement Disorders, vol. 33, no. 3, pp. 497-498. DOI: 10.1002/mds.27258

Sleep disorders in spinocerebellar ataxia type 10
London, E, Camargo, CHF, Zanatta, A, Crippa, AC, Raskin, S, Munhoz, RP, Ashizawa, T & Teive, HAG 2018, Journal of Sleep Research. DOI: 10.1111/jsr.12688

Comprehensive systematic review summary: Treatment of cerebellar motor dysfunction and ataxia
Zesiewicz, TA, Wilmot, G, Han Kuo, S, Perlman, S, Greenstein, PE, Sarah, Y, Tetsuo, A, Subramony, SH, Schmahmann, JD, Figueroa, KP, Mizusawa, H, Schöls, L, Shaw, JD, Dubinsky, RM, Armstrong, MJ, Gronseth, GS & Sullivan, KL 2018, Neurology, vol. 90, no. 10, pp. 464-471. DOI: 10.1212/WNL.0000000000005055

Spinocerebellar ataxias: prospects and challenges for therapy development
Ashizawa, T, Öz, G & Paulson, HL 2018, Nature Reviews Neurology. DOI: 10.1038/s41582-018-0051-6

SCA8 RAN polySer protein preferentially accumulates in white matter regions and is regulated by eIF3F
Ayhan, F, Perez, BA, Shorrock, HK, Zu, T, Banez-Coronel, M, Reid, T, Furuya, H, Clark, HB, Troncoso, JC, Ross, CA, Subramony, SH, Ashizawa, T, Wang, ET, Yachnis, AT & Ranum, LPW 2018, EMBO Journal. DOI: 10.15252/embj.201899023

Therapeutic Genome Editing for Myotonic Dystrophy Type 1 Using CRISPR/Cas9
Wang, Y, Hao, L, Wang, H, Santostefano, K, Thapa, A, Cleary, J, Li, H, Guo, X, Terada, N, Ashizawa, T & Xia, G 2018, Molecular Therapy. DOI: 10.1016/j.ymthe.2018.09.003

Correction to: SPG7 and Impaired Emotional Communication (Cerebellum, (2016), 16, 2, (595-598), 10.1007/s12311-016-0818-5)
Zhang, L, McFarland, KN, Subramony, SH, Heilman, KM & Ashizawa, T 2017, Cerebellum, vol. 16, no. 5-6. DOI: 10.1007/s12311-017-0901-6

Postural tremor and ataxia progression in spinocerebellar ataxias
Gan, SR, Wang, J, Figueroa, KP, Pulst, SM, Tomishon, D, Lee, D, Perlman, S, Wilmot, G, Gomez, CM, Schmahmann, J, Paulson, H, Shakkottai, VG, Ying, SH, Zesiewicz, T, Bushara, K, Geschwind, MD, Xia, G, Subramony, SH, Ashizawa, T & Kuo, SH 2017, Tremor and Other Hyperkinetic Movements, vol. 7. DOI: 10.7916/D8GM8KRH

RAN Translation Regulated by Muscleblind Proteins in Myotonic Dystrophy Type 2
Zu, T, Cleary, JD, Liu, Y, Bañez-Coronel, M, Bubenik, JL, Ayhan, F, Ashizawa, T, Xia, G, Clark, HB, Yachnis, AT, Swanson, MS & Ranum, LPW 2017, Neuron, vol. 95, no. 6, pp. 1292-1305.e5. DOI: 10.1016/j.neuron.2017.08.039

Nonmotor Symptoms in Patients with Spinocerebellar Ataxia Type 10
Moro, A, Munhoz, RP, Moscovich, M, Arruda, WO, Raskin, S, Silveira-Moriyama, L, Ashizawa, T & Teive, HAG 2017, Cerebellum, pp. 1-7. DOI: 10.1007/s12311-017-0869-2

The Initial Symptom and Motor Progression in Spinocerebellar Ataxias
Luo, L, Wang, J, Lo, RY, Figueroa, KP, Pulst, SM, Kuo, PH, Perlman, S, Wilmot, G, Gomez, CM, Schmahmann, JD, Paulson, H, Shakkottai, VG, Ying, SH, Zesiewicz, T, Bushara, K, Geschwind, M, Xia, G, Subramony, SH, Ashizawa, T & Kuo, SH 2017, Cerebellum, vol. 16, no. 3, pp. 615-622. DOI: 10.1007/s12311-016-0836-3

A Comparative Optical Coherence Tomography Study of Spinocerebellar Ataxia Types 3 and 10
Spina Tensini, F, Sato, MT, Shiokawa, N, Ashizawa, T & Teive, HAG 2017, Cerebellum, pp. 1-5. DOI: 10.1007/s12311-017-0856-7

Inheritance patterns of ATCCT repeat interruptions in spinocerebellar ataxia type 10 (SCA10) expansions
Landrian, I, McFarland, KN, Liu, J, Mulligan, CJ, Rasmussen, A & Ashizawa, T 2017, PLoS ONE, vol. 12, no. 4, e0175958. DOI: 10.1371/journal.pone.0175958

Ubiquitin-related network underlain by (CAG)n loci modulate age at onset in Machado-Joseph disease
Chen, Z, Wang, C, Zheng, C, Long, Z, Cao, L, Li, X, Shang, H, Yin, X, Zhang, B, Liu, J, Ding, D, Peng, Y, Peng, H, Ye, W, Qiu, R, Pan, Q, Xia, K, Chen, S, Sequeiros, J, Ashizawa, T, Tang, B, Jiang, H & on behalf of the Chinese Clinical Research Cooperative Group for Spinocerebellar Ataxias (CCRCG-SCA) 2017, Brain, vol. 140, no. 4, pp. e25. DOI: 10.1093/brain/awx028