Tariq Shafi, MD, MHS

Acting Professor of Medicine, Academic Institute
Head, Division of Kidney Diseases, Hypertension & Transplantation, Department of Medicine
Houston Methodist


Biography

Dr. Shafi is the Head of the Division of Kidney Diseases, Hypertension, & Transplantation and Jerold B. Katz Investigator at the Houston Methodist Hospital. 

Dr. Shafi received his medical degree from Dow Medical College in Karachi, Pakistan, in 1990, followed by Internal Medicine residency training at Detroit’s Wayne State University. After several years in leadership roles at the Detroit Medical Center, Dr. Shafi pursued a nephrology fellowship at Johns Hopkins Hospital and an MHS in Clinical Epidemiology at the Johns Hopkins School of Public Health. Dr. Shafi joined the Nephrology Division at Johns Hopkins University School of Medicine in 2008 and was a faculty member there until 2018. Dr. Shafi then joined the University of Mississippi Medical Center as the John D. Bower Director of the Division of Nephrology and Transplantation, a position he held until 2022 when he moved to Houston Methodist Hospital. 

Dr. Shafi is an NIH-funded clinician-scientist focusing on cardiovascular risk factors and outcomes in patients with kidney disease treated with dialysis. Dr. Shafi has extensive expertise in human subjects clinical research, biomarker studies, health services research, and population health. He has been continuously funded by NIH since 2006. Dr. Shafi is a permanent member of the NIH Health Services Quality and Effectiveness (HSQE) Study Section and is a member of the editorial boards of the Clinical Journal of the American Society of Nephrology, the American Journal of Medical Sciences, and Kidney360

Publications

Albuminuria and Heart Failure: JACC State-of-the-Art Review
Khan, MS, Shahid, I, Anker, SD, Fonarow, GC, Fudim, M, Hall, ME, Hernandez, A, Morris, AA, Shafi, T, Weir, MR, Zannad, F, Bakris, GL & Butler, J 2023, , Journal of the American College of Cardiology, vol. 81, no. 3, pp. 270-282. https://doi.org/10.1016/j.jacc.2022.10.028

Traditions and innovations in assessment of glomerular filtration rate using creatinine to cystatin C
Tio, MC, Shafi, T, Zhu, X, Kalantar-Zadeh, K, Chan, A & Nguyen, L 2023, , Current Opinion in Nephrology and Hypertension, vol. 32, no. 1, pp. 89-97. https://doi.org/10.1097/MNH.0000000000000854

Assessment of glycemia in chronic kidney disease
Hassanein, M & Shafi, T 2022, , BMC Medicine, vol. 20, no. 1, 117. https://doi.org/10.1186/s12916-022-02316-1

Physiological Mechanisms of Hypertension and Cardiovascular Disease in End-Stage Kidney Disease
Clemmer, JS, Shafi, T & Obi, Y 2022, , Current Hypertension Reports, vol. 24, no. 10, pp. 413-424. https://doi.org/10.1007/s11906-022-01203-7

Annals On Call - Estimated Glomerular Filtration Rate Variability
Centor, RM & Shafi, T 2022, , Annals of Internal Medicine, vol. 175, no. 10, pp. OC1. https://doi.org/10.7326/A21-0021

Physical Resilience Phenotype Trajectories in Incident Hemodialysis: Characterization and Mortality Risk Assessment
Hladek, MD, Zhu, J, Crews, DC, McAdams-DeMarco, MA, Buta, B, Varadhan, R, Shafi, T, Walston, JD & Bandeen-Roche, K 2022, , Kidney International Reports, vol. 7, no. 9, pp. 2006-2015. https://doi.org/10.1016/j.ekir.2022.06.009

Quantifying Individual-Level Inaccuracy in Glomerular Filtration Rate Estimation A Cross-Sectional Study
Shafi, T, Zhu, X, Lirette, ST, Rule, AD, Mosley, T, Butler, KR, Hall, ME, Vaitla, P, Wynn, JJ, Tio, MC, Dossabhoy, NR, Guallar, E & Butler, J 2022, , Annals of Internal Medicine, vol. 175, no. 8, pp. 1073-1082. https://doi.org/10.7326/M22-0610

Deoxycholic Acid and Coronary Artery Calcification in the Chronic Renal Insufficiency Cohort
Jovanovich, A, Cai, X, Frazier, R, Bundy, JD, He, J, Rao, P, Lora, C, Dobre, M, Go, A, Shafi, T, Feldman, HI, Rhee, EP, Miyazaki, M, Isakova, T & Chonchol, M 2022, , Journal of the American Heart Association, vol. 11, no. 7, e022891. https://doi.org/10.1161/JAHA.121.022891

Trajectories of Uremic Symptom Severity and Kidney Function in Patients with Chronic Kidney Disease
Wulczyn, KE, Zhao, SH, Rhee, EP, Kalim, S & Shafi, T 2022, , Clinical Journal of the American Society of Nephrology, vol. 17, no. 4, pp. 496-506. https://doi.org/10.2215/CJN.13010921

Risk Prediction Models for Atherosclerotic Cardiovascular Disease in Patients with Chronic Kidney Disease: The CRIC Study
Bundy, JD, Rahman, M, Matsushita, K, Jaeger, BC, Cohen, JB, Chen, J, Deo, R, Dobre, MA, Feldman, HI, Flack, J, Kallem, RR, Lash, JP, Seliger, S, Shafi, T, Weiner, SJ, Wolf, M, Yang, W, Allen, NB, Bansal, N & He, J 2022, , Journal of the American Society of Nephrology, vol. 33, no. 3, pp. 601-611. https://doi.org/10.1681/ASN.2021060747

A metabolomics approach identified toxins associated with uremic symptoms in advanced chronic kidney disease
Hu, JR, Myint, L, Levey, AS, Coresh, J, Inker, LA, Grams, ME, Guallar, E, Hansen, KD, Rhee, EP & Shafi, T 2022, , Kidney international, vol. 101, no. 2, pp. 369-378. https://doi.org/10.1016/j.kint.2021.10.035

Deoxycholic Acid and Risks of Cardiovascular Events, ESKD, and Mortality in CKD: The CRIC Study
Chronic Renal Insufficiency Cohort (CRIC) Study Investigators 2022, , Kidney Medicine, vol. 4, no. 1, 100387. https://doi.org/10.1016/j.xkme.2021.09.004

Protein carbamylation and chronic kidney disease progression in the Chronic Renal Insufficiency Cohort Study
Kalim, S, Berg, AH, Karumanchi, SA, Thadhani, R, Allegretti, AS, Nigwekar, S, Zhao, S, Srivastava, A, Raj, D, Deo, R, Frydrych, A, Chen, J, Sondheimer, J, Shafi, T, Weir, M, Lash, JP, Appel, LJ, Feldman, HI, Go, AS, He, J, Nelson, RG, Rahman, M, Rao, PS, Shah, VO, Townsend, RR & Unruh, ML 2022, , Nephrology Dialysis Transplantation, vol. 37, no. 1, pp. 139-147. https://doi.org/10.1093/ndt/gfaa347

Hypertensive Diseases in Pregnancy and Kidney Function Later in Life: The Genetic Epidemiology Network of Arteriopathy (GENOA) Study
Oshunbade, AA, Lirette, ST, Windham, BG, Shafi, T, Hamid, A, Gbadamosi, SO, Tin, A, Yimer, WK, Tibuakuu, M, Clark, D, Kamimura, D, Lutz, EA, Mentz, RJ, Fox, ER, Butler, J, Butler, KR, Garovic, VD, Turner, ST, Mosley, TH & Hall, ME 2022, , Mayo Clinic Proceedings, vol. 97, no. 1, pp. 78-87. https://doi.org/10.1016/j.mayocp.2021.07.018

Time-Updated Changes in Estimated GFR and Proteinuria and Major Adverse Cardiac Events: Findings from the Chronic Renal Insufficiency Cohort (CRIC) Study
CRIC Study Investigators 2022, , American Journal of Kidney Diseases, vol. 79, no. 1, pp. 36-44.e1. https://doi.org/10.1053/j.ajkd.2021.03.021

Patients’ and family members’ perspectives on arrhythmias and sudden death in dialysis: the HeartLink focus groups pilot study
Xu, EJ, Boyer, LPL, Jaar, BG, Ephraim, PL, Gimenez, L, Cheng, A, Chrispin, J, Weir, MR, Raj, D, Guallar, E & Shafi, T 2021, , BMC Nephrology, vol. 22, no. 1, 199. https://doi.org/10.1186/s12882-021-02403-0

Author Correction: Nonalcoholic fatty liver disease accelerates kidney function decline in patients with chronic kidney disease: a cohort study (Scientific Reports, (2018), 8, 1, (4718), 10.1038/s41598-018-23014-0)
Jang, HR, Kang, D, Sinn, DH, Gu, S, Cho, SJ, Lee, JE, Huh, W, Paik, SW, Ryu, S, Chang, Y, Shafi, T, Lazo, M, Guallar, E, Cho, J & Gwak, GY 2021, , Scientific Reports, vol. 11, no. 1, 11139. https://doi.org/10.1038/s41598-021-90150-5

Association of circulating cardiac biomarkers with electrocardiographic abnormalities in chronic kidney disease
Kula, AJ, Katz, R, Zelnick, LR, Soliman, E, Go, A, Shlipak, M, Deo, R, Ky, B, Deboer, I, Anderson, A, Christenson, R, Seliger, SL, Defilippi, C, Feldman, HI, Wolf, M, Kusek, J, Shafi, T, He, J & Bansal, N 2021, , Nephrology Dialysis Transplantation, vol. 36, no. 12, pp. 2282-2289. https://doi.org/10.1093/ndt/gfaa296

Iron status, fibroblast growth factor 23 and cardiovascular and kidney outcomes in chronic kidney disease
CRIC Study Investigators 2021, , Kidney international, vol. 100, no. 6, pp. 1292-1302. https://doi.org/10.1016/j.kint.2021.07.013

Race, genetic ancestry, and estimating kidney function in CKD
the CRIC Study Investigators 2021, , New England Journal of Medicine, vol. 385, no. 19, pp. 1750-1760. https://doi.org/10.1056/NEJMoa2103753