Tariq Shafi, MD, MHS

Acting Professor of Medicine, Academic Institute
Jerold B. Katz Investigator, Academic Institute
Head, Division of Kidney Diseases, Hypertension & Transplantation, Department of Medicine
Houston Methodist


Dr. Shafi is the Head of the Division of Kidney Diseases, Hypertension, & Transplantation and Jerold B. Katz Investigator at the Houston Methodist Hospital. 

Dr. Shafi received his medical degree from Dow Medical College in Karachi, Pakistan, in 1990, followed by Internal Medicine residency training at Detroit’s Wayne State University. After several years in leadership roles at the Detroit Medical Center, Dr. Shafi pursued a nephrology fellowship at Johns Hopkins Hospital and an MHS in Clinical Epidemiology at the Johns Hopkins School of Public Health. Dr. Shafi joined the Nephrology Division at Johns Hopkins University School of Medicine in 2008 and was a faculty member there until 2018. Dr. Shafi then joined the University of Mississippi Medical Center as the John D. Bower Director of the Division of Nephrology and Transplantation, a position he held until 2022 when he moved to Houston Methodist Hospital. 

Dr. Shafi is an NIH-funded clinician-scientist focusing on cardiovascular risk factors and outcomes in patients with kidney disease treated with dialysis. Dr. Shafi has extensive expertise in human subjects clinical research, biomarker studies, health services research, and population health. He has been continuously funded by NIH since 2006. Dr. Shafi is a permanent member of the NIH Health Services Quality and Effectiveness (HSQE) Study Section and is a member of the editorial boards of the Clinical Journal of the American Society of Nephrology, the American Journal of Medical Sciences, and Kidney360


Plasma metabolites and physical function in patients undergoing hemodialysis
Moorthi, RN, Moe, SM, O’Connell, T, Dickinson, S, Kalim, S, Thadhani, R, Clish, CB, Shafi, T, Rhee, EP & Avin, KG 2024, , Scientific Reports, vol. 14, no. 1, 8427. https://doi.org/10.1038/s41598-024-58522-9

Refining GFR estimation: a quest for the unobservable truth?
Shafi, T 2024, , Kidney international, vol. 105, no. 3, pp. 435-437. https://doi.org/10.1016/j.kint.2023.12.004

The Clinical and Pathological Characteristics of Patients with Oxalate Nephropathy
Llanos, M, Kwon, A, Herlitz, L, Shafi, T, Cohen, S, Gebreselassie, SK, Sawaf, H & Bobart, SA 2024, , Kidney360, vol. 5, no. 1, pp. 65-72. https://doi.org/10.34067/KID.0000000000000340

Designing an Implementable Clinical Prediction Model for Near-Term Mortality and Long-Term Survival in Patients on Maintenance Hemodialysis
Goldstein, BA, Xu, C, Wilson, J, Henao, R, Ephraim, PL, Weiner, DE, Shafi, T & Scialla, JJ 2024, , American Journal of Kidney Diseases, vol. 84, no. 1, pp. 73-82. https://doi.org/10.1053/j.ajkd.2023.12.013

Metabolites Associated With Uremic Symptoms in Patients With CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study
CRIC Study Investigators 2024, , American Journal of Kidney Diseases, vol. 84, no. 1, pp. 49-61.e1. https://doi.org/10.1053/j.ajkd.2023.11.013

Evaluation of a large-scale aptamer proteomics platform among patients with kidney failure on dialysis
Ren, Y, Ruan, P, Segal, M, Dobre, M, Schelling, JR, Banerjee, U, Shafi, T, Ganz, P & Dubin, RF 2023, , PLoS ONE, vol. 18, no. 12 December, e0293945. https://doi.org/10.1371/journal.pone.0293945

External Validation of a Novel Multimarker GFR Estimating Equation
Tio, MC, Zhu, X, Lirette, S, Rule, AD, Butler, K, Hall, ME, Dossabhoy, NR, Mosley, T & Shafi, T 2023, , Kidney360, vol. 4, no. 12, pp. 1680-1689. https://doi.org/10.34067/KID.0000000000000304

Association of urine and plasma ADMA with atherosclerotic risk in DKD cardiovascular disease risk in diabetic kidney disease: Findings from the Chronic Renal Insufficiency Cohort (CRIC) study
Schrauben, SJ, Sapa, H, Xie, D, Zhang, X, Anderson, AH, Shlipak, MG, Hsu, CY, Shafi, T, Mehta, R, Bhat, Z, Brown, J, Charleston, J, Chen, J, He, J, Ix, JH, Rao, P, Townsend, R, Kimmel, PL, Vasan, RS, Feldman, HI, Seegmiller, JC, Brunengraber, H, Hostetter, TH & Schelling, JR 2023, , Nephrology Dialysis Transplantation, vol. 38, no. 12, pp. 2809-2815. https://doi.org/10.1093/ndt/gfad103

Residual Kidney Function and Cause-Specific Mortality Among Incident Hemodialysis Patients
Okazaki, M, Obi, Y, Shafi, T, Rhee, CM, Kovesdy, CP & Kalantar-Zadeh, K 2023, , Kidney International Reports, vol. 8, no. 10, pp. 1989-2000. https://doi.org/10.1016/j.ekir.2023.07.020

Excess risk of cardiovascular events in patients in the United States vs. Japan with chronic kidney disease is mediated mainly by left ventricular structure and function
the CRIC Study Investigators 2023, , Kidney international, vol. 103, no. 5, pp. 949-961. https://doi.org/10.1016/j.kint.2023.01.008

Management of Heart Failure With Reduced Ejection Fraction in Patients With Diabetes Mellitus and Chronic Kidney Disease
Khan, MS, Rashid, AM, Shafi, T, Ferreira, JP & Butler, J 2023, , Seminars in nephrology, vol. 43, no. 3, 151429, pp. 151429. https://doi.org/10.1016/j.semnephrol.2023.151429

Incidence and Risk Factors for Pruritus in Patients with Nondialysis CKD
Wulczyn, KE, Rhee, EP, Myint, L, Kalim, S & Shafi, T 2023, , Clinical journal of the American Society of Nephrology : CJASN, vol. 18, no. 2, pp. 193-203. https://doi.org/10.2215/CJN.09480822

Albuminuria and Heart Failure: JACC State-of-the-Art Review
Khan, MS, Shahid, I, Anker, SD, Fonarow, GC, Fudim, M, Hall, ME, Hernandez, A, Morris, AA, Shafi, T, Weir, MR, Zannad, F, Bakris, GL & Butler, J 2023, , Journal of the American College of Cardiology, vol. 81, no. 3, pp. 270-282. https://doi.org/10.1016/j.jacc.2022.10.028

Traditions and innovations in assessment of glomerular filtration rate using creatinine to cystatin C
Tio, MC, Shafi, T, Zhu, X, Kalantar-Zadeh, K, Chan, A & Nguyen, L 2023, , Current Opinion in Nephrology and Hypertension, vol. 32, no. 1, pp. 89-97. https://doi.org/10.1097/MNH.0000000000000854

A Study of Physical Resilience and Aging (SPRING): Conceptual framework, rationale, and study design
Walston, J, Varadhan, R, Xue, QL, Buta, B, Sieber, F, Oni, J, Imus, P, Crews, DC, Artz, A, Schrack, J, Kalyani, RR, Abadir, P, Carlson, M, Hladek, M, McAdams-DeMarco, M, Jones, R, Johnson, A, Shafi, T, Newman, AB & Bandeen-Roche, K 2023, , Journal of the American Geriatrics Society, vol. 71, no. 8, pp. 2393-2405. https://doi.org/10.1111/jgs.18483

Comparative Effectiveness of Alternative Treatment Approaches to Secondary Hyperparathyroidism in Patients Receiving Maintenance Hemodialysis: An Observational Trial Emulation
Comparative Effectiveness Studies in Dialysis Patients Group 2024, , American Journal of Kidney Diseases, vol. 83, no. 1, pp. 58-70. https://doi.org/10.1053/j.ajkd.2023.05.016

Assessment of glycemia in chronic kidney disease
Hassanein, M & Shafi, T 2022, , BMC Medicine, vol. 20, no. 1, 117. https://doi.org/10.1186/s12916-022-02316-1

Physiological Mechanisms of Hypertension and Cardiovascular Disease in End-Stage Kidney Disease
Clemmer, JS, Shafi, T & Obi, Y 2022, , Current Hypertension Reports, vol. 24, no. 10, pp. 413-424. https://doi.org/10.1007/s11906-022-01203-7

Annals On Call - Estimated Glomerular Filtration Rate Variability
Centor, RM & Shafi, T 2022, , Annals of Internal Medicine, vol. 175, no. 10, pp. OC1. https://doi.org/10.7326/A21-0021

Physiological Mechanisms of Hypertension and Cardiovascular Disease in End-Stage Kidney Disease
Clemmer, JS, Shafi, T & Obi, Y 2022, , Current Hypertension Reports, vol. 24, no. 10, pp. 413-424. https://doi.org/10.1007/s11906-022-01203-7