Steven Shen, MD, PhD

Professor of Pathology and Genomic Medicine, Academic Institute
Full Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Dr. Shen is a general surgical pathologist with subspecialty interest in genitourinary pathology. After completing his residency training in Anatomical and Clinical Pathology and fellowship training in Surgical Pathology, Dr. Shen became an assistant professor at Baylor College of Medicine (2002-2003) before joining the Department of Pathology and Genomic Medicine at Houston Methodist Hospital in 2004. In 2005 he joined the Weill Medical College faculty and is a Full Member of the Research Institute.

Dr. Shen is a general surgical pathologist with strong subspecialty expertise in genitourinary cancers. He is currently the Medical Director of the Immunohistochemistry Lab and Associate Director of Surgical Pathology at the Houston Methodist Hospital. He is co-editor of three books and has authored nearly 100 peer reviewed articles, primarily in the areas of diagnostic pathology and genitourinary tumors.

Description of Research

Dr. Shen’s research involves identifying morphologic and molecular abnormalities of neoplasm and correlating these with diagnosis, prognosis, and in some instances, future treatment. He is involved in independent and collaborative studies using conventional histomorphologic techniques, immunohistochemical methods, tissue microarray, and new molecular methods to study cancers of the kidney, urinary bladder, and prostate.

Areas Of Expertise

Cancer Metastasis
Education & Training

Clinical Fellowship, The University of Texas MD Anderson Cancer Center
Residency, Penn State Milton S. Hershey Medical Center
MS, Tongji University
MD, Tongji Medical College, Huazhong University of Science and Technology
Research Fellowship, National Institutes of Health
PhD, University of Texas Health Science Center at Houston
Postdoctoral Fellowship, University of Texas Health Science Center at Houston

International Opinions on Grading of Urothelial Carcinoma: A Survey Among European Association of Urology and International Society of Urological Pathology Members
Beijert, IJ, Cheng, L, Liedberg, F, Plass, K, Williamson, SR, Gontero, P, Ribal, MJ, Babjuk, M, Black, PC, Kamat, AM, Algaba, F, Berman, DM, Hartmann, A, Masson-Lecomte, A, Rouprêt, M, Lopez-Beltran, A, Samaratunga, H, Shariat, SF, Mostafid, AH, Varma, M, Shen, S, Burger, M, Tsuzuki, T, Palou, J, Compérat, EM, Sylvester, RJ, van der Kwast, TH, van Rhijn, BWG & Downes, MR 2023, , European Urology Open Science, vol. 52, pp. 154-165.

Recent Advances in the Classification of Bladder Cancer - Updates from the 5th Edition of the World Health Organization Classification of the Urinary and Male Genital Tumors
Guo, CC, Shen, SS & Czerniak, B 2023, , Bladder Cancer, vol. 9, no. 1, pp. 1-14.

Image-to-image translation of label-free molecular vibrational images for a histopathological review using the UNet+/seg-cGAN model
He, Y, Li, J, Shen, S, Liu, K, WONG, KELVINK, He, T & WONG, STEPHENTC 2022, , Biomedical Optics Express, vol. 13, no. 4, pp. 1924-1938.

Artificial intelligence-augmented, label-free molecular imaging method for tissue identification, cancer diagnosis, and cancer margin detection
Li, J, Liu, J, Wang, Y, He, Y, Liu, K, Raghunathan, R, Shen, SS, He, T, Yu, X, Danforth, R, Zheng, F, Zhao, H & Wong, STC 2021, , Biomedical Optics Express, vol. 12, no. 9, pp. 5559-5582.

Metastatic urothelial carcinoma to the brain, spinal cord and spine: A contemporary multi-institutional clinicopathologic analysis of 24 cases
Ogunbona, OB, Matoso, A, Cheng, L, Shen, S, Powell, SZ & Osunkoya, AO 2021, , Pathology Research and Practice, vol. 224, 153537.

Pleomorphic giant cell carcinoma of prostate: Rare tumor with unique clinicopathological, immunohistochemical, and molecular features
El-Zaatari, ZM, Thomas, JS, Divatia, MK, Shen, SS, Ayala, AG, Monroig-Bosque, P, Shehabeldin, A & Ro, JY 2021, , Annals of Diagnostic Pathology, vol. 52, 151719.

The phylogenetic relationship within SARS-CoV-2s: An expanding basal clade
Shen, S, Zhang, Z & He, F 2021, , Molecular Phylogenetics and Evolution, vol. 157, 107017.

Pathogenesis and diagnosis of genitourinary cancer
Guo, CC, Shen, SS & Ro, JY 2021, , Cancers, vol. 13, no. 2, 347, pp. 1-3.

Improving generalization of deep learning models for diagnostic pathology by increasing variability in training data: Experiments on osteosarcoma subtypes
Tang, H, Sun, N & Shen, S 2021, , Journal of Pathology Informatics, vol. 12, no. 1, 30.

Urinary Bladder Inflammatory Myofibroblastic Tumor with Mutated TP53 and PPFIBP1-ALK Gene Fusion
Barbieri, AN, Tallman, CT, Satkunasivam, R, Annunziata, J, Thomas, JS, Olsen, RJ, Shen, S, Thrall, MJ & Schwartz, MR 2021, , AJSP: Reviews and Reports, vol. 26, no. 1, pp. 45-49.

Seminal vesicle invasion combined with extraprostatic extension is associated with higher frequency of biochemical recurrence and lymph node metastasis than seminal vesicle invasion alone: Proposal for further pT3 prostate cancer subclassification
Rehman, A, El-Zaatari, ZM, Han, SH, Shen, SS, Ayala, AG, Miles, B, Divatia, MK, Ketcham, MS, Chung, BM, Rogers, JT & Ro, JY 2020, , Annals of Diagnostic Pathology, vol. 49, 151611.

Collision Tumor Composed of Renal Oncocytoma and Mucinous Tubular and Spindle Cell Carcinoma: Not a Rare Occurrence
Lin, MS, Jacobi, EM, Mullick, S, Nguyen, CV, Thomas, JS, Olsen, RJ, Shen, S, Ayala, A & Ro, J 2020, , AJSP: Reviews and Reports, vol. 25, no. 6, pp. 270-275.

A T2-Weighty Discovery: Aortitis on Cardiac MRI with Histopathologic Correlation
Al-Sabeq, B, Shen, S, Hinojosa, JJ & Nabi, F 2020, , Methodist DeBakey cardiovascular journal, vol. 16, no. 1, pp. 65-67.

Controversial issues in Gleason and International Society of Urological Pathology (ISUP) prostate cancer grading: proposed recommendations for international implementation
Srigley, JR, Delahunt, B, Samaratunga, H, Billis, A, Cheng, L, Clouston, D, Evans, A, Furusato, B, Kench, J, Leite, K, MacLennan, G, Moch, H, Pan, CC, Rioux-Leclercq, N, Ro, J, Shanks, J, Shen, S, Tsuzuki, T, Varma, M, Wheeler, T, Yaxley, J & Egevad, L 2019, , Pathology, vol. 51, no. 5, pp. 463-473.

Lightning striking twice: Redo mitral valve replacement due to recurrent cardiac sarcoma using partial autotransplantation technique
Al-Sabeq, B, Shen, SS, Reardon, M & Nabi, F 2019, , Journal of Thoracic and Cardiovascular Surgery, vol. 158, no. 1, pp. e1-e4.

Histologic diagnosis of renal mass biopsy
Shen, SS & Ro, JY 2019, , Archives of Pathology and Laboratory Medicine, vol. 143, no. 6, pp. 705-710.

KLF4, A Gene Regulating Prostate Stem Cell Homeostasis, Is a Barrier to Malignant Progression and Predictor of Good Prognosis in Prostate Cancer
Xiong, X, Schober, M, Tassone, E, Khodadadi-Jamayran, A, Sastre-Perona, A, Zhou, H, Tsirigos, A, Shen, S, Chang, M, Melamed, J, Ossowski, L & Wilson, EL 2018, , Cell Reports, vol. 25, no. 11, pp. 3006-3020.e7.

Predominantly cystic clear cell renal cell carcinoma and multilocular cystic renal neoplasm of low malignant potential form a low-grade spectrum
Tretiakova, M, Mehta, V, Kocherginsky, M, Minor, A, Shen, SS, Sirintrapun, SJ, Yao, JL, Alvarado-Cabrero, I, Antic, T, Eggener, SE, Picken, MM & Paner, GP 2018, , Virchows Archiv, vol. 473, no. 1, pp. 85-93.

Renal collision tumor composed of oncocytoma and mucinous tubular and spindle cell carcinoma: case report of an unprecedented entity
Arora, K, Miller, R, Mullick, S, Shen, S, Ayala, AG & Ro, JY 2018, , Human Pathology, vol. 71, pp. 60-64.

Diagnostic histochemistry in medical diseases of the kidney
Cathro, HP, Shen, S & Truong, L 2018, , Seminars in Diagnostic Pathology, vol. 35, no. 6, pp. 360-369.