Steven Shen, MD, PhD

Professor of Pathology and Genomic Medicine, Institute for Academic Medicine
Full Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Dr. Shen is a general surgical pathologist with subspecialty interest in genitourinary pathology. After completing his residency training in Anatomical and Clinical Pathology and fellowship training in Surgical Pathology, Dr. Shen became an assistant professor at Baylor College of Medicine (2002-2003) before joining the Department of Pathology and Genomic Medicine at Houston Methodist Hospital in 2004. In 2005 he joined the Weill Medical College faculty and is a Full Member of the Research Institute.

Dr. Shen is a general surgical pathologist with strong subspecialty expertise in genitourinary cancers. He is currently the Medical Director of the Immunohistochemistry Lab and Associate Director of Surgical Pathology at the Houston Methodist Hospital. He is co-editor of three books and has authored nearly 100 peer reviewed articles, primarily in the areas of diagnostic pathology and genitourinary tumors.

Description of Research

Dr. Shen’s research involves identifying morphologic and molecular abnormalities of neoplasm and correlating these with diagnosis, prognosis, and in some instances, future treatment. He is involved in independent and collaborative studies using conventional histomorphologic techniques, immunohistochemical methods, tissue microarray, and new molecular methods to study cancers of the kidney, urinary bladder, and prostate.

Areas Of Expertise

Cancer Metastasis
Education & Training

Clinical Fellowship, The University of Texas MD Anderson Cancer Center
Residency, Penn State Milton S. Hershey Medical Center
MS, Tongji University
MD, Tongji Medical College, Huazhong University of Science and Technology
Research Fellowship, National Institutes of Health
PhD, The University of Texas Houston Health Science Center
Postdoctoral Fellowship, The University of Texas-Houston Health Science Center
Postdoctoral Fellowship

Predominantly cystic clear cell renal cell carcinoma and multilocular cystic renal neoplasm of low malignant potential form a low-grade spectrum
Tretiakova, M, Mehta, V, Kocherginsky, M, Minor, A, Shen, SS, Sirintrapun, SJ, Yao, JL, Alvarado-Cabrero, I, Antic, T, Eggener, SE, Picken, MM & Paner, GP 2018, Virchows Archiv, pp. 1-9. DOI: 10.1007/s00428-018-2371-8

Prostatic adenocarcinoma in the setting of persistent müllerian duct syndrome: a case report
McCroskey, Z, Koen, TM, Lim, DJ, Divatia, MK, Shen, SS, Ayala, AG & Ro, JY 2018, Human Pathology, vol 75, pp. 125-131. DOI: 10.1016/j.humpath.2017.10.033

Prostatic Adenocarcinoma in the Setting of Persistent Müllerian Duct Syndrome: A Case Report
McCroskey, Z, Koen, TM, Lim, DJ, Divatia, MK, Shen, SS, Ayala, AG & Ro, JY 2017, Human pathology. DOI: 10.1016/j.humpath.2017.10.033

Renal collision tumor composed of oncocytoma and mucinous tubular and spindle cell carcinoma: case report of an unprecedented entity
Arora, K, Miller, R, Mullick, S, Shen, S, Ayala, AG & Ro, JY 2018, Human Pathology, vol 71, pp. 60-64. DOI: 10.1016/j.humpath.2017.08.012

Sarcoid-like granulomas in renal cell carcinoma: The Houston Methodist Hospital experience
Arora, K, Divatia, MK, Truong, L, Shen, SS, Ayala, AG & Ro, JY 2017, Annals of Diagnostic Pathology, vol 31, pp. 62-65. DOI: 10.1016/j.anndiagpath.2017.07.003

A new approach of splint-less orthognathic surgery using a personalized orthognathic surgical guide system: A preliminary study
Li, B, Shen, S, Jiang, W, Li, J, Jiang, T, Xia, JJ, Shen, SG & Wang, X 2017, International Journal of Oral and Maxillofacial Surgery, vol 46, no. 10, pp. 1298-1305. DOI: 10.1016/j.ijom.2017.03.025

Practical applications of immunohistochemistry in the diagnosis of genitourinary tumors
Xiao, X, Hu, R, Deng, FM, Shen, SS, Yang, XJ & Wu, CL 2017, Archives of Pathology and Laboratory Medicine, vol 141, no. 9, pp. 1181-1194. DOI: 10.5858/arpa.2016-0530-RA

Transurethral biopsy of the prostatic urethra is associated with final apical margin status at radical cystoprostatectomy
von Rundstedt, FC, Mata, DA, Shen, S, Li, Y, Godoy, G & Lerner, SP 2016, Journal of Clinical Urology, vol 9, no. 6, pp. 404-408. DOI: 10.1177/2051415815617876

Diagnostic Pathology: Genitourinary
Shen, S (ed.) 2016, . Amirsys.

Neoadjuvant dasatinib for muscle-invasive bladder cancer with tissue analysis of biologic activity
Hahn, NM, Knudsen, BS, Daneshmand, S, Koch, MO, Bihrle, R, Foster, RS, Gardner, TA, Cheng, L, Liu, Z, Breen, T, Fleming, MT, Lance, R, Corless, CL, Alva, AS, Shen, SS, Huang, F, Gertych, A, Gallick, GE, Mallick, J, Ryan, C, Galsky, MD, Lerner, SP, Posadas, EM & Sonpavde, G 2016, Urologic Oncology: Seminars and Original Investigations, vol 34, no. 1. DOI: 10.1016/j.urolonc.2015.08.005

Diagnosis of "poorly formed glands" Gleason pattern 4 prostatic adenocarcinoma on needle biopsy: An interobserver reproducibility study among urologic pathologists with recommendations
Zhou, M, Li, J, Cheng, L, Egevad, L, Deng, FM, Kunju, LP, Magi-Galluzzi, C, Melamed, J, Mehra, R, Mendrinos, S, Osunkoya, AO, Paner, G, Shen, SS, Tsuzuki, T, Trpkov, K, Tian, W, Yang, X & Shah, RB 2015, American Journal of Surgical Pathology, vol 39, no. 10, pp. 1331-1339.

Diagnosis of gleason pattern 5 prostate adenocarcinoma on core needle biopsy: An interobserver reproducibility study among urologic pathologists
Shah, RB, Li, J, Cheng, L, Egevad, L, Deng, FM, Fine, SW, Kunju, LP, Melamed, J, Mehra, R, Osunkoya, AO, Paner, GP, Shen, SS, Tsuzuki, T, Trpkov, K, Tian, W, Yang, XJ & Zhou, M 2015, American Journal of Surgical Pathology, vol 39, no. 9, pp. 1242-1249.

Collagenous micronodules in prostate cancer revisited: Are they solely associated with Gleason pattern 3 adenocarcinomas?
Kim, MJ, Divatia, MK, Lee, JH, Shen, S, Miles, BJ, Hwang, JH, Ayala, AG & Ro, JY 2015, International Journal of Clinical and Experimental Pathology, vol 8, no. 4, pp. 3469-3476.

Usefulness of Transurethral Biopsy for Staging the Prostatic Urethra before Radical Cystectomy
von Rundstedt, FC, Lerner, SP, Godoy, G, Amiel, G, Wheeler, TM, Truong, LD & Shen, SS 2015, Journal of Urology, vol 193, no. 1, pp. 58-63. DOI: 10.1016/j.juro.2014.07.114

Principles of analytic validation of immunohistochemical assays: Guideline from the College of American Pathologists Pathology and Laboratory Quality Center
Patrick, LF, Linda, AB, Lisa, AF, Alsabeh, R, Regan, SF, Jeffrey, DG, Thomas, SH, Karabakhtsian, RG, Patti, AL, Marolt, MJ, Steven, SS, Anthony, TS & Swanson, PE 2014, Archives of Pathology and Laboratory Medicine, vol 138, no. 11, pp. 1432-1443. DOI: 10.5858/arpa.2013-0610-CP

Seminal vesicle intraepithelial involvement by prostate cancer: putative mechanism and clinicopathological significance
Miyai, K, Kristiansen, A, Egevad, L, Pina-Oviedo, S, Divatia, MK, Shen, SS, Miles, BJ, Ayala, AG, Park, YW & Ro, JY 2014, Human Pathology. DOI: 10.1016/j.humpath.2014.05.004

Influence of histologic criteria and confounding factors in staging equivocal cases for microscopic perivesical tissue invasion (pT3a): An interobserver study among genitourinary pathologists
Ananthanarayanan, V, Pan, Y, Tretiakova, M, Amin, MB, Cheng, L, Epstein, JI, Grignon, DJ, Hansel, DE, Jimenez, RE, McKenney, JK, Montironi, R, Oliva, E, Osunkoya, AO, Rao, P, Reuter, VE, Ro, JY, Shen, SS, Srigley, JR, Tsuzuki, T, Yao, JL, Antic, T, Haber, M, Taxy, JB & Paner, GP 2014, American Journal of Surgical Pathology, vol 38, no. 2, pp. 167-175. DOI: 10.1097/PAS.0000000000000096

Intraoperative frozen section evaluation of ureteral and urethral margins: studies of 203 consecutive radical cystoprostatectomy for men with bladder urothelial carcinoma
Zhou, H, Ro, JY, Truong, LD, Ayala, AG & Shen, SS 2014, American Journal of Clinical and Experimental Urology, vol 2, no. 2, pp. 156-60.

Les tumeurs rénales: Recommandations de la conférence de consensus de I'International Society of Urologic Pathology (ISUP) 2012
Rioux-Leclercq, N, Ferran, A, Mahul, A, Argani, P, Billis, A, Bonsib, S, Cheng, L, Cheville, J, Eble, J, Egevad, L, Epstein, J, Grignon, D, Hes, O, Humphrey, P, Magi-Galluzzi, C, Martignoni, G, McKenney, J, Merino, M, Moch, H, Montironi, R, Netto, G, Reuter, V, Samaratunga, H, Shen, S, Srigley, J, Tamboli, P, Tan, PH, Tickoo, S, Trpkov, K, Zhou, M, Delahunt, B & Comperat, E 2014, Annales de Pathologie, vol 34, no. 6, pp. 448-461. DOI: 10.1016/j.annpat.2014.10.003

Intraductal carcinoma of the prostate: Interobserver reproducibility survey of 39 urologic pathologists
Iczkowski, KA, Egevad, L, Ma, J, Harding-Jackson, N, Algaba, F, Billis, A, Camparo, P, Cheng, L, Clouston, D, Comperat, EM, Datta, MW, Evans, AG, Griffiths, DF, Guo, CC, Hailemariam, S, Huang, W, Humphrey, PA, Jiang, Z, Kahane, H, Kristiansen, G, La Rosa, FG, Lopez-Beltran, A, MacLennan, GT, Magi-Galluzzi, C, Merrimen, J, Montironi, R, Osunkoya, AO, Picken, MM, Rao, N, Shah, RB, Shanks, JH, Shen, SS, Tawfik, OW, True, LD, Van Der Kwast, T, Varma, M, Wheeler, TM, Zynger, DL, Sahr, N & Bostwick, DG 2014, Annals of Diagnostic Pathology, vol 18, no. 6, pp. 333-342. DOI: 10.1016/j.anndiagpath.2014.08.010