Steven Shen, MD, PhD

Professor of Pathology and Genomic Medicine, Academic Institute
Full Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Dr. Shen is a general surgical pathologist with subspecialty interest in genitourinary pathology. After completing his residency training in Anatomical and Clinical Pathology and fellowship training in Surgical Pathology, Dr. Shen became an assistant professor at Baylor College of Medicine (2002-2003) before joining the Department of Pathology and Genomic Medicine at Houston Methodist Hospital in 2004. In 2005 he joined the Weill Medical College faculty and is a Full Member of the Research Institute.

Dr. Shen is a general surgical pathologist with strong subspecialty expertise in genitourinary cancers. He is currently the Medical Director of the Immunohistochemistry Lab and Associate Director of Surgical Pathology at the Houston Methodist Hospital. He is co-editor of three books and has authored nearly 100 peer reviewed articles, primarily in the areas of diagnostic pathology and genitourinary tumors.

Description of Research

Dr. Shen’s research involves identifying morphologic and molecular abnormalities of neoplasm and correlating these with diagnosis, prognosis, and in some instances, future treatment. He is involved in independent and collaborative studies using conventional histomorphologic techniques, immunohistochemical methods, tissue microarray, and new molecular methods to study cancers of the kidney, urinary bladder, and prostate.

Areas Of Expertise

Cancer Metastasis
Education & Training

Clinical Fellowship, The University of Texas MD Anderson Cancer Center
Residency, Penn State Milton S. Hershey Medical Center
MS, Tongji University
MD, Tongji Medical College, Huazhong University of Science and Technology
Research Fellowship, National Institutes of Health
PhD, University of Texas Health Science Center at Houston
Postdoctoral Fellowship, University of Texas Health Science Center at Houston

Pleomorphic giant cell carcinoma of prostate: Rare tumor with unique clinicopathological, immunohistochemical, and molecular features
El-Zaatari, ZM, Thomas, JS, Divatia, MK, Shen, SS, Ayala, AG, Monroig-Bosque, P, Shehabeldin, A & Ro, JY 2021, , Annals of Diagnostic Pathology, vol. 52, 151719.

Pathogenesis and diagnosis of genitourinary cancer
Guo, CC, Shen, SS & Ro, JY 2021, , Cancers, vol. 13, no. 2, 347, pp. 1-3.

Seminal vesicle invasion combined with extraprostatic extension is associated with higher frequency of biochemical recurrence and lymph node metastasis than seminal vesicle invasion alone: Proposal for further pT3 prostate cancer subclassification
Rehman, A, El-Zaatari, ZM, Han, SH, Shen, SS, Ayala, AG, Miles, B, Divatia, MK, Ketcham, MS, Chung, BM, Rogers, JT & Ro, JY 2020, , Annals of Diagnostic Pathology, vol. 49, 151611.

A T2-Weighty Discovery: Aortitis on Cardiac MRI with Histopathologic Correlation
Al-Sabeq, B, Shen, S, Hinojosa, JJ & Nabi, F 2020, , Methodist DeBakey cardiovascular journal, vol. 16, no. 1, pp. 65-67.

Controversial issues in Gleason and International Society of Urological Pathology (ISUP) prostate cancer grading: proposed recommendations for international implementation
Srigley, JR, Delahunt, B, Samaratunga, H, Billis, A, Cheng, L, Clouston, D, Evans, A, Furusato, B, Kench, J, Leite, K, MacLennan, G, Moch, H, Pan, CC, Rioux-Leclercq, N, Ro, J, Shanks, J, Shen, S, Tsuzuki, T, Varma, M, Wheeler, T, Yaxley, J & Egevad, L 2019, , Pathology, vol. 51, no. 5, pp. 463-473.

Lightning striking twice: Redo mitral valve replacement due to recurrent cardiac sarcoma using partial autotransplantation technique
Al-Sabeq, B, Shen, SS, Reardon, M & Nabi, F 2019, , Journal of Thoracic and Cardiovascular Surgery, vol. 158, no. 1, pp. e1-e4.

Histologic diagnosis of renal mass biopsy
Shen, SS & Ro, JY 2019, , Archives of Pathology and Laboratory Medicine, vol. 143, no. 6, pp. 705-710.

KLF4, A Gene Regulating Prostate Stem Cell Homeostasis, Is a Barrier to Malignant Progression and Predictor of Good Prognosis in Prostate Cancer
Xiong, X, Schober, M, Tassone, E, Khodadadi-Jamayran, A, Sastre-Perona, A, Zhou, H, Tsirigos, A, Shen, S, Chang, M, Melamed, J, Ossowski, L & Wilson, EL 2018, , Cell Reports, vol. 25, no. 11, pp. 3006-3020.e7.

Predominantly cystic clear cell renal cell carcinoma and multilocular cystic renal neoplasm of low malignant potential form a low-grade spectrum
Tretiakova, M, Mehta, V, Kocherginsky, M, Minor, A, Shen, SS, Sirintrapun, SJ, Yao, JL, Alvarado-Cabrero, I, Antic, T, Eggener, SE, Picken, MM & Paner, GP 2018, , Virchows Archiv, vol. 473, no. 1, pp. 85-93.

Renal collision tumor composed of oncocytoma and mucinous tubular and spindle cell carcinoma: case report of an unprecedented entity
Arora, K, Miller, R, Mullick, S, Shen, S, Ayala, AG & Ro, JY 2018, , Human Pathology, vol. 71, pp. 60-64.

Diagnostic histochemistry in medical diseases of the kidney
Cathro, HP, Shen, S & Truong, L 2018, , Seminars in Diagnostic Pathology, vol. 35, no. 6, pp. 360-369.

Sarcoid-like granulomas in renal cell carcinoma: The Houston Methodist Hospital experience
Arora, K, Divatia, MK, Truong, L, Shen, S, Ayala, A & Ro, J 2017, , Annals of Diagnostic Pathology, vol. 31, pp. 62-65.

Prostatic adenocarcinoma in the setting of persistent müllerian duct syndrome: a case report
McCroskey, Z, Koen, TM, Lim, DJ, Divatia, MK, Shen, SS, Ayala, AG & Ro, JY 2018, , Human Pathology, vol. 75, pp. 125-131.

A new approach of splint-less orthognathic surgery using a personalized orthognathic surgical guide system: A preliminary study
Li, B, Shen, S, Jiang, W, Li, J, Jiang, T, Xia, JJ, Shen, SG & Wang, X 2017, , International Journal of Oral and Maxillofacial Surgery, vol. 46, no. 10, pp. 1298-1305.

Practical applications of immunohistochemistry in the diagnosis of genitourinary tumors
Xiao, X, Hu, R, Deng, FM, Shen, SS, Yang, XJ & Wu, CL 2017, , Archives of Pathology and Laboratory Medicine, vol. 141, no. 9, pp. 1181-1194.

Editorial concerning "impact of the level of urothelial carcinoma involvement of the prostate on survival after radical cystectomy"
Shen, S & Lerner, SP 2017, , Bladder Cancer, vol. 3, no. 3, pp. 171-172.

Transurethral biopsy of the prostatic urethra is associated with final apical margin status at radical cystoprostatectomy
von Rundstedt, FC, Mata, DA, Shen, S, Li, Y, Godoy, G & Lerner, SP 2016, , Journal of Clinical Urology, vol. 9, no. 6, pp. 404-408.

Diagnostic Pathology: Genitourinary
Shen, S (ed.) 2016, . Amirsys.

Neoadjuvant dasatinib for muscle-invasive bladder cancer with tissue analysis of biologic activity
Hahn, NM, Knudsen, BS, Daneshmand, S, Koch, MO, Bihrle, R, Foster, RS, Gardner, TA, Cheng, L, Liu, Z, Breen, T, Fleming, MT, Lance, R, Corless, CL, Alva, AS, Shen, S, Huang, F, Gertych, A, Gallick, GE, Mallick, J, Ryan, C, Galsky, MD, Lerner, SP, Posadas, EM & Sonpavde, G 2016, , Urologic Oncology: Seminars and Original Investigations, vol. 34, no. 1, pp. 4.e11-4.e17.

Diagnosis of "poorly formed glands" Gleason pattern 4 prostatic adenocarcinoma on needle biopsy: An interobserver reproducibility study among urologic pathologists with recommendations
Zhou, M, Li, J, Cheng, L, Egevad, L, Deng, FM, Kunju, LP, Magi-Galluzzi, C, Melamed, J, Mehra, R, Mendrinos, S, Osunkoya, AO, Paner, G, Shen, SS, Tsuzuki, T, Trpkov, K, Tian, W, Yang, X & Shah, RB 2015, , American Journal of Surgical Pathology, vol. 39, no. 10, pp. 1331-1339.