Steven Shen VIEW CLINICAL PROFILE

Steven Shen, MD, PhD

Professor of Pathology and Genomic Medicine, Academic Institute
Houston Methodist
Weill Cornell Medical College


VIEW CLINICAL PROFILE
Biography

Dr. Shen is a general surgical pathologist with subspecialty interest in genitourinary pathology. After completing his residency training in Anatomical and Clinical Pathology and fellowship training in Surgical Pathology, Dr. Shen became an assistant professor at Baylor College of Medicine (2002-2003) before joining the Department of Pathology and Genomic Medicine at Houston Methodist Hospital in 2004. In 2005 he joined the Weill Medical College faculty and is a Full Member of the Research Institute.

Dr. Shen is a general surgical pathologist with strong subspecialty expertise in genitourinary cancers. He is currently the Medical Director of the Immunohistochemistry Lab and Associate Director of Surgical Pathology at the Houston Methodist Hospital. He is co-editor of three books and has authored nearly 100 peer reviewed articles, primarily in the areas of diagnostic pathology and genitourinary tumors.

Description of Research

Dr. Shen’s research involves identifying morphologic and molecular abnormalities of neoplasm and correlating these with diagnosis, prognosis, and in some instances, future treatment. He is involved in independent and collaborative studies using conventional histomorphologic techniques, immunohistochemical methods, tissue microarray, and new molecular methods to study cancers of the kidney, urinary bladder, and prostate.

Areas Of Expertise

Cancer Metastasis
Education & Training

Residency, Penn State Milton S. Hershey Medical Center
MS, Tongji University
MD, Tongji Medical College, Huazhong University of Science and Technology
Research Fellowship, National Institutes of Health
PhD, University of Texas Health Science Center at Houston
Postdoctoral Fellowship, University of Texas Health Science Center at Houston
Clinical Fellowship, University of Texas MD Anderson Cancer Center
Publications

Recent Advances in Genitourinary Tumors Updates From the 5th Edition of the World Health Organization Blue Book Series
Riddle, N, Parkash, V, Guo, CC, Shen, SS, Perincheri, S, Ramirez, AS, Auerbach, A, Belchis, D & Humphrey, PA 2024, , Archives of Pathology and Laboratory Medicine, vol. 148, no. 8, pp. 952-964. https://doi.org/10.5858/arpa.2022-0509-RA

International Society of Urological Pathology (ISUP) Consensus Conference on Current Issues in Bladder Cancer. Working Group 1: Comparison of Bladder Cancer Grading System Performance
Downes, MR, Hartmann, A, Shen, S, Tsuzuki, T, Van Rhijn, BWG, Bubendorf, L, Van Der Kwast, TH & Cheng, L 2024, , American Journal of Surgical Pathology, vol. 48, no. 1, pp. E1-E10. https://doi.org/10.1097/PAS.0000000000002059

International Society of Urological Pathology (ISUP) Consensus Conference on Current Issues in Bladder Cancer. Working Group 2: Grading of Mixed Grade, Invasive Urothelial Carcinoma Including Histologic Subtypes and Divergent Differentiations, and Non-Urothelial Carcinomas
Paner, GP, Kamat, A, Netto, GJ, Samaratunga, H, Varma, M, Bubendorf, L, Van Der Kwast, TH, Cheng, L, Adeniran, A, Al-Ahimadie, H, Algaba, F, Bhattarai, YAS, Black, P, Berman, D, Bertz, S, Bubendorf, L, Carlsen, B, Carvalho, R, Chijioke, O, Cho, YM, Comperat, E, Di Cunha, I, Dagher, J, De Cunha, I, Delahunt, B, Downes, M, Flaig, T, Fleischmann, A, Florescu, C, Fontugne, J, Genitsch, V, Gløersen, GH, Von Gunten, M, Grobholz, R, Hansel, D, Hartmann, A, Hernandez, LH, Hogland, M, Huang, J, Jensen, B, Iczkowski, K, Jimenez, R, Jovanovic, B, Kamat, A, Koellermann, J, Levin, T, Liedberg, F, Lopez-Beltran, A, Loya, AC, Lyngra, M, McHale, T, Mokeddem, K, Netto, G, Nourieh, M, ORourke, D, Ostahi, IA, Paner, G, Picken, MM, Pineda, FG, Raspollini, CRM, Reis, H, Ruoyu, S, Samaratunga, H, Semba, R, Shah, N, Shen, S, Smith, S, Smith, T, Srigley, J, Suzigan, S, Swarbrick, N, Szalay, I, Talleraas, I, Tille, JC, Toma, M, Trias, I, Tsuzuki, T, Van Der Kwast, T, Van Rhijn, B, Varma, M, Verbeke, S, Verma, S, Vlajnic, T, Vlatkovic, L, Warren, A, Warrick, J, Williamson, S, Wobker, S, Woods, C, Yang, C & Yoon, G 2024, , American Journal of Surgical Pathology, vol. 48, no. 1, pp. E11-E23. https://doi.org/10.1097/PAS.0000000000002077

International Society of Urological Pathology Consensus Conference on Current Issues in Bladder Cancer. Working Group 4: Molecular Subtypes of Bladder Cancer - Principles of Classification and Emerging Clinical Utility
Warrick, JI, Al-Ahmadie, H, Berman, DM, Black, PC, Flaig, TW, Höglund, M, Bubendorf, L, Van Der Kwast, TH, Cheng, L, Adeniran, A, Al-Ahimadie, H, Algaba, F, Allory, Y, Bhattarai, S, Black, P, Berman, D, Bertz, S, Bubendorf, L, Carlsen, B, Carvalho, R, Cheng, L, Chijioke, O, Cho, YM, Comperat, E, Di Cunha, I, Dagher, J, De Cunha, I, Delahunt, B, Downes, M, Flaig, T, Fleischmann, A, Florescu, C, Fontugne, J, Genitsch, V, Gløersen, GH, Von Gunten, M, Grobholz, R, Hanselarndt Hartmann, D, Hernandez, LH, Hogland, M, Huang, J, Jensen, B, Iczkowski, K, Jimenez, R, Jovanovic, B, Kamat, A, Koellermann, J, Levin, T, Liedberg, F, Lopez-Beltran, A, Loya, AC, Lyngra, M, McHale, T, Mokeddem, K, Netto, G, Nourieh, M, ORourke, D, Ostahi, IA, Paner, G, Picken, MM, Pineda, FG, Raspollini, CRM, Reis, H, Ruoyu, S, Samaratunga, H, Semba, R, Shah, N, Shen, S, Smith, S, Smith, T, Srigley, J, Suzigan, S, Swarbrick, N, Szalay, I, Talleraas, I, Tille, JC, Toma, M, Trias, I, Tsuzuki, T, Van Der Kwast, T, Van Rhijn, B, Varma, M, Verbeke, S, Verma, S, Vlajnic, T, Vlatkovic, L, Warren, A, Warrick, J, Williamson, S, Wobker, S, Woods, C, Yang, C & Yoon, G 2024, , American Journal of Surgical Pathology, vol. 48, no. 1, pp. E32-E42. https://doi.org/10.1097/PAS.0000000000002053

International Opinions on Grading of Urothelial Carcinoma: A Survey Among European Association of Urology and International Society of Urological Pathology Members
Beijert, IJ, Cheng, L, Liedberg, F, Plass, K, Williamson, SR, Gontero, P, Ribal, MJ, Babjuk, M, Black, PC, Kamat, AM, Algaba, F, Berman, DM, Hartmann, A, Masson-Lecomte, A, Rouprêt, M, Lopez-Beltran, A, Samaratunga, H, Shariat, SF, Mostafid, AH, Varma, M, Shen, S, Burger, M, Tsuzuki, T, Palou, J, Compérat, EM, Sylvester, RJ, van der Kwast, TH, van Rhijn, BWG & Downes, MR 2023, , European Urology Open Science, vol. 52, pp. 154-165. https://doi.org/10.1016/j.euros.2023.03.019

Recent Advances in the Classification of Bladder Cancer - Updates from the 5th Edition of the World Health Organization Classification of the Urinary and Male Genital Tumors
Guo, CC, Shen, SS & Czerniak, B 2023, , Bladder Cancer, vol. 9, no. 1, pp. 1-14. https://doi.org/10.3233/BLC-220106

Image-to-image translation of label-free molecular vibrational images for a histopathological review using the UNet+/seg-cGAN model
He, Y, Li, J, Shen, S, Liu, K, WONG, KELVINK, He, T & WONG, STEPHENTC 2022, , Biomedical Optics Express, vol. 13, no. 4, pp. 1924-1938. https://doi.org/10.1364/BOE.445319

Artificial intelligence-augmented, label-free molecular imaging method for tissue identification, cancer diagnosis, and cancer margin detection
Li, J, Liu, J, Wang, Y, He, Y, Liu, K, Raghunathan, R, Shen, SS, He, T, Yu, X, Danforth, R, Zheng, F, Zhao, H & Wong, STC 2021, , Biomedical Optics Express, vol. 12, no. 9, pp. 5559-5582. https://doi.org/10.1364/BOE.428738

Metastatic urothelial carcinoma to the brain, spinal cord and spine: A contemporary multi-institutional clinicopathologic analysis of 24 cases
Ogunbona, OB, Matoso, A, Cheng, L, Shen, S, Powell, SZ & Osunkoya, AO 2021, , Pathology Research and Practice, vol. 224, 153537. https://doi.org/10.1016/j.prp.2021.153537

Pleomorphic giant cell carcinoma of prostate: Rare tumor with unique clinicopathological, immunohistochemical, and molecular features
El-Zaatari, ZM, Thomas, JS, Divatia, MK, Shen, SS, Ayala, AG, Monroig-Bosque, P, Shehabeldin, A & Ro, JY 2021, , Annals of Diagnostic Pathology, vol. 52, 151719. https://doi.org/10.1016/j.anndiagpath.2021.151719

The phylogenetic relationship within SARS-CoV-2s: An expanding basal clade
Shen, S, Zhang, Z & He, F 2021, , Molecular Phylogenetics and Evolution, vol. 157, 107017. https://doi.org/10.1016/j.ympev.2020.107017

Pathogenesis and diagnosis of genitourinary cancer
Guo, CC, Shen, SS & Ro, JY 2021, , Cancers, vol. 13, no. 2, 347, pp. 1-3. https://doi.org/10.3390/cancers13020347

Improving generalization of deep learning models for diagnostic pathology by increasing variability in training data: Experiments on osteosarcoma subtypes
Tang, H, Sun, N & Shen, S 2021, , Journal of Pathology Informatics, vol. 12, no. 1, 30, pp. 30. https://doi.org/10.4103/jpi.jpi_78_20

Urinary Bladder Inflammatory Myofibroblastic Tumor with Mutated TP53 and PPFIBP1-ALK Gene Fusion
Barbieri, AN, Tallman, CT, Satkunasivam, R, Annunziata, J, Thomas, JS, Olsen, RJ, Shen, SS, Thrall, MJ & Schwartz, MR 2021, , AJSP: Reviews and Reports, vol. 26, no. 1, pp. 45-49. https://doi.org/10.1016/j.advms.2022.02.002

Seminal vesicle invasion combined with extraprostatic extension is associated with higher frequency of biochemical recurrence and lymph node metastasis than seminal vesicle invasion alone: Proposal for further pT3 prostate cancer subclassification
Rehman, A, El-Zaatari, ZM, Han, SH, Shen, SS, Ayala, AG, Miles, B, Divatia, MK, Ketcham, MS, Chung, BM, Rogers, JT & Ro, JY 2020, , Annals of Diagnostic Pathology, vol. 49, 151611. https://doi.org/10.1016/j.anndiagpath.2020.151611

Collision Tumor Composed of Renal Oncocytoma and Mucinous Tubular and Spindle Cell Carcinoma: Not a Rare Occurrence
Lin, MS, Jacobi, EM, Mullick, SS, Nguyen, CV, Thomas, JS, Olsen, RJ, Shen, SS, Ayala, AG & Ro, JY 2020, , AJSP: Reviews and Reports, vol. 25, no. 6, pp. 270-275.

A T2-Weighty Discovery: Aortitis on Cardiac MRI with Histopathologic Correlation
Al-Sabeq, B, Shen, S, Hinojosa, JJ & Nabi, F 2020, , Methodist DeBakey cardiovascular journal, vol. 16, no. 1, pp. 65-67. https://doi.org/10.14797/mdcj-16-1-65

Controversial issues in Gleason and International Society of Urological Pathology (ISUP) prostate cancer grading: proposed recommendations for international implementation
Srigley, JR, Delahunt, B, Samaratunga, H, Billis, A, Cheng, L, Clouston, D, Evans, A, Furusato, B, Kench, J, Leite, K, MacLennan, G, Moch, H, Pan, CC, Rioux-Leclercq, N, Ro, J, Shanks, J, Shen, S, Tsuzuki, T, Varma, M, Wheeler, T, Yaxley, J & Egevad, L 2019, , Pathology, vol. 51, no. 5, pp. 463-473. https://doi.org/10.1016/j.pathol.2019.05.001

Lightning striking twice: Redo mitral valve replacement due to recurrent cardiac sarcoma using partial autotransplantation technique
Al-Sabeq, B, Shen, SS, Reardon, M & Nabi, F 2019, , Journal of Thoracic and Cardiovascular Surgery, vol. 158, no. 1, pp. e1-e4. https://doi.org/10.1016/j.jtcvs.2019.01.096

Histologic diagnosis of renal mass biopsy
Shen, SS & Ro, JY 2019, , Archives of Pathology and Laboratory Medicine, vol. 143, no. 6, pp. 705-710. https://doi.org/10.5858/arpa.2018-0272-RA

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