R. Steven Conlan

R. Steven Conlan, PhD

Full Affiliate Member, Research Institute
Houston Methodist


Homeobox regulator Wilms Tumour 1 is displaced by androgen receptor at cis-regulatory elements in the endometrium of PCOS patients
James, DW, Quintela, M, Lucini, L, Alkafri, NK, Healey, GD, Younas, K, Bunkheila, A, Margarit, L, Francis, LW, Gonzalez, D & Conlan, RS 2024, , Frontiers in Endocrinology, vol. 15, 1368494, pp. 1368494. https://doi.org/10.3389/fendo.2024.1368494

Intracellular Fate of Sub-Toxic Concentration of Functionalized Selenium Nanoparticles in Aggressive Prostate Cancer Cells
Bissardon, C, Proux, O, Gazze, SA, Filhol, O, Toubhans, B, Sauzéat, L, Bouchet, S, Lewis, AR, Maffeis, T, Hazemann, JL, Bayat, S, Cloetens, P, Conlan, RS, Charlet, L & Bohic, S 2023, , Nanomaterials, vol. 13, no. 23, 2999. https://doi.org/10.3390/nano13232999

Elucidating Novel Targets for Ovarian Cancer Antibody–Drug Conjugate Development: Integrating In Silico Prediction and Surface Plasmon Resonance to Identify Targets with Enhanced Antibody Internalization Capacity
Onyido, EK, James, D, Garcia-Parra, J, Sinfield, J, Moberg, A, Coombes, Z, Worthington, J, Williams, N, Francis, LW, Conlan, RS & Gonzalez, D 2023, , Antibodies, vol. 12, no. 4, 65. https://doi.org/10.3390/antib12040065

Transcriptomic analysis of stem cells from chorionic villi uncovers the impact of chromosomes 2, 6 and 22 in the clinical manifestations of Down syndrome
Vaiasicca, S, Melone, G, James, DW, Quintela, M, Preziuso, A, Finnell, RH, Conlan, RS, Francis, LW & Corradetti, B 2023, , Stem Cell Research and Therapy, vol. 14, no. 1, 265, pp. 265. https://doi.org/10.1186/s13287-023-03503-4

Selenium nanoparticles modulate histone methylation via lysine methyltransferase activity and S-adenosylhomocysteine depletion
Toubhans, B, Alkafri, N, Quintela, M, James, DW, Bissardon, C, Gazze, S, Knodel, F, Proux, O, Gourlan, AT, Rathert, P, Bohic, S, Gonzalez, D, Francis, LW, Charlet, L & Conlan, RS 2023, , Redox Biology, vol. 61, 102641, pp. 102641. https://doi.org/10.1016/j.redox.2023.102641

Investigating STEAP2 as a potential therapeutic target for the treatment of aggressive prostate cancer
Jones, LA, Conway, GE, Chi, AN, Burnell, S, Jenkins, GJ, Conlan, RS & Doak, SH 2023, , Cellular and Molecular Biology, vol. 69, no. 4, pp. 179-187. https://doi.org/10.14715/cmb/2023.69.4.28

Bromodomain inhibitor i-BET858 triggers a unique transcriptional response coupled to enhanced DNA damage, cell cycle arrest and apoptosis in high-grade ovarian carcinoma cells
Quintela, M, James, DW, Pociute, A, Powell, L, Edwards, K, Coombes, Z, Garcia, J, Garton, N, Das, N, Lutchman-Singh, K, Margarit, L, Beynon, AL, Rioja, I, Prinjha, RK, Harker, NR, Gonzalez, D, Conlan, RS & Francis, LW 2023, , Clinical Epigenetics, vol. 15, no. 1, 63, pp. 63. https://doi.org/10.1186/s13148-023-01477-x

In silico enhancer mining reveals SNS-032 and EHMT2 inhibitors as therapeutic candidates in high-grade serous ovarian cancer
Quintela, M, James, DW, Garcia, J, Edwards, K, Margarit, L, Das, N, Lutchman-Singh, K, Beynon, AL, Rioja, I, Prinjha, RK, Harker, NR, Gonzalez, D, Steven Conlan, R & Francis, LW 2023, , British Journal of Cancer, vol. 129, no. 1, pp. 163-174. https://doi.org/10.1038/s41416-023-02274-2

Dinaciclib as an effective pan-cyclin dependent kinase inhibitor in platinum resistant ovarian cancer
Howard, D, James, D, Garcia-Parra, J, Pan-Castillo, B, Worthington, J, Williams, N, Coombes, Z, Rees, SC, Lutchman-Singh, K, Francis, LW, Rees, P, Margarit, L, Conlan, RS & Gonzalez, D 2022, , Frontiers in Oncology, vol. 12, 1014280, pp. 1014280. https://doi.org/10.3389/fonc.2022.1014280

Studying Activated Fibroblast Phenotypes and Fibrosis-Linked Mechanosensing Using 3D Biomimetic Models
Paradiso, F, Quintela, M, Lenna, S, Serpelloni, S, James, D, Caserta, S, Conlan, S, Francis, L & Taraballi, F 2022, , Macromolecular Bioscience, vol. 22, no. 4, 2100450, pp. e2100450. https://doi.org/10.1002/mabi.202100450

Progesterone metabolism by human and rat hepatic and intestinal tissue
Coombes, Z, Plant, K, Freire, C, Basit, AW, Butler, P, Conlan, RS & Gonzalez, D 2021, , Pharmaceutics, vol. 13, no. 10, 1707. https://doi.org/10.3390/pharmaceutics13101707

Assessment of the immune landscapes of advanced ovarian cancer in an optimized in vivo model
Pisano, S, Lenna, S, Healey, GD, Izardi, F, Meeks, L, Jimenez, YS, Velazquez, OS, Gonzalez, D, Conlan, RS & Corradetti, B 2021, , Clinical and translational medicine, vol. 11, no. 10, pp. e551. https://doi.org/10.1002/ctm2.551

Chronic Urinary Infection in Overactive Bladder Syndrome: A Prospective, Blinded Case Control Study
Khan, Z, Healey, GD, Paravati, R, Berry, N, Rees, E, Margarit, L, Gonzalez, D, Emery, S & Conlan, RS 2021, , Frontiers in cellular and infection microbiology, vol. 11, 752275, pp. 752275. https://doi.org/10.3389/fcimb.2021.752275

Clinical functional genomics
Carpenter, S & Conlan, RS 2021, , Cancers, vol. 13, no. 18, 4627. https://doi.org/10.3390/cancers13184627

Hyaluronic acid-functionalized nanomicelles enhance saha efficacy in 3d endometrial cancer models
Edwards, K, Yao, S, Pisano, S, Feltracco, V, Brusehafer, K, Samanta, S, Oommen, OP, Gazze, SA, Paravati, R, Maddison, H, Li, C, Gonzalez, D, Conlan, RS & Francis, L 2021, , Cancers, vol. 13, no. 16, 4032. https://doi.org/10.3390/cancers13164032

Functional analysis of non-genetic resistance to platinum in epithelial ovarian cancer reveals a role for the mbd3-nurd complex in resistance development
Bauer, TL, Collmar, K, Kaltofen, T, Loeffler, AK, Decker, L, Mueller, J, Pinter, S, Eisler, SA, Mahner, S, Fraungruber, P, Kommoss, S, Staebler, A, Francis, L, Conlan, RS, Zuber, J, Jeschke, U, Trillsch, F & Rathert, P 2021, , Cancers, vol. 13, no. 15, 3801. https://doi.org/10.3390/cancers13153801

Editorial: Exosomes as Therapeutic Systems
Corradetti, B, Gonzalez, D, Mendes Pinto, I & Conlan, RS 2021, , Frontiers in Cell and Developmental Biology, vol. 9, 714743, pp. 714743. https://doi.org/10.3389/fcell.2021.714743

High content, quantitative AFM analysis of the scalable biomechanical properties of extracellular vesicles
Gazze, SA, Thomas, SJ, Garcia-Parra, J, James, DW, Rees, P, Marsh-Durban, V, Corteling, R, Gonzalez, D, Conlan, RS & Francis, LW 2021, , Nanoscale, vol. 13, no. 12, pp. 6129-6141. https://doi.org/10.1039/d0nr09235e

Dinaciclib, a bimodal agent effective against endometrial cancer
Howard, D, James, D, Murphy, K, Garcia-Parra, J, Pan-Castillo, B, Rex, S, Moul, A, Jones, E, Bilbao-Asensio, M, Michue-Seijas, S, Lutchman-Singh, K, Margarit, L, Francis, LW, Rees, P, Gonzalez, D & Conlan, RS 2021, , Cancers, vol. 13, no. 5, 1135, pp. 1-17. https://doi.org/10.3390/cancers13051135

Highly glycosylated MUC1 mediates high affinity L-selectin binding at the human endometrial surface
Francis, LW, Yao, SN, Powell, LC, Griffiths, S, Berquand, A, Piasecki, T, Howe, W, Gazze, AS, Farach-Carson, MC, Constantinou, P, Carson, D, Margarit, L, Gonzalez, D & Conlan, RS 2021, , Journal of Nanobiotechnology, vol. 19, no. 1, 50, pp. 50. https://doi.org/10.1186/s12951-021-00793-9